• Non-NF1-associated PA and PMA may be the result of an oncogenic tandem duplication at 7q34 that results in a KIAA1549-BRAF fusion gene with constitutive BRAF kinase activity and MAPK pathway activation. (aao.org)
  • Gena BRAF (omolog B1 al oncogenei virale a sarcomului murin v-raf) este localizata pe cromozonul 7q34 si codifica proteina numita serin-treoninkinaza (proteina b-Raf), cu actiune in aval de calea de semnalizare a enzimei protein-kinazae mutagen-activată (MAPK). (synevo.ro)
  • In PA the most frequent genetic alteration consists in a duplication of the 7q34 region leading to a KIAA1549-BRAF fusion protein that is constitutively active whereas in GG the BRAFV600E mutation is more frequent. (biomedcentral.com)
  • Cyp11b3 gene is also located at Chromosome 7q34, next to rat CYP11B1 and CYP11B2. (wikipedia.org)
  • When compared to a physical map three regions were found with two of these markers less than 1.5 Mb apart: chromosomes 6p21.3 (the MHC region), 6q14.1 and 7q34. (ox.ac.uk)