• Here, we show that benzo[a]pyrene diol epoxide (BPDE, the active metabolite of cigarette smoke carcinogen benzo[a]pyrene)-induced human bronchial epithelial cell (HBEC) transformation was enhanced by IL-6 in vitro. (psu.edu)
  • Benzo[a]pyrene-7,8-diol-9,10-epoxide (B[a]PDE) is a well-known carcinogen that is associated with skin cancer. (oregonstate.edu)
  • Carcinogenesis , 7 (11), 1865-1870. (ncsu.edu)
  • Carcinogenesis , 7 (10), 1669-1675. (ncsu.edu)
  • Carcinogenesis , 7 (10), 1663-1667. (ncsu.edu)
  • UPF0488 is a protein that in humans is encoded by the C8orf33 (Chromosome 8 Open Reading Frame 33) gene. (wikipedia.org)
  • Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. (wikipedia.org)
  • This (bi)sulfite-derived peroxyl radical then reacts with BP-7,8-diol to form BP-7,8-diol-9,10-epoxides, the ultimate carcinogenic form of benzo[a]pyrene (BP). (nih.gov)
  • In this case control study, we used two assays with mutagens relevant to tobacco exposure (benzo[a]pyrene diol epoxide (BPDE) and bleomycin) to see whether sensitivity to these mutagens could be used as biomarkers for assessing risk of premalignant lesions. (nih.gov)
  • The potent tumorigen and mutagen (+)-7(R),8(S)-dihydroxy-9(S),10(R)- epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene ((+)-anti-BPDE) is a metabolite of benzo[a]pyrene that binds predominantly to the exocyclic amino group of guanine residues in DNA in vivo and in vitro. (psu.edu)
  • Addition of (bi)sulfite to incubations containing BP-7,8-diol and an active peroxidase resulted in significantly increased levels of BP diol-epoxide formation. (nih.gov)
  • In the case of the (+)-anti-BPDE- modified oligonucleotides, the ratio of circular to linear DNA multimers reaches values of 8-9 for circle contour sizes of 99-121 base pairs, while for the (-)-anti-[BP]-N 2 -dG-modified DNA this ratio reaches a maximum value of only ~1 at 154-176 base pairs. (psu.edu)
  • Peroxidase-catalyzed oxidation of (bi)sulfite: reaction of free radical metabolites of (bi)sulfite with (+/-)-7,8-dihydroxy-7, 8-dihydroxy[a]pyrene. (nih.gov)