• It also acts as a cell surface receptor, in particular for laminin, and is involved in several pathogenic processes. (wikipedia.org)
  • Also functions as a cell surface receptor for laminin. (joplink.net)
  • The RPSA gene encodes a multifunctional protein, which is both a ribosomal protein and a high-affinity, non-integrin laminin receptor. (wikipedia.org)
  • RPSA is a ribosomal protein which has acquired the function of laminin receptor during evolution. (wikipedia.org)
  • Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (joplink.net)
  • The RPSA gene encodes a multifunctional protein, which is both a ribosomal protein and a high-affinity, non-integrin laminin receptor. (wikipedia.org)
  • RPSA is a ribosomal protein which has acquired the function of laminin receptor during evolution. (wikipedia.org)
  • RPSA was initially identified as a laminin binding protein. (wikipedia.org)
  • Both recombinant N-domain and C-domain of RPSA bind laminin in vitro, and they bind with similar dissociation constants (300 nM). (wikipedia.org)
  • Both RPSA and laminin belong to the heparin/heparan sulfate interactome. (wikipedia.org)
  • Moreover, the C-domain of RPSA and heparin compete for binding to laminin, which shows that the highly acidic C-domain of RPSA mimicks heparin (and potentially heparan sulfates) for the binding to laminin. (wikipedia.org)
  • RPSA is a potential cellular receptor for several pathogenic Flaviviruses, including the dengue virus (DENV), and Alphaviruses, including the Sindbis virus (SINV). (wikipedia.org)
  • RPSA is also a receptor for small molecules. (wikipedia.org)
  • Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. (wikipedia.org)
  • Mesenchymal stromal cells and macrophages release tolerogenic cytokines and favor anti-apoptotic signaling pathway activation, while the urokinase plasminogen activator receptor (uPAR) system contributes to migration through an extracellular matrix. (bvsalud.org)
  • It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. (nih.gov)
  • Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. (joplink.net)
  • Microbial infection) Acts as a receptor for the pathogenic prion protein. (nih.gov)
  • These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. (wikipedia.org)
  • It has been recently demonstrated that Neisseria meningitidis targets the laminin receptor (37 LRP/67 LR) on the surface of human brain microvascular endothelial cells, and two meningococcal outer membrane proteins, PorA and PilQ, have been identified as bacterial ligands. (nottingham.ac.uk)
  • Moreover, co-expression of 37 LRP and Gal-3 fused to different fluorescent proteins indicated colocalization of these receptors in COS7 cells. (nottingham.ac.uk)
  • Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. (nih.gov)
  • Microbial infection) Acts as a receptor for the Dengue virus. (nih.gov)
  • Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. (nih.gov)
  • monomeric 37 kDa laminin receptor precursor (37 LRP) and mature 67 kDa laminin receptor (67 LR). (nottingham.ac.uk)
  • The relationship between the 67 LR and its precursor 37 LRP is not completely understood, but previous observations have suggested that 37 LRP can undergo homo- and/or hetero- dimerization with Galectin-3 (Gal-3) to form mature 67 LR. (nottingham.ac.uk)