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  • remission
  • In the current study, 58% of patients in remission had 6-TG levels less than 235. (ovid.com)
  • However, serial measurements of 6-MP metabolite levels in 50 patients with active disease showed that increasing 6-TG levels correlated significantly with disease remission in patients followed up longitudinally (P = 0.04). (ovid.com)
  • These data suggest that the target range of 6-TG levels previously described by others did not apply to 58% of the pediatric patients with IBD in remission. (ovid.com)
  • A Cochrane systematic review that included 13 randomized controlled trials, concluded that azathioprine and 6-mercaptopurine are not effective for inducing remission when a person has Crohn's Disease. (wikipedia.org)
  • Leukemia
  • Drugs Hitchings' team worked on included 2,6-diaminopurine (a compound to treat leukemia) and p-chlorophenoxy-2,4-diaminopyrimidine (a folic acid antagonist). (wikipedia.org)
  • patients
  • Chromosomal analysis of peripheral leukocytes in patients being treated with nitrogen mustard, 6-mercaptopurine, and A-649 demonstrated an increase in polyploidy, including cells showing endoreduplication. (aacrjournals.org)
  • PURIXAN offers patients and healthcare professionals a liquid formulation as an alternative to the mercaptopurine tablet. (purixan-us.com)
  • Folic acid might also be counter-productive for patients taking 6-MP and related drugs that inhibit all cell division. (wikipedia.org)
  • derivatives
  • The aim of this study is to investigate the bioactivity of 6-MP derivatives and discover new anti-cancer agents. (eurekaselect.com)
  • Four 6-mercaptopurine (6-MP) derivatives were synthesized and their anti-cancer activities were analyzed. (eurekaselect.com)
  • Among the synthesized derivatives, 6-((naphthalen-2-ylmethyl)thio)-9H-purine (NMSP) which possessing a β-naphthalene, showed better anti-cancer activity than other compounds, with an IC 50 value 6.09µg/mL. (eurekaselect.com)
  • disposition
  • Moreover, given that the deleterious effect of HDMTX on intracellular 6-MP disposition has been shown to be several folds greater in lymphoblasts than in RBC. (springer.com)
  • levels
  • To clarify the pharmacokinetic interactions between these two antimetabolites, we serially measured RBC 6-TGN and MTX polyglutamates (MTXPG) levels following repeated courses of HDMTX (5 g/m² over 24 h) with daily oral 6-MP (25 mg/m²) during interval therapy in 20 children with ALL. (springer.com)
  • RBC MTX polyglutamates accumulation followed Michaelis-Menten kinetics but was not associated with the change in pre-infusion 6-TGN levels which remained stable during the interval period. (springer.com)
  • median ANC 1.4 vs. 1.7 x 10(9)/L, P = 0.02), TPMTIA continued to have lower WBC and ANC levels compared with TPMTHA during all 28 days after HD-MTX [relative difference 9 % (95 % CI 2-17), P = 0.02 and 21 % (95 % CI 6-39), P = 0. (lu.se)