• In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. (harvard.edu)
  • The UPR normally helps secretory cells to resolve issues with 3D shaping of newly synthesized proteins. (gene.com)
  • Protein Phosphatase 2A (PP2A) is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C) subunit and a structural (A) subunit, in association with a third variable regulatory (B) subunit. (ac.be)
  • The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. (nih.gov)
  • The solution structure of the amino-terminal domain of human DNA polymerase epsilon subunit B is homologous to C-domains of AAA+ proteins. (nih.gov)
  • This manuscript reports the fundamental finding that an oligomeric protein kinase, CaMKII, can be phosphorylated by another molecule of the holoenzyme in a manner that does not involve subunit exchange. (elifesciences.org)
  • The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. (thermofisher.com)
  • Actin was used as a control for protein loading (bottom). (figshare.com)
  • By monoclonal antibodies against HIV-1 proteins p17 and p55 was detected protein with molecular weight of 45-55 kDa. (nel.edu)
  • Using monoclonal antibodies against HIV-1 specific protein gp41 was positive signal identified in 30-35% of samples from both cohorts of patients from Kenya and Cambodia and in 75% of samples from American and Slovak patients. (nel.edu)
  • In separate work, my team identified a set of secreted proteins overexpressed in the tumor microenvironment, and developed antibodies to block their cognate receptors for therapeutic gain. (gene.com)
  • Although viewed as a constitutive housekeeping enzyme in the past, PP2A is a highly regulated phosphatase and is emerging as an important regulator of multiple cellular processes involving protein phosphorylation. (ac.be)
  • 1 Reversible protein phosphorylation is an important regulatory mechanism that controls the activities of a myriad of proteins and is thus involved in virtually every major physiological process. (ac.be)
  • But advances in the understanding of protein phosphatases make now clear that these enzymes are precisely regulated and are as important as kinases in the regulation of cellular processes involving protein phosphorylation. (ac.be)
  • 4 While proteins can be phosphorylated on nine amino acids, serine, threonine and tyrosine phosphorylation are by far the most predominant in eukaryotic cells. (ac.be)
  • The alpha isoform is responsible for synaptic plasticity and participates in memory through its phosphorylation of synaptic proteins. (elifesciences.org)
  • Gene expression is tightly regulated with many genes exhibiting cell-specific silencing when their protein product would disrupt normal cellular function. (exeter.ac.uk)
  • SH2 Homology Protein B (SHB) is a cytoplasmic adaptor protein that serves as a link between phosphotyrosine residues on multiple receptor tyrosine kinases and downstream signaling pathways. (rndsystems.com)
  • In the cytoplasmic domain, there is a docking site for the multifunctional adaptor protein MAGI1. (reliatech.de)
  • Recombinant Protein;25UG;FITC-Labeled Human Siglec-3, His Tag (CD3-HF224) is expressed from human 293 cells (HEK293). (fishersci.com)
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • The steady-state concentrations of p53 were significantly higher in cells infected by the E1B 55 kDa null mutant Hr6 or three mutants carrying small insertions in the E1B 55 kDa protein coding sequence than in Ad5-infected cells. (princeton.edu)
  • AbstractSummaryCurrent tools to annotate the predicted effect of genetic variants are heavily biased towards protein-coding sequence. (exeter.ac.uk)
  • It is well established that the human subgroup C adenovirus type 5 (Ad5) E1B 55 kDa protein can regulate the activity and concentration of the cellular tumor suppressor, p53. (princeton.edu)
  • G55-dependent secreted proteins enhanced the proliferative and invasive activities of TP53-deficient LUAD cells and promoted angiogenesis and CD8+ T cell exhaustion in the tumor microenvironment. (jci.org)
  • Extracellular Domain Of The 55Kda Tumor Necrosis Factor Receptor. (lu.se)
  • Molecular, biochemical, and cell biological studies showed that TP53 loss increased the expression of Golgi reassembly and stacking protein 55 kDa (G55), a Golgi stacking protein that maintains Golgi organelle integrity and is part of a GOLGIN45 (G45)-myosin IIA-containing protein complex that activates secretory vesicle biogenesis in the Golgi. (jci.org)
  • Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
  • Although intracellular signal transduction is often portrayed as a protein kinase 'domino effect', the counterbalancing function of phosphatases, and thus the control of phosphatase activity, is equally relevant to proper regulation of cellular function. (ac.be)
  • The dodecameric protein kinase CaMKII is expressed throughout the body. (elifesciences.org)
  • 2 Protein phosphatase 2A (PP2A) is a very abundant - it accounts for as much as 1% of total cellular proteins - ubiquitous and remarkably conserved enzyme. (ac.be)
  • Transthyretin (TTR) is a homo-tetrameric serum protein associated with sporadic and hereditary systemic amyloidosis. (bvsalud.org)
  • Human ESAM is synthesized as a 390 amino acid (aa) protein composed of a 29 aa signal peptide, a 216 aa extracellular region, a putative 26 aa transmembrane segment, and a 119 aa cytoplasmic domain. (reliatech.de)
  • PD-1 is a 50-55 kDa type I transmembrane protein with a single IgV domain in the extracellular region. (biomedcentral.com)
  • I joined the department of Molecular Biology as Scientist in 1989, and my lab helped establish a technology to fuse biologically important proteins to antibody molecules. (gene.com)
  • Description Western Blot analysis of Rat Brain Membrane showing detection of ~140 kDa Brevican protein using Mouse Anti-Brevican Monoclonal Antibody, Clone S294A-6 (56541). (qedbio.com)
  • A multifunctional protein that is found primarily within membrane-bound organelles. (harvard.edu)
  • Norovirus is a positive sense RNA virus with 7.5 kb nucleotides, encoding a major structural protein VP1 with 50-55kDa. (prospecbio.com)
  • The human PD-1 gene is located on chromosome 2 at band q37, and the full length PD-1 cDNA is 2,106 nucleotides long and encodes a predicted protein of 288 amino acid residues. (biomedcentral.com)
  • It also binds strongly to a protein at ~55 kDa in human lung tissue extracts, which we believe represents a glycosylated form of IL6. (abcam.com)
  • By using MAbs against p24 was found protein of 55-60 kDa in Cambodian and Kenyan samples but, suprisingly, no proteins were detected in bacterial extracts of American and Slovak AIDS patients by this MAbs. (nel.edu)
  • The protein of about 75-85 kDa was detected by MAbs against gp120 only in protein extracts obtained from yeasts Candida sp. (nel.edu)
  • The protein of about 75-85 kDa was detected only in Candida species protein extracts of Cambodian and Kenyan HIV positive children by the MAbs against gp120. (nel.edu)
  • The protein concentration for HTS02 in this assay is approximately 4 mg/ml. (cytoskeleton.com)
  • CD14 functions as a high-affinity receptor for complexes of lipopolysaccharide (LPS) and serum LPS-binding protein and modulates LPS-dependent signal transduction during the immune response to gram-negative pathogens by acting as a co-receptor for TLR 4 and MD-2. (stemcell.com)
  • Immunogen Fusion protein corresponding to aa 219-655 of rat Brevican (accession no. (qedbio.com)
  • Florigen, a protein encoded by FLOWERING LOCUS T (FT), was initially identified as a molecule that promotes flowering and has since been shown to regulate flowering and other developmental phenomena such as tuber formation in potato (Solanum tuberosum). (bvsalud.org)
  • Detection of protein homolougs with HIV-1 antigens in bacteria of positive patients - phase II. (nel.edu)
  • Hainova K, Adamcikova Z, Ciernikova S, Stevurkova V, Krčméry V, Zajac V. Detection of protein homolougs with HIV-1 antigens in bacteria of positive patients - phase II. (nel.edu)
  • Brevican is secreted from astrocytes and neurons as a145kDa core protein that bears up to three covalently-linked CS chains. (qedbio.com)
  • It is also is secreted as a 145kDa core protein without CS chains. (qedbio.com)
  • Interacts with hcv core protein. (lu.se)
  • However, the contribution(s) of these functions of the E1B protein to viral reproduction remains unclear. (princeton.edu)
  • Together with another viral protein, E4orf6, E1B-55 kDa joins an E3 ubiquitin ligase complex and marks p53 for proteasomal degradation. (uni-goettingen.de)
  • Rather, the localization of p53 to E1B containing nuclear sites observed during infection by Ad5 was prevented by mutations that impair interaction of the E1B protein with p53 and/or with the E4 Orf6 protein. (princeton.edu)
  • Protein quantitation was performed using the Pr ecision Red Protein Assay Reagent (Cat. (cytoskeleton.com)
  • An ASSAY UNIT is defined as the amount of HTS02 protein needed to achieve a tubulin polymerization signal of OD340 of 0.1 - 0.15 in 30 minutes at 37°C in G-PEM buffer. (cytoskeleton.com)
  • FT functions as a component of the florigen activation complex (FAC) with a 14-3-3 scaffold protein and FD, a bZIP transcription factor that activates downstream gene expression. (bvsalud.org)
  • Recently, we isolated a novel negative regulator of epidermal growth factor receptor (EGFR), termed EGFR-related protein (ERRP), whose expression attenuates EGFR activation. (aacrjournals.org)
  • Total GAD67 protein expression in the rat cerebellum under treatment conditions. (figshare.com)
  • Variants outside of these regions may have a large impact on protein expression and/or structure and can lead to disease, but this effect can be challenging to predict. (exeter.ac.uk)
  • A neuron-specific in expression RNA-BINDING PROTEIN, involved in neurological disorders and cancer. (bvsalud.org)
  • It functions as a high affinity receptor for the complex of LipoPolySaccharide (LPS) and the LPS-Binding Protein (LBP). (beckman.com)
  • This protein is secreted and is primarily found in bone marrow. (thermofisher.com)
  • In the past, most of the attention was focused primarily on protein kinases and on their regulation, mainly because phosphatases were then viewed as simple housekeeping enzymes. (ac.be)
  • These molecules abrogate the in vitro interaction between the 14-3-3 protein and the OsFD1 peptide, a rice (Oryza sativa) FD, by directly binding to the 14-3-3 protein. (bvsalud.org)
  • These results indicate that the E1B protein fulfills an early function that correlates efficient entry into the late phase with the localization of E1B and p53 in the nucleus of Ad5-infected normal human cells. (princeton.edu)
  • Recombinant full length protein corresponding to Human IL-6. (abcam.com)
  • The mouse SHB ortholog shares 94% aa sequence identity with the human protein. (rndsystems.com)
  • The antimicrobial protein BPI (Bactericidal Permeability Increasing protein) is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. (biovendor.com)
  • Comprised of both empirical and derived data, BMRB has applications in the study of biomacromolecular structure and dynamics, biomolecular interactions, drug discovery, intrinsically disordered proteins, natural products, biomarkers, and metabolomics. (bvsalud.org)
  • More recently, we've turned our attention to an intracellular signaling network dubbed the unfolded protein response (UPR). (gene.com)
  • Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airway disease. (biovendor.com)
  • Although 14-3-3 is an important component of FAC, little is known about the function of the 14-3-3 protein itself. (bvsalud.org)
  • In samples of Cambodian and Kenyan HIV positive children was found 35 kDa protein using MAb against HIV-specific protein p17. (nel.edu)
  • Surprisingly, such proteins were not found in bacterial extract from samples of American and Slovak patients by using the MAbs against HIV-specific protein p24. (nel.edu)
  • In Slovak and American samples, protein reacting with MAbs anti gp120 was not found. (nel.edu)