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  • single-nucleotide po
  • The α-galactosidase gene (GLA) has three single-nucleotide polymorphisms in the 5untranslated region of exon 1, respectively g.1150G>A, g.1168G>A, g.1170C>T. The g.1150A allele is associated with increased plasma α-galactosidase (α-Gal) activity in hemizygotes, while the others are regarded as biologically neutral. (ovid.com)
  • An experiment was conducted to study the association between the single nucleotide polymorphisms (SNPs) in 5′-untranslated regions (5′-UTR) of equine chorionic gonadotropin ( eCG ) genes and the serum eCG levels. (ajas.info)
  • 5'UTR
  • In addition to 5-fluorouracil treatment, the vegf 5'UTR-expressing tumors did not respond to IFN alpha therapy at all. (omicsdi.org)
  • Keywords: genetic modification Overall design: We established HCT116 clones stably expressing vegf 5'UTR (vegf 5'-G5) and vegf 5'UTR mutated between nt 591 and nt 746 (vegf 5' mut-D5) and implanted into the left and the right flanks of the identical mouse, respectively. (omicsdi.org)
  • Amplification, sequencing and phylogenetic analysis of the 5'UTR and VP1 regions was undertaken to determine the HEV serotype associated with the outbreak as well as other cases of aseptic meningitis in the area in the preceding 6 weeks. (biomedcentral.com)
  • Nucleotide sequence analysis of the 5'UTR and VP1 regions identified 2 lineages of CVA9 co-circulating during the outbreak, although the VP1 capsid protein sequence was identical as all nucleotide differences were synonymous. (biomedcentral.com)
  • Reverse transcription PCR (RT-PCR) diagnostic methodologies target the most conserved region of the HEV genome, 5untranslated region (5'UTR), while typing for the investigation of outbreak and clinical disease associations usually targets the VP1 gene. (biomedcentral.com)
  • intron
  • Such neutral processes could account for some of the observed patterns of intron presence [ 5 ], but do not rule out the possibility that adaptive processes are simultaneously contributing to the maintenance of some introns. (biomedcentral.com)
  • Transfection
  • While constructing a plasmid vector for transfection of trypanosome cells, we serendipitously discovered that in vivo expression of dsRNA of the α-tubulin mRNA 5untranslated region (5′ UTR) led to multinucleated cells with striking morphological alterations and a specific block of cytokinesis. (pnas.org)
  • Transfection of synthetic α-tubulin 5′ UTR dsRNA, but not of either strand individually, caused the same phenotype. (pnas.org)
  • For each transfection, 10 8 procyclic T. brucei rhodesiense cells, strain Ytat1.1, were washed four times in Cytomix (120 mM KCl/0.15 mM CaCl 2 /10 mM K 2 HPO 4 /25 mM Hepes (pH 7.6)/2 mM EDTA/5 mM MgCl 2 ) and resuspended in 0.5 ml of Cytomix. (pnas.org)
  • sequences
  • It has been well documented that the 5' untranslated region (5' UTR) of many positive-stranded RNA viruses contain key cis-acting regulatory sequences, as well as high-order structural elements. (nih.gov)
  • In order to investigate the evolutionary diversity and molecular epidemiology in EV-C species, the 5' UTR and VP1 regions were analyzed in 16 clinical isolates from a single public-health laboratory (serving New South Wales, Australia), representing seven types (serotypes/genotypes) in EV-C. Sequences were compared with the 5' UTR and VP1 regions of 183 strains available in GenBank, representing the same seven types. (medcraveonline.com)
  • As these genes can move and insert themselves in to different regions, they can sometimes enhance, reduce, or totally stop the expression of coding sequences based on where they get inserted. (news-medical.net)
  • 5'-UTR as the name suggests, are sequences which are not translated, and they lie adjacent to the coding regions in mRNA. (news-medical.net)
  • variants
  • We investigated 5' UTR mRNA variants of the mouse Gli1 oncogene, which is the terminal transcriptional effector of the Hedgehog (HH) signaling pathway. (biomedcentral.com)
  • In addition to identifying novel transcription start sites, we demonstrated that the expression ratio of the Gli1 splice variants in the 5' UTR is regulated by the genotype of the mouse strain analyzed. (biomedcentral.com)
  • mRNA translation
  • The study shows that the upstream AUG in 5′-UTR of CRHR1 mRNA inhibits receptor expression by inhibiting mRNA translation and suggests the short open reading frame in the 5′-UTR plays a role in regulating translation of the CRH receptor. (aspetjournals.org)
  • upstream
  • The deleted region contains a 13-base sequence named upstream box (bases 123 to 135), which is highly conserved in cspA , cspB , cspG , and cspI , and is located 11 bases upstream of the Shine-Dalgarno (SD) sequence. (asm.org)
  • However, it should be mentioned that the cspA promoter contains an AT-rich upstream element ( 25 ) immediately upstream of the −35 region, which is considered to play an important role in efficient transcription initiation at low temperature ( 8 , 11 , 21 ). (asm.org)
  • analysis
  • Translation of the mouse MOR gene is controlled by 5′UTR-deletion analysis. (nih.gov)
  • After removing contaminated DNA by DNaseI treatment, 10 micro grams each of RNA of vegf 5'-G5-derived tumor from 3 individual mice was mixed and prepared for microarray analysis as sample RNA. (omicsdi.org)
  • Microarray analysis was then performed: briefly, 1 µg of sample RNA (vegf 5'-G5) and reference RNA (vegf 5' mut-D5) were converted to cDNA with oligo dT conjugated T7 promoter primer and reverse transcriptase. (omicsdi.org)
  • Northern blot analysis indicated that the enhanced expression of 5′,3′-UTR-deleted gEpo might be related with the transcription efficiency. (kribb.re.kr)
  • promotes
  • Gallie DR (2002) The 5′-leader of tobacco mosaic virus promotes translation through enhanced recruitment of eIF4F. (springer.com)
  • It stimulates the growth of the dominant follicle [ 5 , 6 ] and promotes the increase of circulating progesterone concentrations in the subsequently estrus cycle [ 6 , 7 ]. (ajas.info)
  • vitro
  • The short open reading frame (ORF) present in the 5′ UTR of rat ODC mRNA does not contribute to the observed inhibitory effect on translation efficiency in vitro . (biochemj.org)
  • At low polyamine concentration the efficiency of translation in vitro of intact ODC mRNA is not relatively increased compared with that of an ODC mRNA having a truncated 5′ UTR or with that of control globin mRNA. (biochemj.org)
  • cells
  • Previously, the 5'-untranslated region (UTR) of the mouse MOR was found to be important for post-transcriptional regulation of the MOR gene in neuronal cells. (nih.gov)
  • To identify potential regulators of the mouse MOR gene, we performed affinity column chromatography using 5'-UTR-specific RNA oligonucleotides using neuroblastoma NS20Y cells. (nih.gov)
  • Dansako T, Kato K, Satoh J, Sekine M, Yoshida K, Shinmyo A (2003) 5untranslated region of the HSP18.2 gene contributes to efficient translation in plant cells. (springer.com)
  • The effect of the 5′-and 3′-untranslated regions (UTR) of human erythropoietin gene (gEpo) on its expression in mammalian cells was investigated. (kribb.re.kr)
  • 5′-UTR-deleted, 3′-UTR-deleted, and 5′,3′-UTR-deleted gEpos were transfected into COS-7 cells, and the amount of transiently expressed Epo was measured. (kribb.re.kr)
  • Cells transfected with the 5′,3′-UTR-deleted gEpo showed the highest expression, 2.6 times that with wild-type gEpo. (kribb.re.kr)
  • Ligands on the surface of parasitized red cells can bind to a number of endothelial cell receptors, including CD36 ( 1 ), intercellular adhesion molecule-1 ( 2 ), thrombospondin ( 3 ), chondroitin-4-sulfate ( 4 ), vascular cell adhesion molecule-1 ( 5 ), E selectin ( 5 ), and platelet/endothelial cell adhesion molecule-1 ( 6 ). (pnas.org)
  • sequence
  • Agalarov SC, Sogorin EA, Shirokikh NE, Spirin AS (2011) Insight into the structural organization of the omega leader of TMV RNA: the role of various regions of the sequence in the formation of a compact structure of the omega RNA. (springer.com)
  • and 4) when extensive base-pairs in the stem region was deleted, an alternative N-SL2-like structure with different sequence was utilized for virus replication. (nih.gov)
  • pathway
  • The remethylation pathway comprises 2 intersecting biochemical pathways and results in the transfer of a methyl group (CH 3 ) to homocysteine from methylcobalamin, which receives its methyl group from S-adenosylmethionine (SAM), from 5-methyltetrahydrofolate (an active form of folic acid), or from betaine (trimethylglycine). (medscape.com)
  • This pathway is dependent on adequate intake of vitamin B-6 and the hepatic conversion of vitamin B-6 into its active form, pyridoxal-5'-phosphate (P5P). (medscape.com)
  • expression
  • The 5′-UTR of the cspA mRNA has a negative effect on its expression at 37°C but has a positive effect upon cold shock. (asm.org)
  • In this report, a series of cspA-lacZ fusions having a 26- to 32-base deletion in the 5′-UTR were constructed to examine the roles of specific regions within the 5′-UTR in cspA expression. (asm.org)
  • The 5′UTR of the GS 1 gene when placed in front of a reporter gene ( uidA ), showed a 20-fold increase in the level of GUS expression in agroinfiltrated leaves when compared to the same gene construct without the 5′UTR. (springer.com)
  • We report the presence of a homology in the 5'untranslated region UTR of the messenger RNA encoding C9orf72 with the iron responsive elements IRE that control expression of iron-associated transcripts and predict that this RNA structure may iron-dependently regulate C9orf72 translation. (duhnnae.com)
  • Translation
  • Our data suggest that vimentin functions as a repressor of MOR translation, dependent on 175-150 of the MOR 5'-UTR. (nih.gov)
  • Our results show that the intact 5′ UTR of rat ODC mRNA, which is 303 nt in length, is a potent inhibitor of translation. (biochemj.org)
  • They can bind to complimentary regions on mRNA and prevent their translation and reduce the stability. (news-medical.net)
  • Recombinant La enhanced the translation of luciferase mRNA containing the N-5′UTR (N-fLuc), and RNA interference of La suppressed N-fLuc translation. (frontiersin.org)
  • These results suggest that La induced predominant translation of N mRNA via binding to its 5′UTR under shutoff conditions. (frontiersin.org)
  • bind
  • The La/SSB autoantigen (La) was found to specifically bind to an N-5′UTR probe. (frontiersin.org)
  • evolutionary
  • the VP1 region correlates well with antigenic typing by neutralization, and can be used for virus identification and evolutionary studies. (medcraveonline.com)
  • Mutation and possible recombination in the two regions play significant roles in the evolutionary diversity of EV-C. (medcraveonline.com)
  • mouse
  • Vimentin interacts with the 5'-untranslated region of mouse mu opioid receptor (MOR) and is required for post-transcriptional regulation. (nih.gov)
  • A ) Schematic representation of the mouse MOR 5′-UTR. (nih.gov)