4-Nitroquinoline 1-oxide (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound used in the assessment of the efficacy of diets, drugs, and procedures in the prevention and treatment of cancer in animal models. (wikipedia.org)
Mice4
To study the role of GPR68 in oral dysplasia, wild-type and GPR68 −/− mice were treated with 4-Nitroquinoline N-oxide (4NQO) in drinking water for 11-13 weeks, followed by normal water for 11-12 weeks. (mcmaster.ca)
4NQO treatment resulted in 45 percent of GPR68 −/− mice developing severe dysplasia or squamous cell carcinoma compared to only 10.5 percent of GPR68 +/+ mice. (mcmaster.ca)
4-Nitroquinoline N-oxide (4NQO) induced OSCC mice were used for verifying the effect of CMTM6 downregulation on M2 macrophage infiltration and tumor growth. (engreen.com.cn)
In addition, in 4NQO-induced OSCC mice, CMTM6 level was positively associated with CD163, CD206 and PD-L1 as well as M2-like macrophage infiltration. (engreen.com.cn)
Chemical2
4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic and mutagenic chemical. (wikipedia.org)
Quinolines, like 4NQO, possess a heterocyclic aromatic structure and the same basic chemical formula of C9H7N. (wikipedia.org)
Drug1
Yrr1 confers 4NQO resistance to wild-type S. cerevisiae yeast, binding upstream from core genes well-known to regulation drug response. (wikipedia.org)
Response to 4NQO2
Yeast species have been used to map polymorphic regions in response to 4NQO, identifying the polymorphic transcription factor Yrr1. (wikipedia.org)
F) DNA-PK2/2 (MO59J) cells do not present RPA2 hyperphosphorylation in response to 4NQO treatment method in comparison to a matched DNA-PK+/+ (MO59K) mobile line. (lckinhibitor.com)
Oral squamous2
Our previous reports have shown that two thirds of 4-nitroquinoline-1-oxide (4NQO)-induced murine oral squamous cell carcinomas (SCC) have Hras1 mutations. (jax.org)
Using a 4NQO-induced oral squamous cell carcinoma (OSCC) model with abundant and absent tenascin-C, we demonstrated that tenascin-C enforced an immune-suppressive lymphoid stroma via CCL21/CCR7 signaling, leading to increased metastatic tumors. (cnrs.fr)
Squamous2
11. Esophageal Squamous cancer from 4NQO-Induced Mice Model: CNV Alterations. (nih.gov)
Metformin (250 or 500 ppm in diet) failed to decrease the incidence or invasiveness of squamous cell cancer of the tongue in a 4-nitroquinoline-1-(4NQO)-induced model. (umn.edu)
Lesions2
4NQO induces DNA lesions usually corrected by nucleotide excision repair. (wikipedia.org)
PCNA in palate and tongue mucosal dysplastic lesions induced by topically applied 4NQO in desalivated rat. (nih.gov)
Rats1
Here, we used a model in which tumors were induced in rats using 4-nitroquinoline 1-oxide (4NQO), which mimicked tobacco-related HNSCC, and analyzed the expression profiles of microRNAs and mRNAs. (figshare.com)
Tumor1
Although amplification of 11q13 occurs rather frequently in human tumors, 4NQO-induced oral cavity tumors in inbred mice are the first example of a murine tumor with consistent amplification. (jax.org)
Model3
DNA damage by 4NQO is a potent model. (wikipedia.org)
To elucidate their role in immune cell recruitment during oral cancer development, we generated a mouse tongue cancer model using the carcinogen 4-nitroquinoline 1-oxide (4NQO) and investigated the carcinogenetic process and chemokine/cytokine gene expression kinetics in the mouse tongue. (immpact-international.org)
To investigate the involvement of ROS in the induced pro-genotoxic activity, parallel experimental sets were set up by considering co-treatment of cells with the model mutagen 4NQO and the antioxidant, glutathione precursor N-acetyl-L-cysteine. (unipg.it)
Cells6
In response to damage from 4NQO, cells attempt to repair and initiate a transcriptional response to detoxify the cell from 4NQO and its metabolites. (wikipedia.org)
Previously, the extent of DNA repair (autoradiographic detection of unscheduled ³HTdR incorporation) in hamster and human cells following exposure to strongly, weakly and non-oncogenic isomers and derivatives of 4-nitroquinoline 1-oxide (4NQO) was examined. (ubc.ca)
Finally, we analyzed chromosomes from cells treated with UV, HU, 4NQO, or CPT by pulsed subject gel electrophoresis. (lckinhibitor.com)
DSBs had been markedly seen in cells dealt with with UV, HU, 4NQO, or CPT with 2.six, 1.seven, nine.9, and 3.6 fold more DSBs than the mock taken care of sample (Fig. S1), which had been the similar confirmed a increased frequency of cells expressing the RPA2 S4A S8A mutant coming into mitosis by counting cells positively stained with phosphohistone H3. (lckinhibitor.com)
Constantly, cells expressing the RPA2 S4A, S8A mutant grew to become slightly more sensitive to the DNA harming agent 4NQO,presumably due to the high degree of cell demise resulting in cells expressing this mutant protein that subsequently entered mitosis with DNA problems (Fig. 4D). (lckinhibitor.com)
High glucose concentrations caused a significant increase in the levels of primary DNA damage, with a pro-genotoxic condition closely related to the concentration of glucose in the culture medium when cells were exposed to 4NQO. (unipg.it)
Treatment1
4-Nitroquinoline 1-oxide (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound used in the assessment of the efficacy of diets, drugs, and procedures in the prevention and treatment of cancer in animal models. (wikipedia.org)
Shown2
4NQO has been shown to trap topoisomerase I cleavage complexes. (wikipedia.org)
In a recent study in yeast, 4NQO was shown to affect chromatin remodelling, cell division and DNA damage repair pathways. (wikipedia.org)
Damage1
Increased cell susceptibility to genotoxic xenobiotics was tested by challenging cell cultures with 4-nitroquinoline-N-oxide (4NQO) and evaluating the extent of primary DNA damage by comet assay. (unipg.it)