4 induces. Medical search. Frequent questions

Blood induced widespread microglial transcriptional changes, including changes involving oxidative stress and neurodegenerative genes. (nature.com)
To discover the molecular programs controlling microglial and macrophage polarization by blood proteins, we developed an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline consisting of deep sequencing of blood-induced transcriptomes, functional single-cell and oxidative stress transcriptomics, global phosphoproteomics and integration with innate immune signatures from AD and MS models (Extended Data Fig. 1 ). (nature.com)
Therefore, H 2 S pathway may be involved in Pb-induced hypertension and treatment with NaHS exerts antihypertensive effect, promotes non-NO-mediated relaxation, and decreases oxidative stress in rats with Pb-induced hypertension. (hindawi.com)
The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. (degruyter.com)
Zinc Reduces Copper Toxicity Induced Oxidative Stress By Promoting Antioxidant Defense in Freshly Grown Aquatic Duckweed Spirodela Polyrhiza L." Journal of Hazardous Materials, vol. 175, no. 1-3, 2010, pp. 1081-4. (unboundmedicine.com)

Diminution of p53 by RNA interference induced necrosis instead of apoptosis in A549 cells following terpinen-4-ol treatment, indicating that terpinen-4-ol-elicited apoptosis is p53-dependent. (hindawi.com)
A549 xenografts by inducing apoptosis, as confirmed by TUNEL assay. (hindawi.com)
Collectively, these data provide insight into the molecular mechanisms underlying terpinen-4-ol-induced apoptosis in NSCLC cells, rendering this compound a potential anticancer drug for NSCLC. (hindawi.com)
Recent reports have indicated that terpinen-4-ol exerts its antitumor effects by triggering caspase-dependent apoptosis in human melanoma cells or by inducing necrotic cell death and cell-cycle arrest in mouse mesothelioma and melanoma cell lines without affecting normal cells [ 14 , 15 ]. (hindawi.com)
Our results indicated that terpinen-4-ol induced apoptosis through a mitochondria-mediated pathway in NSCLC cells and that the apoptosis elicited by terpinen-4-ol was p53 dependent. (hindawi.com)
Moreover, knocking down BDNF partially reversed esketamine-mediated activation of the mBDNF/TrkB/PI3K signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. (degruyter.com)
Apoptosis and cytotoxicity were dose-dependent, with exposure to 10 microM 1,4-BQ resulting in approximately 60% cytotoxicity relative to untreated controls. (rti.org)
Overexpression of miR-128-3p or knockdown of TGFBR2 ameliorated LPS-induced inflammation and apoptosis. (degruyter.com)
Moreover, TGFBR2 was a direct target of miR-128-3p, and its overexpression reversed the inhibitory effects of miR-128-3p overexpression on inflammation and apoptosis in LPS-induced HK2 cells. (degruyter.com)
miR-128-3p could inhibit apoptosis and inflammation by targeting TGFBR2 in LPS-induced HK2 cells, which might provide therapeutic strategy for the treatment of sepsis. (degruyter.com)
New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
Although purvalanol-induced cell cycle arrest and apoptotic cell death were demonstrated in prostate ( 5 ), breast ( 6 ) and colon cancer cells ( 7 ), the exact molecular mechanism of purvanol-induced apoptosis has not been elucidated yet. (spandidos-publications.com)

Specifically, cyclosporine induces endoplasmic reticulum stress and increases mitochondrial reactive oxygen species production: this modifies the redox balance, which causes lipid peroxidation and thereby induces nephrotoxicity. (medscape.com)

Here, we established an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline to define the transcriptome and global phosphoproteome of blood-induced innate immune polarization and its role in microglia neurotoxicity. (nature.com)
As an intravenous anesthetic, propofol has been indicated to induce neurotoxicity in both animal and human brains. (degruyter.com)
It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of propofol. (degruyter.com)
However, its effect on propofol-induced neurotoxicity and the underlying mechanism remain unclear. (degruyter.com)
Therefore, a better understanding of the mechanism underlying propofol-induced neurotoxicity is favorable for eliminating the side effects of propofol. (degruyter.com)
"(+/-)3,4-Methylenedioxymethamphetamine (`Ecstasy')-Induced Serotonin Neurotoxicity: Studies in Animals" Neuropsychobiology . (erowid.org)
MDMA-induced 5-HT neurotoxicity can be demonstrated using a variety of neurochemical, neuroanatomical and, more recently, functional measures of 5-HT neurons. (erowid.org)

The present study tested whether TRVP4 also contributes to neuropathic pain, using a rat model of Taxol-induced painful peripheral neuropathy. (jneurosci.org)
Here we report a case of acute isoniazid-induced peripheral neuropathy with predominant motor functional impairment associated with tetraplegia. (who.int)

Increased sub-G1 population and annexin-V binding, activation of caspases 9 and 3, cleavage of poly(ADPribose) polymerase (PARP), and a decrease of mitochondrial membrane potential (MMP) indicated involvement of the mitochondrial apoptotic pathway in terpinen-4-ol-treated A549 and CL1-0 cells. (hindawi.com)
Purvalanol induced mitochondrial membrane potential loss, caspase-7 and caspase-3 activation and PARP cleavage following a 48 h treatment. (spandidos-publications.com)

Overall, esketamine mitigates propofol-induced cognitive dysfunction and brain injury in rats by activating mBDNF/TrkB/PI3K signaling. (degruyter.com)
Each of these PNN-associated changes is reversed following a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) at a dose that induces sustained diabetes remission in male ZDF rats. (nature.com)
This study is carried out on Wistar rats to evaluate the hepatoprotective activity of Argemone mexicana L aerial part extracts against CCL_4 induced acute liver damages. (airitilibrary.com)

Sildenafil, given shortly before 3,4-methylenedioxymethamphetamine (MDMA), affords protection against 5-hydroxytryptamine (5-HT) depletions caused by this amphetamine derivative by an acute preconditioning-like mechanism. (erowid.org)
Our findings indicate that sildenafil afforded significant protection against MDMA-induced 5-HT deficits without altering the acute hyperthermic response to MDMA or its metabolic disposition. (erowid.org)
An acute and potentially life-threatening complication associated with the recreational use of the 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is hyperthermia. (aspetjournals.org)
Cyclosporine and tacrolimus cause acute kidney injury (AKI) by inducing afferent and efferent arteriolar vasoconstriction. (medscape.com)

As disorders in which stress or fear play major roles present an increasing need for psychiatric care around the world, this volume summarizes current research to determine whether a specific group of stress-induced and fear-based disorders form a distinct syndrome independent from other anxiety disorders such as obsessive-compulsive disorder or generalized anxiety. (appi.org)
Intended to suggest DSM-V revisions regarding the classification of these disorders, Stress-Induced and Fear Circuitry Disorders reflects findings that may lead to more refined treatments for these specific anxiety disorders based on a better understanding of the biological and environmental factors that contribute to their development and symptoms. (appi.org)
Given the importance of changes to DSM for professional education and public health, this book offers important new ways of thinking about stress-induced and fear-based disorders. (appi.org)
Stress-Induced And Fear Circuity Anxiety Disorders: Are They A Distinct Group? (appi.org)

The results demonstrated that GJ-4 treatment significantly improved spatial learning and memory abilities of the AD mice challenged by Aβ Mechanistic study indicated that GJ-4 could alleviate endothelial dysfunction, as GJ-4 markedly reduced endothelial cell edema, as well as improved tight junction structures by up-regulating Zonula occludens-1 (ZO-1), Claudin-5 and Occludin expressions. (physiciansweekly.com)

This administration method is associated with very low serum levels of antibody, which decreases the risk of treatment-induced side effects. (aacrjournals.org)

We conclude that thrombin-induced endostatin release from rat platelets is PAR4-mediated via an ADP-independent mechanism that can occur independently of platelet aggregation. (nih.gov)
The aim of the present study was to explore the mechanism of GJ-4 on a Aβ-intoxicated mouse model. (physiciansweekly.com)

Furthermore, treatment of s.c xenografts derived from A549 cells with intratumor injections of terpinen-4-ol significantly inhibited tumor growth compared with the control group. (hindawi.com)

Asbestos Toxicity: How Does Asbestos Induce Pathogenic Changes? (cdc.gov)
Describe the hypothesis behind the mechanisms scientists currently believe leads asbestos to induce pathogenic changes in the lungs. (cdc.gov)

Our results indicated that terpinen-4-ol elicited a dose-dependent cytotoxic effect, as determined by MTT assay. (hindawi.com)
Significant release of endostatin could be induced by a dose of thrombin below that necessary for induction of aggregation. (nih.gov)
By injecting the antibodies in a subcutaneous slow-release delivery formulation in the tumor area, we show that an eight-fold lower dose of antibody is as effective in inducing tumor eradication as systemic delivery. (aacrjournals.org)
Pediatric dose: 4 mg per kg of body weight twice daily. (cdc.gov)

Purvalanol is a purine-derived CDKI that binds with a high selectivity and competitively to the ATP binding side of CDK1/2 and leads to G2/M cell cycle arrest ( 4 ). (spandidos-publications.com)

Bone marrow stem cells are targets for benzene-induced cytotoxicity and DNA damage that could result in changes to the genome of these progenitor cells, thereby leading to hematopoietic disorders and cancers. (rti.org)
Human bone marrow CD34(+) hematopoietic progenitor cells (HPC) were exposed in vitro to 1,4-BQ to assess cytotoxicity, genotoxicity, and DNA damage responses and the molecular mechanisms associated with these events. (rti.org)
In addition, the p21 mRNA level was elevated in 1,4-BQ-treated cells, suggesting that human CD34(+) cells utilize the p53 pathway in response to 1,4-BQ-induced DNA damage. (rti.org)
These results show that human CD34(+) cells are sensitive targets for 1,4-BQ toxicity that use the p53 DNA damage response pathway in response to genotoxic stress. (rti.org)
In conclusion, our present study proved GJ-4 could protect the neurovascular unit (NVU), through attenuating endothelial cell damage, enhancing tight junction function, inhibiting of glial activation and protecting of neurons. (physiciansweekly.com)
Thus, this study demonstrates that zinc reversed the effect of copper, combating against Cu induced oxidative damage and improvement of duckweed's growth and toxicity under natural condition. (unboundmedicine.com)

All these stressors act on hypothalamic and extra hypothalamic areas inducing specific defensive behavior in the many hypothalamic centers such as those controlling reproduction, body temperature, food intake, sleep regulation [4, 15]. (researchgate.net)
This study used a novel behavior apparatus to assess the effect of intranasal lidocaine in a rat model of carrageenan-induced orofacial pain. (healthpartners.com)

Lead- (Pb-) induced hypertension has been shown in humans and experimental animals and cardiovascular effects of hydrogen sulfide (H 2 S) have been reported previously. (hindawi.com)
Objective: To evaluate the effect of activated charcoal on lactulose-induced breath hydrogen flatus passage and abdominal bloating in healthy controls and patients with complaints of excessive gas. (researchgate.net)

In 2015, mortality from alcohol-induced causes reached the highest rate during 1999-2015 of 9.1 deaths per 100,000 U.S. standard population. (cdc.gov)
Overall, from 1999 to 2015, mortality from alcohol-induced causes increased 28% (7.1 to 9.1). (cdc.gov)

Furthermore, GJ-4 treatment inhibited glial activation mediated neuroinflammation through inhibiting high-mobility group box protein 1(HMGB-1)/RAGE/NF-κB signaling pathway, which might confer to the neuroprotection. (physiciansweekly.com)

For the non-Hispanic black population, the alcohol-induced death rate decreased 33% from 1999 to 2015, while the rate increased by 50% during the same period for the non-Hispanic white population. (cdc.gov)

GJ-4 alleviates Aβ-induced memory dysfunction in mice through protecting the neurovascular unit. (physiciansweekly.com)

However, treatment with CTLA-4 blocking antibodies is associated with autoimmune and inflammatory side effects. (aacrjournals.org)
Drug-induced lupus erythematosus is an autoimmune disorder that is triggered by a reaction to a medicine. (medlineplus.gov)
Cancer immunotherapy drugs such as pembrolizumab can also cause a variety of autoimmune reactions including drug-induced lupus. (medlineplus.gov)

Treatment with NaHS in Pb-induced hypertension seems to induce a protective role in rat aorta which is dependent on endothelium and seems to promote non-NO-mediated relaxation. (hindawi.com)
Elevation of the Bax/Bcl-2 ratio and a decrease in IAP family proteins XIAP and survivin were also observed following terpinen-4-ol treatment. (hindawi.com)
A rat model of propofol-induced brain injury was established with or without the treatment of esketamine. (degruyter.com)
However, there were no significant changes in mRNA levels of the DNA repair genes ku80, rad51, xpa, xpc, and ape1 as well as p53 following treatment with 1,4-BQ. (rti.org)
MDMA (40 mg/kg s.c.) induced a significant increase in thyroxine levels 1 h post-treatment. (aspetjournals.org)
The main target and effector cells of the CTLA-4 blockade treatment in the studied tumor models are tumor-specific endogenous CD8 + T cells that are capable of eradicating also distant tumors, whereas CD4 + T cells do not play a prominent role in the antibody-mediated tumor eradication. (aacrjournals.org)
Moreover, GJ-4 markedly reduced receptor for advanced glycation end products (RAGE) expression and increased low-density lipoprotein receptor-related protein-1 (LRP-1) expression, suggesting endothelial transduction and clearance of toxic species capabilities improved by GJ-4 treatment. (physiciansweekly.com)
The results also indicated that GJ-4 significantly decreased IL-6 and IL-1β mRNA expressions, as well as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expressions, implying the inhibition of glial activation and vascular inflammation by GJ-4 treatment. (physiciansweekly.com)
Early outpatient treatment of mild-to-moderate COVID-19 with a recommended first-line therapy , ritonavir-boosted nirmatrelvir (Paxlovid™) or remdesivir (Veklury®), or the second-line therapy, molnupiravir (Lagevrio™) have been shown to prevent hospitalizations and deaths [4-6]. (cdc.gov)

It is necessary to identify any stressed situation induced by loss, family or working problems, weight loss or eating disorders, or physical training or agonist activity. (researchgate.net)

However, no studies examined involvement of H 2 S in Pb-induced hypertension. (hindawi.com)

Comparative functional multiomics showed that blood proteins induce distinct receptor-mediated transcriptional programs in microglia and macrophages, such as redox, type I interferon and lymphocyte recruitment. (nature.com)
We report a blood-induced microglia gene network and show that blood proteins elicit distinct receptor-mediated transcriptional changes and signaling programs in innate immune cells. (nature.com)
In the present study, we have tested the hypothesis that thrombin-induced endostatin release from rat platelets is mediated via proteinase-activated receptor-4 (PAR4). (nih.gov)

Estimated prevalence of noise induced hearing threshold shifts among children 6 to 19 years of age: The third national health and nutritional examination survey. (cdc.gov)

Drug-induced lupus erythematosus is similar but not identical to systemic lupus erythematosus (SLE). (medlineplus.gov)

In conclusion, our data demonstrate that sildenafil produces a significant, long-lasting neuroprotective effect against MDMA-induced 5-HT deficits. (erowid.org)
GJ-4 is crocin enrichments from Gardenia jasminoides J. Ellis, and our previous studies have shown GJ-4 had potent neuroprotective effects on several AD animal models. (physiciansweekly.com)

In this study, the antitumor effects of terpinen-4-ol and the cellular and molecular mechanisms responsible for it were evaluated and studied, respectively on human nonsmall cell lung cancer (NSCLC) cells. (hindawi.com)
Although interindividual variations were evident in the cellular response to 1,4-BQ, there was no gender difference in the response overall. (rti.org)

The level of miR-128-3p was decreased, and TGFBR2 expression was increased in serum samples of sepsis patients and LPS-induced HK2 cells. (degruyter.com)

The HYPO and TX animals were also resistant to the serotonergic neurotoxic effects of MDMA assessed by serotonin measurements 4 to 7 days later in the striatum and hippocampus. (aspetjournals.org)
Prazosin, an α 1 -antagonist (0.2 mg/kg i.p.), administered 30 min before MDMA significantly attenuated the MDMA-induced increase in rectal temperature, but had no effect on skeletal muscle temperature. (aspetjournals.org)
Cyanopindolol, a β 3 -antagonist (4 mg/kg s.c.), administered 30 min before MDMA (40 mg/kg s.c.) significantly attenuated the increase in skeletal muscle temperature, but had no effect on the rise in rectal temperature. (aspetjournals.org)
The combination of prazosin and cyanopindolol resulted in an abolishment of MDMA-induced hyperthermia. (aspetjournals.org)
The mechanisms of thermogenesis induced by MDMA seem to result from an interaction between the hypothalamic-pituitary-thyroid axis and the sympathetic nervous system, wherein mechanisms leading to core and skeletal muscle hyperthermia after MDMA exposure seem to be differentially regulated by α 1 - and β 3 -adrenergic receptors. (aspetjournals.org)

Patients who receive CTLA-4 blocking therapy or combined ICI therapy are more likely to develop colitis than those taking PD1/PD-L1 blockers alone. (medscape.com)

Rarely, kidney inflammation (nephritis) can develop with drug-induced lupus caused by TNF inhibitors or with ANCA vasculitis due to hydralazine or levamisole. (medlineplus.gov)
Other cell-mediated mechanisms (especially inflammation induced by TNF-α). (cdc.gov)

Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. (nature.com)

Lacking proteosomal function on aggregates of unfolded proteins, ER stress may induce autophagic machinery. (spandidos-publications.com)

However, whether esketamine has an effect on propofol-induced brain injury has not been investigated. (degruyter.com)
We use different preclinical mouse models of cancer to investigate the local administration of CTLA-4 blocking antibody and its effect on cancer progression and the antitumor T-cell response. (aacrjournals.org)
Herein, we report the case of a 77-year-old man with dabigatran -induced esophagitis with blue pigmentation , which is known to be a rare adverse effect. (bvsalud.org)

CD34(+) HPC from 10 men and 10 women were exposed to 0, 1, 5, 10, 15, or 20 microM of 1,4-BQ and analyzed 72 h later. (rti.org)

Although these findings demonstrate the anticancer activity of terpinen-4-ol, the underlying molecular mechanisms of the antitumor activity of terpinen-4-ol remain unclear. (hindawi.com)

In the present study, we demonstrate that TRPV4 plays an essential role in Taxol-induced nociceptive behavioral responses to mechanical and hypotonic stimulation of the hind paw. (jneurosci.org)
Blockade of CTLA-4 by antibodies has potentiated antitumor T-cell responses in both preclinical models and clinical trials. (aacrjournals.org)

This type of hearing loss, termed "noise-induced hearing loss," is usually caused by exposure to excessively loud sounds and cannot be medically or surgically corrected. (cdc.gov)
Noise-induced hearing loss can result from a one-time exposure to a very loud sound, blast, or impulse, or from listening to loud sounds over an extended period. (cdc.gov)
Evaluating the effectiveness of earplugs in preventing noise -induced hearing loss in an auto parts factory in China. (cdc.gov)
Systematic review of interventions to prevent occupational noise -induced hearing loss - a follow-up. (cdc.gov)
Analysis of correlation between window duration for kurtosis computation and accuracy of noise -induced hearing loss prediction. (cdc.gov)
Cochrane method for systematic review and meta-analysis of interventions to prevent occupational noise -induced hearing loss - abridged (Revisão sistemática e metanálise Cochrane de intervenções para prevenção de perda auditiva ocupacional induzida por ruído - abreviada). (cdc.gov)

2001 Oct;134(4):701-4. (nih.gov)

HA occurs generally after severe stressed conditions/situations such as dieting, heavy training, or intense emotional events, all situations that can induce amenorrhea with or without body weight loss and HA is a secondary amenorrhea with a diagnosis of exclusion. (researchgate.net)
It is known as functional hypothalamic amenorrhea (FHA), and it is associated with metabolic, physical, or psychological stress (after severe dieting, heavy training, intense emotional events, or a combination of them) [4, 5] with or without body weight loss [6]. (researchgate.net)
Most of the time, drug-induced lupus erythematosus is not as severe as SLE. (medlineplus.gov)

Chapter 4. (appi.org)

Although the pathogenesis of contrast-induced nephropathy (CIN) remains incompletely understood, it is most likely the result of renal vasoconstriction and direct renal tubular epithelial cell toxicity. (medscape.com)

Terpinen-4-ol, a monoterpene component of the essential oils of several aromatic plants, exhibits antitumor effects. (hindawi.com)
Terpinen-4-ol, a naturally occurring monoterpene found in the essential oils of many aromatic plants including Melaleuca alternifolia (tea tree oil), Hajeb Layoun arboreta (Tunisia) and Alpinia zerumbet, has been shown to have antiviral, antibacterial, antifungal, and insecticidal effects as well as antioxidant and anti-inflammatory activities [ 9 - 13 ]. (hindawi.com)
In addition, there is no report on the antitumor effects of terpinen-4-ol against human nonsmall cell lung cancer cells. (hindawi.com)
Therefore, in this study, the anticancer effects of terpinen-4-ol were evaluated on two NSCLC cell lines, namely, A549 and CL1-0 human lung adenocarcinoma cells. (hindawi.com)
This study provided evidence that the beneficial effects of GJ-4 on AD might be owing to its protection on NVU. (physiciansweekly.com)

Herein, we investigated the role of esketamine in propofol-induced brain injury. (degruyter.com)

The higher temperature (130 °C) induced a higher degree of protein cross-links, an increase in the polymer size, and formation of. (lu.se)
The higher temperature (130 °C) induced a higher degree of protein cross-links, an increase in the polymer size, and formation of β-sheets compared to 110 °C. The combination of plasticizers (glycerol and water) favored a micro-structural morphology with improved gelatinization of starch, processability, as well as strength, stiffness, and extensibility of GT-MPS composites. (lu.se)

Anxiety such as this can be induced by substance abuse, especially prolonged binge drinking. (vanillamist.com)

Propofol (2,6-diisopropylphenol) is an intravenous anesthetic widely used in surgery or intensive care units to induce and maintain anesthesia as well as sedation [ 2 ]. (degruyter.com)

Now, new research has revealed syringelike structures produced by bacteria that induce this metamorphosis. (livescience.com)

Injecting CTLA-4 blocking antibody in a slow-release formulation close to the tumor is an effective way of activating the antitumor T-cell response. (aacrjournals.org)

A significant increase in the percentage of micronucleated CD34(+) cells was detected in cultures treated with 1,4-BQ. (rti.org)

Diseases1

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Oxidative stress5

Apoptosis12

Endoplasmic reticulum1

Neurotoxicity7

Peripheral neuropathy2

Mitochondrial2

Rats3

Acute4

Stress-Induced4

Spatial learning a1

Decreases1

Mechanism2

Tumor growth1

Pathogenic2

Dose4

Cell-cycle arrest1

Damage6

Behavior2

Hydrogen2

Mortality2

Pathway1

19991

Dysfunction1

Autoimmune3

Treatment9

Disorders1

Involvement1

Receptor3

Prevalence1

Systemic1

Neuroprotective2

Cellular2

Serum1

MDMA5

Patients1

Inflammation2

Injection1

Proteins1

Effect3

MicroM1

Remain unclear1

Responses2

Noise6

20011

Severe3

Chapter1

Understood1

Effects5

Role1

Temperature2

Anxiety1

Intensive1

Structures1

Antitumor1

Significant1