• Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses presents the proceedings of a IUPHAR Satellite Symposium in conjunction with the eighth International Congress of Pharmacology held in Paris, France on July 27-29, 1981. (elsevier.com)
  • The Effect of 3-, 4-AP and 3,4-DAP on the Evoked Activity of the Pyramidal Cell Layer (CA 1,2) of the Hippocampus. (elsevier.com)
  • 4-AP inhibits basal and FSH-stimulated progesterone production by pig granulosa cells via drug action at multiple interacting steps in the steroidogenic pathway. (biomedcentral.com)
  • The extracellular parameters evaluated in areas CA3 and CAI were: (1) interictal-type bursting, (2) evoked population spike (PS) amplitude, (3) latency to PS onset, and (4) duration of the excitatory postsynaptic potential (EPSP). (deepdyve.com)
  • Similarly, IA and ID antagonist 4-aminopyridine (4AP) has been shown, in in vivo and in vitro studies, to cause hyperexcitability and the development of seizure-like epileptiform discharges [ 15 - 23 ]. (omicsonline.org)
  • The results show that 4-AP induced changes in vitro can help differentiate drugs with similar in vivo spectrums of anticonvulsant activity. (deepdyve.com)
  • Although we could not isolate strain 4AP-Y on several media, PCR-DGGE analysis and microscopy indicated that the unique bi-polar filamentous bacterial cells gradually became more dominant with increasing 4-aminopyridine concentration in the medium. (biomedcentral.com)
  • Leptin inhibited α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA) receptor-mediated synaptic transmission in mouse hippocampal slices but failed to inhibit synaptic responses in slices from leptin receptor-deficient db/db mice. (jci.org)
  • PHT and CBZ partially reversed the increase in EPSP duration produced by 4-AP in area CA3, while the spontaneous bursting was not affected. (deepdyve.com)
  • LOS partially reversed the 4-AP excitation, but abolished bursting in only one of five slices. (deepdyve.com)
  • It also partially reversed the 4-AP induced increase in the EPSP duration without depressing the normal evoked potential. (deepdyve.com)
  • 4-Aminopyridine is a potent convulsant and is used to generate seizures in animal models for the evaluation of antiseizure agents. (wikipedia.org)
  • Due to the fact that no commercial preparation for 4-AP is available in Belgium, the medication must be compounded by the pharmacist upon medical prescription. (hindawi.com)
  • This study aims to determine whether 4-aminopyridine (4AP) can reduce attacks of ataxia in patients with episodic ataxia type 2 (EA2), a rare but often debilitating condition. (clinicaltrials.gov)
  • Inhibition by 4-aminopyridine (4-AP) of K DR of rabbit portal vein (RPV) myocytes was studied by patch clamp and compared with that of channels composed of Kv1.5 and/or Kv1.2 subunits cloned from the RPV and expressed in mammalian cells. (ahajournals.org)
  • DIDS also prevented 4-AP inhibition of progesterone production. (biomedcentral.com)
  • A study has shown that 4-AP is a potent calcium channel activator and can improve synaptic and neuromuscular function by directly acting on the calcium channel beta subunit. (wikipedia.org)
  • 4-AP block of K DR was pulse-frequency dependent, required channel activation, and was associated with a positive shift in voltage dependence of activation. (ahajournals.org)
  • 4-AP caused a voltage-dependent reduction in mean open time of K DR . Relief of 4-AP block of whole cell currents during washout required channel activation and was unaffected by voltage. (ahajournals.org)
  • All Phe-for-heptad-Leu substitutions produce gating changes suggesting variable stabilization of the channel closed state conformation, with L1F, L2F, and L5F exhibiting the strongest correlations between altered gating and increased 4-AP sensitivity. (aspetjournals.org)
  • Changes in the bacterial populations of 4-aminopyridine, 3,4-dihydroxypyridine, or formate/ammonium chloride enrichment cultures were monitored by denaturing gradient gel electrophoresis (DGGE) profiling of PCR-amplified 16S rRNA gene fragments. (biomedcentral.com)
  • 4AP-Z were predominant in 4-aminopyridine and formate/ammonium chloride enrichment cultures and in the 3,4-dihydroxypyridine enrichment culture, respectively. (biomedcentral.com)
  • 4-AP (2 mM) decreased progesterone accumulation in the media of serum-supplemented and serum-free granulosa cultures, but inhibited cell proliferation only under serum-free conditions. (biomedcentral.com)
  • 1 For example, 4-AP was used to indicate the participation of delayed rectifier K + channels (K DR ) in regulating membrane potential, endothelium-dependent relaxation, and myogenic tone development of VSM (eg, Leblanc et al, 2 Knot and Nelson, 3 and Dong et al 4 ). (ahajournals.org)
  • The results indicated that 4-AP is a potent reversal agent for sedation caused by xylazine in goats. (ac.ke)
  • At the present, 4-AP comes from compounding pharmacies in two formulations. (rutgers.edu)
  • 10-12 Previous studies show considerable variability in the state-dependence of 4-AP block, eg, during or after activation (open-state block), closed (resting)-state block, or block after inactivation. (ahajournals.org)
  • if the dose was sub-lethal, the birds will recover after 4 or more hours without long-term ill effect. (wikipedia.org)
  • We report a case of sustained encephalopathy following status epilepticus induced by 4-AP overdose. (hindawi.com)