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  • inhibitor
  • Concanamycin A, an inhibitor of V-type ATPase, had no effect on the rates of acid extrusion. (edu.au)
  • Intrathecal injection of a VDAC1 inhibitor significantly reversed the pain hypersensitivity and reduced the over-expression of Toll-like receptor 4 (TLR4). (readbyqxmd.com)
  • anion
  • Although voltage dependent anion channel 1 (VDAC1) involved in regulating QCT-induced apoptotic cell death has been established, the role of voltage dependent anion channel 2 (VDAC2) in QCT-induced toxicity remains unclear. (readbyqxmd.com)
  • The rate of citrate release from IPG cells was not affected by the concentration of aluminum (0 and 50 µM), soluble P i (0 or 2 mM) and the pH (4.5-5.6) of the medium, suggesting that anion channels would not be regulated by such external conditions. (oup.com)
  • transporter
  • and was later shown to function as a SO 4 = transporter. (rupress.org)
  • The Cl(-)-independent component has the same properties as the NBC-like transporter previously shown to account for most of the acid extrusion near the resting pH(i). (edu.au)
  • This exchange had the same properties as the AE-like transporter previously identified as a major acid loader near resting pH(i). (edu.au)
  • We have functionally characterized Na+-driven bicarbonate transporter (NBC)4, originally cloned from human heart by Pushkin et al. (ox.ac.uk)
  • metabolic
  • Fifteen patients (9 women and 6 men) aged 16 to 36 years (mean±SEM, 28±4 years) with hypokalemic hyponatremic hypochloremic metabolic alkalosis, hyperreninemic hyperaldosteronism, normotension, and no peripheral edema were chosen as the study group. (ahajournals.org)
  • mechanisms
  • 3 Some mechanisms have been proposed to explain this constellation of findings, such as resistance to the pressor action of angiotensin II, 1 primary prostaglandin excess, 4 and a defect in Na + handling. (ahajournals.org)
  • These acid-loading and acid-extruding transport mechanisms together with the Na(+), K(+), ATPase may be sufficient to account not only for pH(i) regulation in brain endothelial cells but also for the net secretion of HCO(-)(3) across the blood-brain barrier. (edu.au)
  • transport
  • Transport activities involved in intracellular pH (pH(i)) recovery after acid or alkali challenge were investigated in cultured rat brain microvascular endothelial cells by monitoring pH(i) using a pH-sensitive dye. (edu.au)
  • After correcting for a 4.4-fold lower apparent Stern-Volmer constant for intravesicular lucigenin, a maximum rate of Cl(-) transport of 31 nmol m(-2) sec(-1) was calculated, in good agreement with values obtained for the plant vacuolar membrane using other techniques. (ox.ac.uk)
  • Expression
  • In this study, we found that the expression of VDAC1 was upregulated in the L2-5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the tibial cavity. (readbyqxmd.com)
  • results
  • Fifteen volunteers (10 women and 5 men, aged 18 to 37 years, mean±SEM, 25±2 years) were enrolled into the control group after the results of routine blood tests had been obtained and determined to be normal. (ahajournals.org)
  • recovery
  • Following an alkali challenge, the major component of the acid loading leading to recovery of pH(i) occurred by Cl(-)/HCO(-)(3) exchange. (edu.au)
  • Intracellular Cl- depletion of arteries did not affect the rate of pHi recovery in PSS from an acid load. (mysciencework.com)
  • small
  • Following relatively small acid loads with pH(i) approximately 6.5, HCO(-)(3) influx accounted for most of the acid extrusion from the cell with both Cl(-)-independent and Cl(-)-dependent, Na(+)-dependent transporters involved. (edu.au)
  • These data suggest that human small arteries maintain pHi by Na+/H+ exchange and Na(+)-dependent HCO3(-) exchange in response to an acid load, and Na(+)-independent Cl-/HCO3(-) exchange to counteract intracellular alkalosis. (mysciencework.com)
  • least
  • Venous blood was sampled in plastic tubes containing heparin (20 to 50 IU/mL) after the patients had fasted for at least 4 hours (from 8 am to 1 pm ) and kept ice-cold for no more than 12 hours. (ahajournals.org)
  • studies
  • In the course of these studies we discovered that the commercially available CAIX antibody from Novus Biologicals, NB-100, recognizes a beta-tubulin by using 2-dimensional gel electrophoresis and mass spectrometry. (ufl.edu)
  • values
  • This observation, as well as the absolute E(rev) values, are consistent with a 2:1 stoichiometry. (ox.ac.uk)
  • levels
  • The kidney biopsies of patients with Bartter's syndrome showed juxtaglomerular hyperplasia, and elevated prostaglandin levels were found in their blood 2 and urine. (ahajournals.org)