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  • PDPK1
  • This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminal of human PDPK1 protein. (novusbio.com)
  • Antibody
  • a and d ) Akt kinase activity was measured in muscle lysates (500 μg) that were subjected to immunoprecipitation with either an antibody that recognizes both Akt1 and Akt2, or an Akt3 antibody. (nih.gov)
  • downstream
  • Online Cover This week features a Research Article that identifies ARAP3 as the downstream effector of phosphoinositide 3-kinase (PI3K) in the regulation of sprouting angiogenesis during development. (sciencemag.org)
  • The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. (nih.gov)
  • Downstream of TLR4, SHP-1 showed increased interaction with several proteins including IL-1R-associated kinase-4, and modulated LPS signaling by inhibiting NF-κB, AP-1, ERK, and JNK activity, while enhancing p38 activity. (jimmunol.org)
  • Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. (uniprot.org)
  • The emergence of resistance has led to a search for downstream targets of Bcr-Abl kinase signaling that may mediate the altered growth properties of Bcr-Abl-transformed cells. (aacrjournals.org)
  • For example, whereas it is clear the PI3K activation is essential for Bcr-Abl-mediated transformation (1) , it is unclear which of the potential downstream effectors, which include BCL2/BCL-X L -associated death promoter (BAD), FOXO1a, nuclear factor κB, glycogen synthase kinase-3β, mTOR, and murine double minute 2 (MDM2), are actually important. (aacrjournals.org)
  • insulin
  • Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. (nih.gov)
  • Insulin also stimulated IRS-2-associated PI 3-kinase activity 2.2-fold in lean subjects, but only 1.4-fold in diabetic subjects. (nih.gov)
  • Thus, insulin activation of Akt isoforms is normal in muscle of obese nondiabetic and obese diabetic subjects, despite decreases of approximately 50% and 39% in IRS-1- and IRS-2-associated PI 3-kinase activity, respectively, in obese diabetic subjects. (nih.gov)
  • 2,3 The metabolic actions of insulin maintain glucose homeostasis by promoting glucose uptake in skeletal muscle and suppressing glucose production in the liver. (ahajournals.org)
  • The insulin-like growth factor pathway, regulated by a complex interplay of growth factors, cognate receptors, and binding proteins, is critically important for many of the hallmarks of cancer such as oncogenesis, cell division, growth, and antineoplastic resistance. (mdpi.com)
  • substrate
  • This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. (nih.gov)
  • Annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • activation
  • NAC induced p53 and reduced p65 protein expression through activation of PPARα. (biomedcentral.com)
  • Intrinsic differences in mTORC2-dependent Akt activation underlie the region-specific effects of neurofibromatosis-1 on glial progenitor cell development. (sciencemag.org)
  • Activation of intracellular NLR by a variety of microbial molecules leads to PF-5274857 inflammasome formation caspase-1 activation and subsequent formation and release of interleukin-1β (IL-1β) thereby creating an intracellular surveillance system for pathogens [3]. (exposed-skin-care.net)
  • Upon activation NALP3 assembles with the adaptor protein ASC to form a protein-complex termed the PF-5274857 NALP3 inflammasome . (exposed-skin-care.net)
  • CCR7 upregulation allows DCs to migrate to local LNs where they encounter T cells ( 3 ), and depending on their activation state, they can induce a variety of immunogenic or tolerogenic responses ( 4 , 5 ). (jimmunol.org)
  • IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. (senescence.info)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • genes
  • We have previously reported PF-5274857 on a patient with a long history of inflammatory disease resulting from excessive IL-1β production who was found to be a heterozygous carrier of two common polymorphisms in genes encoding proteins of the NALP3 inflammasome (Q705K) and (C10X) (Gen Lender: NM 001184900) . (exposed-skin-care.net)
  • kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. (senescence.info)
  • Membrane
  • Membrane fusion proteins cooperate to promote rapid secretory vesicle exocytosis from neuroendocrine cells. (sciencemag.org)
  • 100 μg, ABP-PAB- (100 μg) The ADP-ribosylation factor related protein 1 (ARFRP1) is a membrane-associated GTP-ase and localizes to the plasma membrane. (allelebiotech.com)
  • murine
  • The murine hematopoietic cell line Ba/F3 was cultured in RPMI 1640 supplemented with 10% FCS and 10 ng/ml murine IL-3. (aacrjournals.org)
  • cell
  • CML 3 is a pluripotent stem cell disorder characterized by the presence of the Philadelphia chromosome. (aacrjournals.org)