3 of platelet. Medical search. Frequent questions

Thus, altered or deregulated platelet function underpins many diseases, and platelet proteins are potential targets for novel therapeutic agents. (hindawi.com)

Considering that riluzole enhances BDNF levels in the serum of patients, we investigated if treatment with this drug could stimulate the release of this neurotrophin from human platelets obtained from healthy subjects. (hindawi.com)
The direct action of riluzole evoking BDNF release from human platelets at therapeutic concentrations is important and may contribute to the understanding of its mechanisms of action in the treatment of depression. (hindawi.com)
Here, we describe an experimental approach that fractionates proteins released from human platelets, linking bioassay activity to identity. (hindawi.com)
Moreover, αB-crystallin significantly reduced thrombin-induced Ca 2 influx and phosphoinositide hydrolysis by phospholipase C in human platelets. (bioone.org)

These findings provide insight into the prothrombotic effects of disturbed blood flow parameters and suggest a fundamental reinterpretation of the mechanisms driving platelet aggregation and thrombus growth. (nature.com)

Intensive glucose control with insulin in patients with an acute coronary syndrome reduces platelet reactivity during hospitalization, compared to conventional control. (revespcardiol.org)
However, the effect of strict, long-term glucose control on platelet reactivity in these patients remains uncertain. (revespcardiol.org)
180 mg/dL), on platelet reactivity after hospital discharge in patients with an acute coronary syndrome and hyperglycemia. (revespcardiol.org)
Platelet Activation and Reactivity in a Large Cohort of Patients with Gaucher Disease. (harvard.edu)
The preserved reactivity of IBS-platelets was further confirmed in perfusion studies over adhesive protein-coated surfaces under relevant shear rates, in accordance with previously reported results. (haematologica.org)
We also looked at the reactivity of platelets in their storage milieu and, indeed, found there was already inhibition of platelet aggregation in response to ADP on Day 1.5, and to collagen on Day 6.5, which was, however, similar between the untreated and the IBS-PCs 2 (see Online Supplementary Figure S2B). (haematologica.org)
This comparative effectiveness review evaluated the analytic validity, prognostic value, and comparative effectiveness of two types of medical tests (genetic testing for CYP2C19 variants and phenotypic testing to measure platelet reactivity) to identify patients who are most likely to benefit from clopidogrel-based antiplatelet therapy and to guide antiplatelet therapy in patient populations who are eligible to receive or are already receiving clopidogrel treatment. (ahrq.gov)
use of genetic testing (for CYP2C19 variants) or phenotypic testing (for platelet reactivity). (ahrq.gov)
Studies had to report information on the analytic validity, prognostic ability for intermediate (platelet reactivity) or clinical outcomes, use of tests to guide antiplatelet therapy, or adverse events from testing itself or from test-directed treatment. (ahrq.gov)
Eleven studies provided information for the analytic validity of genotyping assays and 105 for the analytic validity of platelet reactivity assays. (ahrq.gov)
Agreement between assays for measuring platelet reactivity was poor to moderate. (ahrq.gov)
One hundred six studies provided information on the ability of genetic testing for CYP2C19 variants to predict clinical outcomes or platelet reactivity during followup. (ahrq.gov)
One hundred twenty-eight studies provided information on the ability of baseline on-clopidogrel platelet reactivity to predict clinical outcomes or platelet reactivity during followup. (ahrq.gov)

The present study aimed to investigate the effect of lyophilized platelet‑rich fibrin (L‑PRF) on the repair of osteochondral defects in rabbits. (spandidos-publications.com)
Platelet-rich fibrin (PRF), commonly known as a second-generation PC, was shown to have a high capacity to improve wound healing and tissue repair owing to the gradual release of growth factors during its slow degradation along with its intrinsic fibrin scaffolding, which offers a unique three-dimensional (3-D) microstructure for promoting proliferation and differentiation of recruited cells ( 12 , 13 ). (spandidos-publications.com)
The initial hemostatic plug, composed primarily of platelets, is stabilized further by a fibrin mesh generated in secondary hemostasis. (medscape.com)
PRF-Platelet Rich Fibrin Therapy is the Next Generation of PRP-Platelet Rich Plasma Therapy . (newlookskincenter.com)
Can Platelet Rich Fibrin Be Combined with Other Fillers? (newlookskincenter.com)
Thrombin, which is generated at these phosphatidylserine sites, triggers the formation of fibrin fibers, which consolidate the platelet thrombus into a stable clot sealing the breach in a vessel wall ( 2 ). (frontiersin.org)
Platelet-rich plasma (PRP) (also referred to as platelet-rich in growth factors, platelet-rich fibrin matrix, platelet-rich fibrin, fibrin sealant, platelet concentrate) is now being widely used to treat musculoskeletal injuries in sports and draws widespread media attention despite the absence of robust clinical studies to support its use. (bmj.com)
Platelet-rich fibrin is a second-generation platelet concentrate, showing a substantial regenerative property with minimal to no inflammatory reactions upon application in defects [10]. (termedia.pl)
Case reports have shown significant results of adding platelet-rich fibrin to bone grafting procedures for bone regeneration in sinus augmentation, cleft reconstruction, and fistula management [11, 12]. (termedia.pl)

Results of a phase 3 study presented Sunday found efgartigimod allowed a third of patients with immune thrombocytopenia (ITP) to quickly achieve platelet levels that signal an ability to avoid sudden bleeding events. (ajmc.com)
Efgartigimod, already approved as Vyvgart to treat myasthenia gravis, allowed a third of patients with immune thrombocytopenia (ITP) to quickly achieve platelet levels that signal an ability to avoid sudden bleeding events in a randomized clinical trial, with other results showing sustained responses compared with placebo. (ajmc.com)
A lower than normal platelet count is called thrombocytopenia. (medlineplus.gov)
The workup of a patient with a platelet-type bleeding pattern typically includes correlation with platelet count ( thrombocytopenia ), evaluation of platelet morphology on peripheral smear, exclusion of acquired causes of platelet dysfunction, and testing for von Willebrand disease (VWD) . (arupconsult.com)
This study is investigating the safety and efficacy of platelet transfusion as a treatment for infants with thrombocytopenia. (nih.gov)
This study investigates immature platelet counts as a marker for bleeding risk in newborns with thrombocytopenia, compared with platelet counts alone. (nih.gov)
Platelet transfusions may be given for thrombocytopenia or platelet dysfunction to treat active platelet-related bleeding or as prophylaxis in those at serious risk of bleeding. (medscape.com)
In these cases, a type of blood clot called cerebral venous sinus thrombosis (CVST) was seen in combination with low levels of blood platelets (thrombocytopenia). (cdc.gov)
Based on studies conducted among the patients diagnosed with immune thrombotic thrombocytopenia after the AstraZeneca COVID-19 vaccine in Europe, the pathogenesis of these rare and unusual adverse events after vaccination may be associated with platelet-activating antibodies against platelet factor-4 (PF4), a type of protein. (cdc.gov)
150,000 platelets per microliter of blood), consistent with a condition known as thrombotic thrombocytopenia, with platelet nadir counts ranging from 10,000 to 127,000 during their hospitalizations. (cdc.gov)

Figure 2: Platelet aggregation induced shear microgradients occurs independently of ADP, TXA 2 and thrombin. (nature.com)
Following activation by agonists such as thrombin, platelets release storage granules and membrane vesicles that contain prothrombotic (e.g., fibrinogen), mitogenic (e.g., platelet derived growth factor), immunomodulatory (e.g., neutrophil-activating peptide 2), and adhesive (e.g., platelet endothelial cell adhesion molecule) proteins. (hindawi.com)
A previous study from our laboratory using a MuDPIT (multidimensional protein identification technology) approach identified over 300 proteins secreted by platelets upon thrombin activation [ 1 ]. (hindawi.com)
Platelets were activated with ADP, thrombin, or the thrombin receptor agonist peptide SFLLRN (TRAP 1-6 ). (nature.com)
This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
αB-crystallin inhibited platelet aggregation induced by thrombin or botrocetin in hamsters and humans. (bioone.org)
This study provides results of early diminished platelet function in IBS-treated PCs as compared to conventional PCs, i.e., reduced aggregation response to collagen or thrombin and adhesion to collagen or vWF under flow, increased platelet apoptosis, MAPK p38 activation, and glycoprotein Ibα (GPIbα) shedding and enhanced clearance from the circulation of mice. (haematologica.org)
Indeed, we showed that washed IBS-platelets were fully responsive to various agonists including collagen, thrombin, and the so-called weak platelet agonist ADP up to Day 4.5, while a slight decline in responsiveness was observed on Day 6.5, which was, however, exactly the same in washed IBS-platelets as washed untreated platelets, whatever the agonist. (haematologica.org)

It has long been assumed that platelet aggregation and thrombus growth are initiated by soluble agonists generated at sites of vascular injury. (nature.com)
By using high-resolution intravital imaging techniques and hydrodynamic analyses, we show that platelet aggregation is primarily driven by changes in blood flow parameters (rheology), with soluble agonists having a secondary role, stabilizing formed aggregates. (nature.com)
Platelet aggregometry is a standard clinical technique that measures the in vitro aggregability of platelets in response to agonists by using the amount of light transmitted through platelet-rich plasma (PRP) ( Holmsen, 1987 ). (nature.com)
Severe abnormalities in platelet function, such as Bernard-Soulier syndrome, Glanzmann's thrombasthenia, or platelet storage-pool deficiency, are characterized by the inability of platelets to aggregate in response to certain agonists. (nature.com)
After initial sample preparation (preparing PRP and PPP plasma) and loading, systems can perform platelet aggregation testing automatically for five agonists without additional pipetting steps or other dedicated hands-on time. (siemens-healthineers.com)

After tirofiban administration , platelet glycoprotein Ia , Ib, IIb and IIIa mutations did not influence the degree of inhibition of platelet aggregation or intrahospital mortality . (bvsalud.org)

It has been shown that more than 99% of blood BDNF proteins are stored in platelets and that these proteins can be released into the serum [ 6 ] through pharmacological treatment [ 15 , 16 ]. (hindawi.com)
Over 300 proteins were identified in the releasate, with a wide range of annotated biophysical and biochemical properties, in particular platelet activation, adhesion, and wound healing. (hindawi.com)
The presence of PEDF and involucrin, two proteins not previously reported in platelet releasate, was confirmed by western blotting. (hindawi.com)
A number of bleeding disorders arise as a result of mutations in the genes for proteins involved in platelet aggregation. (hindawi.com)
Previous proteomic studies of intact platelets have collectively identified hundreds of proteins using a variety of fractionation strategies including 2-dimensional electrophoresis (2DE), multidimensional chromatographic separations, membrane prefractionation techniques, and adsorption to combinatorial hexapeptide ligand libraries [ 1 - 6 ]. (hindawi.com)
These proteins may modulate the interaction of platelets with their local cellular environment. (hindawi.com)
Platelet activation allows binding of these proteins, which bridges adjacent platelets. (medscape.com)
The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
Plasma is the liquid part of the blood and is composed of water and various proteins, and platelets are specific blood cells that have natural healing qualities that can help repair the body. (newlooknewlife.com)
We describe how these are activated, which are their target proteins, and how their proteolytic activity modulates platelet functions. (frontiersin.org)
This is a test that uses lasers to look for proteins on the surface of platelets. (medlineplus.gov)
High platelet counts can limit how well the von Willebrand proteins clot. (lls.org)

Consequently, different types of platelet concentrates (PCs) should also be regarded as alternative sources of autologous growth factors for cartilage regeneration ( 11 ). (spandidos-publications.com)
There are two types of platelet tests: a platelet count test and platelet function tests. (medlineplus.gov)

1 recently published in Haematologica, evaluating the structural and functional consequences induced by Amotosalen/UVA treatment using the Intercept Blood System (IBS) on platelets from apheresis platelet concentrates (PCs) during storage. (haematologica.org)
Typical dosing for an adult is a pool of 6 whole blood derived (sometimes referred to as random donor) platelets or one apheresis platelet. (medscape.com)

Timeline of MPXV-infected blood donor (red) and platelet recipient (blue), Thailand, 2023. (cdc.gov)

My counts dropped a bunch after 9 months but that was right when I changed my diet and coincided with the platelets climbing back up again. (pdsa.org)
Patients with very high platelet counts may be tested for acquired von Willebrand disease, a blood disorder that can impair normal blood clotting and cause major bleeding. (lls.org)
Certain patients with more serious conditions might not be suitable candidates for PRP, like individuals with cancer, anemia, an infection, or low platelet counts. (sedermatologyspecialists.com)
Platelet counts of >100,000/uL are recommended for ophthalmic and neurosurgery. (medscape.com)
No significant changes occurred in leukocyte or platelet counts. (cdc.gov)

Platelet-rich plasma (PRP), also known as autologous conditioned plasma, is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to remove red blood cells. (wikipedia.org)
How Does Platelet-Rich Plasma (PRP) Reverse Hair Loss? (newlooknewlife.com)
For years, we have known about the positive, healing effects that platelet-rich plasma (PRP) has on various injured parts of the body. (newlooknewlife.com)
What Is Platelet-Rich Plasma (PRP)? (newlooknewlife.com)
Our blood is made up of white blood cells, red blood cells, plasma, and platelets. (newlooknewlife.com)
PRP therapy injects platelet-rich plasma that has been extracted from your body back in your body to stimulate natural healing and growth. (newlooknewlife.com)
Platelet-rich plasma (PRP) has emerged as a new treatment modality in regenerative plastic surgery, and preliminary evidence suggests that it might have a beneficial role in hair regrowth. (nih.gov)
The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)
Although these platelet activation processes are relatively well-studied as a function of the platelet environment, only since recently it is becoming clear that a multitude of proteases present in plasma or produced by platelets themselves are important for the distinct properties of platelet populations, often by cleaving specific receptors. (frontiersin.org)
Is the Pro-Adhesive Activity of Plasma Von Willebrand Factor Counteracted by a Physiological Inhibitor of Platelet Adhesiveness? (portlandpress.com)
1. Abnormal plasma levels of von Willebrand factor are accompanied by abnormal platelet function in some disease states. (portlandpress.com)
A relatively new phenomenon in the treatment of this condition is the use of autologous blood injections (ABI) and platelet-rich plasma injections (PRPI). (humankinetics.com)
Simvastatin is one of nine known statins, specific inhibitors of hepatic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting step of cholesterol biosynthesis, and is believed to reduce plasma cholesterol levels by decreasing the activity of this enzyme. (degruyter.com)
Platelet-rich plasma treatments are a tailored option to treat certain skin conditions in a personal way. (sedermatologyspecialists.com)
How Do Platelet-Rich Plasma Treatments Work? (sedermatologyspecialists.com)
Platelet-rich plasma is the concentrated result of drawing a patient's blood and using a centrifuge machine to separate the blood's plasma and blood platelets from the rest of the blood liquid. (sedermatologyspecialists.com)
Certain aspects of the platelet-rich plasma treatment will change your life for the better. (sedermatologyspecialists.com)
Your dermatologist or doctor can verify whether you're a good candidate for platelet-rich plasma treatments. (sedermatologyspecialists.com)
Schedule an appointment with us today to find out if platelet-rich plasma treatments are the right solution for you! (sedermatologyspecialists.com)
To compare the efficacy of platelet rich plasma (PRP) associated with bioactive glass (BG) and BG alone in the treatment of periodontal intrabony defects. (bvsalud.org)
Platelet-rich plasma: Growth factor enhancement for bone grafts. (bvsalud.org)
Blood-borne transmission of pathogens has highlighted the crucial importance of effective policies, strategies, quality systems, and legislative and regulatory frameworks in the collection, testing, processing and supply of blood components, such as red cells, platelets and plasma, for clinical use. (who.int)
3 Blood products are defined as any therapeutic substances derived from human blood, including whole blood, labile blood components and plasma-derived medicinal products. (who.int)

Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
It helps screen for different platelet disorders . (medlineplus.gov)
It can help diagnose inherited platelet disorders. (medlineplus.gov)
It was once commonly used to screen for a variety of platelet disorders. (medlineplus.gov)
700+ publications in peer-reviewed journals confirm the convenient and reliable testing of platelet-function disorders using Siemens Healthineers PFA Systems. (siemens-healthineers.com)
Integrated platelet aggregation provides cost-effective system consolidation for detection of inherited, acquired, or drug-induced platelet disorders. (siemens-healthineers.com)
Functional platelet disorders affect the adhesion, activation, or aggregation of platelets and are frequently associated with excessive bleeding, often following trauma or surgery. (arupconsult.com)
How do functional platelet disorders manifest clinically? (arupconsult.com)
The clinical features of functional platelet disorders vary. (arupconsult.com)
rarely, it may be observed in functional platelet disorders). (arupconsult.com)
Functional platelet disorders are generally associated with immediate bleeding in response to surgery or trauma, whereas factor deficiencies are associated with delayed bleeding. (arupconsult.com)
What are some causes of acquired functional platelet disorders? (arupconsult.com)
Which functional platelet disorders are inherited? (arupconsult.com)
Bernard-Soulier syndrome (an adhesion disorder) and Glanzmann thrombasthenia (an aggregation disorder) are among the most well-recognized inherited disorders of platelet function and are severe clinical conditions. (arupconsult.com)
Refer to the table, Laboratory Findings in Selected Inherited Functional Platelet Disorders , for additional information and a more comprehensive list of inherited functional platelet disorders. (arupconsult.com)
Laboratory testing for functional platelet disorders is appropriate in individuals with bleeding manifestations that suggest a functional platelet disorder (eg, easy bruising, prolonged bleeding following dental work or surgery, menorrhagia), particularly those with a family history of a bleeding disorder and in whom VWD has been previously excluded. (arupconsult.com)

The body's reaction to vessel wall injury is rapid adhesion of platelets to the subendothelium. (medscape.com)
The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)

Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow. (nature.com)
Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
The process of thrombus formation is considered to be initiated by von Willebrand factor (VWF) binding to exposed collagen or laminin in the damaged vessel wall, followed by shear-dependent platelet binding to VWF through the glycoprotein (GP)Ib-V-IX complex ( 1 , 3 , 4 ). (frontiersin.org)
Platelet Glycoprotein GPIIb-IIIa Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. (harvard.edu)
This graph shows the total number of publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Harvard Catalyst Profiles by year, and whether "Platelet Glycoprotein GPIIb-IIIa Complex" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Profiles. (harvard.edu)
Intrahospital evolution and platelet aggregation in response to tirofiban were analyzed in relation to four glycoprotein mutations in 50 patients indicated for percutaneous coronary intervention 17 (34%) with unstable angina and 33 (66%) with non-ST-segment elevation myocardial infarction . (bvsalud.org)

We describe how these are activated, their targets, their effect on platelet functions, and the consequences for platelet population formation. (frontiersin.org)
1 and others 6 4 is the fact that we isolated platelets from the storage milieu in order to explore their intrinsic functional properties, independently of the storage milieu which may have an inhibitory-yet-reversible effect on platelet responsiveness. (haematologica.org)

She currently receives platelet transfusions weekly and red blood cells about every two weeks. (redcross.org)
Prophylactic platelet transfusions may be appropriate at 5,000- 10,000/uL to prevent spontaneous bleeding. (medscape.com)

Platelet aggregation at sites of vascular injury is essential for hemostasis and arterial thrombosis. (nature.com)
Platelets are anucleate cells that are important for haemostasis, thrombosis, and atherosclerotic disease. (hindawi.com)
Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)
Results Our findings indicate that the platelets in HD are dysfunctional with respect to the release of angiogenic factors and functions including thrombosis, angiogenesis and vascular haemostasis. (bmj.com)
All 3 cases of intraprocedural thrombosis (3.1%) were observed only in the poor-response group. (ajnr.org)
Platelet inhibition is a prerequisite for the prevention of acute or subacute thrombosis in various neurointerventional procedures such as stent placement in atherosclerotic lesions or stent-assisted coiling of aneurysms. (ajnr.org)
According to a common concept of thrombosis and hemostasis, damage or injury of a vessel wall and ensuing exposure of extracellular matrix components to the blood stream triggers platelets from the circulation to become adherent and to assemble into a thrombus, thus limiting the extravasation of blood ( 1 , 2 ). (frontiersin.org)
Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt Activation in Platelets. (harvard.edu)
Platelet ionized calcium mobilization (Aequorin method) in patients with primary platelet dysfunction' Thrombosis and Haemostasis. (nii.ac.jp)

Savage, B., Saldivar, E. & Ruggeri, Z.M. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. (nature.com)
On resting platelets, GP IIb/IIIa is unable to bind fibrinogen or vWf. (medscape.com)
This provokes the release of thromboxane A 2 and the secretion of granular contents including ADP and, via these autocrine agents, the subsequent recruitment of additional flowing platelets, which assemble into a growing thrombus via α IIb β 3 -fibrinogen interactions (aggregating platelet population) ( 1 ). (frontiersin.org)

Different types of autologous platelet concentrate (PCs) are used in bone and cartilage regeneration. (spandidos-publications.com)

Once activated, platelets have two major mechanisms to recruit additional platelets to the growing hemostatic plug. (medscape.com)

Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling. (jci.org)
The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. (frontiersin.org)
An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. (frontiersin.org)
Here, we review current knowledge how proteases act on platelet receptors and the platelet membrane surface. (frontiersin.org)
We reasoned that the presence of prostacyclin (PGI 2 ) during the washing procedure to inhibit platelet activation and of apyrase in the suspending milieu to degrade trace amounts of ADP released from platelets and thus prevent the desensitization of the ADP receptors, might mimic the inhibitory role of the vascular endothelium, known to express ectonucleotidase activities and to produce PGI 2 , the natural strong vasodilator and inhibitor of platelet activation. (haematologica.org)

Both platelet-derived growth factor (PDGF) A- and B-chains are expressed in mammalian neurons, but their precise roles still remain to be clarified. (jci.org)
Platelets are cells derived from the bone marrow containing or producing several biomolecules, such as platelet-derived growth factors (PDGF), interleukin 1, platelet-derived endothelial growth factors, basic fibroblast growth factor, transforming growth factors (TGF-1 and TGF-2), and vascular endothelial growth factors. (termedia.pl)
Rat Platelet-derived growth factor DD (PDGF-DD) ELISA kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)

2. Platelet retention in glass bead columns, platelet aggregation in vitro , β-thromboglobulin and 6-oxo-prostaglandin F 1α were monitored in six normal male volunteers before and after an acute rise of von Willebrand factor, as induced by the intravenous administration of 1-deamino-8-d-arginine vasopressin (DDAVP). (portlandpress.com)
3. After DDAVP a steady twofold rise of von Willebrand factor occurred. (portlandpress.com)

26 ] showed that gene expression of BDNF in lymphocytes and its protein expression in platelets from adult and pediatric depressed patients were significantly decreased, and the authors proposed that it could be a target for antidepressant drugs. (hindawi.com)
Methods We assessed the functional status of platelets by performing ELISA, western blot and RNA sequencing in a cohort of 71 patients and 68 age- and sex-matched healthy control subjects. (bmj.com)
Of the 23 patients enrolled, 3 were excluded. (nih.gov)
At the end of the 3 treatment cycles, the patients presented clinical improvement in the mean number of hairs, with a mean increase of 33.6 hairs in the target area, and a mean increase in total hair density of 45.9 hairs per cm² compared with baseline values. (nih.gov)
During the study, all patients received treatment intravenously weekly but could switch to biweekly after week 4 if their platelet levels increased sufficiently. (ajmc.com)
The primary end point was the proportion of chronic ITP patients with a sustained platelet response of ≥50×109/L in at least 4 of 6 visits between weeks 19 and 24 without intervening events, such as rescue therapy after week 12. (ajmc.com)
Blood and platelet donations are critically needed in the coming days so that patients can continue to receive the lifesaving treatments they are counting on," said Nick Gehrig, communications director, Red Cross Blood Services. (redcross.org)
Sex-specific platelet activation through protease-activated receptor-1 in patients undergoing cardiac catheterization. (harvard.edu)
It is concluded that furosemide is not effective in protecting against platelet-activating factor challenge in patients with asthma despite its potential inhibition of leukotriene synthesis. (ersjournals.com)
In patients with ET, the platelet count is higher than normal. (lls.org)
In patients with ET, the platelets may appear enlarged and/or clumped together. (lls.org)
aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are common causes of abnormal platelet function, and platelet function testing may need to be deferred if patients have been taking these medications. (arupconsult.com)
Mutations of glycoproteins Ia, Ib, IIb and IIIa did not influence platelet aggregation in response to tirofiban in patients with unstable angina and non-ST-segment elevation myocardial infarction . (bvsalud.org)
Typical indications include leukemia, myelodysplasia, aplastic anemia, solid tumors, congenital or acquired/medication-induced platelet dysfunction, central nervous system trauma, and patients undergoing extracorporeal membrane oxygenation or cardiopulmonary bypass may also need platelet transfusion. (medscape.com)
Higher transfusion thresholds may be appropriate for patients with platelet dysfunction. (medscape.com)
Patients with autoimmune destruction of platelets, such as ITP, may not receive therapeutic benefit from prophylactic transfusion, but may however benefit from transfusion if bleeding. (medscape.com)
The antigenic target in most patients appears to be the platelet GP IIb/IIIa complex. (medscape.com)

It can help show if there are defects in the platelets. (medlineplus.gov)
Bone regeneration is required to treat these defects, provide support for dental implants, jaw reconstruction after cystic lesion removal, cleft repair, etc. [3, 4]. (termedia.pl)

An acceptable P2Y12 switching strategy, in nearly all clinical situations, would consist of a loading dose of the new P2Y12 agent followed by a maintenance dose regimen to avoid any gap in adequate anti-platelet inhibition [2]. (scai.org)
To obtain an independent test set, the remaining 11 of the 58 tumors were selected from an ongoing clinical trial and used here as a blinded sion via ER,3 however the details of the estrogen effect on down- test set. (lu.se)
The clinical parameters plaque index, gingival index, gingival bleeding index, pocket probing depth (PPD), clinical attachment level (CAL) and gingival recession were recorded, and the defect fill was evaluated radiographically at baseline and 3 and 6 months after surgery. (bvsalud.org)

The Platelet Disorder Support Association does not provide medical advice or endorse any medication, vitamins or herbs. (pdsa.org)

This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with each other to form an aggregate (see image below). (medscape.com)

Stehbens and Biscoe, 1967 ), platelet shape change was, and still is, generally regarded to be the initial stage of platelet activation. (nature.com)
Platelet activation pathways. (medscape.com)
Independently of such activation processes, platelet heterogeneity can be achieved by aging and an accompanied inactivation ( 3 ). (frontiersin.org)
Peripheral versus central venous blood sampling does not influence the assessment of platelet activation in cirrhosis. (harvard.edu)
Finally, IBS did not substantially alter platelet proteome as could be evaluated by the 2D-DIGE technology, indicating overall that IBS did not induce any clear intrinsic defect in integrity, function or increased spontaneous activation of platelets isolated from the storage milieu. (haematologica.org)

We investigated a physiological role of αB-crystallin in platelet function. (bioone.org)
Therefore, our results suggest that αB-crystallin, which is discharged from vessel walls in response to endothelial injury, acts intercellularly as a regulator of platelet function. (bioone.org)
The role of potential risk factors (e.g. liver function, platelets count, number of rubber bands placed, etc.) for PRB has not yet been entirely clarified, but a better understanding of these factors could help to avoid such complications. (springer.com)
Should we monitor platelet function during antiplatelet therapy? (bmj.com)
Conclusion Taken together, our results provide a better understanding for the impact of mHtt on platelet function. (bmj.com)
12 , 13 Monitoring platelet function, however, has not been part of our daily practice, due to the difficulty and impracticality of laboratory testing. (ajnr.org)
Platelet function tests check your platelets' ability to form clots. (medlineplus.gov)
Now, other platelet function tests are used more often. (medlineplus.gov)
Check platelet function during complex surgical procedures , such as cardiac bypass and trauma surgery. (medlineplus.gov)
You may need platelet count and/or platelet function testing if you have symptoms of having too few or too many platelets. (medlineplus.gov)
If you are getting a platelet function test, you may need to stop taking certain medicines, such as aspirin and ibuprofen, before your test. (medlineplus.gov)
There were no differences between groups in baseline characteristics or platelet function. (revespcardiol.org)
Shear-Mediated Platelet Microparticles Demonstrate Phenotypic Heterogeneity as to Morphology, Receptor Distribution, and Hemostatic Function. (harvard.edu)
Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets. (harvard.edu)
The present proposal will evaluate the pharmacodynamics of 2 strategies with specialized platelet function testing. (scai.org)
Probably the most controversial threshold is for the clinically stable patient with an intact vascular system and normal platelet function. (medscape.com)

Intercellular calcium communication regulates platelet aggregation and thrombus growth. (nature.com)
Bioactive agents, including cytokines and growth factors such as stromal cell-derived factor-1, platelet-derived growth factor, VEGF, and others, were shown to promote cell recruitment and have a helpful effect on the repair of articular cartilage injuries ( 8 , 10 , 11 ). (spandidos-publications.com)
Some of the aforementioned growth factors are released from activated platelets. (spandidos-publications.com)
They found that PRP was effective and that the concentration of the platelets and healing factors such as epidermal growth factor (EGF) were correlated with success of treatment. (wikipedia.org)
These platelets contain bioproteins and hormones, called growth factors, that trigger cell reproduction and stimulate tissue repair in the area where they're injected. (sedermatologyspecialists.com)

The primary endpoint was assessment of platelet aggregation after stimulation with adenosine diphosphate 20 μM at 12-month follow-up. (revespcardiol.org)

WASp−/− mouse blood displays impaired platelet aggregate formation at arteriolar shear rates. (harvard.edu)
Analysis of blood flow dynamics revealed that discoid platelets preferentially adhere in low-shear zones at the downstream face of forming thrombi, with stabilization of aggregates dependent on the dynamic restructuring of membrane tethers. (nature.com)
The BDNF concentration in the serum increases after intravenous treatment with an antidepressant, and the effect of these drugs on BDNF release from platelets was related to the level of this neurotrophin in the peripheral blood [ 15 ]. (hindawi.com)
The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
Objectives Seeking to elucidate the origin of these vascular and BBB abnormalities, we studied platelets that are known to play a role in maintaining the integrity of the vasculature and thrombotic pathways linked to this, given they surprisingly contain the highest concentration of mHtt of all blood cells. (bmj.com)
The American Red Cross has a severe winter blood shortage and is issuing an emergency call for blood and platelet donors to make a donation appointment now and help save patient lives. (redcross.org)
Right now, blood and platelet donations are being distributed to hospitals faster than they are coming in. (redcross.org)
The Red Cross is extending hours at many donation sites for more donors to give blood or platelets. (redcross.org)
Platelets, also known as thrombocytes, are small blood cells that are essential for blood clotting . (medlineplus.gov)
A platelet count test measures the number of platelets in your blood. (medlineplus.gov)
This test measures the time it takes for platelets in a blood sample to plug a small hole in a tiny tube. (medlineplus.gov)
A platelet count may be included in a complete blood count , a test that is often done as part of a regular checkup . (medlineplus.gov)
Most platelet tests are done on a blood sample. (medlineplus.gov)
Based on end-user, the global platelet incubator market has been segmented into blood banks, hospitals, academic & research institutes, and others. (bccresearch.com)
The blood banks segment is expected to dominate the global platelet incubator market during the forecast period. (bccresearch.com)
In the discussion of our study we speculated that transfused platelets are isolated from the storage milieu and somehow "washed" in the recipient blood stream. (haematologica.org)
This test measures the number red blood cells, white blood cells and platelets in a sample of blood. (lls.org)
This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin -like molecules. (wikidoc.org)
Researchers are looking at the positive effects of platelet transfusion against the negative effects, such as the release of inflammatory molecules and the formation of blood clots. (nih.gov)
1990. Increased isotransferrin ratio and reduced erythrocyte and platelet volumes in blood from thermoplastic industry workers. (cdc.gov)
Features of HUS include low platelet count, anemia due to broken blood cells, and kidney failure. (cdc.gov)
White cells and platelets in blood transfusion : proceedings of the Eleventh Annual Symposium on Blood Transfusion, Groningen 1986, organized by the Red Cross Blood Bank Groningen-Drenthe / edited by C. Th. (who.int)

Savage, B., Almus-Jacobs, F. & Ruggeri, Z.M. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. (nature.com)

The systems enable access to platelet aggregation testing to provide additional information for therapeutic decisions and complete the diagnostic picture. (siemens-healthineers.com)

Figure 1: Shear microgradients promote platelet aggregate formation in vivo . (nature.com)

These interactions further activate platelets. (medscape.com)
The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). (medscape.com)

Exclusion criteria were the following: 1) unclear antiplatelet medication history, 2) platelet count lower than 150 × 10 3 /μL, and/or 3) hematocrit level lower than 33% at the time of admission. (ajnr.org)

Moreover, to produce acceptable structural and functional repair, all three kinds of tissues involved in osteochondral lesions, including subchondral bone, the osteochondral interface and articular cartilage, need to be reconstructed simultaneously ( 3 ). (spandidos-publications.com)
this method is widely used to assess the functional status of platelets. (nature.com)
It is important to rule out acquired conditions during an evaluation for a functional platelet disorder. (arupconsult.com)
Initial laboratory testing for a functional platelet disorder includes a CBC with platelet count and a peripheral smear. (arupconsult.com)

For preparation of PRP, various protocols are used, with an underlying principle of concentrating platelets to 3-5 times physiological levels, then injecting this concentrate in the tissue where healing is desired. (wikipedia.org)

Platelet 1987 -- Platelet and Lipids (Kagakuhyoronsya, Tokyo). (nii.ac.jp)

Immature platelets are the most recently produced platelets and may be a better marker of platelet production. (nih.gov)

Platelets contain two unique types of granules: alpha granules and dense granules. (medscape.com)
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. (wikidoc.org)

In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)
Phosphatidylserine-exposing platelets, usually located around a thrombus, provide a negatively charged membrane surface, which supports coagulation factor binding and the formation of tenase and prothrombinase complexes ( 6 , 7 ). (frontiersin.org)

Figure 4: The magnitude and spatial distribution of the shear microgradient directly affects platelet aggregate size. (nature.com)
Figure 6: Working model of shear microgradient platelet aggregation. (nature.com)

Indeed, platelet releasate has previously been shown to induce endothelial cell permeability, endothelial cell chemotaxis, and corneal epithelial cell proliferation in cellular assays [ 7 - 9 ]. (hindawi.com)

Whereas ticagrelor is a cyclopentyltriazolopyrimidine that directly and reversibly inhibits through allosteric modulation the platelet ADP P2Y12 receptor [1]. (scai.org)

Microaggregation appeared to be distinct from full aggregation, as it was not inhibited by the addition of CD61, an antibody to the β 3 integrin. (nature.com)
Upon prolonged high intracellular rises in Ca 2+ , platelets develop a procoagulant phenotype that is characterized by the surface membrane exposure of phosphatidylserine and by the inactivation of integrin α IIb β 3 (procoagulant platelet population) ( 5 ). (frontiersin.org)

Studies on a new type of platelet release mechanism defect (irresponsibility to thromboxane A_2). (nii.ac.jp)

Nodule formation is dependent on Wiskott-Aldrich syndrome protein (WASp) and the ARP2/3 complex. (harvard.edu)

We conclude that platelet aggregation occurs independently of shape change and that shape change is not necessarily followed by aggregation. (nature.com)
Of note, independently of IBS, we showed that the level of spontaneous P-selectin expression on platelets kept in their storage milieu resulted in approximately 30% positive cells at Day 1.5, which is the lowest amount reported by others. (haematologica.org)

Platelet retention increased by 74% immediately after DDAVP but returned to baseline values within 60-120 min. (portlandpress.com)

These findings reinforce the view that the pulmonary effects of platelet-activating factor are mediated through different pathways. (ersjournals.com)

In fact, some antidepressants increase BDNF expression [ 27 ] and also may evoke BDNF release from platelets, in a dose-dependent manner after direct treatment in vitro [ 15 ]. (hindawi.com)

Because the initial decrease in light transmission in platelet aggregometry is attributed to platelet shape change, it is widely held that platelet shape change is a prerequisite for platelet aggregation. (nature.com)
Since then, the initial decrease in light transmission detected in aggregometry is used as a measure for the extent of platelet shape change. (nature.com)
Platelet aggregometry. (medlineplus.gov)

Anatomy21

Organisms7

Diseases21

Chemicals and Drugs142

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes35

Disciplines and Occupations1

Information Science2

Health Care1

Deregulated platelet function1

Human platelets4

Driving platelet aggregation1

Reactivity13

Fibrin9

Thrombocytopenia10

Thrombin8

Agonists5

Inhibition of Platelet Aggregation1

Proteins12

Types of platelet2

Apheresis platelet2

20231

Counts5

Plasma23

Disorders16

Adhesion of platelets2

Glycoprotein8

Effect on platelet2

Transfusions2

Thrombosis9

Fibrinogen3

Autologous1

Additional platelets1

Receptors5

PDGF3

Willebrand2

Patients17

Defects2

Clinical3

Disorder Support Association1

Adhesive1

Activation5

Function16

Growth5

Assessment1

Blood23

Thrombus formation1

Therapeutic1

Aggregate formation1

Interactions2

Antiplatelet1

Functional4

Concentrate1

19871

Immature1

Alpha granules2

Negatively charged2

Shear2

Endothelial cell1

Receptor1

Integrin2

Mechanism1

Protein1

Independently2

Baseline1

Pathways1

Vitro1

Aggregometry3