• This gene encodes the beta chain of the branched chain alpha ketoacid dehydrogenase (Bckdh) complex. (nih.gov)
  • Pharmacological activation of branched-chain α-ketoacid dehydrogenase (BCKDH), the rate-limiting enzyme of BCAA oxidation, lowers plasma BCAAs and improves insulin sensitivity. (princeton.edu)
  • The branched-chain α-keto acid dehydrogenase (BCKDH) complex is the most important regulatory enzyme in branched-chain amino acid (BCAA) catabolism. (fujita-hu.ac.jp)
  • We examined the regulation of hepatic BCKDH complex activity in spontaneous type 2 diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats and Zucker diabetic fatty rats. (fujita-hu.ac.jp)
  • Molecular cloning and analysis of the expression of the E1 beta subunit of branched chain alpha-ketoacid dehydrogenase in mice. (nih.gov)
  • In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups. (expasy.org)
  • 2. Reed, L.J., Damuni, Z. and Merryfield, M.L. Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation. (qmul.ac.uk)
  • An amino acid oxidoreductase that catalyzes the oxidative hydroxylation of L-VALINE to 3-methyl-2-oxobutanoate and AMMONIA in the presence of NADP . (online-medical-dictionary.org)
  • A mitochondrial enzyme associated with the 3-methyl-2-oxobutanoate dehydrogenase complex. (qmul.ac.uk)
  • alpha-ketoisovalerate decarboxylase Kivd from Lactococcus lactis combined with alcohol dehydrogenase Adh3 from Zymomonas mobilis are the optimum candidates for 3-methyl-1-butanol production in Corynebacterium glutamicum. (brenda-enzymes.info)
  • construction of a synthetic pathway for bioalcohol production at 70°C by insertion of the gene for alcohol dehydrogenase AdhA into the archaeon Pyrococcus furiosus. (brenda-enzymes.info)
  • deletion of the hypoxanthine phosphoribosyltransferase gene in ethanol tolerant strain adhE*(EA), carrrying mutation P704L/H734R in the alcohol dehydrogenase gene, and deletion of lactate dehydrogenase (ldh) to redirect carbon flux towards ethanol reults in a strain producing 30% more ethanol than wild type on minimal medium. (brenda-enzymes.info)
  • Leucine dehydrogenase catalyzes the reversible oxidative deamination of L-LEUCINE, to 4-methyl-2-oxopentanoate (2-ketoisocaproate) and AMMONIA, with the corresponding reduction of the cofactor NAD+. (lookformedical.com)
  • A component of the multienzyme 2-oxo-acid dehydrogenase complexes. (expasy.org)
  • It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes. (expasy.org)
  • Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice. (nih.gov)
  • Cleavage of the C-terminal inhibitory domain by caspase-3 during apoptosis can also activate the kinase. (cloudfront.net)
  • LSADH catalyzed the enantioselective reduction of some ketones with high enantiomeric excesses: phenyl trifluoromethyl ketone to (S)-1-phenyltrifluoroethanol (>99% e.e.), acetophenone to (R)-1-phenylethanol (99% e.e.), and 2-heptanone to (R)-2-heptanol (>99% e.e.) in the presence of 2-propanol without an additional NADH regeneration system. (brenda-enzymes.info)
  • A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the reversible transamination of branched-chain AMINO ACIDS to 2-oxoglutarate. (lookformedical.com)
  • 1. Fatania, H.R., Patston, P.A. and Randle, P.J. Dephosphorylation and reactivation of phosphorylated purified ox-kidney branched-chain dehydrogenase complex by co-purified phosphatase. (qmul.ac.uk)
  • It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168 , dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, which also binds multiple copies of EC 1.8.1.4 , dihydrolipoyl dehydrogenase. (enzyme-database.org)
  • [3] However, BMPR2 can't bind BMP15 and GDF9 without the assistance of bone morphogenetic protein receptor 1B (BMPR1B) and transforming growth factor β receptor 1 (TGFβR1) respectively. (wikidoc.org)
  • It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2-oxopentanoate and ( S )-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine. (enzyme-database.org)
  • Leucine-induced activation of translational initiation is partly regulated by the branched-chain alpha-keto acid dehydrogenase complex in C2C12 cells. (nih.gov)
  • Pettit, F.H., Yeaman, S.J. and Reed, L.J. Purification and characterization of branched chain α-keto acid dehydrogenase complex of bovine kidney. (enzyme-database.org)
  • C-ring cleavage products of quercetin and kaempferol, i.e., 2-protocatechuoyl-phloroglucinol carboxylic acid (2-PCPGCA), were produced, whereas two phosphate derivatives of fisetin (fisetin 4'-O-phosphate and fisetin 3'-O-phosphate) were generated by cultivation with B. subtilis BCRC 80517. (bvsalud.org)
  • In this study, Synthesis of ethyl 2-(4-halobenzyl)-3-oxobutanoate was carried out by using addition of substituted benzyl bromide to a suspension of t-BuOK (Potassium tert-butoxide) in THF (tetrahydrofuran). (ajpsonline.com)
  • Synthesis of Ethyl 2-(4-halobenzyl)-3-oxobutanoate and determination of its Biological activity by using prediction of activity spectra for substance. (ajpsonline.com)
  • 7. Katakam, N.K., Seifert, C.W., D'Auria, J. and Li, G. Efficient synthesis of methyl (s)-4-(1-methylpyrrolidin-2-yl)-3-oxobutanoate as the key intermediate for tropane alkaloid biosynthesis with optically acitve form. (ajpsonline.com)
  • 10. Kishan D. P, Chhaganbhai N. P, Grishma M. P. Synthesis and Antidiabetic activity of noval 4-((2,4-dioxothiazolidin-5-ylidene)methyl) substituted Benzene sulphonamide. (ajpsonline.com)
  • production of (4S,6S)-5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3b]thiopyran-7,7dioxide, which is an intermediate in the synthesis of the carbonic anhydrase inhibitor trusopt. (brenda-enzymes.info)
  • Elevated levels of plasma branched-chain amino acids (BCAAs) have been associated with insulin resistance and type 2 diabetes since the 1960s. (princeton.edu)
  • 3. Dai, Y., Huan, B., Zhang, H.S. and He, Y.C. Effective biotransformation of ethyl 4-chloro-3-oxobutanoate into ethyl (S)-4-chloro-3-hydroxybutanoate by recombinant E. coli CCZU-T15 whole cells in [ChCl][Gly]-water media. (ajpsonline.com)
  • The recombinant strain produces 0.182 g/l of 3-methyl-1-butanol and 0.144 g/l of isobutanol after 12 h of incubation. (brenda-enzymes.info)
  • Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase (EC 2.4.1. (systemsbiology.net)
  • These results suggest that BCAA catabolism in type 2 diabetes is downregulated and enhanced by BCAA supplementation. (fujita-hu.ac.jp)
  • GTPase-RhoA binding can increase the activity of ROCK1 by 1.5-2-fold. (cloudfront.net)
  • During weeks 2 and 3, glucose tolerance tests (GTT), insulin tolerance tests (ITT), and meal tolerance tests (MTT) were performed to evaluate blood glucose, plasma, and insulin. (frontiersin.org)
  • An amino acid oxidoreductase that catalyzes the oxidative hydroxylation of L-VALINE to 3-methyl-2-oxobutanoate and AMMONIA in the presence of NADP . (nih.gov)
  • An enzyme that catalyzes the oxidation of (R)-2,3-dihydroxy-3-methylbutanoate to (S)-2-hydroxy-2-methyl-3-oxobutanoate in the presence of NADP. (ouhsc.edu)
  • This gene encodes the E2 subunit of the branched-chain α-keto acid dehydrogenase (BCKDH) complex, a core component of branched-chain amino acid (BCAA) metabolism. (nih.gov)
  • I. Isolation, purification, and partial characterization of bovine liver α-ketoisocaproic:α-keto-β-methylvaleric acid dehydrogenase. (enzyme-database.org)
  • Pettit, F.H., Yeaman, S.J. and Reed, L.J. Purification and characterization of branched chain α-keto acid dehydrogenase complex of bovine kidney. (enzyme-database.org)
  • For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. (lbl.gov)
  • It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168 , dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, which also binds multiple copies of EC 1.8.1.4 , dihydrolipoyl dehydrogenase. (enzyme-database.org)
  • 601 1-acyl-sn-glycerol-3-phosphate acyltransferase plsC BBZA01000001 CDS ARMA_0002 604. (go.jp)
  • In L-threonine degradation III, tdh forms L-2-amino-3-oxobutanoate, and oxidase tynA forms methylglyoxal. (lbl.gov)
  • GlcDEF from E. coli (EC 1.1.99.14 ) is usually described as glycolate dehydrogenase or glycolate oxidase, but it has similar activity on D-lactate ( PMID:4557653 ), and homologs from various Proteobacteria are important for D-lactate utilization. (lbl.gov)
  • Overview: L-threonine degradation in GapMind is based on MetaCyc pathway I via 2-ketobutyrate formate-lyase ( link ), pathway II via glycine ( link ), pathway III via methylglyoxal ( link ), and pathway IV via threonine aldolase ( link ). (lbl.gov)
  • In L-threonine degradation II, a dehydrogenase (tdh) forms L-2-amino-3-oxobutanoate, and a C-acetyltransferase (kbl) cleaves this to acetyl-CoA and glycine. (lbl.gov)
  • part of family of 3'-to5' exonucleases. (lbl.gov)
  • 3 Ribeirão Preto Regional Center of Hematology, National Institute of Science and Technology in Cell Therapy and Cell Therapy Center, Ribeirão Preto, Brazil. (nih.gov)
  • [3] When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced. (cloudfront.net)
  • Single sequence: For the sequence a multiple alignment is constructed with PSI-BLAST (3 iteratoins). (tu-muenchen.de)