3 kinase phospholipase src homology 3 domain. Medical search. Frequent questions

SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and many others. (wikipedia.org)
The SH3 proteins interact with adaptor proteins and tyrosine kinases. (wikipedia.org)
Interacting with tyrosine kinases, SH3 proteins usually bind far away from the active site. (wikipedia.org)
Approximately 300 SH3 domains are found in proteins encoded in the human genome. (wikipedia.org)
In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction pathways and regulating the interactions of proteins involved in the cytoplasmic signaling. (wikipedia.org)
The classical SH3 domain is usually found in proteins that interact with other proteins and mediate assembly of specific protein complexes, typically via binding to proline-rich peptides in their respective binding partner. (wikipedia.org)
Classical SH3 domains are restricted in humans to intracellular proteins, although the small human MIA family of extracellular proteins also contain a domain with an SH3-like fold. (wikipedia.org)
Many SH3-binding epitopes of proteins have a consensus sequence that can be represented as a regular expression or Short linear motif: -X-P-p-X-P- 1 2 3 4 5 with 1 and 4 being aliphatic amino acids, 2 and 5 always and 3 sometimes being proline. (wikipedia.org)
Examples are the C-terminal SH3 domains of adaptor proteins like Grb2 and Mona (a.k.a. (wikipedia.org)
Signal transducing adaptor proteins CDC24 Cdc25 PI3 kinase Phospholipase Ras GTPase-activating protein Vav proto-oncogene GRB2 p54 S6 kinase 2 (S6K2) SH3D21 ARMH3 (potentially) STAC3 Some myosins SH3 and multiple ankyrin repeat domains: SHANK1, SHANK2, SHANK3 YAP1 ARHGAP12 vexin (VXN) TANGO1 Integrase Focal Adhesion Kinase (FAK, PTK2) Proline-rich tyrosine kinase (Pyk2, CADTK, PTK2beta) TRIP10 (cip4) Src homology 2 domain-containing Structural domain Pawson T, Schlessingert J (July 1993). (wikipedia.org)
Outcomes Inhibitions of PDGF receptor kinase, the docking proteins element Src-family kinases, as well as the success component PI3K all eradicated PDGF-stimulated ROS creation and corroborated using the suppressed cell development. (thetechnoant.info)
Transiently transfected cells with plasmid from little GTP-binding proteins Rac N17 or Ras N17 reduced PDGF actions in ROS era, cell proliferation and MAP kinase activation, while cells with Rac V12 improved the PDGF impact. (thetechnoant.info)
Among the goals for ROS in vivo may be the reversible oxidation of phosphatases, which as well as proteins tyrosine kinases are in charge of maintaining a standard proteins tyrosine phosphorylation-dephosphorylation homeostasis in cell signaling in vivo [5,14]. (thetechnoant.info)
Included in these are Src family members kinases, phosphatidylinositol-3-kinase (PI3K), phospholipase C (PLC) and little GTP-binding proteins Ras [34-36]. (thetechnoant.info)
CAPN3 provides some exclusive domains including its NH2-terminal domains I which has 20C30 additional proteins not within - and m-calpains and two exclusive insertion sequences' of 62 and 77 proteins on the COOH-terminal parts of domains II (known as Is normally1) and domains III (known as IS2). (exposed-skin-care.net)
Domain commonly found in eukaryotic signalling proteins. (embl.de)
The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)
Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
Pleckstrin is one of the rare proteins to contains two PH domains. (embl.de)
Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
There are 196127 PH domains in 171590 proteins in SMART's nrdb database. (embl.de)
Taxonomic distribution of proteins containing PH domain. (embl.de)
The complete taxonomic breakdown of all proteins with PH domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing PH domain in the selected taxonomic class. (embl.de)
Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signalling pathways. (eu.org)
Mutations identified in many SH2 domain-containing proteins as well as the SH2 domain itself are associated with human diseases ranging from cancers, diabetes, to immunodeficiencies. (eu.org)
SH2 domains are phosphotyrosine recognition domains, often mediating transient interactions with target proteins. (eu.org)
Receptor dimerization and autophosphorylation attracts proteins containing Src homology 2 (SH2) or phosphotyrosine binding (PTB) domains including adaptor proteins like FRS2 and GRB2. (springer.com)
Therefore, FAK-Src signaling complicated activates a great many other signaling proteins, involved with success, motility and metastatic, intrusive phenotype in tumor cells. (cahrr.org)
proteins O activation pursuing hydrogen peroxide (H2O2)-induced oxidation, that was related to reduced lipid oxidative harm and caspase-3 activation in these cells. (liveconscience.com)
The addition of Rp-cyclic 3,5-hydrogen phosphorothioate adenosine triethylammonium sodium (a cyclic 3′,5′-adenosine monophosphate antagonist) and calphostin C (a proteins kinase C inhibitor), or a PTH type 1 receptor antagonist, abrogated the consequences of N-terminal PTHrP, whereas proteins phosphatase 1 (an Src kinase activity inhibitor), SU1498 (a vascular endothelial development aspect receptor 2 inhibitor), or an anti osteostatin antiserum, inhibited the consequences of C-terminal PTHrP. (liveconscience.com)
Parathyroid hormone-related proteins displays antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains. (liveconscience.com)
Activated TCR triggers the assembly of a signalosome, with key components including tyrosine kinases like Lck and Zap70, scaffold proteins such as Lat, SLP76, and Themis, and phospholipase Cγ1 (PLC γ1), as well as tyrosine phosphatases and E3 ubiquitin ligases like SHP1 and Cbl, among others. (medicaltrend.org)
Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. (biomedcentral.com)
In vitro, the FH2 domain competes with barbed-end capping proteins and is necessary and sufficient to nucleate actin polymerization, but the FH1 domain, which interacts with profilin-actin, funnels actin to the nucleation vicinity and confers full activity to the molecule [ 1 ]. (biomedcentral.com)
The FH1 domain is also a binding site for diverse SH3-domain containing proteins like Src-like non-receptor tyrosine kinases, WISH (WASP-interacting SH3 protein) and IRSp53 (insulin receptor substrate) in mammals, and Hof1p in yeast [ 6 ]. (biomedcentral.com)
interaction( Hh) is a bound transfer that is very proteins in modifications resulting past plasma mRNA, fibril-associated information DNA, isoform kinase and activity( characterised in Hui and Angers, 2011). (evakoch.com)

signaling in the zoom lens epithelial cells, where concerted efforts from the upstream the different parts of PDGF receptor kinase, Src-family kinases, PI3K, Rac, and Ras protein are needed. (thetechnoant.info)
CD28 enhances TCR-driven tyrosine phosphorylation and interacts with phosphatidylinositol 3-kinase (PI3K) and Grb2, initiating the Akt-mTOR and Ras-MAPK pathways. (medicaltrend.org)

As the main component, extracellular structure contains some cysteine-rich repeats domains marked as D1-D2-D3 in GFRα1-3, and D2-D3 in GFRα4 ( Figure 1 a ). (medsci.org)
ERK, extracellular signal-regulated kinases. (spandidos-publications.com)
Structurally, PD-1 consists of extracellular immunoglobulin (Ig)-like variable domains, a transmembrane domain, and a cytoplasmic tail responsible for signal transduction and binding to scaffold molecules. (medicaltrend.org)

The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)
Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). (nih.gov)
A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation. (nih.gov)
To better understand the molecular changes associated with AD, genome-wide association studies (GWAS) have identified hundreds of candidate genes linked to the disease, like the receptor tyrosine kinase EphA1. (sdbonline.org)
Roles for Eph receptor tyrosine kinase signaling in the formation of topographic patterns of axonal connectivity have been well established in vertebrate visual systems. (sdbonline.org)
A role for a Drosophila Eph receptor tyrosine kinase (Eph) in the control of photoreceptor axon and cortical axon topography in the developing visual system is described. (sdbonline.org)

Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)
Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)

A combination of genetic mapping and candidate gene analysis presents Cdkn2c, a gene encoding for cyclin kinase inhibitor p18INK4c (p18), as the top candidate gene for inducing the Slec2c1 associated expansion of B1a cells. (gsea-msigdb.org)
The TEC family kinase, BTK (Bruton's tyrosine kinase) is best known as the target of ibrutinib (IMBRUVICA®), the first-in-class covalent kinase active site inhibitor used to treat chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), Waldenström's macroglobulinemia (WM), and chronic graft-versus-host disease (cGVHD). (elifesciences.org)

pp60c-src variants containing lesions that affect phosphorylation at tyrosines 416 and 527. (wikidata.org)
These two levels serve degraded by a phosphorylation including at least 6 membranes in a such tail that both leaves the 2' disorder ubiquitination and adducts the 3' heart to the 5' cell. (evakoch.com)
This methylation is formed below with: an phosphorylation acetyl-CoA with an calcium maltose, a level with a setting a004614, a consistent domain with an alpha, and a process with A, water and actomyosin dynamics to occur these three melanocytes of loop. (evakoch.com)
BTK, a TEC-family tyrosine kinase activated by the B-cell antigen receptor, contains a variety of regulatory domains and it is subject to complex regulation by membrane phospholipids, protein ligands, phosphorylation, and dimerization. (elifesciences.org)

The ↑[Ca 2+ ] i activates a signaling cascade that involves, sequentially, calcium-calmodulin, nitric oxide synthase, guanylyl cyclase, and protein kinase G. This signal transduction pathway enables Cl − to pass through vesicular channels and act as a counterion for the transport of H + , so that the vesicles of secretogogue-stimulated cells become acidic. (jneurosci.org)
and transmembrane receptor protein tyrosine kinase signaling pathway. (nih.gov)
Interestingly, DAG to which PKD1 is recruited in this pathway is formed downstream of phospholipase D1 (PLD1) and a lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocked PKD1 activation under oxidative stress. (biologists.com)
Here, employing an inducible B cell expression system, we have determined that M2 activates the NFAT pathway in a Src kinase-dependent manner - leading to induction of the plasma cell-associated transcription factor, Interferon Regulatory Factor-4 (IRF4). (prelekara.sk)
This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. (nih.gov)
The main pathway is the cleavage of membrane phospholipids into lysophospholipids by the removal of a fatty acid chain by phospholipase A (PLA1 or PLA2). (hindawi.com)

The inositol trisphosphate (IP 3 ) generated by PI-PLC mobilizes Ca 2+ from internal stores ([Ca 2+ ] i ). (jneurosci.org)
These negative signals are mediated by key signaling transducers, such as tyrosine kinases, inositol phosphatases, and diacylglycerol kinases, allowing them to counteract T-cell receptor (TCR)-mediated activation. (medicaltrend.org)

Phosphorylated Y397 FAK can recruit another essential signaling protein, p85 PI3-kinase (phosphoinositide 3-kinase), development factor receptor destined protein Grb 7, phospholipase Cgamma(PLCgamma) and. (cahrr.org)

Mammalian phosphatidylinositol-specific phospholipase C (PI-PLC) (see IPR000909 ) isoforms gamma and delta. (embl.de)
PF cells were found to express regulatory (p85) and catalytic (p110α and p110β) subunits of phosphatidylinositol 3′-kinase (PI3′-kinase). (jneurosci.org)

A download Hanging Sam: A Military Biography of General Samuel T. Williams: From Pancho Villa to of residues are experienced regulated for the high 3-phosphate by which SP1 assemblies present to connected formation phagosome by UCP1 in transmembrane C1q-mediated fusion momenta, and preferentially by the intracellular genes as Once. (evakoch.com)

Each isoform serves via two receptor tyrosine kinases of PDGFR and PDGFR inducing dimerization of receptors and autophosphorylation of distinct tyrosines in the intracellular domains from the receptor. (thetechnoant.info)
Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs (Olsen et al. (beauty104.com.tw)
In recent years, the search for intracellular signaling integrator downstream of receptor tyrosine kinases provided valuable novel substrates. (springer.com)
This gene encodes an intracellular tyrosine kinase expressed in T-cells. (nih.gov)
The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. (nih.gov)

pp60c-src has less affinity for the detergent-insoluble cellular matrix than do pp60v-src and other viral protein-tyrosine kinases. (wikidata.org)

Open in another window Shape 1 Focal Adhesion Kinase Besifloxacin HCl can be overexpressed in tumor examples. (cahrr.org)
Open up in another window Shape 2 Focal Adhesion Kinase (FAK) framework. (cahrr.org)

much like PTH, intermittent administration of PTHrP shows anabolic activities in rodents and/or human beings.22 Actually, the N-terminal area of PTHrP displays homology using the same area of PTH and interacts with the normal PTH type 1 receptor (PTH1R), which really is a course II G PIK-294 protein-coupled receptor. (liveconscience.com)
BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors (1).Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. (signalchem.com)

moreover, PI3′-kinase inhibitors (wortmannin and LY294002) antagonized secretion. (jneurosci.org)
B cell receptor (BCR) signaling plays a critical role in driving proliferation and survival of the malignant clone in chronic lymphocytic leukemia (CLL), supported by the clinical activity of inhibitors targeted toward BCR-associated kinases [ 1 ]. (nature.com)

Pleckstrin homology domain. (embl.de)
Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
Precisely how the BTK N-terminal domains (the Pleckstrin homology/Tec homology (PHTH) domain and proline-rich regions (PRR) contain linker) contribute to BTK regulation remains unclear. (elifesciences.org)

The TSEN placement Typically triggers 5' and 3' to the home', proliferating a downstream' vascular maturation on the 5' T and a 5' receptor nucleus on the 3' mitosis. (evakoch.com)

You can find over 440 noted mutations within the calpain 3 gene up to now, included in this 212 (50%) are missense mutations, a lot of which alter its catalytic activity (22). (exposed-skin-care.net)
The Kinase site offers Y576/577 tyrosines very important to catalytic activity of FAK. (cahrr.org)
Structures of the autoinhibited SRC family kinases were solved in 1997 revealing, for the first time, the compact arrangement of the SH3 and SH2 domains assembled onto the distal side of the catalytic kinase domain [ 4 ]. (elifesciences.org)

1. Cheng, G. et al: Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. (signalchem.com)
2. Vassilev, A O. et al: Therapeutic potential of inhibiting Bruton's tyrosine kinase, (BTK).Curr Pharm Des. (signalchem.com)

The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor for reactive oxygen species, which can initiate cell survival through NF-κB signaling. (biologists.com)

Over 120 SH2 domains are predicted in the human genome ( Liu,2011 ). (eu.org)
The TEC kinases are the second largest sub-family of non-receptor tyrosine kinases in the human genome after the SRC family [ 1 - 3 ]. (elifesciences.org)

The sequence binds to the hydrophobic pocket of the SH3 domain. (wikipedia.org)
the preferred GFRα coreceptor for GDNF is GFRα1, although GDNF also weakly binds to GFRα2 and GFRα3 [ 3 ]. (medsci.org)
The Tir protein of EPEC binds NCK1/NCK2 SH2 domains through a high affinity pYDEV motif ( Frese,2006 ). (eu.org)

Calpain 3 provides 54 and 51% series homology towards the 80 kDa subunits of - and m-calpains, respectively, and stocks similar properties with one of these ubiquitously portrayed calpains such as for example Ca2+- reliant activation and maximal activity at natural pH (1). (exposed-skin-care.net)
The communication in subunit: enabling lymphoid GT-domains preventing membrane as a subunits addition: A ATM identified to the Faculty of Graduate Studies and Research in isolated pore of the heterotrimers for the use of Master of Nursing. (evakoch.com)

The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)

What are physical characteristics found in all tyrosine kinase receptors? (flashcardmachine.com)
The 3' replication has freely activated by RNase Z surface, a mature binding in receptors( reviewed in Maraia and Lamichhane 2011). (evakoch.com)

A PDGF receptor domain essential for mitogenesis but not for many other responses to PDGF. (wikidata.org)

This cascade causes following cytoskeletal adjustments and activation of RAS-MAPK (mitogen-activated protein kinase) signaling pathways (26, 28). (cahrr.org)

Launch Calpain 3 (CAPN3) belongs to a Rabbit polyclonal to CDH1 family group of Ca2+- turned on natural cysteine proteinases which have been discovered in a multitude of microorganisms as disparate as human beings and worms (1,2). (exposed-skin-care.net)
HGF forms a family with HGF-like protein (HLP), a unique protein with a domain structure similar to that of HGF ( 12 ). (spandidos-publications.com)
Several different binding motifs are known, for example: pYEEI (Src-family SH2 domains), pY [IV]. (eu.org)
The human NCK1 (Nckα) and NCK2 (Nckβ/GRB4) SH2 domains show a degree of partner specificity but share the same mode of ligand binding ( Frese,2006 ) and belong to the class IA family which contains an aromatic residue (Phe) at the specificity-determining βD5 position ( Kaneko,2010 ). (eu.org)
Regulation of MT dynamics via direct binding of an Abl family kinase. (nih.gov)
TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. (ersjournals.com)
These motifs are phosphorylated by Src family kinases (SFKs) upon receptor activation and play crucial roles in regulating the immune system. (medicaltrend.org)

Membrane-induced dimerization activates BTK and we present here a crystal structure of an activation loop swapped BTK kinase domain dimer that likely represents the conformational state leading to trans-autophosphorylation. (elifesciences.org)

Isoform gamma contains two PH domains, the second one is split into two parts separated by about 400 residues. (embl.de)
PKC involvement can be accounted for by PKCγ and an isoform sensitive to inhibition by pseudoZ, probably PKCζ, which is activated via PI3′-kinase. (jneurosci.org)

The human being FAK (also called PTK2, protein tyrosine kinase 2) gene continues to be mapped to chromosome 8 (15, 16). (cahrr.org)

P90 ribosomal S6 kinases: A bona fide target for novel targeted anticancer therapies? (lu.se)

The N-terminal site (1C415 a.a) of FAK protein provides the main autophosphorylation site Con397-tyrosine, that in phosphorylated form becomes a binding site of SH-2 site of Src, resulting in its conformational adjustments and activation (19). (cahrr.org)

The C-terminal half of the SH2 domain exhibits greater structural variability and provides a platform for accommodating different kinds of SH2-binding motifs. (eu.org)
Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. (wikidata.org)
Together, these data provide the first structural elucidation of full-length BTK and allow a deeper understanding of allosteric control over the BTK kinase domain during distinct stages of activation. (elifesciences.org)

SH3 domain-mediated protein-protein interaction networks, i.e. (wikipedia.org)
The interaction between SH2 domains and their substrates is however dependent also on cooperative contacts of other surface regions. (eu.org)
The Src Homology 2 (SH2) domain is a major protein interaction module that is central to tyrosine kinase signaling. (eu.org)
On the way to activation, disassembly of the SH3-SH2- kinase core opens a new autoinhibitory site on the kinase domain for PHTH domain binding that is ultimately released upon interaction of PHTH with PIP3. (elifesciences.org)

The Tudor domain protein p100-TSN reads the symmetric methylation mark, and binding of p100-TSN downregulates E2F-1 apoptotic activity. (embl.de)
Based on the amino acid sequence homology and biological activity in macrophages, Shimamoto et al ( 15 ) identified that HLP was identical to MSP ( 15 ). (spandidos-publications.com)
and protein tyrosine kinase activity. (nih.gov)
Sample Kinase Activity Plot. (signalchem.com)
other specificity is tiny gene activity and distribution browser through the kinase of the R-RasGAP complex ileal to suitable or through the functionality of RhoA. (evakoch.com)

The consensus core of HRE sequence is 5′-RCGTG-3′ (where R is A or G). (biomedcentral.com)

More recently, SH3 domains that bind to a core consensus motif R-x-x-K have been described. (wikipedia.org)
Non-phosphorylated peptides do not bind to the SH2 domains. (eu.org)
Both motifs are phosphorylated by the tyrosine kinase Lck when PD-1 ligands bind to PD-1. (medicaltrend.org)

This domain is also present in the molecules of phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src. (wikipedia.org)
The particularly phosphorylated tyrosine enables docking and following activation of some responding molecules filled with Src homology 2 or SH2 domains [33]. (thetechnoant.info)
We have previously shown that excretory-secretory product-62 (ES-62), a homologue of phosphorylcholine-containing molecules that are secreted by human parasites and which is active in rodent models of filarial infection, is able to polyclonally activate certain protein tyrosine kinase and mitogen-activating protein kinase signal transduction elements in B lymphocytes. (eurekamag.com)

HGF was cloned as a growth factor for hepatocytes ( 1 , 2 ), is identical to scatter factor (SF) and was originally discovered as a fibroblast-derived cell motility factor for epithelial cells ( 3 ). (spandidos-publications.com)
The many processes involving SH2 domains range from mitogenic signaling to T cell activation. (eu.org)
3) T cell deficiencies result usually in combined immunodeficiencies (CIDs), where both T cells and antibody production are defective. (lu.se)
Interleukin-2 inducible T-cell kinase: a potential prognostic biomarker and tumor microenvironment remodeling indicator for hepatocellular carcinoma. (nih.gov)
A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3+ TREG differentiation. (nih.gov)
Inherited Interleukin 2-Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma. (nih.gov)

Rac could be involved with regulating the degrees of ROS after ligand-evoked activation [16-19] or it could serve as an activator for cytosolic phospholipase A2, which produces arachidonic acid in the membrane for mobile features [20]. (thetechnoant.info)
BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. (signalchem.com)
5 ]. The three domains (SH3, SH2, kinase), the SH2-kinase linker, the activation loop and the active site are labeled. (elifesciences.org)

These transcription factors are composed of an alpha subunit (HIF-1α, HIF-2α and HIF-3α), and a beta subunit (HIF-1β) [ 20 ]. (biomedcentral.com)

Anatomy17

Organisms10

Chemicals and Drugs159

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes49

Information Science3

Proteins39

PI3K2

Extracellular3

Receptor tyrosi6

Protein kinases3

Inhibitor2

Phosphorylation4

Pathway6

Inositol2

Phosphoinositide 3-kina1

Phosphatidylinositol2

Transmembrane1

Intracellular5

Pp60c-src1

Focal Adhesi2

Interacts2

Inhibitors2

Pleckstrin3

Downstream1

Catalytic3

Bruton's2

Serine1

Human genome2

Binds3

Subunits2

Cytoskeleton1

Receptors2

PDGF1

Pathways1

Family7

Activates1

Isoform2

PTK21

Ribosomal1

Autophosphorylation1

Structural3

Interaction4

Activity5

Sequence1

Bind3

Molecules3

Cell6

Activation3

Subunit1