• Beta oxidation, in the mitochondrial matrix, then cuts the long carbon chains of the fatty acids (in the form of acyl-CoA molecules) into a series of two-carbon (acetate) units, which, combined with co-enzyme A, form molecules of acetyl CoA, which condense with oxaloacetate to form citrate at the "beginning" of the citric acid cycle. (wikipedia.org)
  • Once inside the cell long-chain-fatty-acid-CoA ligase catalyzes the reaction between a fatty acid molecule with ATP (which is broken down to AMP and inorganic pyrophosphate) to give a fatty acyl-adenylate, which then reacts with free coenzyme A to give a fatty acyl-CoA molecule. (wikipedia.org)
  • It is convenient to think of this reaction as marking the "starting point" of the cycle, as this is when fuel - acetyl-CoA - is added to the cycle, which will be dissipated as CO2 and H2O with the release of a substantial quantity of energy captured in the form of ATP, during the course of each turn of the cycle. (wikipedia.org)
  • The beta subunit has acetyl-CoA C-acyltransferase ( EC:2.3.1.16 ) activity. (ebi.ac.uk)
  • It was the aim of this study to elucidate the organization of its CoA-derived pathways and to use the genomic information of X. dendrorhous for a phylogenomic investigation of the Basidiomycota. (biomedcentral.com)
  • A detailed characterization of the CoA-related pathways was done and all genes for fatty acid, sterol and carotenoid synthesis have been assigned. (biomedcentral.com)
  • The Centers for Disease Control and Prevention's Newborn Screening Quality Assurance Program (NSQAP) helps NBS laboratories ensure that testing accurately detects these disorders, does not delay diagnosis, minimizes false-positive reports, and sustains high-quality testing performance [ 3 ]. (mdpi.com)
  • However, all steps of 3-hydroxylation and 4-ketolation at both terminal β-ionone rings leading to the formation of astaxanthin are carried out by a very unique P450 monooxygenase. (biomedcentral.com)