Here, we showed that hepatocyte growth factor (HGF), a ligand of MET oncoprotein, induces gefitinib resistance of lung adenocarcinoma cells with EGFR -activating mutations by restoring the phosphatidylinositol 3-kinase/Akt signaling pathway via phosphorylation of MET, but not EGFR or ErbB3. (aacrjournals.org)
Organic2
3,3′-Diaminobenzidine (DAB) is an organic compound with the formula (C6H3(NH2)2)2. (wikipedia.org)
A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a human kidney cDNA library. (aspetjournals.org)
Phenotype3
We have previously reported that a maternal dietary n-3 PUFA deficiency alters the microglial phenotype and reduces their motility in the developing hippocampus 17 . (nature.com)
We generated mice with combined inactivation of the genes coding for SOCS-3 and PTP-1B in brain cells, examined their sensitivity to hormone action, and analyzed the contribution of each gene to the resulting phenotype. (diabetesjournals.org)
Moreover, a SOCS-3-specific lean phenotype was revealed on the standard diet. (diabetesjournals.org)
Progression1
There is increasing interest in the role played by the innate and adaptive immune systems in the regulation of tumour development and progression 2 , 3 and it is anticipated that a better understanding of the molecular and cellular immunology of NSCLC will lead to the identification of novel targets for immunotherapy. (ersjournals.com)
Induces2
For example, even though glucocorticoids are recommended to women at risk of preterm birth to accelerate fetal lung maturation [ 2 ], a growing body of evidence indicates that prenatal glucocorticoid exposure induces a variety of adult diseases, including hypertension [ 3 - 5 ]. (hindawi.com)
This signal together with the T Cell Receptor (TCR) induces the expression of GATA-3. (bvsalud.org)
Synaptic2
Our results show that maternal dietary n-3 PUFA deficiency increases microglia-mediated phagocytosis of synaptic elements in the rodent developing hippocampus, partly through the activation of 12/15-lipoxygenase (LOX)/12-HETE signaling, altering neuronal morphology and affecting cognitive performance of the offspring. (nature.com)
Using multidisciplinary approaches, we reveal that maternal exposure to an n-3 PUFA deficient diet impairs offspring's microglial homeostatic signature and phagocytic activity, underpinning excessive synaptic pruning and subsequent behavioral abnormalities. (nature.com)
Roles3
During inflammation, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory cells and are considered to play key roles in carcinogenesis [ 3 ]. (hindawi.com)
These results show that the biological roles of SOCS-3 and PTP-1B do not fully overlap and that targeting both factors might improve therapeutic effects of their inhibition in obesity and type 2 diabetes. (diabetesjournals.org)
Usually, protective and destructive roles are assigned to the Th1 and Th17 3,9-11 cells, while Th2 and Treg cells are more involved in processes that reduce the destruction of the periodontium 10 . (bvsalud.org)
Familial1
Most hereditary colorectal cancers are and hMSH6 ) in colorectal cancer stained with haematoxylin, dehydrated attributable to 2 recognized syndromes: cases operated at our institution over in ascending concentrations of alcohol familial adenomatous polyposis and a 3-year period. (who.int)
Mutations1
Inflammation-associated tissue injury may activate stem/progenitor cells, and mutagenic stimuli from inflammation can accumulate multiple mutations and epigenetic changes in stem/progenitor cells [ 3 , 10 ]. (hindawi.com)
Immune cells1
To understand the mechanisms by which n-3/n-6 PUFA imbalance affects CNS development, we investigated the impact of maternal dietary n-3 PUFA deficiency on offspring's microglia, the resident immune cells involved in CNS development and homeostasis 11 . (nature.com)
Diseases2
Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental diseases in Humans. (nature.com)
Low n-3 PUFA consumption globally has raised concerns about its potential detrimental effects on the neurodevelopment of human infants 9 and the incidence of neurodevelopmental diseases, such as Autism Spectrum Disorder (ASD) and schizophrenia 10 . (nature.com)
20201
Urothelial carcinoma (UC) as a common genitourinary cancer, accounting for 4.5% of all new cancer cases and 3% of cancer-related deaths in 2020, is the sixth most common type of cancer [ 1 ]. (biomedcentral.com)
Dairy2
In the United States, ≈38% of beef herds, 84% of all dairy herds, and 100% of large-scale dairy operation herds are infected ( 3 , 4 ). (cdc.gov)
AA and DHA are either biosynthesized from their respective dietary precursors, linoleic acid (LA, 18:2n-6), and α-linolenic acid (ALA, 18:3n-3), or directly sourced from the diet (mainly meat and dairy products for AA, fatty fish for DHA) 2 . (nature.com)
Molecular2
Here, we identify a molecular mechanism for detrimental effects of low maternal n-3 PUFA intake on hippocampal development in mice. (nature.com)
Suppressor of cytokine signaling (SOCS)-3 and protein-tyrosine phosphatase 1B (PTP-1B) are two endogenous inhibitors of tyrosine kinase signaling pathways and suppress both insulin and leptin signaling via different molecular mechanisms. (diabetesjournals.org)
Intake2
Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. (nature.com)
An overall increase in the dietary LA/ALA ratio and a reduction in LC n-3 PUFA intake, as found in the Western diet, leads to reduced DHA and increased AA levels in the brain 7 . (nature.com)
High1
Diaminobenzidine, which is commercially available, is prepared by treating 3,3′-dichlorobenzidine with ammonia with a copper catalyst at high temperature and pressure, followed by acidic workup. (wikipedia.org)
Cells2
These findings suggest that the response to anti-PD-1 hinges on pre-existing anti-tumor immune response and that anti-PD-1 acts to free the CD8 T cells from inhibition to exert their anti-tumor activities [ 3 ]. (biomedcentral.com)
Results: Light microscopy analysis revealed a decreased expression of GATA-3-positive cells when bone loss progressed. (bvsalud.org)
Show1
Estrone sulfate did not show any trans -stimulatory effects on either influx or efflux of [ 3 H]estrone sulfate via hOAT3. (aspetjournals.org)
Cases2
TNBC accounts for 170,000 cases of the global breast cancer burden and has been associated with disparities in racial incidence [ 3 ]. (ecancer.org)
Genetics the status of 2 major microsatellite in- Diamino benzidine was used as a chro- may play a role in up to 30% of cases [3]. (who.int)
Effects1
Nonetheless, combined inactivation of SOCS-3 and PTP-1B in brain revealed additive effects on several parameters, including partial resistance to DIO and associated glucose intolerance. (diabetesjournals.org)
Treatment1
This adjuvant treatment is accompanied by considerable morbidity [ 3 ]. (medsci.org)
Four thoroughbreds, ranging in aged from 3 to 4 years old were used for this study. (scielo.org.ar)
Function1
Therefore, we investigated the effect of maternal (i.e. gestation and lactation) n-3 PUFA deficiency on microglial function and its consequences on hippocampal development. (nature.com)
Long1
Among these, arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3) are the principal forms of the long chain (LC) polyunsaturated fatty acids, omega-6 and omega-3 (referred to as n-6 or n-3 PUFAs) of the grey matter. (nature.com)
Development1
However, the n-3 PUFAs deficiency-mediated mechanisms affecting the development of the central nervous system are poorly understood. (nature.com)