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  • genes
  • Up to 4% of the human genome is predicted to code for over 400 miRNAs, which are estimated to regulate at least 30% of all human genes 3 - 5 . (pubmedcentralcanada.ca)
  • Germline variants in the 3′-UTR of miRNA target genes might alter miRNA binding and thus associated with risk of cancer by affecting gene expression [ 11 ]. (jcancer.org)
  • Incubation of synthetic RNAs corresponding to the 3UTRs of Chlamydomonas chloroplast genes atpB and petD with a chloroplast protein extract resulted in the accumulation of stable processing products. (deepdyve.com)
  • To examine 3′ UTR function in vivo, the atpB 3′ UTR was replaced with the 3′ UTR sequences of the Chlamydomonas chloroplast genes petD, petD plus trnR, rbcL, petA and E. coli thrA by biolistic transformation of Chlamydomonas chloroplasts. (deepdyve.com)
  • A second, homologous protein, Gis2, was identified in the genome of C. neoformans and also bound the 3′-UTR probe, and deletion of both genes resulted in loss of binding in cell extracts. (asm.org)
  • MicroRNAs regulate gene expression by binding to the 3′‐untranslated region (UTR) of target genes. (aacrjournals.org)
  • RNAs
  • Dividing immune cells tend to synthesize messenger RNAs with shorter 3' regulatory regions, possibly because less control is required over RNA functions. (sciencemag.org)
  • Synthetic RNAs of the petA 3′ UTR and the antisense strand of atpB 3′ UTR were degraded in the extract. (deepdyve.com)
  • The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA- binding proteins and non-coding RNAs). (iospress.com)
  • loci
  • Previous genome-wide association study (GWAS) found several genetic loci that was associated with ESCC susceptibility [ 3 - 5 ]. (jcancer.org)
  • differentiation
  • In addition, expression profiles obtained by custom-designed microarrays on three different developmental systems (myoblast differentiation, male gonadal ridge formation, embryonic stem cell differentiation) showed that uaRNA expression is highly regulated and tissue-specific, and might be either concordant or discordant with respect to the upstream coding region depending on the cell type and on the developmental stage. (unimi.it)
  • enhances
  • The 3′-end of the human β-actin gene enhances activity of the β-actin expression vector system: construction of improved vectors," Journal of Biochemical and Biophysical Methods, 1997, vol. 36, No. 1, pp. 63-72. (freepatentsonline.com)
  • transcripts
  • Three transcripts were found in HepaRG cells and liver tissues: one represented a canonical mRNA with full-length 3′-untranslated region (UTR), one had a shorter 3′-UTR, and one contained partial intron-6 retention. (aspetjournals.org)
  • The alternative mRNA transcripts were validated by either rapid amplification of cDNA 3′-end or endpoint polymerase chain reaction (PCR). (aspetjournals.org)
  • Quantification of the transcripts by RNA-Seq and real time quantitative PCR revealed that the CYP3A4 transcript with shorter 3′-UTR was preferentially expressed in developed livers, differentiated hepatocytes, and in rifampicin- and phenobarbital-induced hepatocytes. (aspetjournals.org)
  • stop codon
  • Deletion of 3'-UTR near stop codon in rat DAT cDNA reduced the [3H]DA uptake activity when expressed transiently in COS-7 cell, as compared to the original 3.4 kb DAT cDNA, which includes 1.5 kb 3'-UTR.Although rat DAT does not have variable number of tandem repeat (VNTR) in its 3'-UTR, the results F Uggest the importance of 3'-UTR in DAT functional expression. (nii.ac.jp)
  • miRNA
  • In this study, we confirmed that KRAS is a target of let-7g in lung cancer cells, and that introduction of rs712 minor allele into 3'-UTR significantly compromised the miRNA/mRNA interaction by using a luciferase reporter system. (dovepress.com)
  • Our results demonstrated that upon arrival in cytoplasm, miRNA activities can be modulated locally by the 3′UTR. (pubmedcentralcanada.ca)
  • human
  • 3'-RACE in human substantia nigra cDNA library revealed a single amplification identical to the reported human DAT cDNA. (nii.ac.jp)
  • variants
  • We systematically searched for variants in the 3'-UTR of CUL3 using the Ensembl database. (jcancer.org)
  • In the present study, we searched for variants in the 3'-UTR of CUL3 and performed a case-control study to test whether these variants are associated with ESCC susceptibility. (jcancer.org)
  • Variants in the 3′-UTR of MTHFR are potential biomarkers for RPL. (ecerm.org)
  • structures
  • RNA modeling showed that the structures predicted in the 3′UTR were not affected by the tn insertion. (deepdyve.com)
  • regulate
  • Ribosome-induced RNA conformational changes in a viral 3'-UTR sense and regulate translation levels. (ucdenver.edu)
  • These results demonstrated that the ADAMTS1 3'-UTR may regulate the expression of ADAMTS1 mRNA. (okayama-u.ac.jp)
  • sequences
  • These results revealed that the 3′UTR can tolerate foreign sequences that do not disrupt essential signals required for virus replication. (deepdyve.com)
  • Since there are no recognized alignment programs that can adequately accommodate very divergent sequences, a method has been devised to construct and analyse a substantially improved 3′UTR alignment between these highly divergent viruses, based on the concept that deletions and/or insertions, in addition to substitutions, are important drivers of 3′UTR evolution. (microbiologyresearch.org)
  • Here, we review the mutations in 3′UTR regulatory sequences as well as the aberrant levels, subcellular localization, and posttranslational modifications of trans-acting factors that can promote or enhance the malignant phenotype of cancer cells. (iospress.com)
  • 2017
  • Clinical and Experimental Reproductive Medicine 2017;44(3):152-158. (ecerm.org)
  • allele
  • Furthermore, the association between A allele of rs10464867 and decreased risk of gastric cancer was more significantly in elder individuals per-allele OR = 0.720.59-0.88, P = 1.07×10−3, and male individuals per-allele OR = 0.730.62-0.87, P = 3.68×10−4. (duhnnae.com)
  • induces
  • Here we report that expression of versican 3′UTR induces organ adhesion in transgenic mice by modulating miR-199a* activities. (pubmedcentralcanada.ca)
  • Characterization
  • Characterization of the mutant virus (A24-3′UTR8110) revealed no significant differences in virus growth, translation efficiency or virulence in cattle compared to the A24 wild-type virus. (deepdyve.com)
  • contains
  • The RPL2 3′ UTR contains four G-triplets (GGG) that have the potential to form a G-quadruplex, and temperature gradient gel electrophoresis revealed a potassium-dependent structure consistent with a G-quadruplex that was abrogated by mutation of G-triplets. (asm.org)
  • regulatory
  • To identify the associations between polymorphisms of the 3′-untranslated region (UTR) of methylenetetrahydrofolate reductase ( MTHFR ) gene, which codes for an important regulatory enzyme primarily involved in folate metabolism, and idiopathic recurrent pregnancy loss (RPL) in Korean women. (ecerm.org)
  • produces
  • Proximal site use produces a short 3' UTR of approximately 195 bases, whereas distal site usage results in an approximately 6300-base UTR. (sigmaaldrich.com)
  • These results suggested that 3'-UTR of DAT plays an important role in the functional expression, however, its involvement differs from the case of norepinephrine transporter (NET), in which we have demonstrated that alternative splicing of NET 'at 3'-region produces functionally different isoforms. (nii.ac.jp)
  • distinct
  • This fraction also contained proteins which formed two distinct ARE-specific complexes with the TNF-alpha mRNA 3' UTR in electrophoretic mobility shift assays (EMSAs). (ox.ac.uk)
  • control
  • C ) Luciferase assay in HEK293 and Neuro2a cell lines using vectors with a control 3′UTR or the patient 3′UTR. (nih.gov)
  • cells
  • 5′-UTR-deleted, 3′-UTR-deleted, and 5′,3′-UTR-deleted gEpos were transfected into COS-7 cells, and the amount of transiently expressed Epo was measured. (kribb.re.kr)
  • Cells transfected with the 5′,3′-UTR-deleted gEpo showed the highest expression, 2.6 times that with wild-type gEpo. (kribb.re.kr)
  • association
  • Genotype variation within the 3′-UTR of the SEP 15 gene showed no association with breast cancer risk or clinico-pathological parameters in Caucasian women. (springer.com)
  • reporter
  • Patient 3′UTR is associated with a significant reduction in endogenous FMRP and reporter activity in multiple cell types. (nih.gov)