2020 claudin 5. Medical search. Frequent questions

Epub 2022 May 5. (nih.gov)

Agamben (2021, 8) vergleicht beispielsweise die 2020 verabschiedeten Notstandsgesetze mit der Aufhebung der Weimarer Verfassung im Jahr 1933, und Davis (2021b) erklärt, wie Großbritannien durch eine Reihe von Eil-Gesetzen, die durch das Parlament gepeitscht werden, während sich die Aufmerksamkeit der Bevölkerung auf andere Dinge richtete, in eine konstitutionelle Diktatur verwandelt wird. (alschner-klartext.de)
2021 May 5;41(5):1625-1637. (nih.gov)
Agamben (2021, 8), for example, likens the emergency legislation passed in 2020 to the suspension of the Weimar Constitution in 1933, and Davis (2021b) explains how, through a raft of legislation being rammed through Parliament while the population's attention is focused elsewhere, the UK is being turned into a constitutional dictatorship. (cvpandemicinvestigation.com)

Mull, Cory (July 5, 2016). (wikipedia.org)
2016;96(5):967-75. (ac.ir)

Bell, Jack (May 5, 2023). (wikipedia.org)

Human claudin-5 ELISA kit can measure concentrations of CLDN5 (claudin-5, BEC1, CPETRL1, TMVCF1) present is human biological fluids, serum, plasma and tissue homogenate samples. (elisakits.co.uk)
For this claudin-5 ELISA kit it is recommended that a standard curve is generated for each assay carried out. (elisakits.co.uk)

Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles. (elisakits.co.uk)
In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. (thermofisher.com)
Diffusion of the complex E1/E2-EGFR-SCARB1-CD81 to the cell lateral membrane allows further interaction with Claudin 1 (CLDN1) and occludin (OCLN) to finally trigger HCV entry (PubMed:12970454, PubMed:24038151, PubMed:12913001, PubMed:20375010, PubMed:19182773) (By similarity). (proteopedia.org)

Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Mini Samples Claudin 5 (CLDN5) were tested 20 times on one plate, respectively. (biomatik.com)
Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Mini Samples Claudin 5 (CLDN5) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
This assay has high sensitivity and excellent specificity for detection of Mini Samples Claudin 5 (CLDN5). (biomatik.com)
No significant cross-reactivity or interference between Mini Samples Claudin 5 (CLDN5) and analogues was observed. (biomatik.com)

Claudin-5 regulates the paracellular permeability in the blood-brain barrier and is the enriched tight junction protein at the BBB. (elisakits.co.uk)
Protein kinase D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1. (rndsystems.com)
Area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to assess the accuracy of the molecular classifier in differentiating immunological subgroups of PDAC.5 Result: The protein level of molecular classifier was verified by immunohistochemistry in human PDAC tissue. (bvsalud.org)
Chapter 4 and Chapter 5) Next, we investigated the role of an RNA binding protein, HuR, in pancreatic cancer EMT and CSCs. (ku.edu)
7) nuclear protein reflecting the level of proliferative activity (Ki-67) [4, 5]. (cttjournal.com)
The tight junctions protein Claudin-5 limits endothelial cell motility. (unibas.ch)

This triggered an increase in paracellular permeability via cellular redistribution of claudin 3 (CLDN3) from TJs into cell nuclei followed by disruption of epithelial integrity and formation of epithelial lesions. (springer.com)
Computational study of ion permeation through claudin-4 paracellular channels. (uchicago.edu)
Molecular Dynamics Simulations of Ion Selectivity in a Claudin-15 Paracellular Channel. (uchicago.edu)

Epub 2020 Jul 15. (nih.gov)

Furthermore, overexpression of Claudin-2 is sufficient to promote the ability of breast cancer cells to colonize and grow out in the liver. (thrombin-inhibitor.com)

Modifying the blood-brain barrier by targeting claudin-5: Safety and risks. (elisakits.co.uk)

The expression of genes encoding tight-junctional proteins were elevated (Claudin-2) or lost (Claudin-3, -4, -5 and -7) in highly liver aggressive in vivo selected cell populations. (thrombin-inhibitor.com)

Abstract fra European Association of Archaeologists Virtual Meeting 2020. (au.dk)

We demonstrate that loss of claudin expression, in conjunction with high levels of Claudin-2, is associated with migratory and invasive phenotypes of breast cancer cells. (thrombin-inhibitor.com)
Wild-type SARS-CoV-2 infection in dogs can induce formation of neutralizing antibodies, and low viral titers in dogs demonstrate seroconversion ( 5 , 6 ). (cdc.gov)

Vascular Biology, 5 (1). (unibas.ch)

JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function. (nih.gov)
Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases , BRITISH JOURNAL OF CANCER 121: (3) pp. 257-263. (doktori.hu)
Claudin-low breast cancers are aggressive tumors defined by the low expression of key components of cellular junctions, associated with mesenchymal and stemness features. (hal.science)
Finally, examination of clinical samples revealed that Claudin-2 expression is evident in liver metastases from patients with breast cancer. (thrombin-inhibitor.com)

5 Department of Abdominal Surgery, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. (jci.org)

He opted to transfer to play for the Alcorn State Braves in 2020, although they did not play that year due to COVID-19. (wikipedia.org)
We describe a case of PTPR in a 9-year-old girl who presented with a 5-month history of excessive appetite and weight gain. (surgicalneurologyint.com)

Cells are prepared and manufactured in an ISO 9001:2015 certified environment and ISO 5 cleanroom. (neuromics.com)
[ 4 , 5 ] are small perivascular nodules that are histologically and ultrastructurally identical to meningothelial cells of the CNS. (medscape.com)

In addition to intrathymic selection, and during this medullary residency period, CD4 + and CD8 + single positive (CD4SP, CD8SP) thymocytes acquire the ability to proliferate in response to TCR stimulation, and undergo licensing for cytokine production, prior to exiting the thymus to join the peripheral T-cell pool as Recent Thymus Emigrants (RTE) ( 5 , 6 ). (frontiersin.org)

Moreover, compared with normocalciuric stone formers, hypercalciuric patients have an average bone density that is 5-15% lower. (medscape.com)
The patients were also offered a patient experience questionnaire, with domains of comfort, scan time, scan noise, and claustrophobia assessed using a 5-point Likert scale. (snmjournals.org)
According to the global cancer database (GLOBOCAN), 34650951 cases of breast cancer were detected in the world in 2020, and 11210413 patients died from this disease [1, 2]. (cttjournal.com)

This time period includes the transit time for us to receive your return from the shipper (5 to 10 business days), the time it takes us to process your return once we receive it (3 to 5 business days), and the time it takes your bank to process our refund request (5 to 10 business days). (biomatik.com)

TGF-β1 acts predominantly through phosphorylation of the C-terminal MH2 domains of SMAD2 and SMAD3 via activin receptor-like kinase 5 (ALK5), of which activity is located at the C-terminal part of TGFBR1. (springer.com)

Claudin s are integral membrane proteins and components of tight junction strands. (dbcls.jp)
Tight junctions restrict the flow of ions and aqueous molecules between cells, and their permeability is determined by the profile of claudin expression and arrangement of claudins with other proteins at the paracellular barrier. (biocare.net)
1 In several cancers, this family of proteins is abnormally regulated, but certain claudins, like Claudin-4, are more frequently overexpressed in neoplasias. (biocare.net)
A recent study has suggested that COVID-19 can promote the secretion of "cytokines that have been associated with increases in barrier dysfunction and mislocalization of tight junction proteins, such as… Claudin-4. (biocare.net)
The multi-gene claudin (CLDN) family of tight junction proteins have isoform-specific roles in blood-tissue barrier regulation. (stanford.edu)
Application of electroacupuncture to GV20 and ST36 "reduces brain damage and related behavioral deficits" by upregulation of tight junction proteins occludin, caludin-5, and ZO-1. (healthcmi.com)

2018 ). Recently, according to a mathematical model that analyzed the nuclear bomb test-derived 14 C level in oligodendrocyte nuclei of the human brain, myelin exchange occur at a high rate, while the oligodendrocyte population is remarkably stable in white matter after 5 years of age. (springeropen.com)

CYP1B1 KD in MDA-MB-231 cells resulted in the loss of mesenchymal morphology, altered expression of epithelial-mesenchymal genes, and increased claudin (CLDN) RNA and protein. (nih.gov)

This study will become the basis for further studies on biological functions of Claudin-4 in B. japonicus formosus and the drug development for tumor theraputics. (zafu.edu.cn)
Immunohistochemical stains show that the tumor cells are positive for pancytokeratin, MOC-31, claudin-4, and PAX-8. (cancer.org)

We used Poly I:C as a surrogate to investigate the effects of dsRNA on EC function and showed activation via TLR3, loss of tight junction molecules (cladin-5) and increased permeability of EC membranes. (fda.gov)

CLDN26" /note=" claudin 15-like b" /db_xref="GeneID:108278410" exon 1. (dbcls.jp)
1006 /gene="CLDN3" /gene_synonym=" Claudin -3" /note=" claudin 3" /db_xref="GeneID:403648" /db_xref="VGNC:VGNC:39319" exon 1. (dbcls.jp)
953 /gene="CLDN2" /gene_synonym=" Claudin -2" /note=" claudin 2" /db_xref="GeneID:403649" /db_xref="VGNC:VGNC:39316" exon 1. (dbcls.jp)
Targeting PVT1 Exon 9 Re-Expresses Claudin 4 Protein and Inhibits Migration by Claudin-Low Triple Negative Breast Cancer Cells. (cuny.edu)
Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. (antikoerper-online.de)

Here, we use atomic force microscopy to quantify Claudin-5-dependent adhesion and find that this strongly contributes to the adhesive forces between arterial endothelial cells. (zfin.org)
Based on genetic manipulations, we reveal a non-canonical role of Claudin-5a during zebrafish vasculogenesis, which involves the regulation of adhesive forces between adjacent dorsal aortic endothelial cells. (zfin.org)
In vitro and in vivo studies demonstrate that loss of Claudin-5 results in increased motility of dorsal aorta endothelial cells and in a failure of the dorsal aorta to lumenize. (zfin.org)
The expression levels of claudin-5 and MCP-1 in the endothelial cells were determined using qRT-PCR and ELISA. (aging-us.com)
The down-regulated claudin-5 by hypoxic incubation in endothelial cells was up-regulated by treatment with Agomelatine. (aging-us.com)

1. https://www.rndsystems.com/target/claudin-4 2. (biocare.net)

During a pregnancy/lactation cycle, the mammary epithelial cells proliferate rapidly to form ducts and secretory alveoli through hormonal regulation, resulting in remodeling of the glandular tissue architecture into a milk-secretory organ [2, 3].Estrogen (mainly 17β-estradiol) is a key regulator of mammary gland development, especially for its essential in the epithelial cell proliferation and ductal morphogenesis of the mammary gland [4, 5]. (researchsquare.com)

Ictalurus punctatus claudin 15-like b (cldn15lb), mRNA. (dbcls.jp)
Canis lupus familiaris claudin 3 (CLDN3), mRNA. (dbcls.jp)
Homo sapiens claudin 7 (CLDN7), transcript variant 3, mRNA. (dbcls.jp)
Canis lupus familiaris claudin 2 (CLDN2), mRNA. (dbcls.jp)
RESULTS: We observed age-related increases in oxidative stress, AhR, CYP1B1, Aβ, BACE1, and AT1 receptor in the CA1 region of the hippocampus, and elevation of cerebral AβPP, AhR, and CYP1B1 mRNA, associated with decreased cerebral microvascular TJ protein claudin-5. (nih.gov)

Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease. (cdc.gov)

Cells with CYP1B1 KD had an enhanced chemosensitivity to paclitaxel, 5-fluorouracil, and cisplatin. (nih.gov)
[ 4 , 5 ] are small perivascular nodules that are histologically and ultrastructurally identical to meningothelial cells of the CNS. (medscape.com)
2020 ). However, the source of myelin-forming cells in remyelination has been a central theme for several decades (Franklin and Ffrench-Constant 2008 ). (springeropen.com)
This hypothesis supports that OPCs account for 5-8% of all cells in the adult brain (Franklin and Ffrench-Constant 2008 ) , that OPCs appear before myelin recovery in the plaque areas of MS patients (Scolding et al. (springeropen.com)

PA also caused significant BBB dysfunction characterized by leakage of different sized molecules across cerebral microvessels and a decreased expression of cell-cell junctions (VE-cadherin, claudin-5) in the brain. (bvsalud.org)
The expressions of CD68 and claudin-5 in the cerebral cortex were determined using an immunofluorescence assay. (aging-us.com)
The expression level of down-regulated claudin-5 in the cerebral cortex of MCAO mice was significantly suppressed by Agomelatine. (aging-us.com)

Wild-type SARS-CoV-2 infection in dogs can induce formation of neutralizing antibodies, and low viral titers in dogs demonstrate seroconversion ( 5 , 6 ). (cdc.gov)

Depending on the type of cancer, expression of Claudin-4 has been associated with either poor prognosis or a more favorable diagnosis. (biocare.net)
Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer. (biocare.net)
Claudin-3 and claudin-4: distinct prognostic significance in triple-negative and luminal breast cancer. (biocare.net)
Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer. (biocare.net)

Claudin-4 (Clostridium perfringens enterotoxin (CPE) receptor) is a tight junction protein encoded by the gene CLDN4. (biocare.net)

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression. (nih.gov)

doi: 10.1038/s42003-018-0051-5. (nih.gov)
doi: 10.1038/s41586-022-05163-5. (nih.gov)

Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress. (stanford.edu)

As part of the formation and maintenance of epithelial tight junctions, Claudin-4 participates in creating a barrier that can repel pathogenic invaders. (biocare.net)

Dual-Stained Cervical Cytology and Histology with Claudin-1 and Ki67 , PATHOLOGY AND ONCOLOGY RESEARCH 25: (2) pp. 477-486. (doktori.hu)

Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials. (nih.gov)

1006 /gene="CLDN3" /gene_synonym=" Claudin -3" /inference="alignment:Splign:2.1.0" misc_feature 56. (dbcls.jp)
58 /gene="CLDN3" /gene_synonym=" Claudin -3" /note="upstream in-frame stop codon" CDS 209. (dbcls.jp)
865 /gene="CLDN3" /gene_synonym=" Claudin . (dbcls.jp)
Summary: This gene encodes a member of the claudin family. (dbcls.jp)
953 /gene="CLDN2" /gene_synonym=" Claudin -2" /inference="alignment:Splign:2.1.0" CDS 59. (dbcls.jp)

This assay has high sensitivity and excellent specificity for detection of Mini Samples Claudin 5 (CLDN5). (biomatik.com)

Our findings uncover a novel role of Claudin-5 in limiting arterial endothelial cell motility, which goes beyond its traditional sealing function during embryonic development. (zfin.org)

On Aug 14, 2020 this sequence version replaced NM_001185023.1. (dbcls.jp)
On Aug 14, 2020 this sequence version replaced NM_001185022.1. (dbcls.jp)
Cloning and sequence analysis of claudin-4 cDNA from Bufo japonicus formosus[J]. Journal of Zhejiang A&F University, 2013, 30(4): 561-566. (zafu.edu.cn)

Moreover, compared with normocalciuric stone formers, hypercalciuric patients have an average bone density that is 5-15% lower. (medscape.com)

2. Serum zonulin and claudin-5 levels in children with attention-deficit/hyperactivity disorder. (nih.gov)
3. Serum zonulin and claudin-5 levels in children with obsessive-compulsive disorder. (nih.gov)
Claudin-5 protein levels didn't modify drastically inside 4 h immediately after lorlatinib administration, and vegf protein was up-regulated inside four h soon after administration. (jnkinhibitor.com)

NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to Temozolomide (TMZ) via NELFB and RPS6KB2 interaction. (cuny.edu)

Results revealed two full length cDNAs of claudin-4. (zafu.edu.cn)

Through this localization, Pgp restricts or prevents brain entry of a wide variety of small lipophilic drugs, which presents a significant hurdle to the treatment of various central nervous system (CNS) diseases [ 1 , 3 , 4 , 5 ]. (biomedcentral.com)
Indeed, anticancer drugs such as doxorubicin enter the lysosome either by passive diffusion along the cytoplasmic to lysosomal pH gradient (the lysosomal pH is approximately 5) or may be actively transported across the membrane by inward-turned Pgp pumps embedded in the lysosomal membrane. (biomedcentral.com)
Evidence regarding the efficacy of treatment with antiplatelets, anticoagulants, lipid-regulating drugs, and other methods in cSVD is lacking ( 5 - 7 ). (frontiersin.org)

We included 20 studies investigating migraine without aura ( N = 4), migraine with aura ( N = 8), both migraine with and without aura ( N = 3), or hemiplegic migraine ( N = 5). (biomedcentral.com)

In China, the mortality of cardiovascular disease has remained in the top three for many years and increases with aging [ 5 ]. (aging-us.com)

Anatomy28

Organisms7

Diseases10

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes28

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ELISA Kit2

Occludin3

CLDN54

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Vascular1

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20181

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