20202018Coronavirus2016ProteinZhang2021Genomic2022MammalianHomologicalIsomorphismGeneGeometryHomotopySequenceGenesDiseaseClassificationPandemicClinicalDeficiencyHttpsDomainsMETHODSInhibitorsStructuralLossesPathwayGroupsStrainsPathwaysProteinsSpacesInclusiveStudiesSearch ResultsShowDomainAvianRespiratoryMoleculesSpeciesImmune responsesMainPatientsNADPHMutantsChinaData
20205
- 2019). In the 2020 edition of "Chinese pharmacopeia", P. polyphylla var. (researchsquare.com)
- 2020), and antitumor results. (unscburma.org)
- These studies resulted in late 2020, with the first doses of immunization in the population, and there are currently 2,988,941,529 doses of the vaccine administered until July 5, 2021[ 1 ]. (medrxiv.org)
- Since the virus presented the potential to result in a pandemic, the WHO declared a public health emergency of international concern on this epidemic on the 31st January 2020. (spandidos-publications.com)
- 12-13 to be valid from 2019-12-13, autumn semester 2020. (lu.se)
20181
- VBI Vaccines Inc. ( NASDAQ: VBIV ) ("VBI"), a commercial-stage biopharmaceutical company developing next-generation infectious disease and immuno-oncology vaccines, today provided a corporate update, outlook for 2019, and announced its financial results for the fourth quarter and twelve months ended December 31, 2018. (vbivaccines.com)
Coronavirus6
- To identify the epidemiological characteristics and transmission patterns of pediatric patients with the 2019 novel coronavirus disease (COVID-19) in China. (aap.org)
- After the description of this new human coronavirus in December 2019, there was a global effort by researchers, public and private companies in the search for an effective vaccine to control this pandemic[ 2 - 4 ]. (medrxiv.org)
- Recently, severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS‑CoV‑2)‑causing CoV disease 2019 (COVID‑19) emerged in China and has become a global pandemic. (spandidos-publications.com)
- The virus was first officially named the 2019 novel coronavirus (nCoV) by the World Health Organization (WHO) and subsequently termed 'severe acute respiratory syndrome CoV 2 (SARS-CoV-2)' by The International Committee on Nomenclature of Viruses. (spandidos-publications.com)
- Collectively, all the associated diseases caused by SARS-CoV-2 are termed Coronavirus Disease of 2019 (COVID-19). (spandidos-publications.com)
- One of these five patients had Lassa virus disease and a coronavirus disease 2019 (COVID-19) co-infection. (bvsalud.org)
20161
- An Automatic Malware Homology Identification Method Based on Calling Habits", Chinese Journal of Electronic, Vol.44, No.10, pp.2410-2414, 2016. (ejournal.org.cn)
Protein10
- HHpred is an online server for protein structure prediction that uses homology information from HH-suite. (wikipedia.org)
- 2019 ). Structure-guided protein engineering has replaced the natural mutation of enzymes as one of the main tools of evolution (Cheng et al. (springeropen.com)
- For this purpose, NLRP3 homology model was built and the putative protein binding region of a non-covalent inhibitor MCC950 (used as a probe) was investigated using a combination of in silico techniques. (mdpi.com)
- Phosphopeptides with homology to the treacle protein (TCOF1) were disproportionately increased in progenitor cells, compared to their radiosensitive counterparts. (cdc.gov)
- Plasmodium parasites possess a protein with homology to Niemann-Pick Type C1 proteins (Niemann-Pick Type C1-Related protein, NCR1). (psu.edu)
- PfNCR1 protein knockdown results in severely attenuated growth and confers hypersensitivity to the compounds. (psu.edu)
- Results Seroconversion by day 40 occurred in 129 (97%) HCWs for the S1 protein, and in 69 (51.87%) HCWs for the N protein. (medrxiv.org)
- Homology modeling of the BCS1L protein was performed to analyze the structural and functional changes of the protein. (bvsalud.org)
- Structural analysis of the homology modeling showed that the compound heterozygous mutation had a significant impact on protein function. (bvsalud.org)
- Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
Zhang1
- PG), a meals and medication homology traditional Chinese language therapeutic natural herb, continues to be trusted as a normal Asian medication for the treating pulmonary and respiratory disorders (Zhang et al. (unscburma.org)
20214
- A retrospective analysis was conducted on the clinical characteristics of two siblings with developmental delay and lactic acidosis who were treated at the Neonatal Department of Children's Hospital of Chongqing Medical University in May 2019 and December 2021, respectively. (bvsalud.org)
- During 2019–2021, we isolated 62 swine influenza A viruses in Belgium and the Netherlands. (cdc.gov)
- In this study, we identified the prevailing swine IAVs circulating in Belgium and the Netherlands during 2019–2021 and determined their genotypes by whole-genome characterization. (cdc.gov)
- Samples were nasal and tracheobronchial swab specimens and lung tissues from pigs in Belgium and the Netherlands, collected during November 2019–December 2021. (cdc.gov)
Genomic2
- Results We have shown that the presence of ITRs flanking a gene targeting vector made up of homology to its genomic target decreased the frequency of random integration, leading to an increase in the gene targeting/random integration ratio. (scienceexhibitions.org)
- Here, we characterized neuronal death in B. schlosseri, a marine colonial tunicate that shares substantial genomic homology with mammals and has a life history in which controlled neurodegeneration happens simultaneously in the brains of adult zooids during a cyclical phase named takeover. (stanford.edu)
20221
- Rosen Law Firm, a global investor rights law firm, reminds purchasers of the securities of Homology Medicines, Inc. (NASDAQ: FIXX) between June 10, 2019 and February 18, 2022, inclusive (the "Class Period"), of the important May 24, 2022 lead plaintiff deadline . (globenewswire.com)
Mammalian4
- The N-terminus of Cvs7 provides homology to mammalian arrestins and the PY motifs can be found following this homology domain. (bioskinrevive.com)
- The useful homology of Cvs7 to mammalian arrestins was set up by verifying that the mutation of conserved residues within the arrestin motif ablated Cvs7 function. (bioskinrevive.com)
- To investigate the usefulness of mammalian Eps15 homology domain 1 (EHD1) as a prognostic marker for osteosarcoma, the expression of EHD1 in 57 osteosarcoma patients was measured using immunohistochemistry techniques and correlated with the clinicopathological features of patients. (biomedcentral.com)
- Mammalian Eps15 homology domain 1 (EHD1) is located in the chromosomal band 11q13 and is associated with lung, breast, head, neck, and small-cell lung cancer [ 4 ]. (biomedcentral.com)
Homological2
- We determine the structure of the Khovanov homology groups in homological grading 1 of positive links. (hu-berlin.de)
- The classical Künneth formula in homological algebra provides a relationship between the homology of a product space and those of its factors. (hiteshgakhar.com)
Isomorphism4
- In the cohomology case, we get some results which are equivalent to the notion of dependence of cohomology classes (by René Thom) and we can show that the set of isomorphism classes of complex vector bundles can be captured as a poset-stratified space via the poset of the subrings consisting of all the characteristic classes. (intlpress.com)
- A classical theorem of Whitehead in algebraic topology says that a continuous map between two simply connected topological spaces induces an isomorphism on homotopy groups if and only if it induces an isomorphism on integral homology groups (or equivalently if the map induces a quasi-isomorphism between singular chains with integer coefficients). (miami.edu)
- In this talk I will outline a proof of the following new extension of Whitehead's classical result: a continuous map between path connected spaces induces an isomorphism on homotopy groups if and only if it induces a quasi-isomorphism after applying the singular chains functor followed by the "cobar" functor with respect to the Alexander-Whitney coalgebra structure of the singular chains. (miami.edu)
- Update includes rationality results for spectra admitting a T-duality isomorphism, and extended comments on higher categorical aspects of iterated K-theory. (arxiv.org)
Gene6
- On the other hand, the expression of Rep Avibactam small molecule kinase inhibitor proteins, which produce a nick in the ITR, significantly increased non-homologous integration of the DNA fragment writing no homology towards the genome, but got no influence on gene concentrating on or arbitrary integration when the DNA fragment distributed homology using the genome. (scienceexhibitions.org)
- Moreover, AAV-mediated gene targeting has been reported to be less dependent on the extent of homology between the vector and the genome target than other methods [14]. (scienceexhibitions.org)
- Thus, to review the result of ITRs on fungus gene concentrating on, we built a book vector pAAVLUL known Avibactam small molecule kinase inhibitor as, formulated with the gene interrupted by gene and flanked with the ITRs (Body?1B). (scienceexhibitions.org)
- Homology-dependent gene silencing is definitely attained in by introduction of gene coding locations in to the somatic nucleus at high duplicate number, leading to reduced expression of most homologous genes. (thetechnoant.info)
- In order to determine the relationship that may exist between homology-dependent gene silencing in d4-2, derived from stock 51. (thetechnoant.info)
- these processes resulted in multiple genotypes with gene segments of swine, avian, and human origin. (cdc.gov)
Geometry1
- 22 April 1929 - 11 January 2019) was a British-Lebanese mathematician specialising in geometry . (wikipedia.org)
Homotopy2
- Furthermore via homology and cohomology the homotopy set $[X, Y ]$ can have other poset-stratified space structures. (intlpress.com)
- This theorem is important since homology groups are in general easier to compute than homotopy groups. (miami.edu)
Sequence1
- most organisms convert phosphoenolpyruvate (PEP) to pyruvate via pyruvate kinase, producing ATP from ADP [78], sequence selleckchem homology-based annotation has not revealed the presence of a pyruvate kinase in C. thermocellum. (hsp90-inhibitors.com)
Genes3
- These results were confirmed by transcriptomic analyses that highlighted the specific genes involved in these cell death pathways. (stanford.edu)
- Mutations in specific genes responsible for producing the enzymes required to break down GAGs result in their deficiency or malfunction. (cbinsights.com)
- Appearance of most endogenous genes writing homology using the international nucleic acidity is normally silenced or decreased, in what continues to be likened to a hereditary immune system. (thetechnoant.info)
Disease2
- Here we studied the effect of C. intestinalis AOX on mice engineered to express a disease-equivalent mutant of Uqcrh, encoding the hinge subunit of mitochondrial respiratory complex III, which results in a complex metabolic phenotype beginning at 4-5 weeks, rapidly progressing to lethality within a further 6-7 weeks. (bvsalud.org)
- Although most global melioidosis cases are reported from tropical regions in Southeast Asia and northern Australia, there are multiple occurrences from sub-tropical regions, including the United States (U.S.). Most melioidosis cases reported from the continental U.S. are the result of acquiring the disease during travel to endemic regions or from contaminated imported materials. (cdc.gov)
Classification3
- The homology classification of the unknown malicious code can find its corresponding family in which all the code share inherent similarities from the database, so that the defenders can make rapid response and processing. (ejournal.org.cn)
- We use the algorithm of malicious code visualization to translate the homology classification problem into the image classification problem. (ejournal.org.cn)
- We train it to complete the malicious code homology classification on two different datasets. (ejournal.org.cn)
Pandemic1
- During the Middle of December 2019, a virus-induced pneumonia emerged in Wuhan, China, which ultimately resulted in the current global pandemic ( 1 ). (spandidos-publications.com)
Clinical3
- With a more homogenous patient cohort in Part B, we look forward to identifying potential initial correlations between immunologic responses and clinical outcomes by year-end 2019. (vbivaccines.com)
- Although several FLT3 inhibitors have been developed and showed promising results in clinical trials, many patients develop drug resistance shortly after treatment starts and display poor outcome. (lu.se)
- However, for surveillance purposes, CDC will accept results obtained from NAAT approved by the Food and Drug Administration (FDA) and used according to the approved product labeling on the package insert, or a test produced and validated in accordance with applicable FDA and Clinical Laboratory Improvement Amendments regulations. (cdc.gov)
Deficiency1
- Regardless of the etiology, a deficiency of cyclooxygenase (COX), a key regulatory enzyme in the synthetic pathway of eicosanoid production, results in beneficial and detrimental physiologic conditions relative to imbalances of the eicosanoids. (medscape.com)
Https1
- To join the Homology class action, go to https://rosenlegal.com/submit-form/?case_id=4851 or call Phillip Kim, Esq. (globenewswire.com)
Domains2
- Hence, an appreciation of the interactions of WW domains with PY motifs resulted in the identification of the Artwork family. (bioskinrevive.com)
- The particularly phosphorylated tyrosine enables docking and following activation of some responding molecules filled with Src homology 2 or SH2 domains [33]. (thetechnoant.info)
METHODS2
- The major goal of the Journal of Computational Methods in Sciences and Engineering (JCMSE) is the publication of new research results on computational methods in sciences and engineering. (iospress.com)
- Methods and results: 25 rabbit hearts were excised, retrogradely perfused and assigned to two groups. (researchgate.net)
Inhibitors1
- Our results suggest that SLAP2 and ABL2 regulate FLT3 signaling and modulation of SLAP2 expression levels or targeting ABL2 could potentially synergize with FLT3 inhibitors to treat FLT3-ITD positive AML. (lu.se)
Structural1
- Gender relations and Modernity 177 between body and language take place around castration, that is to say, in more a structural way, the subtraction to a mythical pleasure (Chaboudez, 2019). (bvsalud.org)
Losses1
- Since its introduction to North America in the early 1900s, white pine blister rust (WPBR) caused by the fungal pathogen Cronartium ribicola has resulted in substantial economic losses and ecological damage to native North American five-needle pine species. (frontiersin.org)
Pathway4
- In senju mutants, reduced expression of galactose-containing glycans resulted in hyperactivation of the Toll signaling pathway in the absence of immune challenges. (sdbonline.org)
- In addition, gain of JNK signalling results in Toll pathway activation, revealed by stimulated transcription of Drosomycin ( Drs ) and increased cytoplasm-to-nucleus translocation of Dorsal. (sdbonline.org)
- However, several alternative proteins are expressed that may result in a tightly regulated pathway node (Figure 3a, Additional file 4) leading to pyruvate synthesis. (hsp90-inhibitors.com)
- Our results show that SLAP2 suppresses FLT3 downstream signaling pathways including AKT, ERK, p38 and STAT5 and facilitates FLT3 degradation through enhancing ubiquitination while ABL2 expression does not alter FLT3 stability or ubiquitination but partially suppresses FLT3 downstream signaling through the PI3K/AKT pathway. (lu.se)
Groups1
- From these facts, we deduce results on the fundamental group and the homology groups of our spaces. (aus.edu)
Strains1
- Figure 10 presents a panel of results for six of the strains tested. (plcsignaling.com)
Pathways5
- ROS subsequently take part and regulate different downstream buy Kinetin signaling pathways resulting in specific mobile functions [7-13]. (thetechnoant.info)
- The precise binding of the molecules can start signaling pathways resulting in cell proliferation and motility [37,38]. (thetechnoant.info)
- In response to PDGF arousal, there's a crosstalk between signaling pathways resulting in cell development. (thetechnoant.info)
- GWAS results updated to include EMBL-EBI expression data and Plant Reactome Pathways. (triticeaetoolbox.org)
- We present a model regarding to which different pathways of RNA fat burning capacity contend for transcripts and suggest that the comparative efficiencies of dsRNA development and of 3 RNA digesting of feeling transgene transcripts determine the results of transformation tests. (thetechnoant.info)
Proteins1
- This resulted in the identification of the yeast proteins category of arrestin-related trafficking adaptors (ARTs)which includes nine members which have conserved arrestin and PY motifs, seven which are predicted to really have the arrestin foldand hence Cvs7 was renamed Artwork1. (bioskinrevive.com)
Spaces2
- In this talk, I survey recent results (from joint research with Gabriel Katz and Boris Shapiro) about spaces of real polynomials of fixed degree n and restrictions on root multiplicities. (aus.edu)
- We further obtain results for the 3-torus and lens spaces. (hu-berlin.de)
Inclusive1
- All results are based on the pairwise analysis of inclusive sequences using the Maximum Composite Likelihood method in MEGA 4.0 [46]. (hsp90-inhibitors.com)
Studies2
- 2019). Modern phytochemistry studies indicate that the dried rhizomes of Paris species mainly contain steroidal saponins, flavonoids, triterpenoid saponins, ecdysis hormone, and other chemical components. (researchsquare.com)
- These 7 species are approximately identical in DNA homology studies. (cdc.gov)
Search Results2
Show3
- In this talk, we will show that the map induced by a ribbon concordance on knot Floer homology is an injection. (rutgers.edu)
- More concretely, we show that the first Khovanov homology is supported in a single quantum grading determined by the Seifert genus of the link, where the group is free abelian and of rank determined by the Seifert graph of any of its positive link diagrams. (hu-berlin.de)
- We also show that several infinite families of Heegaard Floer L-space knots have vanishing first Khovanov homology. (hu-berlin.de)
Domain2
- Based on these results and the crystal structure of the JAK2 kinase domain name, we hypothesize that small changes in the conformation of the regions of JAK2 surrounding tyrosines 868, 966, and 972 due to kinase assay. (biobender.com)
- Based on these results and the crystal structure of the JAK2 kinase domain name, we hypothesize that small changes in the conformation of the regions of JAK2 surrounding Tyr 868, 966, and 972 due, for example, to phosphorylation, binding to a ligand-bound cytokine receptor, and/or binding to SH2B1, may be essential for JAK2 to presume a maximally active conformation. (biobender.com)
Avian1
- Nomenclature updates resulting from the evolution of avian influenza A(H5) nmol/L) (Appendix). (cdc.gov)
Respiratory1
- The virus primarily infects the respiratory tract, resulting in pneumonia, acute respiratory distress syndrome (ARDS) and other fatal complications, including acute kidney injury, coagulation dysfunction and shock, according to a published report ( 4 ). (spandidos-publications.com)
Molecules1
- Nevertheless, many structurally different transgenes can cause the sensation (29,30) and exactly how these molecules result in the forming of dsRNA continues to be obscure. (thetechnoant.info)
Species2
- Purpose The mitogenic action of PDGF has been proven to associate with reactive air species (ROS) generation, however the mechanism resulting in ROS production and following cell proliferation isn't clear. (thetechnoant.info)
- Because many laboratories use tests that do not routinely distinguish Mycobacterium tuberculosis from closely related species, these laboratories report culture results as being positive or negative for " Mycobacterium tuberculosis complex. (cdc.gov)
Immune responses1
- Delayed and/or inadequate innate immune responses can result in failure to combat pathogens, whereas excessive and/or inappropriate responses cause runaway inflammation. (sdbonline.org)
Main1
- Despite the fact that study on PG as well as the main components is becoming significantly in-depth, it continues to be unfamiliar whether PG enables to accomplish antitumor results through immune rules, aswell as the system(s) of how PG promotes antitumor immunity. (unscburma.org)
Patients2
- A combination of surgery and chemotherapy results in the long-term survival of approximately 60-70% of osteosarcoma patients [ 3 ]. (biomedcentral.com)
- Results: Nine of the 13 EVD patients (age range: 22-70 years) survived. (bvsalud.org)
NADPH1
- This results in higher levels of NADPH and GSH, which improve antioxidant capacity during Erastin-induced ferroptosis. (bvsalud.org)
Mutants1
- Coexpression with Src-homology 2B1 (SH2B1), like coexpression with GH-bound GH receptor, partially restores the activity of all three JAK2 mutants. (biobender.com)
China1
- 2019). It is mainly distributed in southwestern China, Vietnam, and Uttarakhand and Manipur of India, Nepal, and Europe (Yang et al. (researchsquare.com)
Data1
- In February 2019, the independent Data and Safety Monitoring Board (DSMB) reviewed all safety data from Part A and unanimously recommended the continuation of the study without modification. (vbivaccines.com)