• Infrequent cell divisions also help reduce the risk of acquiring DNA mutations that would be passed on to daughter cells. (wikipedia.org)
  • These mutations are usually somatic (only within the involved tissues, not in the blood or germ cells and therefore, not heritable) and tend to cluster in the VEGF-PIK3CA and RAS-MAP signaling pathways. (medscape.com)
  • Recently, vascular anomalists have begun to repurpose drugs from adult oncology that specifically target pathogenic mutations. (medscape.com)
  • Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease. (nih.gov)
  • Most patients with mastocytosis have activating somatic mutations in the receptor tyrosine kinase kit (CD117). (digs-bb.de)
  • We want to understand how the hierarchical organization of mature blood cell regeneration from stem and progenitor cells shapes the accumulation of somatic mutations and hence the risk of developing blood cancer. (digs-bb.de)
  • Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC). (cdc.gov)
  • In collaboration with a group at the University of Geneva (Dr S.I. Nikolaev and Dr S.E. Antonarakis) and the group of Dr J.E. Fish from University of Toronto, they performed exome DNA sequencing of the tissue samples of 26 patients and found somatic activating KRAS mutations in some of them. (medscape.com)
  • In total, the researchers detected somatic activating KRAS mutations in tissue samples from 45 of 72 patients and in none of the 21 paired blood samples. (medscape.com)
  • 2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
  • As on 2019, there were about 1161.17 million cell phone users in India [ 2 ]. (biomedcentral.com)
  • In 2018, she has been selected as a Young Investigator by the Turkish Academy of Sciences and in 2019 she has been awarded Scientific Encouragement Award by the Ankara University. (yilmazerlab.com)
  • This notice announces the final Federal share (FS) disproportionate share hospital (DSH) allotments for FY 2018 and FY 2019, and the preliminary FS DSH allotments for FY 2020 and FY 2021. (alston.com)
  • This notice also announces the final FY 2018 and FY 2019 and the preliminary FY 2020 and FY 2021 limitations on aggregate DSH payments that States may make to institutions for mental disease and other mental health facilities. (alston.com)
  • Comorbidities and clinical outcomes in adult- and juvenile-onset Huntington's disease: a study of linked Swedish National Registries (2002-2019). (lu.se)
  • Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. (wikipedia.org)
  • Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
  • Although tardigrades are sometimes reported as eutelic animals, mitosis has been reported in several somatic tissues of adult eutardigrades. (researchgate.net)
  • iii potential uses of stem cells for generating human tissues and, Although it is not possible to What are the potential applications of cloning animals? (curtisrobertmacdonald.com)
  • She is also the vice director of the Stem Cell Institute of the same university since 2016. (yilmazerlab.com)
  • Increase in storage cell mitoses has been related to moulting and the late developmental stage of eggs (Czernekova and Jönsson 2016). (researchgate.net)
  • These and other studies - including the determination of the crystal structure of the entire spike ectodomain (Pancera 2014 Nature 514, 455-461) and the determination of the crystal structure of fully glycosylated envelope trimers (Stewart-Jones 2016 Cell 165, 813-826) - have led to an understanding of the molecular trickery that protects HIV-1 from the humoral immune response. (nih.gov)
  • It became a hot topic in 1996 when Dolly the sheep was cloned via a process called somatic cell nuclear transfer. (archstl.org)
  • 체세포 핵 치환 (Somatic-cell nuclear transfer, SCNT)은 난자 의 핵 을 제거한 후에, 체세포 의 핵을 이식하여 복제 를 하는 기술을 말한다. (wikipedia.org)
  • Dolly was the first successful cloning of a mammal from an adult somatic cell, demonstrating the viability of somatic cell nuclear transfer (SCNT). (yahoo.com)
  • Somatic mosaicism in the Wiskott-Aldrich syndrome: Molecular and functional characterization of genotypic revertants. (medscape.com)
  • Also known as somatic stem cells (from Greek σωματικóς, meaning of the body), they can be found in juvenile, adult animals, and humans, unlike embryonic stem cells. (wikipedia.org)
  • Unlike embryonic stem cells, the use of human adult stem cells in research and therapy is not considered to be controversial, as they are derived from adult tissue samples rather than human embryos designated for scientific research. (wikipedia.org)
  • Father Tad Pacholczyk is convinced that embryonic stem cells will someday cure diseases. (archstl.org)
  • That's why Father Pacholczyk, director of education at the National Catholic Bioethics Center in Philadelphia, said that the efforts to help people understand the immorality of embryo reserch, including human cloning, must focus on humanizing the issue and appreciating our own embryonic origins, not just on the desired results of embryonic or other types of stem-cell research. (archstl.org)
  • A decade later, cloning came to the forefront in Missouri with the narrow passage of Amendment 2, a ballot initiative in 2006 that constitutionally protects embryonic stem-cell research and human cloning. (archstl.org)
  • 2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)
  • Embryonic stem cells (ESC) can be expanded indefinitely without undergoing replicative senescence or aging due to their high telomerase expression. (biomedcentral.com)
  • Researchers create embryonic stem cells without embryo. (curtisrobertmacdonald.com)
  • Researchers create embryonic stem cells mature cells turn off some of the epigenetic controls that Stem Cell Science Frequently Asked Questions. (curtisrobertmacdonald.com)
  • Rb homeostasis is also essential for self-renewal and survival of human embryonic stem cells 10 . (biolegend.com)
  • Role of Otx2 in Embryonic Stem Cells (ESCs): Otx2 is an intrinsic determinant required to maintain the ESC metastable state by antagonizing ground state pluripotency and promoting commitment to differentiation. (cnr.it)
  • Almost all cases of this condition result from new (de novo) variants in the CDKL5 gene that occur during the formation of reproductive cells (eggs or sperm) or in early embryonic development. (medlineplus.gov)
  • These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)
  • Multipotency or multidifferentiative potential is the ability to generate progeny of several distinct cell types, (for example glial cells and neurons) as opposed to unipotency, which is the term for cells that are restricted to producing a single cell type. (wikipedia.org)
  • Div-Seq: single-nucleus RNA-seq reveals dynamics of rare adult newborn neurons. (nature.com)
  • Role of Otx2 in adult dopaminergic neurons: Otx2 specify post-mitotic neuron subtype identity in ventral tegmental area (VTA) and antagonizes dopaminergic vulnerability to the Parkinsonian neurotoxin MPTP. (cnr.it)
  • Cell assemblies and central pattern generators (CPGs) are related types of neuronal networks: both consist of interacting groups of neurons whose collective activities lead to defined functional outputs. (degruyter.com)
  • It is likely that constituent neurons in a cell assembly can be spread over large territories, intermixed with many other neurons ( Wallace and Kerr, 2010 ). (degruyter.com)
  • Variants in the CDKL5 gene reduce the amount of functional CDKL5 protein or alter its activity in nerve cells ( neurons ). (medlineplus.gov)
  • Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
  • First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
  • Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
  • This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. (lu.se)
  • The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
  • In this regard, developmentally generated DGCs are preferentially located in the outer GCL (in close contact with the ML) and show wider dendritic angles and more primary dendrites than adult-born DGCs. (biomedcentral.com)
  • While human induced pluripotent stem cells (hiPSCs) provide novel prospects for disease-modeling, the high phenotypic variability seen across different lines demands usage of large hiPSC cohorts to decipher the impact of individual genetic variants. (frontiersin.org)
  • The advent of the human induced pluripotent stem cells (hiPSCs) technology offers unprecedented opportunities for disease modeling, personalized medicine, and the development of new therapeutic interventions. (frontiersin.org)
  • Induced pluripotent stem cells (iPS) can be generated from various somatic cells and can subsequently be differentiated to multiple cell types of the body. (biomedcentral.com)
  • The main property that sets ESC apart from other cells is their pluripotent nature, meaning they can give rise/differentiate to cells of the three primary germ layers (mesoderm, endoderm and ectoderm) [ 13 ]. (biomedcentral.com)
  • This provided a proof-of-evidence of in vivo reprogramming of adult somatic cells towards a pluripotent state with high efficiency and fast kinetics. (yilmazerlab.com)
  • In an ongoing project, we are investigating how this mast cell ontogeny modifies the effect of a somatic kit mutation and may explain the heterogeneous phenotype of mastocytosis. (digs-bb.de)
  • Researchers have identified a genetic mutation in patients with an arteriovenous malformation (AVM) of the brain, a leading cause of hemorrhagic stroke in young adults and children. (medscape.com)
  • I think the value of the study is to show, as a principle, that a genetic mutation in a somatic cell can cause sporadic brain AVMs. (medscape.com)
  • Our hypothesis was that maybe it's a somatic genetic disease" or due to a mutation in the genes of a single cell. (medscape.com)
  • It's important to determine whether the mutation is specific to one type of vascular cell, for example, endothelial cells that line the lumen of vessels and regulate exchanges between tissue and blood and help prevent clotting, or vascular smooth muscle cells in the vessel wall that regulate the vessel diameter and adjust the blood flow like a faucet would. (medscape.com)
  • The Catholic Church has always held that stem-cell research and therapies are morally acceptable, as long as they don't involve the creation and destruction of human embryos. (archstl.org)
  • A year before Dolly, he successfully cloned two lambs (Megan and Morag) whose cells were taken from sheep embryos. (yahoo.com)
  • Automatically expanded hiPSCs exhibit normal growth characteristics, and show sustained expression of the pluripotency associated stem cell marker TRA-1-60 over at least 5 weeks (10 passages). (frontiersin.org)
  • To gain pluripotency, the reprogramming process typically involves transfecting adult somatic cells with certain pluripotency markers. (biomedcentral.com)
  • Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)
  • There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell plasticity. (wikipedia.org)
  • Transcription factor over-expression is a proven method for reprogramming cells to a desired cell type for regenerative medicine and therapeutic discovery. (nature.com)
  • Therapeutic cloning uses has some deficiency regarding the use of stem cells? (curtisrobertmacdonald.com)
  • We also molecularly defined the development of Sertoli, Leydig and peritubular myoid cells during the perinatal period, allowing us to identify candidate signaling pathways acting between somatic and germ cells in a stage-specific manner during the perinatal period. (biologists.com)
  • One line involves understanding the B cell pathways that produce broadly neutralizing antibodies and seeking to replicate their development. (nih.gov)
  • 2021. " Metabolic Adaptation to Hypoxia: Do Worms and Cancer Cells Share Common Metabolic Responses to Hypotic Stress? . (princeton.edu)
  • The adult stem cell can be labeled in vivo and tracked, it can be isolated and then transplanted back into the organism, and it can be isolated in vivo and manipulated with growth hormones. (wikipedia.org)
  • However, it is known that in vitro cell culture conditions can alter the behavior of cells, proving that a particular subpopulation of cells possesses stem cell properties in vivo is challenging, and so considerable debate exists as to whether some proposed stem cell populations in the adult are indeed stem cells. (wikipedia.org)
  • A recent report 35 demonstrates efficient in vivo prime editing in enriched degenerating retinitis pigmentosa mouse retinas with dual-AAV delivery of PE-SpRY, but this system may not be applicable to uses that do not confer a survival advantage among edited cells. (nature.com)
  • Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
  • Hemoglobin electrophoresis and blood-group testing may show elevated levels of fetal hemoglobin (HbF) and red cell I antigen, suggesting stress erythropoiesis. (medscape.com)
  • Similar to tissue-resident macrophages, mast cells are of dual ontogeny and are generated during both fetal and adult ("definitive") hematopoiesis. (digs-bb.de)
  • Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
  • Symmetric division gives rise to two identical daughter stem cells, whereas asymmetric division produces one stem cell and one progenitor cell with limited self-renewal potential. (wikipedia.org)
  • The Gerbaulet group studies the biology of hematopoietic stem and progenitor cells in their native environment. (digs-bb.de)
  • For decades, hematopoietic stem and progenitor cells have been studied primarily through such transplantation-based assays. (digs-bb.de)
  • Preconditioning of recipients by lethal irradiation or chemotherapy forces transplanted hematopoietic stem and progenitor cells to realize their maximum potential, but this does not necessarily reflect their fate and behavior in the native bone marrow environment. (digs-bb.de)
  • To investigate the proliferation and differentiation of hematopoietic stem and progenitor cells in their physiologic environment, we use state-of-the-art mouse models. (digs-bb.de)
  • At steady-state, HSC infrequently divide and slowly but continuously spawn rapidly dividing progenitor cells. (digs-bb.de)
  • Instead, for sporadic patient cells alternative strategies need to be evaluated. (lu.se)
  • Using single-cell RNA sequencing (RNAseq), we studied the development of ProSG, their SG descendants and testicular somatic cells during the perinatal period in mice. (biologists.com)
  • RUNX1-deficient mice fail to generate hematopoietic stem cells. (biolegend.com)
  • Excitingly, by combining both second and third lines of investigation, we succeeded in inducing cross-clade neutralizing antibodies in mice, guinea pigs, and rhesus macaques (Xu 2018 Nat Med. (nih.gov)
  • 6 ] successfully isolated OGSCs from the ovaries of pups and adult mice for the first time, transfected them with GFP virus in an appropriate environment in vitro, and then transplanted them into the ovaries of immunodeficient mice. (biomedcentral.com)
  • RNA-seq following PCR-based sorting reveals rare cell transcriptional signatures. (nature.com)
  • Progenitors can go through several rounds of cell division before finally differentiating into a mature cell. (wikipedia.org)
  • Based on the clinical finding, radiologic, and routine histopathological examination, this case was concluded as mature teratoma with somatic-type solid malignancy in the form of mucinous adenocarcinoma. (ejournals.ca)
  • A human being produces approximately 3 × 10 11 mature blood cells per day, representing 90% of all cells regenerated on a daily basis. (digs-bb.de)
  • Hematopoietic stem cells (HSCs) are at the top of the hematopoietic hierarchy and can differentiate into all types of mature blood cells throughout life. (digs-bb.de)
  • According to this concept, HSCs are activated by an increased demand for mature blood cells in situations such as systemic infection or severe blood loss. (digs-bb.de)
  • Loss of mature blood cells as well as systemic inflammation does not stimulate additional HSC contribution. (digs-bb.de)
  • Antibody production is severely impaired even when mature B cells are present, because of the lack of T-cell help. (medscape.com)
  • It is worth noting that the proliferation and differentiation of stem cells cannot be separated from the surrounding microenvironment, and immune system related cells are an important part of the microenvironment of the OGSCs nest [ 14 ]. (biomedcentral.com)
  • It is believed that the molecular distinction between symmetric and asymmetric divisions lies in the differential segregation of cell membrane proteins (such as receptors) and their associated proteins between the daughter cells. (wikipedia.org)
  • [ 64 ] Screening for PNH involves detection of deficiency of glycosylphosphatidyl-inositol (GPI) anchored proteins, such as CD14, CD16 and CD24, as well as fluorescent aerolysin (FLAER) for white blood cells, and CD55 and CD59 for red cell analysis, on flowcytometry. (medscape.com)
  • Initially the arrest is due to lack of sufficient cell cycle proteins to allow meiotic progression. (wikipedia.org)
  • [7] The cells that comprise the follicle, known as granulosa cells, are connected to each other by proteins known as gap junctions, that allow small molecules to pass between the cells. (wikipedia.org)
  • Our scientists have developed a wide array of stem cell-focused reagents and resources for many applications including flow cytometry , western blotting , ELISAs , and recombinant proteins for cell differentiation. (biolegend.com)
  • To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
  • Molecular Biology of the Cell 23: 975-75. (princeton.edu)
  • Hovén E , Flynn KE, Weinfurt KP, Eriksson LE, Wttergren L. Psychometric evaluation of the Swedish version of the PROMIS Sexual Function and Satisfaction Measures in clinical and nonclinical young adult populations. (cancercentrum.se)
  • Like the Knechts, the vast majority of Hodgkin patients are adolescents or young adults, and the disease almost never strikes before age 10. (stjude.org)
  • In young adults and children, a leading cause of stroke is an underlying vascular malformation, or abnormal connections between arteries and veins in the brain's vasculature. (medscape.com)
  • Stress, cell senescence and organismal ageing. (sens.org)
  • Wilmut moved to the University of Edinburgh the following decade, focusing on using cloning to make stem cells for regenerative medicine. (yahoo.com)
  • Results of their new study suggest that these malformations are a result of KRAS -induced activation of the mitogen-activated protein kinase-extracellular signal-regulated kinase (MAPK-ERK) signaling pathway in brain endothelial cells. (medscape.com)
  • Some studies underway include Novartis' international Alpelisib (Piqray) clinical trial for adults and children with PIK3CA-related overgrowth syndromes (NCT04589650) and Merck's follow-up study of the AKT inhibitor miransertib for PROS and Proteus syndrome. (medscape.com)
  • Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
  • Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)
  • Hundreds of current clinical trials attempt to develop new drugs for adult-type diffuse gliomas, but RT remains one of the few viable therapy options to improve both local control and survival. (biomedcentral.com)
  • Clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA in peripheral blood cells. (google.com)
  • The draft guidance includes CAR T cell-specific recommendations regarding chemistry, manufacturing, and control (CMC), pharmacology and toxicology, and clinical study design. (alston.com)
  • Blood Stem Cells Clinical Trials Cord Blood Eye Disease. (curtisrobertmacdonald.com)
  • Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)
  • Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)
  • The draft guidance document is intended to assist sponsors, including industry and academic sponsors, developing Chimeric Antigen Receptor (CAR) T cell products. (alston.com)
  • The VRC01 antibody, which we helped to identify in 2010 (Wu 2010 Science 329, 856-861), uses mimicry of the CD4 receptor to neutralize over 90 percent of HIV-1 isolates, though the inability of germline versions of VRC01 to bind to HIV-1 Env and its extraordinary level of somatic hypermutation suggest roadblocks to eliciting similar antibodies (Zhou 2010 Science 329, 811-817). (nih.gov)
  • [ 5 ] Ideally, SCID can be detected in a newborn before the onset of infections, with one well-documented example by screening of T-cell-receptor excision circles. (medscape.com)
  • Discoveries in recent years have suggested that adult stem cells might have the ability to differentiate into cell types from different germ layers. (wikipedia.org)
  • To dissect the role of PMN in this context, we pretreated rats with Repertaxin (Rep), a small molecule inhibitor of CXCR1 and CXCR2, to block recruitment and activation of PMN by CXCL1 or CXCL2 after cell transplantation. (p450inhibitors.com)
  • Direct neuronal conversion of resident glial cells is advantageous since they are ubiquitously distributed brain cells able to self-renew and replenish their number, making them ideal candidates for endogenous repair. (lu.se)
  • In hematopoietic stem cells, the MAPK/ERK pathway and PI3K/AKT/mTOR pathway regulate this transition. (wikipedia.org)
  • The first of which is their ability to divide or self-renew indefinitely, and the second their ability to generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. (wikipedia.org)
  • To ensure self-renewal, stem cells undergo two types of cell division (see Stem cell division and differentiation diagram). (wikipedia.org)
  • Here we examine the success rate of methods and data for differentiation by testing the ability of nine computational methods (CellNet, GarNet, EBseq, AME, DREME, HOMER, KMAC, diffTF and DeepAccess) to discover and rank candidate factors for eight target cell types with known reprogramming solutions. (nature.com)
  • Fig. 1: Identifying transcription factors that reprogram starting cells to target cell types. (nature.com)
  • Systematic analysis of telomere length and somatic alterations in 31 cancer types. (sens.org)
  • These two types of cells, somatic cells and gametes, mirror the type of responsibilities we have in different phases of our lives. (jewinthecity.com)
  • Some of the most serious A significant hurdle to this use and most uses of stem cells is that scientists do not yet it may become possible to generate healthy What specific types of conditions can stem cell therapy help treat? (curtisrobertmacdonald.com)
  • This subset of transcription factors, known as pioneer transcription factors (PTFs), possess the ability to engage closed chromatin that is not accessible by other types of transcription factors, establish gene expression, and elicit cell reprogramming. (cytoskeleton.com)
  • Differential dosage-dependent roles of OTX2 in specifying regional identities and neuronal cell types during brain development. (cnr.it)
  • These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)
  • HUTCHMED plans to develop and seek approval for TAZVERIK ® in various hematological and solid tumors, including ES, FL and diffuse large b-cell lymphoma ("DLBCL") in its Territory. (businesswire.com)
  • These germ cell tumors are rare, accounting for only about 2% of all germ cell tumors in men. (ejournals.ca)
  • These tumors are often located in the anterior mediastinum and occur in adult males with a peak incidence between 20-40 years. (ejournals.ca)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • Work in our lab is focused on studying astrocytes, a specialized class of non-neuronal cells in the nervous system known as glia, and their roles in regulating the formation and function of developing neural circuits in the healthy and diseased or injured brain. (drexel.edu)
  • Firstly, the cell constancy which is not a true eutely being several mitoses present even after hatching, even though some organs, such epidermis and nervous ganglia, have the same cell number in juveniles and adults. (researchgate.net)
  • The bladder and urethra are innervated by 3 sets of peripheral nerves arising from the autonomic nervous system (ANS) and somatic nervous system. (medscape.com)
  • This study describes a novel "maturation phase transient reprogramming" (MPTR) method to restore the epigenome of cells to a more youthful state. (elifesciences.org)
  • We identified both gene and protein markers for three temporally distinct ProSG cell subsets, including a migratory cell population with a transcriptome distinct from the previously defined T1- and T2-ProSG stages. (biologists.com)
  • Analysis of alternative lengthening of telomere markers in BRCA1 defective cells. (sens.org)
  • These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages 2,3 . (biolegend.com)
  • This experimental paradigm revealed the existence of a rare population of somatic stem cells that can stably reconstitute all blood lineages lifelong. (digs-bb.de)
  • However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
  • However, the specific life cycle of tardigrades, where energy intake and depletion, egg development, and moulting is highly intertwined and synchronized, make conclusions about the functional role of mitosis in storage cells difficult, however, and more studies are needed to reveal the mechanisms inducing mitosis in these interesting cells. (researchgate.net)
  • Cancer stem cells are a selective clonal subset of tumour cells that have avoided various cell regulatory mechanisms, including terminal differentiation, and yet have retained the self-renewal properties and proliferative potential of adult stem cells. (who.int)
  • Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
  • Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
  • Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
  • Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
  • Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
  • Some unipotent stem cells, such as mesenchymal stem cells. (curtisrobertmacdonald.com)
  • Recent work has demonstrated that the epigenome is already rejuvenated by the maturation phase of somatic cell reprogramming, which suggests full reprogramming is not required to reverse ageing of somatic cells. (elifesciences.org)
  • The morphological maturation of this cell population is crucial for the establishment of appropriate afferent connections from the perforant pathway. (biomedcentral.com)
  • However, some researchers do not consider multipotency to be essential and believe that unipotency self-renewing stem cells can exist. (wikipedia.org)
  • Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract, and skin, which are derived from endoderm and mesoderm. (wikipedia.org)
  • The Church also supports research and therapies using adult stem cells, which are cells that come from any person who has been born - including umbilical cord blood, bone marrow, skin and other organs. (archstl.org)
  • The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
  • This condition is defined by the finding of a hypoplastic bone marrow that has fatty replacement and that may have relatively increased nonhematopoietic elements, such as mast cells. (medscape.com)
  • Transfers are most likely to a bone marrow transplantation unit for stem cell reconstitution. (medscape.com)
  • SCID is considered a pediatric emergency because survival depends on expeditious stem cell reconstitution, usually by bone marrow transplantation (BMT). (medscape.com)
  • In juveniles, none of the measured phenotypic characters had significant predictive power for mitosis, whereas in adult animals in moult or in late egg developmental or post-laying stage were more likely to have mitotic storage cells. (researchgate.net)
  • Beyond this basic grouping, SCID may be categorized according to phenotypic lymphocyte profiles that include both B-cell status (B + or B - ) and NK-cell status (NK + or NK - ) in addition to T-cell status (T - , because there is always a T-cell deficiency in SCID). (medscape.com)
  • A recent article that reviewed publications on the genetics and epigenetics of fatigue in adults reported that phenotypic heterogeneity and the lack of a uniform systematic approach severely limited the findings from those studies (Landmark-Høyvik et al. (cdc.gov)
  • Stem cells are unique due to their ability to limitlessly self-renew and differentiate into each cell type in the adult body. (biolegend.com)
  • The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
  • This intermediate (I)-ProSG subset translocates from the center of seminiferous tubules to the spermatogonial stem cell (SSC) 'niche' in its periphery soon after birth. (biologists.com)
  • However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
  • These cells are the most abundant neuronal population of the DG and their morphology is closely related to their function and connectivity. (biomedcentral.com)
  • Retrospectively investigate the differences in outcomes of 118 adult-type diffuse gliomas patients between these two treatment plans. (biomedcentral.com)
  • The ovarian microenvironment affects the proliferation and differentiation of OGSCs, and immune cells and related cytokines are important components of the microenvironment. (biomedcentral.com)
  • With increasing time, the fluorescence intensity of cells gradually increased, and the cytokines IL-2 and TNF-α significantly promoted the proliferation of OGSCs. (biomedcentral.com)
  • It was found that ovoid cells in the epithelial layer of the ovary simultaneously expressed the germ cell specific marker MVH and the proliferation of cell marker BrdU using double-immunofluorescence staining. (biomedcentral.com)
  • Another functional constraint involves the viral fusion machinery, including the fusion peptide, which grabs hold of the target cell membrane, as an essential step in virus entry. (nih.gov)
  • Dolly's successful birth in 1996 marked the first time a mammal was successfully cloned from an adult cell. (yahoo.com)
  • Applying MPTR to dermal fibroblasts from middle-aged donors, we found that cells temporarily lose and then reacquire their fibroblast identity, possibly as a result of epigenetic memory at enhancers and/or persistent expression of some fibroblast genes. (elifesciences.org)
  • However, a general method for the identification of reprogramming factors to create an arbitrary cell type is an open problem. (nature.com)
  • Radiation therapy is the cornerstone of treatment for adult-type diffuse gliomas, but recurrences are inevitable. (biomedcentral.com)
  • Treatment target volume had no effect on the outcome in patients with adult-type diffuse gliomas. (biomedcentral.com)
  • Germ cell tumor with somatic-type solid malignancy is a germ cell tumor accompanied by a non-germ cell, the somatic-type malignant component in the form of sarcomas or carcinomas. (ejournals.ca)
  • Mediastinal teratoma with coexisting adenovarcinoma and carcinoid tumour (somatic-type malignancy): A case report with a review of the literature. (ejournals.ca)