Although the sequence homology of PrP among mammals is high, the ability of particular prion strains to cause disease in different species is determined by the conformational compatibility between a given strain and the host PrP C ( 2 ). (cdc.gov)
Based on the amino acid sequence homology and biological activity in macrophages, Shimamoto et al ( 15 ) identified that HLP was identical to MSP ( 15 ). (spandidos-publications.com)
A sequence homology search identified the protein as a member of the structural family Glyoxalase I. We have shown that the enzyme possesses glyoxalase I activity in the presence of Zn 2+ , Mg 2+ , Ni 2+ , and Co 2+ , in this order of preference. (rcsb.org)
20161
2016). In addition, Vihinen has introduced widely followed guidelines, recommendations and policies, he has founded a new sub-discipline of immunome, and introduced systematics to biological prediction methods and their assessment. (lu.se)
Pleckstrin2
Pleckstrin homology domain (PH domain) or (PHIP) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. (wikipedia.org)
Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)
Genome7
As reviewed in 2017, jumbo bacteriophages have diverse genome sizes (ranging from 208 to 497 kb) as well as diverse virion morphology and complex virion structure ( Yuan and Gao, 2017 ). (frontiersin.org)
This debate broke before a wider church audience in 2017, when Venema and theologian Scot McKnight co-wrote Adam and the Genome , arguing that Adam and Eve are as decisively refuted by science as the geocentric model of the solar system. (salvomag.com)
However the name from the family members derives from their homology with proteins involved in the formation of voltage-gated K+ (Kv) channels, the twenty-three KCTD genes present in the human genome encode for proteins implicated in a variety of biological processes not connected with voltage channels. (cancer-pictures.org)
Pan-genome approaches afford the discovery of homology relations in a set of genomes, by determining how some gene families are distributed among a given set of genomes. (biomedcentral.com)
A challenge on this field is that of designing fast and adaptive similarity measures in order to find a suitable pan-genome structure of homology relations. (biomedcentral.com)
Homologous genes can be distinguished into paralogous, when homology occurs within the same genome, or orthologous, when homology occurs between different genomes. (biomedcentral.com)
We use natureâ s mutagenesis (the set of related sequences present in the genome databases) and combine it with bioinformatics techniques such as homology modeling to perform structure/function analysis. (nd.edu)
Phosphatidylinositol lipids1
This domain can bind phosphatidylinositol lipids within biological membranes (such as phosphatidylinositol (3,4,5)-trisphosphate and phosphatidylinositol (4,5)-bisphosphate), and proteins such as the βγ-subunits of heterotrimeric G proteins, and protein kinase C. Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (wikipedia.org)
Protein2
Structural and functional literature studies have highlighted that specific domains, shared by proteins involved in completely different biological processes often, have been particularly created by progression to mediate protein-protein connections AG-014699 also to promote oligomerization. (cancer-pictures.org)
However, the cellular signaling process upon which hang acts remains unclear, and how the broadly expressed hang protein mediates specific behavioral changes in response to global increases of cellular stressors such as ethanol remains an open question (Ruppert, 2017). (sdbonline.org)
Computational2
These tasks were approached with computational methods: homology modeling, docking, ligand-based pharmacophore modeling and virtual screening. (helsinki.fi)
The Goodson laboratory uses multifaceted approaches including biochemistry, molecular biology, and computational biology to address cell biological questions. (nd.edu)
Structural3
Despite their biological relevance, the molecular and structural characterization of these proteins is still limited. (cancer-pictures.org)
A novel DNA-binding motif shares structural homology to DNA replicationand repair nucleases and polymerases. (embl.de)
This new DNA-binding motif shares structuralhomology with T4 RNase H, E. coli endonuclease III and Bacillus subtilisDNA polymerase I. The structural homology suggests a mechanism forsubstrate recognition by these enzymes. (embl.de)
20221
Jonasson, E. M. and Goodson, H. V. "The CLIP-170 N-Terminal Domain Binds Directly to both F-Actin and Microtubules in a Mutually Exclusive Manner" 2022 Journal of Biological Chemistry , 298 (5), 101820. (nd.edu)
Domains2
POZ/BTB domains are widespread modules detected in a variety of different biological contexts. (cancer-pictures.org)
The long-term research goal of the lab is to apply computer modeling to gain insight into cellular signal transduction pathways, specifically to provide deeper insight into both the normal and aberrant subcellular targeting of domains contained in proteins which are part of macromolecular complexes and function in various biological processes. (cuny.edu)
Genes3
The chapter considers why scientists are unable to name every gene that is discovered, and explains how genetic analysis uses the properties of genes as an approach to solve or dissect a complex biological problem. (oxfordsciencetrove.com)
Homology candidate relations are integrated into a global network and groups of homologous genes are extracted by applying a community detection algorithm. (biomedcentral.com)
ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. (embl.de)
Processes3
Secreted phospholipases A 2 (sPLA 2 s) participate in a very broad spectrum of biological processes through their enzymatic activity and as ligands for membrane and soluble receptors. (ijbs.com)
The enzymatic activity of sPLA 2 s define their participation in a very broad spectrum of biological processes. (ijbs.com)
This study provides insight into how nuclear Hangover/RNA signaling is linked to the cytoplasmic regulation of cAMP levels and results in neuronal adaptation and behavioral changes (Ruppert, 2017). (sdbonline.org)
Prediction1
Current studies are devoted into analysis of variations and their effects, including prediction method development, and systems biological studies. (lu.se)
Gene1
The dnc gene encodes for at least eight isoforms with high homology to the human phosphodiesterase 4 class of PDEs. (sdbonline.org)
This close phylogenetic relationship has led scholars from a diverse set of disciplines (e.g., biological and social sciences, notably psychology and anthropology) and theoretical perspectives (e.g., kinship theory, multilevel selection, social interactions, cultural traditions, competition, cooperation, innovation) to examine a broad range of research topics and methodologies in primatology. (springer.com)
Insights1
Biological insights from 108 schizophrenia-associated genetic loci. (nih.gov)
Methods1
Throughout his career, his aim has been to combine experimental, theoretical and data analysis methods to obtain holistic understanding of biological and medical problems. (lu.se)
Identifying Candidate Targets of Immune Responses in Zika Virus Based on Homology to Epitopes in Other Flavivirus Species. (cdc.gov)
Results1
The results of the biological tests will decide how well the models represent the theory of the 11β-HSD2 selectivity. (helsinki.fi)
Artificial1
Emerging from this nexus of Hayles' work, the posthuman reimagines the concept of the "human" as embodied in ecological relation to other beings, whether biological life, artificial life, or nonlife. (politicaltheology.com)
Deep2
Deep homology in the age of next-generation sequencing. (unibas.ch)
The structures are however derived from scutes , common to all classes of amniotes and are an example of what has been termed deep homology . (wikipedia.org)
Distinct2
these strains exhibit distinct biological properties in deer and transgenic cervidized mice. (cdc.gov)
sPLA 2 isoforms have unique tissue and cellular distributions, and therefore it is evident that individual sPLA 2 s have distinct enzyme-activity-related biological functions. (ijbs.com)
Principles2
In the present article, we perform cortical type analysis of the neocortex of adult rats, Rhesus macaques, and humans to propose hypotheses on homology of cortical areas applying the principles of the Hypothesis on the Dual Origin of the Neocortex. (springer.com)
A review on machine learning principles for multi-view biological data integration. (cdc.gov)
Effects1
2017), multiple protecting effects for the liver organ (Wu et al. (unscburma.org)
Mice1
2017). Additionally, they considerably inhibit tumor development in mice bearing liver organ tumor cells (Li et al. (unscburma.org)
Physical1
Under certain energetic relations between the combinable elements for the two-link homologies in the space of physical and (or) the chemical characteristics can be observed phenomenon with simple unitary symmetry invariants. (ss-pub.org)
Important1
The long-term research goal of her lab is to apply computer modeling to address important biological questions. (cuny.edu)
Activity1
therefore, they are considered to be phytoestrogens, but little is known about their biological activity. (medscape.com)
Debate1
How best to define "cognition" is an area of debate (Allen 2017). (edu.au)