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Reperfusion InjuryMyocardial Reperfusion InjuryIschemiaReperfusionMyocardial IschemiaMyocardial ReperfusionBrain IschemiaIschemic PreconditioningIschemic Preconditioning, MyocardialMyocardiumRats, Sprague-DawleyRats, WistarDisease Models, AnimalMyocardial InfarctionIschemic PostconditioningCardiotonic AgentsWarm IschemiaTime FactorsSoftwarePeroxidaseCold IschemiaProtective AgentsIschemic Attack, TransientMyocytes, CardiacMalondialdehydeHeartInfarction, Middle Cerebral ArteryApoptosisOxidative StressNeuroprotective AgentsMice, Inbred C57BLPerfusionCoronary CirculationMitochondria, HeartNecrosisSpinal Cord IschemiaL-Lactate DehydrogenaseKidneyCreatine KinaseConstrictionRandom AllocationMyocardial ContractionComputational BiologyHemodynamicsCytoprotectionSuperoxide DismutaseNeutrophil InfiltrationReactive Oxygen SpeciesAntioxidantsLiverWorkflowTioproninMice, KnockoutMyocardial StunningGerbillinaeNitric OxideDogsOrgan PreservationAspartate AminotransferasesHigh-Throughput Nucleotide SequencingModels, AnimalAcute Kidney InjuryAlanine TransaminaseVentricular Function, LeftAlgorithmsHydroxy AcidsDecanoic AcidsHindlimbMicrocirculationFree Radical ScavengersCerebral InfarctionOrgan Preservation SolutionsGenomicsIn Situ Nick-End LabelingBrainRabbitsIntestinesDatabases, GeneticCaspase 3User-Computer InterfaceHeme Oxygenase-1Molecular Sequence AnnotationCerebrovascular CirculationSignal TransductionMesenteric Artery, SuperiorHeart Arrest, InducedBlotting, WesternEnzyme InhibitorsCell DeathNeutrophilsCardioplegic SolutionsSequence Analysis, DNARNA, MessengerImmunohistochemistryInternetFree RadicalsAdenosineRats, Inbred LewVentricular PressureLipid Peroxidation
2019Ischemic2018OutcomesAneurysmsInflammatoryInflammationPreprintInjuryTreatmentMechanismsPeerPotentialPatientsFutureSuppliesCerebralMyocardialIschemic strokeEmbolization DeviceCathetersCannabinoidClinicalStrokeSystematicallyProvidePeer-reviewedPublicationArticlesHigherCurrentStrategiesDataArticleMajor
20192
  • The draft application was accepted for registration on December 10, 2018 and will be followed by the full submission and review in early January 2019. (archbiopartners.com)
  • La información más reciente sobre el nuevo Coronavirus de 2019, incluidas las clínicas de vacunación para niños de 6 meses en adelante. (stanfordchildrens.org)
Ischemic4
  • PURPOSE: Reperfusion therapy enables effective treatment of ischemic stroke presenting within 4-6 hours. (harvard.edu)
  • CONCLUSIONS: Diffusion time dependence predicted tissue outcome in ischemic stroke more accurately than the ADC, and may be useful for predicting reperfusion benefit. (harvard.edu)
  • nanoRBC in small quantities has been shown in preclinical studies to be superior over fresh blood in preventing ischemic damage and reperfusion injury in critical care situations. (invivosciences.com)
  • The objective of this study is to review the closing or open endovascular procedures for intracranial aneurysm, arteriovenous malformation, acute ischemic stroke, and carotid stenosis and related anesthetic implications. (anesth-pain-med.org)
20182
  • We compared the safety profiles of endovascular coiling (EC) and neurosurgical clipping (NC) performed for the treatment of ruptured and unruptured IA during pregnancy and the postpartum period.MethodsPregnancy-related or postpartum hospitalizations undergoing surgical intervention for IA were identified from the Nationwide Readmissions Database 2016-2018. (journaltocs.ac.uk)
  • This is a cross-sectional observational design study with retrospective review of medical records of patients with brain metastases treated with VMAT- RS between 2012 and 2018. (preprints.org)
Outcomes1
  • Due to its mechanism of action, it may also be of interest to pharmaceutical companies for improving outcomes in treating disease using their own commercialized or pipeline drugs or therapeutic intervention. (invivosciences.com)
Aneurysms1
  • 2016 ). Up to 70% of pseudoaneurysms and 20% of true aneurysms are liable to rupture and in this context, expected mortality can be unpredictable ranging from 25 to 100% (Pitton et al. (springeropen.com)
Inflammatory1
  • Carleton Hsia, NanoBlood: NanoBlood LLC has developed VitalHemeTM (nanoRBC), an innovative multifunctional neurovascular protective agent for the prevention and treatment of ischemia, reperfusion injury and damaging inflammatory reactions caused by superoxide generation. (invivosciences.com)
Inflammation2
  • Metablok (renamed "LSALT peptide" in Arch communications with the U.S. FDA) is a novel peptide drug candidate in the Arch development pipeline and a potential treatment for the following highly problematic indications: (i) inflammation, (ii) sepsis and (iii) cancer metastasis. (archbiopartners.com)
  • Inflammation is known to contribute to AKI related to ischemia-reperfusion and other insults to the kidney that may occur in the course of cardiac surgery. (archbiopartners.com)
Preprint1
  • Published from the original preprint after peer review and assessment by eLife. (elifesciences.org)
Injury2
  • Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion injury remains incomplete. (elifesciences.org)
  • Furthermore, we reviewed the current treatments available for neonates who have undergone intrapartum asphyxia, and highlight the emergence of maternal dietary creatine supplementation as a preventative therapy, which has been shown to provide multi-organ protection from birth asphyxia-induced injury in our preclinical studies. (frontiersin.org)
Treatment2
  • However, tissue progression from ischemia to infarction is variable, and some patients benefit from treatment up until 24 hours. (harvard.edu)
  • This paper reviews intercellular spontaneous mitochondrial transfer modes, mechanisms, and the latest methods of AMT/T. Furthermore, potential application value and mechanism of AMT/T in disease treatment are also discussed. (biomedcentral.com)
Mechanisms3
  • Many organisms in nature have evolved mechanisms to tolerate severe hypoxia or ischemia, including the hibernation-capable Arctic ground squirrel (AGS). (elifesciences.org)
  • Although hypoxic or ischemia tolerance in AGS involves physiological adaptations, little is known about the critical cellular mechanisms underlying intrinsic AGS cell resilience to metabolic stress. (elifesciences.org)
  • This article reviews the underlying molecular mechanisms, the latest updates, and future directions for pathophysiology-based TBI management. (preprints.org)
Peer1
Potential1
  • Each of the companies has been rigorously vetted through the SBIR/STTR review process prior to receiving the non-dilutive funding to engage in R&D that has the potential for commercialization. (invivosciences.com)
Patients1
  • This review aims to assimilate the latest developments in CSP and its application in children and CHD patients. (stanfordchildrens.org)
Future1
  • The latest advancements in microelectrode technology are reviewed and condensed, and future possibilities are explored. (preprints.org)
Supplies1
  • If you are unsure hither the choicest supplies and tack an eye to your particular needs, you can each esteem the person reviews. (yawatax.com)
Cerebral3
  • Background and purpose The first-pass effect (FPE), defined as a first-pass Expanded Treatment in Cerebral Ischaemia (eTICI) 2c/3 reperfusion, has emerged as a key metric of efficacy in mechanical thrombectomy (MT) for acute ischaemic stroke. (bmj.com)
  • Studies have found that individual pretreatments with chlorophyll and aqueous extracts of B. Monniera and Tagara (Valeriana wallichii) markedly attenuated ischaemica-reperfusion induced cerebral injury in terms of decreased infarct size, increase in short-term memory, motor in coordination and lateral push response. (ayurvedamagazine.org)
  • The results suggest that chlorophyll and aqueous extracts of both the plants prevent ischaemia-reperfusion induced cerebral injury with comparable potency. (ayurvedamagazine.org)
Myocardial2
Ischemic stroke1
  • Reperfusion using thrombolytic agents will therefore remain an important therapy for hyperacute ischemic stroke. (j-stroke.org)
Embolization Device1
  • Twelve cases were treated with ≥1 Pipeline Embolization Device of ≤3-mm diameter, including 2 with adjunctive coiling, with a median follow-up of 18 months (range, 4-42 months). (ajnr.org)
Catheters1
  • Conclusion Further development of combined MT by incorporating larger-bore aspiration catheters is associated with higher reperfusion rates, shorter procedure times, and lower need of rescue therapy while reducing the complication rates. (bmj.com)
Cannabinoid1
  • 10 6 Since pain is a manifestation of complex sickle pathobiology including inflammation, vascular dysfunction and ischemia/reperfusion injury, we investigated cannabinoid receptor-specific modulation of vascular function, inflammation and hyperalgesia. (haematologica.org)
Clinical2
  • In this review, we systematically summarize the advances in EV (especially exosomes) engineering for clinical application, focusing on strategies toward high yield, facile isolation, efficient cargo loading, improved delivery, and optimized manufacturing, which might unleash the infinite power of EVs in clinical translation. (thno.org)
  • A comprehensive understanding of basic and clinical research pipelines as well as the current status of thrombolytic therapy will help facilitate the development of new thrombolytics. (j-stroke.org)
Stroke2
  • In Phase 1, the NINDS asked the Stroke Progress Review Group (SPRG) to conduct a final review of the stroke research landscape, ten years after the first SPRG established research priorities for the field. (nih.gov)
  • Development of novel and more effective strategies to prevent stroke, protect the brain during ischemia and reperfusion, and facilitate its recovery after stroke hinges on basic and translational preclinical research. (nih.gov)
Systematically1
  • Our aim was to systematically review all available literature investigating the mechanism of action of flow diverters in both human patients and preclinical models. (ajnr.org)
Provide2
  • This review summarizes a fraction of the existing data to provide some guidance in future research efforts. (karger.com)
  • The primary aim of this review is to provide a roadmap for therapy development for rare, ultra-rare, and difficult to diagnose diseases, as well as increase awareness of the genetic component of SSMD. (biomedcentral.com)
Peer-reviewed2
Publication1
Articles1
  • Ten articles were eligible for inclusion in this review. (ajnr.org)
Higher1
  • The rate of FPE was higher with Catalyst 7 (54%) than Catalyst 6 (33%, p=0.009) and Catalyst 5 (32%, p=0.005), in addition to higher final eTICI 2c/3 reperfusion rates, shorter procedural times, lower need of rescue therapy and fewer procedure-related complications. (bmj.com)
Current1
  • The current review study will be extremely important and beneficial as a desk review as a result of the growing human population and rapid development in the area. (degruyter.com)
Strategies1
  • Here, we review the currently available thrombolytics, strategies for the development of new clot-dissolving substances, and the assessment of thrombolytic efficacies in vitro and in vivo . (j-stroke.org)
Data1
  • A systematic search of PubMed, Cochrane Central Register of Controlled Trials MEDLINE, EMBASE, and the Web of Science electronic data bases was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. (ajnr.org)
Article1
  • A 1995 article briefly reviewed the historical past of Bendectin in the United States and in contrast it with an identical Canadian product, Diclectin (fifty five). (ehd.org)
Major1
  • The focus of this review is on exosomes, a major subgroup of EVs. (thno.org)