• Multiple-drug resistance in burn patients: a retrospective study on the impact of antibiotic resistance on survival and length of stay. (oregonclinic.com)
  • Her current research analyzes multiple antibiotic resistance plasmids in different clinical isolates of Salmonella and their role in the pathogenesis of the bacteria. (marian.edu)
  • Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant bacterial populations. (elifesciences.org)
  • The extent of resistance loss was found to be generally antibiotic-specific, driven by mutations that reduce both resistance level and fitness costs of antibiotic-resistance mutations. (elifesciences.org)
  • The phenomena of antibiotic resistance can be attributed to inappropriate, self medication and excessive prescription of antibiotics over the past several years all over the world according to Carlet et al (2012). (bbrc.in)
  • Looking at the SDGs, many of the goals are almost impossible to achieve against a backdrop of antibiotic resistance. (avivainvestors.com)
  • However, these miracle antibiotic resistance and to encourage drugs are quickly losing their power Global response to antibiotic best practices among the general public, and becoming ineffective, as bacteria resistance health workers and policy makers to have increasingly become resistant to In order to address the growing threat of avoid the further emergence and spread them. (who.int)
  • The global rates of antimicrobial antibiotic resistance, a global coordinat- of antibiotic resistance. (who.int)
  • sustainability of public health response tackle AMR, world leaders gathered at WHO is encouraging all countries, to many communicable diseases, in- the United Nations General Assembly health partners, and the public to join cluding pneumonia, diarrhoea, tuber- (UNGA) in New York in September this campaign and help raise awareness culosis, malaria, HIV/AIDS, sexually 2016 and committed to taking a broad of antibiotic resistance. (who.int)
  • There is a great demand for completely new types of antibiotics and means to minimize the development and dissemination of antibiotic resistance. (lu.se)
  • It also provides insights about bacterial physiology as well as industrial and clinical aspects of antibiotics and about evolution of antibiotic resistance. (lu.se)
  • And the Antibiotic Resistance Lab Network performed more than 12,000 tests to contain the spread of resistant infections, just to name a few accomplishments. (cdc.gov)
  • Every day we are learning more about antibiotic resistance, which continues to be among the biggest health concerns in our country . (cdc.gov)
  • In 2017, CDC took several important steps to combat antibiotic resistance , including rolling out a containment strategy to slow the spread of drug-resistant diseases in healthcare facilities-starting with a single case-and supporting 25 innovators through a CDC pilot project to develop solutions to antibiotic resistance crises. (cdc.gov)
  • As we continued to work on lingering threats like antibiotic resistance and Zika, CDC also responded to new outbreaks in 2017, both at home and abroad. (cdc.gov)
  • Evidence for wastewaters as environments where mobile antibiotic resistance genes emerge. (janusinfo.se)
  • At the 15th annual Discovery on Target conference held in Boston, MA in September 2017, scientists described developments in designing epigenetic cancer drugs. (genengnews.com)
  • 13 June 2017 - The Global Action Plan on Antimicrobial Resistance (AMR) was adopted in May 2015 by all of WHO's Member States at the Sixty-eighth World Health Assembly, the governing conference of the Food and Agriculture Organization of the United Nations (FAO), and the World Assembly of Delegates of the World Organisation for Animal Health (OIE) on the same year. (who.int)
  • The database currently contains data for the reporting year 2016-2017. (who.int)
  • However, in other cases, such deleterious side effects of resistance mutations are undetectable, and resistance can even confer benefits in specific, antibiotic-free environmental settings ( Maharjan and Ferenci, 2017 ). (elifesciences.org)
  • Zika was often in the headlines in 2016 and 2017, and the mosquito-borne virus continues to be a threat, especially for pregnant women and their fetuses. (cdc.gov)
  • The database displays country responses on their progress developing the national antimicrobial resistance action plans, working with multiple sectors, and implementing key actions to address antimicrobial resistance. (who.int)
  • The survey will be repeated annually and in 2018 countries' progress made on the implementation of their antimicrobial resistance action plans can be tracked. (who.int)
  • Yet by overusing them, we are increasing the emergence of drug-resistant strains - what is known as antimicrobial resistance, or AMR. (avivainvestors.com)
  • All these issues have multiple, interrelated drivers, which can only be solved by policymakers globally (see COVID-19 and antimicrobial resistance: The next heath crisis? ). (avivainvestors.com)
  • The way that bacteria grow-either floating in liquid or attached to a surface-affects their ability to evolve antimicrobial resistance and our ability to treat infections. (elifesciences.org)
  • Resistance to antimicrobial treatments, also known as AMR, evolves rapidly, often over the course of a single infection. (elifesciences.org)
  • To understand how bacterial lifestyle influences the evolution antimicrobial resistance, strains of the bacterium A.baumannii were experimentally evolved either in liquid culture ( A ) or as biolfims on plastic beads ( B ). Santos-Lopez et al. (elifesciences.org)
  • found that liquid-grown and biofilm-grown strains of A.baumannii evolved resistance to the antimicrobial CIP in different ways: liquid-grown bacteria evolved a single resistant lineage that dominated the population ( C ), whereas biofilm-grown bacteria evolved multiple resistant lineages that co-exist within the population ( D ). Other important characteristics of the two evolved strains (such as resistance to CIP) are discussed in the main text. (elifesciences.org)
  • La Revue de Santé de la Méditerranée orientale national action plans, with technical as- Antimicrobial Resistance Surveillance other partners to enact effective public sistance provided by WHO, as needed. (who.int)
  • Towards monitoring of antimicrobial resistance in the environment: For what reasons, how to implement it, and what are the data needs? (janusinfo.se)
  • The present review mainly focused on the latest updates on RUNX2 in BCSCs and their roles in breast cancer progression and drug resistance, providing insight that may aid the development of RUNX2‑based diagnostics and treatments for breast cancer in clinical practice. (spandidos-publications.com)
  • Taken together, these studies indicated the involvement of RUNX2 in BCSCs and its roles in breast cancer diagnosis and drug resistance, revealing its promising prospective clinical application and utility as an antitumor drug target in the future. (spandidos-publications.com)
  • 2 A clinical trial to test the efficacy of combining the epigenetic cancer drug with pembrolizumab, a humanized antibody that inhibits PD-1, is currently underway. (genengnews.com)
  • Epigenetic drugs show significant effects on both preclinical and clinical studies in which the target development and research offer a promising direction for cancer therapy. (frontiersin.org)
  • The implication of this work for patients is that sequencing defined multiple clinically relevant mutations in metastatic breast cancer, which can inform the choice of next therapy after endocrine resistance develops, help select patients for clinical trials of drugs that target those mutations, and identify novel drug targets. (ascopost.com)
  • Multiple myeloma is of great concern since existing therapies are unable to cure this clinical condition. (agu.edu.tr)
  • Impact of Delays between the Clinical and Laboratory Standards Institute (CLSI) and the Food and Drug Administration (FDA) Revising Interpretive Criteria for Carbapenem-Resistant Enterobacteriaceae (CRE). (cdc.gov)
  • [ 20 ] See Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America . (medscape.com)
  • One such group of proteins, called the ATP-binding cassette (ABC) transporters, is able to expel some chemotherapy drugs, including doxorubicin , and some targeted therapies, like imatinib (Gleevec®) . (blogspot.com)
  • Therefore, autophagy is currently considered as a promising target for anticancer therapy that can also be successful in mutant Ras-expressing tumors characterized by chemotherapy resistance due to the protective autophagy. (aging-us.com)
  • The drug was particularly effective among patients with a poor prognosis, including patients whose tumors do not respond to treatment with the chemotherapy drug fludarabine , Dr. Dunleavy explained. (blogspot.com)
  • Collectively, our in vivo results demonstrating 4'-ethynyl-2-fluoro-2'-deoxyadenosine's excellent efficacy in preventing both vaginal and oral HIV transmission together with its relatively low toxicity and high potency against drug-resistant HIV strains support 4'-ethynyl-2-fluoro-2'-deoxyadenosine as a potential PrEP agent for use in women and infants, two of the most vulnerable populations at risk for acquiring HIV. (natap.org)
  • However, there is some incidence for antifungal resistance among some Candida strains, limiting treatment options. (intechopen.com)
  • Executive director of the project Professor Jackie J Yang said: "Our latest breakthrough with IBM allows us to specifically target and eradicate drug-resistant and drug-sensitive fungi strains and fungal biofilms, without harming surrounding healthy cells. (edie.net)
  • We present our study on the efficacy and phenotypic impact of compensatory evolution in Escherichia coli strains carrying multiple resistance mutations. (elifesciences.org)
  • Over 95% of RIF-resistant M. tuberculosi s strains have mutations within the RIF resistance-determining region (RRDR) of the rpoB gene, and several molecular genetic tests to detect RRDR mutations have been developed. (msdmanuals.com)
  • RIF resistance is used as a surrogate marker for MDR TB, because 95% of the strains resistant to RIF are also resistant to INH. (msdmanuals.com)
  • Several molecular mechanisms with antifungal agents have been reported for C. albicans where insertions, deletions, and point mutations in genes codifying target proteins are frequently related to the antifungal drug resistance. (intechopen.com)
  • Following her doctoral research, Dr. Akbar studied regulation of virulence genes in the Gram-Negative pathogen Salmonella Typhimurium, virulence gene expression in Chlamydia Trachomatis, and multiple drug resistance in Salmonella Enterica species. (marian.edu)
  • Abnormalities in genes such as ESR1, ERBB2, PIK3CA, AKT1 , and RBI can be acquired in the metastatic setting, and they appear to represent resistance mechanisms to endocrine therapy. (ascopost.com)
  • The goal of the research at Dana-Farber is to use next-generation sequencing technology to tease out resistance genes from tumor samples of patients with resistant estrogen receptor-positive metastatic breast cancer. (ascopost.com)
  • We highlight genes that increase the metastatic potential and the endocrine therapy resistance. (ascopost.com)
  • It occurs either by bacteria exchanging with one another the genes that confer resistance, or by an individual bacterium becoming resistant through mutations in its own genes. (elifesciences.org)
  • Researchers in the field of vector biology have put together an editorial outlining the need for a more urgent and proactive approach to insecticide resistance, if the gains made in malaria prevention in the 21st century are not to be lost. (sciencedaily.com)
  • Following the first indication of malaria parasites becoming resistant to drugs, the World Health Organization (WHO) recommended artemisinin combination as the front line treatment for malaria in order to minimise treatment failure. (sciencedaily.com)
  • The authors point out that this has meant that for more than a decade mosquito vectors of malaria have been targeted with a monotherapy, and inevitably resistance has been selected and pyrethroids are no longer capable of killing mosquitoes in some parts of Africa. (sciencedaily.com)
  • The 2012 WHO Global Plan for Insecticide Resistance Management in malaria vectors has raised awareness of the issue and put a framework in place to manage it. (sciencedaily.com)
  • Malaria is a serious infection and requires treatment with multiple medicines. (who.int)
  • Drug Resistance, Multiple, Bacterial" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • This graph shows the total number of publications written about "Drug Resistance, Multiple, Bacterial" by people in this website by year, and whether "Drug Resistance, Multiple, Bacterial" was a major or minor topic of these publications. (wakehealth.edu)
  • Below are the most recent publications written about "Drug Resistance, Multiple, Bacterial" by people in Profiles. (wakehealth.edu)
  • The treatment attacks drug-resistant fungal infections as well as targeting MRSA, a bacterial infection which has developed a resistance to common antibiotics. (edie.net)
  • Such strategies implicitly presume that resistance leads to reduced bacterial fitness in an antibiotic-free environment, and therefore these resistant populations should be rapidly outcompeted by antibiotic-sensitive variants. (elifesciences.org)
  • Bacterial resistance to antimicrobials has reached an unacceptable level which threatens the very existence of man and animal alike if the situation is not corrected in the near future. (bbrc.in)
  • This is another important reason to study bacteriocins and tap their therapeutic potential to combat drug resistant bacterial infections. (bbrc.in)
  • The story of drug resistance in TB is paralleled in many other bacteria over use and improper use of antibiotics stimulates drug resistance, which makes treatment of bacterial infections more difficult. (cdc.gov)
  • However, TB bacteria can develop resistance to multiple drugs. (cdc.gov)
  • This plasmid mobility makes it easier for bacteria to acquire resistance to multiple drugs. (scienceblogs.com)
  • So the Italian discovery signals two things that medicine has feared: that MCR has landed in bacteria that are already good at spreading through healthcare, and that it has begun the process of stacking up in bacteria, alongside other resistance DNA, on the way to creating what could be a truly untreatable bug. (scienceblogs.com)
  • The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. (wakehealth.edu)
  • In theory, the extent of fitness costs determines the long-term stability of resistance, and consequently, the rate by which the frequency of resistant bacteria decreases in an antibiotic-free environment. (elifesciences.org)
  • This paper is a review of MDR (Multiple rug Resistance) related issues which have become a global problem and on the possible role of bacteriocins as an effective option for fighting against MDR disease causing bacteria. (bbrc.in)
  • Experimental evolution of resistance to ciprofloxacin (CIP) in liquid-grown and biofilm-grown bacteria. (elifesciences.org)
  • However, for the bacteria grown in biofilms, the researchers found that there was less competition between lineages - presumably because they are not as free to move as the liquid-grown bacteria - and that multiple co-existing lineages were able to emerge ( Figure 1D ). (elifesciences.org)
  • Further experiments showed that liquid-grown and biofilm-grown bacteria had evolved unique strategies to resist CIP, resulting in different degrees of CIP resistance. (elifesciences.org)
  • Liquid-grown bacteria evolved low-level CIP resistance via mutations that increased the number of pump proteins that transport CIP out of cells. (elifesciences.org)
  • However, they are becoming less effective as bacteria develop resistance against them. (lu.se)
  • They found that in a 3D environment (where cells normally reside), unlike a glass slide, multiple melanoma cell lines and primary melanoma cells (from patients with varied genetic mutations) form many small protrusions called blebs. (phys.org)
  • However, the cost of resistance can be mitigated by compensatory mutations elsewhere in the genome, and therefore the loss of resistance may proceed too slowly to be of practical importance. (elifesciences.org)
  • We conclude that phenotypic reversion to the antibiotic-sensitive state can be mediated by the acquisition of additional mutations, while maintaining the original resistance mutations. (elifesciences.org)
  • It is frequently assumed that such compensatory mutations mitigate the fitness costs of resistance mutations without affecting the level of resistance. (elifesciences.org)
  • As the range of targets for compensation is much broader, compensatory mutations are more likely than the reversion of resistance mutations. (elifesciences.org)
  • If compensatory mutations are indeed widespread, pathogens can reach both high level of resistance and high fitness. (elifesciences.org)
  • Using HIV-1 as a model system, we optimized and validated PANDAA to detect HIV drug resistance mutations (DRMs). (nature.com)
  • Resistance to multiple drugs is the consequence of the accumulation of several of these mutations. (msdmanuals.com)
  • However, not all mutations conferring resistance are known. (msdmanuals.com)
  • The WHO-endorsed GeneXpert MTB/RIF (Cepheid) is an automated closed system that uses rapid PCR techniques to detect DNA sequences in sputum samples that are specific for M. tuberculosis, as well as certain mutations that confer resistance to RIF. (msdmanuals.com)
  • As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli , we identified a sequence type 131 strain harboring bla IMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C 2 plasmid. (ox.ac.uk)
  • So far, the isolates with mcr-1 haven't carried resistance to all other antibiotic classes. (scienceblogs.com)
  • Another cause for concern is that testing of C auris isolates demonstrated that nearly all exhibited varying levels of resistance to multiple classes of antifungal drugs. (jucm.com)
  • Use of next generation sequence to investigate potential novel macrolide resistance mechanisms in a population of Moraxella catarrhalis isolates. (cdc.gov)
  • In May, the hospital laboratory reported that the number of isolates of Mycobacterium tuberculosis resistant to multiple anti-TB drugs had increased during 1989 (Figure 1). (cdc.gov)
  • Drug-resistant isolates were identified by review of microbiology records at the hospital and at the state mycobacteriology laboratory. (cdc.gov)
  • To identify risk factors for MDR-TB, a case-control study was conducted by comparing case-patients with randomly selected TB patients at the hospital with drug-susceptible M. tuberculosis isolates. (cdc.gov)
  • A second case-control study compared case-patients with randomly selected patients at the hospital who had both HIV infection and TB with drug-susceptible M. tuberculosis isolates. (cdc.gov)
  • any fluoroquinolone (FQ) and at least one of three injectable second-line drugs, amikacin (AMK), kanamycin (KAN), or capreomycin (CAP). (msdmanuals.com)
  • Multiple myeloma (MM) with 1q21 gains invariably has a poor prognosis. (karger.com)
  • Saki N, Abroun S, Hajizamani S, Rahim F, Shahjahani M: Association of chromosomal translocation and miRNA expression with the pathogenesis of multiple myeloma. (karger.com)
  • Bergsagel PL, Mateos MV, Gutierrez NC, Rajkumar SV, San MJ: Improving overall survival and overcoming adverse prognosis in the treatment of cytogenetically high-risk multiple myeloma. (karger.com)
  • Abdi J, Jian H, Chang H: Role of micro-RNAs in drug resistance of multiple myeloma. (karger.com)
  • Bong I, Ng CC, Baharuddin P, Zakaria Z: MicroRNA expression patterns and target prediction in multiple myeloma development and malignancy. (karger.com)
  • As part of a panel discussion on Sunday about advances in understanding the genomics of multiple myeloma, Sagar Lonial, MD will describe novel state-of-the-art therapies for newly diagnosed patients. (emory.edu)
  • Background Multiple myeloma (MM) remains an incurable disease and oncolytic viruses offer a well-tolerated addition to the therapeutic arsenal. (bmj.com)
  • Multiple myeloma (MM) is a tumor of terminally differentiated plasma cells which expand in the bone marrow (BM). (bmj.com)
  • Multiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy. (agu.edu.tr)
  • When cancer cells resist the effects of drugs used for treatment, they can grow and reform tumors, a process known as recurrence or relapse. (blogspot.com)
  • Another approach is to treat patients with drugs that block the particular mechanism of resistance their tumors have developed, and then treat them again with the drug to which they grew resistant. (blogspot.com)
  • Specifically, the use of leukocyte-derived membrane proteins to functionalize nanovesicles (leukosomes) can enable their long circulation and target the inflamed endothelium present in many inflammatory pathologies and tumors, making them a promising and versatile drug delivery system. (frontiersin.org)
  • CSCs derived from both CSCs and non-CSCs give rise to tumors through self-renewal and are able to differentiate into multiple cell types [6]-[9]. (exposed-skin-care.net)
  • Resistant tumors are the most common cause of death, yet resistance mechanisms are poorly understood, he explained. (ascopost.com)
  • We acknowledge that tumors may develop resistance through other mechanisms. (ascopost.com)
  • Temozolomide (TMZ) is widely used for treating glioblastoma multiforme (GBM), however, the treatment of such brain tumors remains a challenge due to the development of resistance. (nature.com)
  • The Food and Drug Administration (FDA) approved venetoclax (Venclexta®) on April 11 for patients with chronic lymphocytic leukemia (CLL) whose tumors have a specific genetic alteration. (blogspot.com)
  • This study assesses the incidence of ADEs among participants on second-line drugs for tuberculosis (TB) in Cameroon. (bvsalud.org)
  • Multiple-drug resistant tuberculosis (MDR-Tb) has become a global issue especially in many African countries. (southsudanmedicaljournal.com)
  • Mycobacterium tuberculosis is defined as multidrug-resistant when it becomes resistant to first-line drugs as isoniazid and rifampin. (southsudanmedicaljournal.com)
  • Multiple antibiotics are needed to adequately treat tuberculosis. (cdc.gov)
  • Drug-resistant tuberculosis (TB) is a continuing threat that significantly complicates TB eradication efforts.The rising number of TB infections resistant to multiple drugs (MDR TB) in many countries has led to the demand for rapid and accurate same-day drug susceptibility testing (DST) for both first- and second-line anti-TB drugs, which would allow point-of-care therapeutic decision-making. (msdmanuals.com)
  • To overcome these drawbacks, rapid genetic DSTs have been developed that shorten the turn-around time from months to several hours.The rapid diagnosis of drug resistance by molecular methods is essential to immediately initiate effective antibiotic therapy, and thus improve treatment outcomes and reduce the transmission of MDR TB. (msdmanuals.com)
  • People with TB symptoms often visit multiple diagnosis and treatment exist and delays are common. (who.int)
  • In 2016 Paul became the Professor of Virus Genomics at Imperial College London and the Vice President of Infectious Diseases & Vaccines at Kymab Ltd. The Imperial College laboratory is continuing its research theme of investigating virus and host genetic variation during infection. (imperial.ac.uk)
  • Resistance can occur when cancer cells-even a small group of cells within a tumor-contain molecular alterations that make them insensitive to a particular drug before treatment even begins. (blogspot.com)
  • Because cancer cells within the same tumor often have a variety of molecular alterations, this so-called intrinsic resistance is common. (blogspot.com)
  • In other cases of resistance, cancer cells may adapt to the drug while it is being administered, acquiring molecular changes that allow them to escape its effects. (blogspot.com)
  • Molecular alterations that contribute to intrinsic or acquired treatment resistance include mutation of the drug's molecular target, changes in the way the drug interacts with the tumor, broad cellular changes, and changes in the tumor microenvironment , among others. (blogspot.com)
  • One combination treatment approach is to "co-administer drugs that work by different molecular mechanisms," Bissan Al-Lazikani, Ph.D., of Cancer Research UK and her colleagues wrote in Nature Biotechnology , "thereby increasing tumor cell killing while reducing the likelihood of drug resistance and minimizing overlapping toxicity. (blogspot.com)
  • And more than a dozen Winship researchers are contributing to the multidisciplinary program at this important annual meeting by presenting research papers and posters on topics that include mechanisms of drug resistance, experimental and molecular therapeutics, radiation oncology, biomarkers, and immuno-oncology. (emory.edu)
  • This chapter summarizes the main molecular mechanisms to C. albicans antifungal drug resistance, besides offering an overview of new antifungal agents and new antifungal targets to combat fungal infections. (intechopen.com)
  • Although we know a lot about the molecular and genomic landscape of primary estrogen receptor-positive breast cancer, this landscape is underexplored in the metastatic setting," said Ofir Cohen, MD , of Dana-Farber Cancer Institute, Boston, who presented his work in progress at the 2016 San Antonio Breast Cancer Symposium (SABCS). (ascopost.com)
  • Multiple-locus variable number of tandem repeat analysis as a tool for molecular epidemiology of botulism: The Italian experience. (cdc.gov)
  • Even when there is a broad range of antifungals drugs for Candida infections, azoles, polyenes, and echinocandins are considered among the most effective treatment. (intechopen.com)
  • 446,964 - RAPID DETECTION & RESPONSE to emerging drug-resistant germs is critical to contain the spread of these infections. (cdc.gov)
  • IBM estimates that the global cost of treating fungal infections will hit £7.4bn by 2016. (edie.net)
  • This was a cross sectional hospital- vancomycin as the drug of choice in the treatment of based study involving 300 patients of all ages with 6 infections caused by MRSA. (who.int)
  • Multiple factors control it, including more cautious use sible for saving millions of lives from are responsible for the rise of antibiotic of antibiotics, better hygiene and infec- previously deadly infections, but also resistance, with the main driving fac- tion control, and better prevention of made it possible to perform complex tor being the widespread overuse and infection through the use of vaccines. (who.int)
  • In early 2016, we knew about outbreaks of C. auris infections on multiple continents, but we were not sure whether C. auris was in the United States. (cdc.gov)
  • It makes possible to elucidate disease mechanisms, to predict protein functions and to select promising targets for drug development. (biomedcentral.com)
  • Venetoclax is the first FDA-approved drug that targets the BCL2 protein in cancer cells. (blogspot.com)
  • Controlled interrupted time series analyses were used to compare routinely-collected programmatic TB case notification rates in the intervention versus control area for 12 quarters prior to (2016-2018) and for 8 quarters after the start of the intervention (2019-2020). (bvsalud.org)
  • This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS). (wakehealth.edu)
  • ABSTRACT The bla IMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. (ox.ac.uk)
  • Furthermore, gene overexpression is also frequently associated to antifungal resistance as well as an increase in the activity of proteins that reduce oxidative damage. (intechopen.com)
  • Paul's research has identified how HIV develops resistance to antiviral drugs and has identified the first influenza disease severity gene in people hospitalised with influenza virus. (imperial.ac.uk)
  • Laboratory trials found that the polymer treatment eradicated more than 99.9% of Candida fungi cells after one hour of incubation - and no signs of drug resistance were noted after multiple treatments. (edie.net)
  • Resistance of fungi to polyenes is rare, but some Candida species, such as Candida glabrata and Candida krusei , are innately less susceptible to azoles, and Candida albicans can acquire azole resistance). (medscape.com)
  • It falls apart, everything falls out and there's little opportunity for it to develop resistance to these polymers. (edie.net)
  • Dr. Cohen provided two examples of how his research is potentially applicable in selecting second-line treatment for patients who develop resistance to endocrine therapy. (ascopost.com)
  • MDR TB which is also resistant to a fluoroquinolone and any second-line injectable drug, is called XDR TB, which means extensively drug resistant. (cdc.gov)
  • Rapid identification of resistance to FQs and the second-line injectable drugs AMK, KAN, and CAP is urgently needed for detection of XDT-TB. (msdmanuals.com)
  • Michael Gottesman, M.D. , head of the multidrug resistance section of NCI's Center for Cancer Research , and his colleagues study how ABC transporters contribute to cancer drug resistance. (blogspot.com)
  • However this original resistance mechanism was caused by a single site mutation, now a more potent form of resistance has seen resilient populations surviving up to 1000 times the concentration of insecticide that kills susceptible mosquitoes. (sciencedaily.com)
  • Suresh S. Ramalingam, MD is an invited speaker for a regulatory science and policy session, "New Drugs: A Review of Recent Breakthrough Therapies," that will take place on Tuesday, April 19. (emory.edu)
  • Like the developers of LSD1 combination therapies, 4SC AG researchers are pairing an epigenetic drug, in this case an HDAC inhibitor, with immunotherapies. (genengnews.com)
  • many had received multiple therapies. (blogspot.com)
  • However, activation of cytoprotective autophagy overcomes antiproliferative effect of the inhibitors and develops drug resistance. (aging-us.com)
  • Despite a large number of promising inhibitors for Ras/Raf/MEK/ERK pathway, recent works show that cancer cells often develop an autophagy-dependent resistance to inhibitors of Ras pathway [ 16 ]. (aging-us.com)
  • Inactivation of RBI predicts resistance to cyclin-dependent kinase (CDK) 4/6 inhibitors and to phosphatidylinositol 3-kinase -(PIK3CA) inhibitors, so these drugs would not be good choices for second-line therapy. (ascopost.com)
  • Although more than 25 antiretroviral medications are available from 6 major classes, an ART regimen for treatment-naive patients generally consists of 2 nucleoside reverse transcriptase inhibitors (NRTIs) in combination with a third active ART drug from 1 of 3 drug classes: an integrase strand transfer inhibitor (INSTI), a non-nucleoside reverse transcriptase inhibitor (NNRTI), or a protease inhibitor (PI) with a pharmacologic enhancer (ie, cobicistat or ritonavir). (medscape.com)
  • His laboratory produced the virus genome analysis of the Middle East Respiratory Syndrome Coronavirus (MERS CoV) outbreaks working with the Department of Health in Saudi Arabia, showing that the transmission pattern of the virus was consistent with multiple transfer events from an animal reservoir and contributing to the identification of camels as the animal reservoir. (imperial.ac.uk)
  • Together, the drugs appear to prevent cancer cells from evading detection. (genengnews.com)
  • the Strategy to respond to antimalarial drug resistance in Africa aims to improve detection, delay emergence, and limit selection and spread of resistant parasites. (who.int)
  • However, rapid detection of resistance to second-line drugs has lagged behind. (msdmanuals.com)
  • In par- and understanding of AMR through ef- to guide their efforts to curb antibiotic ticular, the viability of achievements fective communication, education and resistance. (who.int)
  • Researchers believe one possible way to overcome or delay the development of resistance is to treat patients with combinations of different drugs. (blogspot.com)
  • Commonly known as drug resistance , this phenomenon is one of the most challenging problems facing cancer researchers and patients today. (blogspot.com)
  • One hypothesis is that this blebbing may help the cancer cells survive or move around and could thus play a role in skin cancer cell invasiveness or drug resistance in patients. (phys.org)
  • A team of researchers in San Francisco set up a demonstration project to find out if Cabenuva could successfully be used in patients with HIV who had one or more challenges, particularly the following: unstable housing, major mental illness, drug use (mostly methamphetamine) and insufficient access to food. (eatg.org)
  • Patients with regular, or fully drug-susceptible TB, are treated with 4 drugs, the so-called first line drugs. (cdc.gov)
  • These drugs are safe, cheap and effective more than 95 percent of patients can be cured with these drugs, if they take the treatment as prescribed. (cdc.gov)
  • Patients with MDR TB need to be treated with second-line drugs, which are more toxic, more expensive, and less effective. (cdc.gov)
  • PETTS was a prospective observational study of patients with MDR TB in 9 countries, studying risk factors for, and the consequences of acquired drug resistance in the treatment of MDR TB. (cdc.gov)
  • This study was conducted to investigate the prevalence of methicillin resistance Staphylococcus aureus among patients in two health facilities in Akwa Ibom State, Nigeria. (who.int)
  • In fact, there are about 14 different classes of anti-TB drugs, all with different tuberculocidal or tuberculostatic effects, as well as toxicity profiles. (cdc.gov)
  • Scientists are pioneering many different methods to discover and test novel drug combinations that may be able to overcome multiple mechanisms of resistance or delay their emergence. (blogspot.com)
  • Growing resistance to antibiotics already causes over a million deaths a year. (avivainvestors.com)
  • Yet the overuse of antibiotics in farming and healthcare, and failures in water treatment are leading to increased resistance, while research and development (R&D) into new antibiotics is drying up. (avivainvestors.com)
  • The theme of resistance (AMR) have become alarm- ed effort involving all countries and key the campaign, "Antibiotics: Handle ingly high with dire consequences: over stakeholders has been initiated. (who.int)
  • Antibiotics were once regarded as miracle drugs. (lu.se)
  • The increasing occurrence of micro-organisms that are resistant to multiple antibiotics constitutes a serious threat to human health. (lu.se)
  • Overall, our study offers a novel conceptual framework for biomimetic NPs using a DoE strategy and consolidates the high therapeutic potential of leukosomes as a viable drug delivery system for anti-inflammatory and antineoplastic applications. (frontiersin.org)
  • Increasing studies have found that TMZ treatment could induce autophagy that may link to therapeutic resistance in GBM, but, the precise mechanisms are not fully understood. (nature.com)
  • To enhance the benefit of TMZ and avoid therapeutic resistance, effective combination strategies were tested using a small molecule inhibitor blocking the Wnt/β-catenin pathway in addition to TMZ. (nature.com)
  • Collectively, these data show that oral administration of 4'-ethynyl-2-fluoro-2'-deoxyadenosine protects BLT mice from HIV infection following multiple high-dose vaginal HIV challenges (P = 0.0002) (Figure 2h). (natap.org)
  • It is important to obtain testing for drug resistance and hepatitis co-infection before intitiation of ART, as these results can impact choice of regimen. (medscape.com)
  • Researchers have begun to home in on these proteins, looking for drugs that inhibit their actions in the cell. (genengnews.com)
  • However, the researchers subsequently made entry criteria more restrictive and did not allow people into the project with any degree of resistance to these drugs. (eatg.org)
  • Observing the number of reported cases of leishmaniasis and the difficulties in the treatment and prevention, it is clear the need for approaches that allow a wider understanding of the mechanisms of the diseases, and then we will be able to accelerate the steps toward the development of new drugs. (biomedcentral.com)
  • Hear how advances in diagnostic and treatment options are reducing the overall morbidity from multi-drug resistant TB. (cdc.gov)
  • We assessed the prevalence, trends and transmission dynamics of pre-treatment HIVDR within and between MSM, people who inject drugs (PWID), female sex workers (FSWs), heterosexuals (HETs) and perinatally infected children in Kenya. (lu.se)
  • Sometimes resistance develops quickly, within a matter of weeks of starting treatment. (blogspot.com)
  • Although endocrine therapy is effective for estrogen receptor-positive metastatic breast cancer, endocrine resistance frequently develops. (ascopost.com)
  • Viral supression allows for immunologic improvement (as measured by CD4 counts), prevents the selection of drug-resistance mutation, and decreases HIV transmission to others. (medscape.com)
  • The recurrence and drug resistance of breast cancer are intractable due to the presence of breast cancer stem cells (BCSCs), which are adequate to initiate tumor formation and refractory to conventional remedies. (spandidos-publications.com)
  • One mechanism by which cancer cells resist treatment is by expelling cancer drugs. (blogspot.com)
  • The overexpression of the demethylating enzyme O 6 -methylguanine-DNA methyltransferase (MGMT), removing alkyl groups from the O 6 position of guanine directly, has been implicated as one mechanism of TMZ-resistance 6 . (nature.com)
  • The current situation in Africa has, in part, been caused due to complacency when resistance first appeared to this class of insecticide in the 1970s, mainly due to pyrethroids being used to protect crops from insect damage. (sciencedaily.com)
  • Evidence on the distribution of pre-treatment HIV-1 drug resistance (HIVDR) among risk groups is limited in Africa. (lu.se)
  • If the acquisition of drug resistance that leads to treatment failure and to patient death can be substantially delayed, then cancer could become a chronic condition," Robert Brown, Ph.D., and his colleagues at the Imperial College London wrote in Nature Reviews Cancer . (blogspot.com)
  • These parasites cause Leishmaniasis, a worldwide distributed and neglected disease, with limited treatment options using currently available drugs. (biomedcentral.com)
  • Overall, pre-treatment HIVDR increased consistently, from 6.9% (before 2005) to 24.2% (2016-20). (lu.se)
  • Among HETs, pre-treatment HIVDR increased from 6.6% (before 2005) to 20.2% (2011-15), but dropped to 6.5% (2016-20). (lu.se)
  • If the NRTI abacavir (ABC) is considered as part of treatment, HLA-B*5701 must be obtained and ABC only prescribed if the patient is negative for this haplotype, as persons who are positive are at risk for a potentially serious hypersensitivity reaction to the drug. (medscape.com)
  • State‑of‑the‑art research has indicated the retention of RUNX2 expression in a more invasive subtype of breast cancer, and in particular, triple‑negative breast cancer development and drug resistance are associated with estrogen receptor signaling pathways. (spandidos-publications.com)
  • Recently it has been securely founded that CSCs are linked to epithelial-mesenchymal transition (EMT) metastasis drug resistance progression and relapse of lung malignancy [11]-[15]. (exposed-skin-care.net)
  • Aporte a la rutina de la trinchera asistencial donde los conocimientos se funden con las demandas de los pacientes, sus necesidades y las esperanzas de permanecer en la gracia de la SALUD. (blogspot.com)
  • In terms of new products, it is vital that we do all that we can to overcome hurdles that are preventing them being brought to market now, and introduce them in a format that will ensure they are not rapidly compromised by resistance. (sciencedaily.com)
  • In conclusion, the present study identified the mechanisms of TMZ-resistance of GBM mediated by DAB2IP and ATG9B which provides insight into a potential strategy to overcome TMZ chemo-resistance. (nature.com)