ANCAGranulomatosisBiomarkersVessel vasculitisRenalAnnals of the RPatientsVasculitidesRemissionEpubImmuneInfectious diseasesClinicallyRheumatic diseasesAutoimmune diseaseRetrospectivelyMyeloperoxidaseEndocrineDiagnosis2021PeripheralInterstitial lung diSerumVasculitis activity0.001RheumatologyOnsetDiabetesTherapeutic approachesCorrelationPositiveRareSpinal cordGeneticSymptomsAssessmentClinicalStudyHighPrevalenceProteinDrugsEarlyBlood
ANCA9
- Type 17 T-helper (Th17) cells have been suggested to be involved in the pathogenesis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). (nih.gov)
- There were significant positive correlations between the serum DcR3 levels and Birmingham Vasculitis Activity Score (BVAS), myeloperoxidase (MPO)-ANCA titers, white blood cell counts, serum creatinine levels, and serum C-reactive protein levels. (nih.gov)
- GPA is one of the antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic disorders. (medscape.com)
- An elevated classic antineutrophil cytoplasmic antibody (C-ANCA) level is 80% specific for granulomatosis with polyangiitis. (medscape.com)
- To investigate whether serum chitinase-3-like 1 protein (YKL-40) is associated with disease activity in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). (biomedcentral.com)
- Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a rare disease characterised by necrotizing inflammation of predominantly small vessels [ 1 ]. (biomedcentral.com)
- We are presenting a case of renal failure with anti-GBM and p-ANCA antibodies positive. (dokumen.tips)
- We recommend that patients suspected with pulmonary-renal syndrome should be checked for anti-GBM and p-ANCA antibodies, should undergo renal biopsy and should should have close long term follow up to watch for recurrence. (dokumen.tips)
- Those who suffer from these rare autoimmune diseases-termed anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides-produce antibodies that attack immune cells called neutrophils, causing inflammation in small- to medium-sized blood vessels. (blogspot.com)
Granulomatosis6
- Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is a rare multisystem autoimmune disease of unknown etiology. (medscape.com)
- Granulomatosis with polyangiitis, formerly known as Wegener granulomatosis , is a disease that typically consists of a triad of airway necrotizing granulomas, systemic vasculitis, and focal glomerulonephritis. (medscape.com)
- If the disease does not involve the kidneys, it is called limited granulomatosis with polyangiitis. (medscape.com)
- Objectives Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils and monocytes. (bmj.com)
- Although the structure of the granulomas and multinucleated giant cells in granulomatosis with polyangiitis (GPA) is known, little is established about what drove granuloma formation and why it is infrequently found in patients with myeloperoxidase-antineutrophil cytoplasm antibodies. (bmj.com)
- Although Henoch-Schonlein purpura (HSP) and Kawasaki disease (KD) are quite common forms of vasculitis, polyarteritis nodosa (PAN), Wegener's granulomatosis (WG) and Takayasu arteritis (TA) are diagnosed less commonly in children. (cyberleninka.org)
Biomarkers1
- Objective The objectives of this study were to investigate the mRNA and protein expression of biomarkers related to absorption in the small intestinal mucosa of humans and determine the relationships between small intestinal diseases and nutrition. (go.jp)
Vessel vasculitis1
- In this cross-sectional study, 25-hydroxy (OH) vitamin D3 levels were measured in adult patients with systemic small and medium vessel vasculitis including antineutrophil cytoplasmic antibody-associated vasculitis (AAV), cryoglobulinaemic vasculitis (CryV), IgA vasculitis (IgAV) and polyarteritis nodosa (PAN), and age- and sex-matched healthy subjects (HS) and patients with rheumatoid arthritis (RA) as control groups. (reumatologiaclinica.org)
Renal4
- Systemic scleroderma is a rare disease in which visceral manifestations occur, particularly peripheral vascular, digestive, cardiopulmonary and renal. (scirp.org)
- In the present case, the management of this disease required a high dose of corticosteroid therapy and extra-renal purification. (scirp.org)
- Subgroup analysis was performed to determine whether PN correlated with disease activity, renal involvement, or serum immune markers. (hku.hk)
- For unselected patients with HSP, the risk of end stage renal disease (ESRD) is reportedly very low, between 1.5% and 3% [3]. (cyberleninka.org)
Annals of the R1
- Annals of the Rheumatic Diseases. (lu.se)
Patients19
- To evaluate the Th17-TL1A systems as disease activity markers in AAV, we investigated the serum levels of TL1A and DcR3 in AAV patients. (nih.gov)
- Correlation of vitamin D3 levels with demographic characteristics and disease activity parameters of patients. (reumatologiaclinica.org)
- Rheumatoid arthritis is the most common coexisting autoimmune disorder in patients with Grave's disease and Hashimoto thyroiditis. (springer.com)
- RA patients are more likely to have thyroid-related antibodies, and some studies indicate an increased prevalence of thyroid diseases in RA. (springer.com)
- Hypothyroidism contributes to the increased risk for cardiovascular diseases and metabolic syndrome in RA patients and may be correlated with RA disease activity and response to treatment. (springer.com)
- In most studies, thyroid diseases (mainly hypothyroidism) are more common in SLE patients. (springer.com)
- Pregnant SLE patients are more prone to develop thyroid diseases and pospartum thyroitidis, and in case they suffer from thyroid disease, they have an increased prevalence of preterm delivery. (springer.com)
- Elevated prolactin during pregnancy in SLE patients is associated with lupus activity and poor outcome. (springer.com)
- Hypoparathyroidism was found to be increased in SLE patients and may be secondary to anti-parathyroid antibodies. (springer.com)
- In patients with suspected connective tissue disease (CTD)-associated interstitial lung disease (ILD) (CTD-ILD), referral to a center with expertise in management of CTD-ILD is recommended. (medscape.com)
- Educate patients about the natural history, progression, and treatment of the disease. (medscape.com)
- Chronic inflammation is connected to neoplastic transformation, and it is known that patients with autoimmune diseases have increased risks for some types of tumors [ 3 , 4 ], with neoplastic transformation often occurring [ 5 - 8 ]. (medsci.org)
- On kidney tissues obtained from AAGN patients, strong cytoplasmic staining of YKL-40 was found in cells present in inflammatory lesions. (biomedcentral.com)
- To examine endothelial dysfunction in SSc patients and to correlate findings with biochemical markers of endothelial injury, circulating EPC count, disease activity and organ involvement. (hku.hk)
- Median FMD% (4.8% vs. 7.8%, P<0.001) and NTG% (17.0% vs. 21.4%, P=0.002) were found to be significantly lower in SSc patients (n=52) than controls (n=52), especially in patients with limited disease (lSSc). (hku.hk)
- This was accompanied by higher level of sVCAM-1 in these patients compared to those with diffuse disease (P=0.01). (hku.hk)
- Patients with dual antibodies are con- sidered to be a vasculitis-variant of anti-GBM antibody nephritis. (dokumen.tips)
- Among 52 patients included in the analysis, 14 (27%) had a known exposure to a person with mpox, including sexual activity and other close intimate contact (eight) and household contact (six). (cdc.gov)
- 26%). These findings suggest that sexual activity remains an important route of mpox exposure among patients who do not report MMSC. (cdc.gov)
Vasculitides2
- Childhood systemic vasculitides are a group of rare diseases with multi-organ involvement and potentially devastating consequences. (cyberleninka.org)
- The primary systemic vasculitides (PSV) in children encompass a group of rare diseases that are characterized by the inflammation of blood vessels [1]. (cyberleninka.org)
Remission5
- Here, we report a severe case of IA with high arthritis disease activity in advanced pulmonary adenocarcinoma, causing permanent withdrawal of pembrolizumab, but the patient remained in complete remission (CR) 20 mo after the development of IA. (wjgnet.com)
- Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized rial. (mediar-press.net)
- Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis. (mediar-press.net)
- Researchers from the Immune Tolerance Network (ITN), an international clinical trials group funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), found that rituximab is as effective as the standard therapy at inducing and maintaining disease remission. (blogspot.com)
- This drug regimen has turned these once-fatal diseases into chronic conditions in which most people can achieve remission, although relapse is common. (blogspot.com)
Epub1
- Epub 2016 Jun 1. (nih.gov)
Immune3
- Rheumatic manifestations of endocrine disorders may present as a definite rheumatic disease (such as pseudogout in hyperparathyroidism), as rheumatic symptoms such as arthralgia and myalgia, as positive immune serology, or may mimic rheumatic diseases (e.g., skeletal abnormalities in hypoparathyroidism can mimic ankylosing spondylitis). (springer.com)
- Immunoglobulin G4-related disease (IgG4-RD) is a chronic immune-mediated fibroinflammatory disorder that often manifests with tumor-like masses and/or painless enlargement of multiple organs. (msdmanuals.com)
- in allergic disease, it is thought to have an immune-inhibitory role in preventing anaphylactic reactions to allergens. (msdmanuals.com)
Infectious diseases2
- During the preceding six weeks the girl had no signs or symptoms of infectious diseases nor she had assumed any drugs. (biomedcentral.com)
- Clinical Infectious Diseases. (vircell.com)
Clinically1
- Our findings suggest that serum YKL-40 may be a clinically useful biomarker to assess AAV disease activity. (biomedcentral.com)
Rheumatic diseases3
- Rheumatic diseases are associated with endocrine disorders which may have an impact on the clinical aspects of those diseases. (springer.com)
- Cushing syndrome in the rheumatic diseases is mainly secondary to glucocorticoid treatment. (springer.com)
- Autoimmune thyroid disease is the most common, while rheumatic diseases are rare. (springer.com)
Autoimmune disease1
- Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined to represent a paraneoplastic syndrome. (medscape.com)
Retrospectively1
- According to the guidelines of the International Gastrointestinal Standardization Group, after exclusion of extra-intestinal, infectious or parasitic diseases, CEs can be subdivided retrospectively based on the response to different treatment into: food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE) and idiopathic inflammatory bowel disease (IBD). (frontiersin.org)
Myeloperoxidase1
- Recent studies have reported an association between elevated myeloperoxidase levels and the severity of coronary artery disease. (wikipedia.org)
Endocrine5
- Endocrine diseases are a heterogeneous group of disorders which can affect nearly any body system including the musculoskeletal system. (springer.com)
- The rheumatic manifestations may result from a direct effect of the hormones, the occurrence of several autoimmune phenomena in the same person (due to genetic or environmental influences), secondary to endocrine disease complications or effects of advanced glycation end products in the case of diabetes. (springer.com)
- Addison's disease is mainly related to endocrine autoimmunities, and the association with connective tissue diseases is rare. (springer.com)
- Although the etiology of Hashimoto's thyroiditis (HT), a common autoimmune endocrine disease, is unknown, studies suggest a potential association with genetic factors and environmental conditions inducing excessive iodine intake. (medsci.org)
- Hashimoto's thyroiditis (HT), also known as lymphocytic thyroiditis, is a common autoimmune endocrine disease with an increasing prevalence in recent decades [ 1 , 2 ]. (medsci.org)
Diagnosis1
- Diagnosis of Behçet?s disease : comparison of two sets of classification criteria. (unican.es)
20211
- 2021) Is the new VirClia effective in cat scratch disease? (vircell.com)
Peripheral1
- Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)
Interstitial lung di2
- As mentioned previously, immunosuppression is the cornerstone of the medical management of connective tissue disease (CTD)-associated interstitial lung disease (ILD) (CTD-ILD). (medscape.com)
- Interstitial lung disease related to rheumatoid arthritis : what do we don?t know? (unican.es)
Serum2
- The serum level of DcR3 may be a useful marker for disease activity in AAV. (nih.gov)
- 1 ] of the Mayo Clinic first reported and confirmed GFAP-IgG in cerebrospinal fluid (CSF) and/or serum as a specific biomarker for this disease in 2016. (biomedcentral.com)
Vasculitis activity3
- Birmingham vasculitis activity score (BVAS) (version 3), five factor score (FFS), and short form-36 (SF-36), as well as clinical and laboratory data were collected. (biomedcentral.com)
- After defining the classification criteria for primary systemic childhood vasculitis, the next step was to perform a validation study using the original Birmingham vasculitis activity score as well as the disease extent index to measure disease activity in childhood vasculitis. (cyberleninka.org)
- Presently, there are efforts in place to develop a pediatric vasculitis activity score. (cyberleninka.org)
0.0011
- Lower circulating EPC count was found to be associated with high disease activity (P=0.04), abnormal forced vital capacity (P=0.003), longer disease duration (P=0.04), total skin score>20 (P=0.03) and lSSc subset (P<0.001). (hku.hk)
Rheumatology2
- Open Journal of Rheumatology and Autoimmune Diseases , 7 , 158-166. (scirp.org)
- Assessment of disease activity is likely to become a major area of interest in pediatric rheumatology in the near future. (cyberleninka.org)
Onset1
- Prognosis for individuals with PAN varies with a better outcome in children compared to adult onset disease where the mortality rate can be as high as 20-30% despite aggressive therapy [5]. (cyberleninka.org)
Diabetes2
- The impact of diabetes on disease activity is yet to be fully elucidated. (springer.com)
- Prolonged treatment with corticosteroids leads to a large number of comorbidities such as diabetes mellitus, hypertension, osteoporosis, and psychiatric disease. (medscape.com)
Therapeutic approaches1
- In recent decades, the clinical outcome of AAV has significantly improved owing to advances in understanding of the disease and to the advent of novel therapeutic approaches [ 4 ]. (biomedcentral.com)
Correlation1
- There was a significant correlation between PN and anti-SM antibody, and there was a trend showing decreased motor and sensory action potential amplitudes in our systemic lupus erythematosus group compared to the controls. (hku.hk)
Positive1
- These are positive antinuclear antibodies, positive anti-SSB and positive anti- Scl 70. (scirp.org)
Rare1
- Clinical bone disease secondary to primary hyperparathyroidism is rare today thanks to early detection. (springer.com)
Spinal cord3
- Thus, diseases affecting the anterior horn of the spinal cord cause flaccid paralysis. (emcrit.org)
- This may be harder than it sounds, because spinal cord disease is uncommon and not generally high on our list of considerations. (emcrit.org)
- Autoimmune glial fibrillary acidic protein astrocytopathy (A-GFAP-A) is a newly discovered autoimmune nervous system disease involving the brain, spinal cord, meninges and optic nerve. (biomedcentral.com)
Genetic1
- HSP is a complex disease, caused by several genetic and environmental factors. (biomedcentral.com)
Symptoms1
- Granulomatous diseases cause a great range of symptoms not only in the head and neck but also throughout the body. (medscape.com)
Assessment2
- By comparison to adult vasculitis, there is no consensus for indices of activity and damage assessment in childhood vasculitis. (cyberleninka.org)
- This paper reviews the current understanding about the assessment tools (i.e., clinical features, laboratory tests, radiologic assessments, etc.) widely used for evaluation of the disease activity and damage status of the children with vasculitis. (cyberleninka.org)
Clinical1
- Systemic treatment in Behcet's disease According to clinical phenotypes. (unican.es)
Study1
- Does this study address an important problem related to vasculitis disease? (vasculitisfoundation.org)
High1
- Some studies have found that high levels of antithyroid peroxidase antibody (TPO-Ab) and increased thyroid-stimulating hormone (TSH) are related to HT-related thyroid tumors. (medsci.org)
Prevalence1
- The most frequent coexisting disease is autoimmune thyroid disease (AITD) which may be partially explained by the higher prevalence of thyroid dysfunction in middle-aged women rather than a true association. (springer.com)
Protein1
- The protein forms a deep crevice which holds the heme group at the bottom, as well as a hydrophobic pocket at the entrance to the distal heme cavity which carries out its catalytic activity. (wikipedia.org)
Drugs1
- Medscape Drugs & Diseases. (medscape.com)
Early1
- Subspecialty consultations including pulmonologists and rheumatologist should be considered early in the management of these diseases. (medscape.com)
Blood1
- MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach. (wikipedia.org)