RecipientsTransplantsTissuesAssociated with solid organ transplantationPancreas transplantationLiverProcurementWeeks after undergoing traBlood transfusionPatientsClinicalTissue transplantationDialysis and transplantationPost-transplantationKidneyCadavericRenalDonationUnited NetworkKidneysNephrologySurvivalRecipientComplicationsLungAbdominal organCysticReceived by the organ donorAutologous2020ImmunosuppressionOutcomesEthical issuesAllograftFalun GongInfectionRejectionBoneColleaguesXenograftDiabetesInfectiousTherapeutic
Recipients21
- We describe parasitologically confirmed cases of babesiosis diagnosed ≈8 weeks posttransplantation in 2 recipients of renal allografts from an organ donor who was multiply transfused on the day he died from traumatic injuries. (cdc.gov)
- The organ donor and recipients had no identified risk factors for tickborne infection. (cdc.gov)
- Nevertheless, diagnosis and management of perioperative complications of organ transplantation still plays a prominent role in determining the postoperative course of allograft recipients. (medscape.com)
- Future developments in the field of organ transplantation, including newer immunosuppressive medications and xenograft, pluripotent stem cell and neural tissue transplantation, will further change the spectrum of neurologic and other complications in transplant recipients. (medscape.com)
- Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). (medscape.com)
- In November 2009, a second transplant center (UPMC) identified two incidents of conduit transplantation from hepatitis-seropositive donors into seronegative recipients. (cdc.gov)
- recipients who are seronegative for Herpes Simplex Virus (HSV) receiving an organ from HSV seropositive donors [2D]. (bts.org.uk)
- The transplantation of HIV-positive donor kidneys to HIV-infected recipients is now a viable alternative to chronic dialysis or transplantation of HIV-negative donor kidneys. (scielo.org.za)
- Arguments are presented that led to our initiation of renal transplantation from HIV-positive deceased donors to HIV-positive recipients at Groote Schuur Hospital, Cape Town. (scielo.org.za)
- Since 2002, several types of emerging donor-derived infections have been reported with increasing frequency among solid organ transplant recipients seeking medical care for encephalitis. (cdc.gov)
- Since 2002, the Centers for Disease Control and Prevention has investigated clusters of encephalitis among transplant recipients. (cdc.gov)
- It is likely that signs and symptoms of encephalitis among transplant recipients during a West Nile virus outbreak led to the recognition that West Nile virus had been transmitted through organ transplants. (cdc.gov)
- In July 2004, CDC was notified that 3 recipients of solid organs and 1 recipient of an iliac artery segment from a common donor had died from encephalitis, which was eventually found to be caused by rabies virus infection. (cdc.gov)
- Apheresis can also be used to help prevent transplantation recipients from rejecting donor organs. (ynhh.org)
- In September 2005, West Nile virus (WNV) infection was confirmed in three of four recipients of organs transplanted from a common donor. (cdc.gov)
- After unexplained neurologic illness occurred in two organ recipients, an investigation was initiated. (cdc.gov)
- Infection rates among lung transplant recipients appear to be higher than those encountered in other solid organ transplant populations, likely related to the unique exposure of the lung allograft to the external environment and to the greater magnitude of immunosuppression employed 1 , 2 . (ersjournals.com)
- Solid organ transplant recipients, who are medically immunosuppressed to prevent graft rejection, have increased melanoma risk, but risk factors and outcomes are incompletely documented. (cdc.gov)
- We tested various specimens (blood, cerebrospinal fluid, intraocular fluid, serum, and tissues) from the organ donor and recipients by serology, RT-PCR, immunohistochemistry, metagenomic next-generation sequencing, and host gene expression, and conducted a traceback of blood transfusions received by the organ donor. (cdc.gov)
- Recent infection with yellow fever virus was confirmed in all four organ recipients by identification of yellow fever virus RNA consistent with the 17D vaccine strain in brain tissue from one recipient and seroconversion after transplantation in three recipients. (cdc.gov)
- Assessing Solid Organ Donors and Monitoring Transplant Recipients for Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infection - U.S. Public Health Service Guideline, 2020. (cdc.gov)
Transplants12
- these outnumber organ transplants by more than tenfold. (wikipedia.org)
- Most human tissue and organ transplants are allografts. (wikipedia.org)
- The risk for infections caused by pathogens transmitted through solid organ or tissue transplants, referred to here as donor-derived or transplant-transmitted infections, has been recognized for decades and remains a worldwide public health problem. (cdc.gov)
- Forexample, the report states that "there are many more [organ]transplants" in China - about 10,000 per year - than there are "identifiable sources" for the organs that were procured. (cbc-network.org)
- But China isa non-transparent society, and even though the organ-procurementnumbers do indeed seem insufficient to support the number of reported transplants, this fact alone would not support their charge. (cbc-network.org)
- Forexample, the authors compare the numbers of total organ transplants in China in the six years before the crackdown on Falun Gong began withthe numbers reported in the six years since the sect was outlawed. (cbc-network.org)
- Where do the organs come from for the [additional] 41,500 transplants? (cbc-network.org)
- But," they argue, "theconverse, a full explanation of the source of all organ transplants,would disprove the allegation. (cbc-network.org)
- Modern medicine has made organ transplants a viable way of saving lives - and in the process, observers say, it has helped remove religious reservations about donating vital organs. (jewish-funerals.org)
- Though nearly 110,000 people are on the organ transplant waiting list, only 77 people receive organ transplants daily. (gotomydoctor.com)
- Living donor liver transplantation ( LDLT ), which can help to bridge the current organ supply/demand mismatch, accounts for only 3%-4% of adult liver transplants in the United States. (medscape.com)
- BACKGROUND: In 2021, four patients who had received solid organ transplants in the USA developed encephalitis beginning 2-6 weeks after transplantation from a common organ donor. (cdc.gov)
Tissues7
- Organs and/or tissues that are transplanted within the same person's body are called autografts. (wikipedia.org)
- citation needed] An isograft is a subset of allograft in which organs or tissues are transplanted from a donor to a genetically identical recipient (such as an identical twin). (wikipedia.org)
- Transplantation of Organs and Tissues of Human Origin, adopted by the Council of Europe in 2002. (who.int)
- Use of human tissues and organs for therapeutic purposes : a survey of existing legislation. (who.int)
- Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
- The Food and Drug Administration (FDA) approved the use of GalSafe pigs in the production of drugs, for organs/tissues for human transplant, and for meat to be consumed by people with the Alpha-Gal meat allergy. (pigprogress.net)
- The field of organ printing aiming at the printing of cells, tissues, and scaffolds to create organs flowed from industrial rapid prototyping and stereo-lithography and has emerged as the most innovative solution to organ shortage and transplantation. (com.pk)
Associated with solid organ transplantation2
- In contrast to transmission by blood transfusion, which has been well documented, transmission associated with solid organ transplantation has not been reported. (cdc.gov)
- In addition to these traditional risk factors, other risk factors are associated with solid organ transplantation. (medscape.com)
Pancreas transplantation7
- Organ transplantation may also improve neurologic function in various disorders with neurologic manifestations such as Wilson disease (liver transplantation), familial amyloidosis with neuropathy (liver transplantation), and diabetic neuropathy (pancreas transplantation). (medscape.com)
- In this setting therefore, IGL-1 solution appears promising for perfusion and organ preservation in clinical pancreas transplantation, compared to other commonly used solutions. (frontierspartnerships.org)
- For patients with diabetes mellitus (DM) type 1, pancreas transplantation (PTx) is the only therapeutic option capable of normalizing blood glucose and minimizing secondary complications of diabetes, resulting in an increase in the survival and an improved quality of life ( 1 ). (frontierspartnerships.org)
- In this scenario, four preservation solutions are currently in use for pancreas transplantation. (frontierspartnerships.org)
- Pancreas transplantation with portal venous drainage is gaining wide interest among pancreas transplantation centers primarily because of documented physiologic benefits. (johnshopkins.edu)
- Of equal interest, however, is that pancreas transplantation with portal venous drainage mimics experimental animal models of portal tolerance. (johnshopkins.edu)
- Philosophe, B 2002, ' Portal versus systemic delivery of insulin: Immunologic benefits for pancreas transplantation ', Current opinion in organ transplantation , vol. 7, no. 2, pp. 180-184. (johnshopkins.edu)
Liver9
- Worldwide, the kidneys are the most commonly transplanted organs, followed by the liver and then the heart. (wikipedia.org)
- In September 2009, CDC was notified of an anti-HCV negative patient who, during liver transplantation 4 months earlier, had been given a vessel conduit inadvertently from an anti-HCV positive donor. (cdc.gov)
- Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem. (annalsoftransplantation.com)
- Even before transplantation, bone homeostasis may be adversely influenced by the disease process or diseased organ itself (eg, liver, lung, or kidney failure). (medscape.com)
- Transplantation modalities were heart , lung , kidney , liver , pancreas , combined pancreas and kidney and bone marrow transplantation . (bvsalud.org)
- Some of the concepts that emerged from the many outstanding presentations in liver transplantation, primary sclerosing cholangitis, primary biliary cirrhosis , biliary atresia , and pediatric liver disease are highlighted here. (medscape.com)
- Liver Transplantation: Can We Improve Outcomes? (medscape.com)
- The data suggest that immunosuppression withdrawal may be possible for selected children after liver transplantation. (medscape.com)
- Goldberg and colleagues [ 2 ] examined national Organ Procurement and Transplantation Network/United Network for Organ Sharing data from 2002 to 2012 to determine whether LDLT (n = 2103) conferred a long-term survival benefit relative to deceased donor liver transplantation (DDLT) (n = 46,674). (medscape.com)
Procurement4
- Other ethical issues include transplantation tourism (medical tourism) and more broadly the socio-economic context in which organ procurement or transplantation may occur. (wikipedia.org)
- In contrast, Histidine-Tryptophan-Ketoglutarate (HTK) and Celsior (CS) solutions, which were originally designed for cardiac graft protection, have the advantage of a much lower viscosity, providing more rapid cooling and better washout during organ procurement. (frontierspartnerships.org)
- HRSA is also responsible for organ procurement, transplantation, and vaccine injury. (cdc.gov)
- 3 days before organ procurement, the organ donor received a blood transfusion from a donor who had received a yellow fever vaccine 6 days before blood donation. (cdc.gov)
Weeks after undergoing tra1
- For these infections, the initial link to the transplanted organ was made by histopathologic evaluation and immunohistochemical testing of tissue from an organ recipient who died 4 weeks after undergoing transplantation. (cdc.gov)
Blood transfusion2
- Transmission also can occur congenitally, via blood transfusion and organ transplantation, and by ingestion of food and drink contaminated with feces from infected bugs. (medscape.com)
- Laboratory and epidemiologic data substantiated this mode of virus transmission and documented that the organ donor had likely acquired West Nile virus through a blood transfusion. (cdc.gov)
Patients24
- In the opposite direction, attempts are being made to devise a way to transplant human fetal hearts and kidneys into animals for future transplantation into human patients to address the shortage of donor organs. (wikipedia.org)
- Organ transplantation has developed at an incredibly rapid pace since its introduction in the 1950s, and it has become a life-saving procedure for patients with end-stage organ failure. (medscape.com)
- The posttransplantation clinical course is generally complicated by dysfunction of various organ systems, and early or delayed neurologic complications may develop in 30-60% of patients. (medscape.com)
- Answers to questions of this nature, of course, underlie both treatment decisions in a small group of patients and the uses to which the organs of the "deceased" patient may be put (transplantation). (bmj.com)
- However, with the advent of highly active antiretroviral therapy (HAART), renal transplantation using HIV-negative donor kidneys has successfully been employed for HIV-infected patients with end-stage renal failure. (scielo.org.za)
- Before deciding to commence HIV-positive-to-positive transplantation at GSH, HIV-infected patients with ESRF were believed to be poor transplant candidates and were not accepted for RRT. (scielo.org.za)
- Moreover, until 2004, HIV-infected patients were deemed unsuitable for renal transplantation owing to the lack of an ART programme, and the dangers of using immunosuppressive anti-rejection drugs in the absence of HAART. (scielo.org.za)
- This concern has abated as good outcomes have been confirmed after transplantation in HIV-infected patients receiving HAART. (scielo.org.za)
- Improvements in immune-modulating therapy, critical care medicine, and surgical techniques have led to the increased success of organ transplantations, and more patients are now eligible for these procedures. (cdc.gov)
- Rational guidelines for transplantation in patients with psychotic disorders. (bvsalud.org)
- Low bone mass is extremely common among patients awaiting solid organ transplantation. (medscape.com)
- Because patients often wait 2 or more years before transplantation, this represents an opportunity to prevent further bone loss and to help restore what may already have been lost. (medscape.com)
- Osteoporosis is very common among patients awaiting lung transplantation. (medscape.com)
- [ 7 ] Prior to transplantation, BMD was decreased at all sites measured, and 35% of patients awaiting transplant had established osteoporosis, as defined by the World Health Organization (WHO). (medscape.com)
- Moreover, following lung transplantation, nearly three quarters (73%) of patients were at or below the fracture threshold. (medscape.com)
- When Lu returned to Shanghai to visit relatives in 2002, his sister-in-law's sister Zhou Qing and Zhou's husband asked Lu to help refer U.S. patients to Shanghai for organ transplant surgeries. (minghui.org)
- Transplantation of patients with underlying cystic fibrosis (CF), whose native airways and sinuses are chronically infected with virulent bacterial pathogens, initially raised unique concerns about the potential excessive risk of postoperative infections. (ersjournals.com)
- Two recent series from North American centres with extensive experience in transplantation of CF patients have documented 1-yr survival rates of 50% versus 83% and 67% versus 96% among CF patients with and without B. cepacia , respectively 7 , 8 . (ersjournals.com)
- ABSTRACT Objective To evaluate retinal changes in patients who underwent solid organ or bone marrow transplantation . (bvsalud.org)
- All patients who underwent pancreas or combined pancreas and kidney transplantation had diabetic retinopathy . (bvsalud.org)
- At least partial response (organ or haematological) was seen in 64% of the patients. (lu.se)
- In patients with cardiac involvement or multiple organ involvement, survival was significantly shorter, median overall survival 49 and 56 months, respectively. (lu.se)
- For patients treated in the earlier time period (1994-2001), 100-day mortality was 23.8% compared with 7.8% in the later period (2002-2009). (lu.se)
- Key presentations addressed questions about donor shortages and the challenges facing patients who have undergone transplantation-specifically, recurrence of disease and complications of immune suppression. (medscape.com)
Clinical3
- The clinical focus should be to both optimize bone mass before transplantation and to prevent bone loss in the postoperative period. (medscape.com)
- Clinical and demographic data regarding transplantation and ophthalmological changes were collected. (bvsalud.org)
- Venkat and colleagues [ 1 ] described the clinical response to protocolized immunosuppression withdrawal in an ongoing multicenter study of 74 children who were more than 4 years post-transplantation, had normal alanine aminotransferase (ALT) and gamma-glutamyltransferase levels, and were receiving calcineurin inhibitor monotherapy. (medscape.com)
Tissue transplantation1
- Organ and tissue transplantation in the European union : management of difficulties and health risks linked to donors / edited by Yvon Englert. (who.int)
Dialysis and transplantation1
- Some 550 000 individuals may be expected to require renal replacement therapy (RRT) comprising dialysis and transplantation, considerably more than the SA population currently receiving dialysis, and exceeding the health service renal replacement capacity. (scielo.org.za)
Post-transplantation1
- In addition toallograft rejection (a topic covered elsewhere in this series), a multitude of medical complications mark the post-transplantation course. (ersjournals.com)
Kidney3
- Authors discuss sensitive aspects in societal perception of the Polish Transplantation Act, ethical issues of living donor kidney transplantation, the role of mass media and economic aspects of transplantation. (annalsoftransplantation.com)
- It may be that transmission is possible because of viral persistence in donated organs after peripheral viremia has cleared or because of intermittent viremia from a reservoir organ, such as a kidney. (cdc.gov)
- Acquired knowledge in the field of Cadaveric kidney transplantation. (mpuh.org)
Cadaveric1
- Among those are:availability of the treatment, consent for cadaveric donation, allocation of available organs, new categories of living unrelated donors and economic aspects of this method of treatment. (annalsoftransplantation.com)
Renal2
- HIV infection was previously an absolute contraindication to renal transplantation. (scielo.org.za)
- Durugkar SD, Hegde UN ,Gang SD, Rajapurkar MM Outcome of renal transplantation in Diabetics(DM) : A comparison with matched non diabetic subjects. (mpuh.org)
Donation5
- My only criticism of the book is that the concept of brain death is repeatedly linked with organ donation and transplantation without qualification. (bmj.com)
- The maintenance of organ viability from donation to transplantation is a decisive factor for the adequate function and survival of the graft, especially in organs such as the pancreas, which is highly susceptible to ischemic damage. (frontierspartnerships.org)
- The most comprehensive source for information about traditional Jewish perspectives on organ donation. (jewish-funerals.org)
- The discussion of the appropriateness of organ donation from the perspective of halacha is fascinating from two perspectives. (jewish-funerals.org)
- Requirements a hospital must meet that are designed to increase organ donation. (jewish-funerals.org)
United Network1
- The potential disease transmission was identified when the United Network for Organ Sharing (UNOS) retrospectively recognized the serologic discordance between the HCV-seronegative recipient and the HCV-seropositive vessel donor. (cdc.gov)
Kidneys2
- Kidneys (and other organs) from HIV-infected deceased donors are discarded. (scielo.org.za)
- When Lu asked what kind of transplant surgeries were involved, Mao replied, "organs such as kidneys, livers, or corneas. (minghui.org)
Nephrology2
Survival2
- Long-term survival following organ transplantation has improved considerably. (medscape.com)
- Surgical advances, in conjunction with more effective immunosuppressive strategies, have propelled the field of lung transplantation forward and have made intermediate-term survival an achievable goal. (ersjournals.com)
Recipient7
- Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. (wikipedia.org)
- The donor and recipient may be at the same location, or organs may be transported from a donor site to another location. (wikipedia.org)
- Some of the key areas for medical management are the problems of transplant rejection, during which the body has an immune response to the transplanted organ, possibly leading to transplant failure and the need to immediately remove the organ from the recipient. (wikipedia.org)
- Due to the genetic difference between the organ and the recipient, the recipient's immune system will identify the organ as foreign and attempt to destroy it, causing transplant rejection. (wikipedia.org)
- Solid organ transplantation sometimes requires the use of blood vessels from a deceased donor as conduits to connect transplanted organ vessels to recipient vessels. (cdc.gov)
- A case was defined as transplantation of a vessel conduit from a hepatitis-seropositive donor into a seronegative recipient at UPMC during May 2006--November 2009. (cdc.gov)
- Although passive transfer of occult infection with the transplanted organ is an additional concern, the presence of organisms on Gram stain of donor bronchial washings is not predictive of subsequent pneumonia in the recipient 4 . (ersjournals.com)
Complications3
- Neurologic complications are related to the surgical procedure of transplantation, posttransplant immunosuppression, opportunistic infection, or the inherent disorders that led to transplantation. (medscape.com)
- The variety of conditions that led to organ failure requiring transplantation may also be associated with neurologic complications, including amyloid and diabetic neuropathy. (medscape.com)
- Neurologic complications of organ transplantation occur internationally with a similar frequency as in the United States. (medscape.com)
Lung1
- Initial attempts to perform lung transplantation (LTx) were marred by technical limitations that often resulted in early postoperative death. (ersjournals.com)
Abdominal organ1
- University of Wisconsin (UW) solution has been considered for organ perfusion in abdominal organ transplantation since the late 80s ( 8 ). (frontierspartnerships.org)
Cystic1
- Cystic fibrosis, a common indication for transplantation, is itself associated with low bone mass and fragility fractures because of (1) delayed puberty and hypogonadism and (2) chronic malnutrition with pancreatic insufficiency causing calcium and vitamin D malabsorption. (medscape.com)
Received by the organ donor1
- The PRBC unit received by the organ donor was donated on July 30 and was negative for WNV RNA by minipool nucleic acid-amplification test (mpNAT). (cdc.gov)
Autologous1
- High-dose melphalan and autologous stem cell transplantation (HDM/ASCT) is widely used in immunoglobulin light chain (AL) amyloidosis, but the benefit is debated mainly because of the high treatment-related mortality (24% in a randomised study comparing HDM/ASCT with oral melphalan/dexamethasone). (lu.se)
20202
- In late December 2020, the World Organization to Investigate the Persecution of Falun Gong (WOIPFG) published a document from a witness who detailed information on the contacts, facility, process, and description of organ harvesting. (minghui.org)
- The witness remained anonymous out of safety concerns until December 2020, when he felt compelled to reveal his real name and what he knew about the organ harvesting crime. (minghui.org)
Immunosuppression2
- A combined multiorgan transplantation approach may offer a lower rate of allograft rejection and lower immunosuppression needs. (medscape.com)
- After transplantation, high-dose steroid therapy and immunosuppression further promote bone loss and fracture development. (medscape.com)
Outcomes1
- Hegde UN ,Gang SD, Desai MR. Comparion of outcomes of Laproscopic donor nephrectomy with Open donor nephrectomy, Indian Society of Organ Transplantation at Hyderabad 2003. (mpuh.org)
Ethical issues1
- Transplantation medicine, like no other medical specialty, is connected with a wide range of very difficult ethical issues. (annalsoftransplantation.com)
Allograft1
- citation needed] An allograft is a transplant of an organ or tissue between two genetically non-identical members of the same species. (wikipedia.org)
Falun Gong6
- But do many of these organs really come from executed Falun Gong? (cbc-network.org)
- But the depth of evil described byprominent human-rights attorney David Matas and former Canadian memberof parliament David Kilgour in their sobering " Report into Allegations of Organ Harvesting of Falun Gong Practitioners in China "simply boggles the mind. (cbc-network.org)
- M: Do you have Falun Gong [organ] suppliers? (cbc-network.org)
- (Minghui.org) In the persecution of Falun Gong in China, and among all kinds of human rights violations in the modern world, forced organ harvesting is the gravest known atrocity. (minghui.org)
- But after participating in organ harvesting from Falun Gong practitioners several times, she stopped-the horrifying scenes often brought her nightmares. (minghui.org)
- This indicated at least two things: first, they were detained Falun Gong practitioners, not death-row prisoners as the CCP had claimed to be sources of organs until 2015. (minghui.org)
Infection2
- In 2002, several cases of serologically confirmed West Nile virus infection occurred in persons with little or no known exposure to mosquitoes, and epidemiologic evidence suggested transmission of the virus through blood transfusions. (cdc.gov)
- Similar to the molecule on the cell surface that resulted in rejection of an organ," Roland explained, "the molecule responsible for PRRS virus infection may also be located on the surface of the cell. (pigprogress.net)
Rejection1
- Several investigators have now documented lower rejection rates when pancreas transplantations are portal venous drained compared with systemic venous drainage. (johnshopkins.edu)
Bone1
- A large and rapid decrease in bone mineral density (BMD) occurs within the first year following virtually all forms of solid organ transplantation. (medscape.com)
Colleagues1
- He and his colleagues published a paper in 2002 about removing a protein through gene editing in pigs to make their organs suitable for transplantation to humans. (pigprogress.net)
Xenograft1
- A xenograft is a transplant of organs or tissue from one species to another. (wikipedia.org)
Diabetes2
- For some days after transplantation, the woman's urine was free of glucose, then the diabetes returned as her body rejected the pancreas. (abs.gov.au)
- The main pre- transplantation comorbidities were diabetes and arterial hypertension . (bvsalud.org)
Infectious1
- The recognition of this risk led to the screening of donors for some infectious agents, such as, HIV, which made the organ supply substantially safer. (cdc.gov)
Therapeutic1
- Stockton, CA: Therapeutic Research Faculty, 2002:1530. (jptcp.com)