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  • Mitchison
  • In 1984 Mitchison and Kirschner discovered an intriguing property of microtubules they termed `dynamic instability' ( Mitchison and Kirschner, 1984 ). (biologists.org)
  • Dis1
  • These results reveal both a new biochemical activity for a Dis1/XMAP215 family member and a novel mechanism for microtubule destabilization. (rupress.org)
  • basal
  • Basal bodies organize the nine doublet microtubules found in cilia. (rupress.org)
  • Like centrioles, basal bodies consist of a core structure (with peripheral components) of nine triplet microtubules organized into a cylinder. (rupress.org)
  • To examine this problem, we studied microtubules on basal plasma membranes isolated from fully polarized MDCK epithelial cells. (rupress.org)
  • These basal membranes allow us to observe microtubule networks that are associated with the plasma membrane in considerably more detail than is possible in an intact cell. (rupress.org)
  • cell
  • Microtubule organizational defects led to aberrant chromosomal arrangements, misaligned or incomplete cell plates, and multinucleate cells. (plantphysiol.org)
  • Furthermore, the growth rate and the catastrophe frequency of microtubules vary both during development and through the cell cycle. (rupress.org)
  • Microtubules control cell motility by positively regulating polarization in many cell types. (biologists.org)
  • These results provide new insight into the role of microtubules in neutrophil migration in a living vertebrate and show that the motility of these professional migratory cells are subject to distinctly different rules from those established for other cell types. (biologists.org)
  • The results indicate that integrin-mediated adhesion is not sufficient to promote rapid microtubule regrowth in either cell type. (biologists.org)
  • Regulated by several factors, Katanin manifests connective crosstalks in network motifs in regulation of anisotropic severing pattern of microtubule protofilaments in cell type and stage dependent way. (hindawi.com)
  • MAP1S controls microtubule stability throughout the cell cycle in human cells. (nih.gov)