• Loop-mediated isothermal amplification (LAMP), an isothermal nucleic acid amplification technique, has been extensively used in many areas such as food safety and clinic diagnosis. (scirp.org)
  • Integrated Sensing Chip for Ultrasensitive Label-Free Detection of the Products of Loop-Mediated Isothermal Amplification. (bvsalud.org)
  • Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification technique that has been widely used for the detection of pathogens in many organisms. (bvsalud.org)
  • Mitchison later demonstrated the cell-mediated features of this response. (medscape.com)
  • The heart, kidneys, and liver are highly vascular organs and transplantation leads to a vigorous cell-mediated response in the host. (medscape.com)
  • Although the exact mechanism is unknown, recent research suggests a cell-mediated process that initiates both the active and quiescent lesions. (medscape.com)
  • The process may involve an antibody-dependent, cell-mediated cytotoxic response. (medscape.com)
  • Understanding the cellular and molecular basis of epitope spreading in various chronic immune-mediated human diseases and their animal models is crucial to understanding the pathogenesis of these diseases and to the ultimate goal of designing antigen-specific treatments. (nature.com)
  • For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). (cdc.gov)
  • This document provides the scientific rationale and framework for the assignment of multiple hazard-specific skin notations (SK) that clearly distinguish between the systemic effects, direct (localized) effects, and immune-mediated responses caused by skin contact with chemicals. (cdc.gov)
  • The implications for the treatment of centrally mediated erectile dysfunction are discussed, with predictions that high SIS2 individuals will respond to psychological treatment, whereas high SIS1 individuals will respond better to pharmacological methods of treatment. (researchgate.net)
  • To evaluate the influence of food supplements with fatty acid omega 3 on the remission of a neurogenic inflammation denoted as centrally mediated chronic myalgia. (bvsalud.org)
  • Fast inhibition in the nervous system is commonly mediated by GABA A receptors comprised of 2α/2β/1γ subunits. (jneurosci.org)
  • Fast inhibition in the CNS is principally mediated by the neurotransmitter GABA acting on GABA A and GABA C ionotropic receptors ( Macdonald and Olsen, 1994 ). (jneurosci.org)
  • For example, prostaglandins activate G s -protein-coupled receptors and initiate cAMP- and protein kinase A (PKA)-mediated processes. (jneurosci.org)
  • In this review, we summarized the current knowledge of hemocyte-mediated phagocytosis, in particular focusing on the related receptors for recognition and internalization of pathogens as well as the downstream signal pathways and intracellular regulators involved in the process of hemocyte phagocytosis. (frontiersin.org)
  • The present study determined whether the serotonin2A (5-HT2A) receptors in the hypothalamic paraventricular nucleus mediate the neuroendocrine responses to a peripheral injection of the 5-HT2A/2Creceptor agonist (−)DOI [(−)1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane]. (ku.edu)
  • These data provide the first direct evidence that neuroendocrine responses to a peripheral injection of (−)DOI are predominantly mediated by activation of 5-HT2A receptors in the hypothalamic paraventricular nucleus. (ku.edu)
  • Significant contributions of other mechanisms such as inhibition of mdr1-mediated drug efflux during gastrointestinal absorption, inhibition of bosentan metabolism, or inhibition of hepatobiliary excretion seemed to be unlikely. (aspetjournals.org)
  • It is, however, clear that inhibition of CYP3A4-mediated metabolism by cyclosporin A alone is insufficient to explain the increased bosentan concentrations and that inhibition of hepatocellular uptake offers an attractive mechanistic alternative also in human. (aspetjournals.org)
  • and the observed pharmacokinetic interaction was initially assigned to the inhibition of CYP3A4-mediated clearance in the liver. (aspetjournals.org)
  • We aimed to see whether vascular injury mediated by cytotoxic T lymphocytes and microvessel loss arises in patients with chronic GVHD. (nih.gov)
  • The above results demonstrate that RSV ameliorates caveolae-mediated hyperpermeability induced by high glucose via VEGF/KDR pathway. (springer.com)
  • however, there are evidences indicating that caveolae was indispensable to the process, and it was suggested that VEGF-induced permeability was mediated by caveolae (Feng et al. (springer.com)
  • 1999 ). Report showed that VEGF increased the permeability through caveolae-mediated transcellular pathway in the blood-tumor barrier (Zhao et al. (springer.com)
  • Citation: Ding Z, Cao J, Shen Y, Zou Y, Yang X, Zhou W, Guo Q and Huang C (2018) Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury. (vinomis.com)
  • Resveratrol activated p300 acetyltransferase-mediated VEGF signaling in the affected ventral spinal cord, which may have thus contributed to the acceleration of nerve regeneration and motor repair. (vinomis.com)
  • rAAV mediated genome-editing improves the efficiency of this technique to permit genome engineering in any pre-established and differentiated human cell line, which, in contrast to mouse ES cells, have low rates of HR. The technique has been widely adopted for use in engineering human cell lines to generate isogenic human disease models. (wikipedia.org)
  • These single-stranded DNA viral vectors have high transduction rates and have a unique property of stimulating endogenous HR without causing double strand DNA breaks in the genome, which is typical of other homing endonuclease mediated genome editing methods. (wikipedia.org)
  • To date, the use of rAAV mediated genome engineering has been published in over 2100 peer reviewed scientific journals. (wikipedia.org)
  • explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)
  • Conserved proteins drive clathrin-mediated endocytosis (CME), which universally involves a burst of actin assembly. (biorxiv.org)
  • In contrast to budding yeast, WASP-mediated actin nucleation activity plays an essential role in fission yeast endocytosis. (biorxiv.org)
  • Clathrin-mediated endocytosis (CME) takes up nutrients, regulates responses to extracellular stimuli, and controls the chemical composition and surface area of the plasma membrane. (biorxiv.org)
  • In this study, we analyzed the dynamics of fluorescently tagged cofilin and the role of cofilin-mediated actin turnover during endocytosis in Saccharomyces cerevisiae . (rupress.org)
  • However, the role of actin filament disassembly (a key step in actin dynamics) during actin-mediated endocytosis is less clear. (rupress.org)
  • Taken together these separate lines of evidence suggest that the effects of GABA in central neurons can be mediated by heteromeric complexes of GABA A and GABA C receptor subunits. (jneurosci.org)
  • 2002. Evidence for the involvement of CYP1A2 in the metabolism of bromodichloromethane. (cdc.gov)
  • It has long been believed that the number of neurons does not increase after birth, but some studies have shown that in adult rodents and primates new neurons are formed after damage (Rakic, 2002). (encyclopedia.com)
  • It was reported that LDL-derived cholesterol, the major component of atherosclerotic plaque, enters the subendothelial space through the caveolae-mediated pathway (Sun et al. (springer.com)
  • However, the molecular mechanism of cofilin recruitment to actin networks during dynamic actin-mediated processes in living cells and cofilin's precise in vivo functions have not been determined. (rupress.org)
  • These results suggest that cofilin-mediated actin filament flux is required for the multiple steps of endocytic trafficking. (rupress.org)
  • Apart from exciting nociceptors, inflammatory mediators increase nociceptor responsiveness, frequently by initiating G-protein-mediated processes, to cause hyperalgesia. (jneurosci.org)
  • Caveolae-mediated permeability plays a major role in the transport of large molecules across endothelium (Komarova and Malik 2010 ). (springer.com)
  • Mediating Role of Engagement. (igi-global.com)
  • Mediating Role of Engagement," Journal of Electronic Commerce in Organizations (JECO) 18, no.2: 64-79. (igi-global.com)
  • Thus, the objective of this article is to examine the mediating role of engagement in the relationship between skill and perceived learning as well as between challenge and perceived learning in game-based learning environments. (igi-global.com)
  • The purpose of the present investigation was to explore the mediating role of self-compassion on the relation between goal orientation and sport-confidence, as well as exploring whether these factors differed between male and female student-athletes. (humankinetics.com)
  • TMP/SMX plus tobramycin exhibit a greater killing cate that class 1 integrons and IS CR elements linked to sul 2 genes can mediate TMP/SMX resistance in S. mal- capacity then TMP/SMX alone ( 7 , 8 ). (cdc.gov)
  • Vesterlund, E 2023, Mediating society: Gallup polls as a statistical attraction in the Swedish press, 1941-1948 . (lu.se)
  • Non-specific (colloidal-type) and receptor-mediated interactions of Staphylococcus aureus to surfaces will be measured using total internal reflection microscopy and three dimensional laser optical trapping. (usda.gov)
  • As mediating artefacts, writing group oral interactions were closely examined with reference to the student's motives and her subsequent writing. (jbe-platform.com)
  • During the past few decades, hemocyte-mediated phagocytosis, as one of the most important innate cellular immune function, has also received great attention in crustacean, and a good progress in elucidating the involvement of hemocyte-mediated phagocytosis, as well as its protective roles and mechanisms, against bacterial and viral infections has been achieved. (frontiersin.org)
  • In the present study, our aim was to determine the time-dependent, ER-mediated apoptotic and autophagy induction of purvalanol in HCT 116 colon cancer cells. (spandidos-publications.com)
  • The aim of this study was to assess whether work-related fatigue is a mechanism that mediates the relationship between job stress, health indicators and occupational traffic crashes of long-haul truck drivers (LHTD). (dovepress.com)
  • Objective To assess the potential mediating effects of ambient air pollution on the association between race/ethnicity and blood pressure levels. (cdc.gov)
  • Furthermore, the study characterized an RTX variant, named NAV‑006 (RTX‑N109D), which was more refractory to the immunosuppressive effects mediated by CA125 as evidenced by its reduced CA125 interaction and increased activity of ADCC and CDC when compared with parent RTX. (spandidos-publications.com)
  • This article was previously published in the NCMA Quarterly Newsletter, Spring 2002, Number 63. (mediate.com)
  • PF indicators fully or partially mediate the relationship between MVPA and FOF. (frontiersin.org)
  • Thus, the PKA/AKAP/VR-1 module presents as the molecular correlate of G s -mediated inflammatory hyperalgesia. (jneurosci.org)
  • In the 1950s, studies on mediated cross-border communication started to increasingly stress its assumed function as development and modernization prompter ( development communication ), not least due to the dozens of countries in Asia, Africa, and South America who gained their political independence at that time. (wikipedia.org)
  • Journal of Computer-Mediated Communication 171: 501-21. (benjamins.com)
  • Journal of Computer-Mediated Communication , 21, pp 105-120. (lu.se)
  • This study aimed to explore the association between physical activity (PA) and fear of falling (FOF) and to determine whether this relationship was mediated by physical fitness (PF) in community-dwelling older women. (frontiersin.org)
  • BMI completely mediated the relationship between MVPA and FOF while sit and reach, five times sit-to-stand, and forced vital capacity partially mediated the relationship between MVPA and FOF. (frontiersin.org)
  • Mediated cross-border communication is a scholarly field in communication studies and refers to any mediated form of communication in the course of which nation state or cultural borders are crossed or even get transgressed and undermined (e.g., world news , satellite television , transnational media events ). (wikipedia.org)
  • Thematically, research is often concerned with the political dimension of mediated cross-border communication. (wikipedia.org)
  • An at least implicit common feature to almost all of the aforementioned topics is their general interest in answering the question to what extent nationally, culturally or otherwise defined media systems influence each other, converge or whether they can pertain distinct identities under conditions of mediated cross-border communication. (wikipedia.org)
  • Mediated cross-border communication is considered as becoming increasingly important both as a real world phenomenon and field of research as there has been a steady strengthening of the conditions of globalization and media innovations that offer fast and low-cost forms of cross-border communication since the second half of the twentieth century. (wikipedia.org)
  • Throughout the time, technological innovations such as satellite television or the Internet and the expansion of media markets across national borders have further stimulated research interest in mediated cross-border communication. (wikipedia.org)
  • Use and Adaptation of Written Language to the Conditions of Computer-Mediated Communication (Doctoral Dissertation). (lu.se)
  • Caseload statistics for the superior court Mediated Settlement Conference Program are archived here by fiscal year. (nccourts.gov)
  • Moreover, we determined that during purvalanol-mediated ER stress, autophagic machinery was also activated prior to apoptotic cell death finalization. (spandidos-publications.com)
  • CFS is currently defined exclusively by a number of non-specific symptoms that are common to many conditions, but there has been speculation that many of the neurological symptoms might be cholinergically mediated ( 1 ). (meresearch.org.uk)