2002 cell divides cell cycle. Medical search. Frequent questions

Thirty-six virus isolates from outbreaks in 6 districts were analyzed from 2000 to 2002. (cdc.gov)
2000). We of glial cell line-derived neurotrophic factor (GDNF) in models of have recently reported that this vector directs transgene expression to Parkinson's disease (Georgievska et al. (lu.se)

Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
We found that curcumin inhibited cell growth , enhanced apoptosis , induced cell cycle arrest and retarded cell invasion in pancreatic cancer cells . (bvsalud.org)
Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells. (baseis.org.py)
After treatment with β-iminophosphonate (E,Z)(3-Methyl-2-(pyridin2-ylimino)butyl)diphenylphosphine oxide (4e) proliferation/viability of cancer cells was strongly inhibited and in 65.61% of the cells signs of early apoptosis were observed. (japsonline.com)
In this review, we focused our attentions on carcinogenic metal-induced signal transduction pathways leading to the activation of NF-kappaB, cell apoptosis and cell cycle progression, three crucial steps or events involved in the transformation and carcinogenesis. (cdc.gov)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Upon treatment with Plk1 inhibitors, p53 in tumor cells is activated and induces strong apoptosis, whereas tumor cells with inactive p53 arrest in mitosis with DNA damage. (oncotarget.com)
In addition, compared to the mono-treatment, combination of Polo-like kinase 1 inhibition with anti-mitotic or DNA damaging agents boosts more severe mitotic defects, effectually triggers apoptosis and strongly inhibits proliferation of cancer cells with functional p53. (oncotarget.com)
Then, the chemical count kit-8 cell viability assay, Annexin V-FITC apoptosis detection, EdU labeling proliferation detection, transwell and wound healing experiments were performed. (researchsquare.com)
The NFAT2 overexpression suppressed the cell viability, invasion and migration capabilities, and promoted apoptosis of HepG2 cells. (researchsquare.com)
In this study, we constructed NFAT2 overexpressed cells (HepG2/NFAT2) based on HepG2 and investigated the effect of NFAT2 overexpression on HepG2 cells' viability, apoptosis, proliferation, invasion and migration. (researchsquare.com)

In mouse embryonic stem cells (ESCs), Cdc7 is needed for proliferation. (wikipedia.org)
Enriched expression of genes in LRECb was associated with stem cell attributes and identified WNT, TGF-β, and MAPK pathways of self renewal and proliferation. (frontiersin.org)
During rapid mammary growth in the mouse, label retaining epithelial cells (LREC) appear to retain label by asymmetric distribution of DNA strands, as evidenced by a rapid proliferation index of the LREC ( Smith, 2005 ). (frontiersin.org)
During periods of low mammary proliferation, quiescence of the stem cell population may account for retention of label. (frontiersin.org)
Furthermore, our results demonstrated that overexpression of Cdc20 enhanced cell proliferation and invasion, and abrogated the cytotoxic effects induced by curcumin in pancreatic cancer cells . (bvsalud.org)
Among the proteins identified was Yph1p, a homologue of zebrafish pescadillo, mutations in which lead to cell proliferation defects. (rupress.org)
Excessive proliferation of smooth muscle cells is a common phenomenon in diseases such as atherosclerosis, but the role of growth factors in the mechanism which modulate this process has yet to be clarified. (torvergata.it)
Aim of the present study was to investigate the possible involvement of ANF on rat aortic smooth muscle (RASM) cells proliferation induced by known mitogens and the mechanism involved. (torvergata.it)
Our data show that ANF, at physiological concentration range, inhibits RASM cell proliferation induced by known mitogens such as PDGF and insulin, and the effect seems to be elicited through the modulation of phosphatidic acid (PA) production and MAP kinases involvement. (torvergata.it)
Multiple myeloma (MM) is an incurable hematologic malignancy characterized by the clonal proliferation of malignant plasma cells in the bone marrow. (haematologica.org)
More than a decade later, sustained proliferation was still considered as, arguably, the main feature of cancer cells [ 2 ]. (biomedcentral.com)
Therefore, besides the regulation of immune cells, NFAT2 also exerts modulatory effect of proliferation, invasion, metastasis and malignancy in breast cancer, lung cancer, melanoma and leukemia [13-15]. (researchsquare.com)

It was found that the C . crescentus genome encodes for more two-component signal transduction proteins that assist in cell cycle progression than any other bacterial genome sequenced so far. (kenyon.edu)
Several two-component signal transduction proteins are involved in the cell cycle progression by accumulating at one or both poles "in a spatial and temporal pattern that is reproduced during each cycle" (Jacobs-Wagner 2003). (kenyon.edu)
Throughout the cell cycle, the chromosome progressively goes from being fully methylated to hemimethylated during DNA replication - this results in differential binding of regulatory proteins to activate or repress transcription. (kenyon.edu)
Yph1p was also found in complex with a variety of other proteins, including those involved in ribosome biogenesis, cell cycle regulation, and checkpoint control. (rupress.org)
TACC proteins are localised at centrosomes and coordinate the formation of the mitotic spindle at least in part through their conversation with members of the XMAP/chTOG family, a group of microtubule plus end stabilising proteins (Gergely, 2002;Wiese and Zheng, 2006). (euromed2016.com)
Centrosomes play a role in cell division and the assembly of microtubules, which are proteins that transport materials in cells and help the cell maintain its shape. (medlineplus.gov)
These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)

whereas LREC in suprabasal epithelial layers are enriched for more committed progenitor cells, expressing some genes that are associated with stem cell attributes along with those indicative of cell differentiation. (frontiersin.org)
This dictates cycles of mammary growth, differentiation, lactation, and regression, during which mammary stem cells (MaSC) provide for the lineages of luminal and basal (myoepithelial) epithelial cells in the ducts and alveoli. (frontiersin.org)
The complex mechanism thought to be responsible is the interplay between Notch and Wnt, two signaling pathways playing critical roles in epithelial and mesenchymal precursor cell maintenance and differentiation. (medscape.com)
The abnormalities observed on a cytologic smear or tissue biopsy of the cervix represent alterations in the degree of differentiation of cervical epithelial cells. (justia.com)
An infection is established in the basal layer of the epithelium, and a complex viral life cycle is carried out, dependent on the differentiation state of the host cell [ 1 - 3 ]. (biomedcentral.com)
As progeny cells migrate towards the epithelial surface, a differentiation pathway is triggered, leading to changes in viral gene expression, genome amplification, and assembly of progeny virions. (biomedcentral.com)
Polyploidy is often witnessed in cells prior to differentiation, in embryonic cells or in diseases such as cancer. (ias.ac.in)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
Nuclear factor of activated T cells 2 (NFAT2, also known as NFATc and NFATc1) is an important member of NFAT family which plays a vital role in T cell activation and differentiation [4]. (researchsquare.com)

It has been suggested that the protein is essential for initiation of DNA replication and that it plays a role in regulating cell cycle progression. (wikipedia.org)
It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
Several of these kinases have known roles in regulating cell cycle progression. (biomedcentral.com)
Caulobacter also uses DNA methylation as a regulatory mechanism in cell cycle progression. (kenyon.edu)
Alteration of signalling pathways regulating cell cycle progression is a common feature of cancer cells. (biomedcentral.com)
Downregulation of PI3K-C2β delays mitosis progression in PC3 and HeLa cells, resulting in reduced ability to form colonies in clonogenic assays in vitro. (biomedcentral.com)

Mol Cell Biol 29(9): 2359-2371. (bio-protocol.org)
Mol Biol Cell 18(10): 4050-4061. (bio-protocol.org)
Trends Cell Biol 13(9): 484-492. (bio-protocol.org)
J Cell Biol (2002) 158 (3): 384-385. (rupress.org)
J Cell Biol (2004) 166 (6): 853-863. (rupress.org)

Retention of labeled DNA strands may be attributed to the ability of stem cells to retain the parental DNA strand during asymmetric cell division ( Cairns, 1975 ) or to quiescence of the stem cell population such that the DNA label is not diluted by frequent cell divisions ( Klein and Simons, 2011 ). (frontiersin.org)
Caulobacter crescentus is a single-celled, small bacterium that divides asymmetrically producing cells that differ in structure and function - it is an ideal model system for the mechanisms of asymmetric cell division and has been studied thoroughly. (kenyon.edu)

To evaluate the role of mitochondrial genes, stem cell-specific genes and DNA repair genes in cancer development, their mutation frequency was determined via further analysis. (biomedcentral.com)
It has also been shown that although this organism contains sequence homologs of genes which are known to control the cell cycle of most eukaryotes, these genes may be structurally altered and their equivalent function yet to be demonstrated in amoeba. (ias.ac.in)
Brenner shared the Nobel Prize in medicine in 2002 for his contribution to work unraveling how genes control cell division. (gktoday.in)
14 , 15 HIF-1 and HIF-2 mediate adaptive responses to hypoxia by inducing the transcription of genes associated with erythropoiesis, glycolytic metabolism, cell survival and angiogenesis. (haematologica.org)
Gene Ontology (GO) enrichment analysis of these genes identified an overrepresentation of genes related to the cell cycle. (biomedcentral.com)
We discovered an unprecedented burst of differential expression of cell cycle related genes at one particular point during transition to flowering. (biomedcentral.com)
Expression and Activity of Methionine Cycle Genes Are Altered Following Folate and Vitamin E Deficiency Under Oxidative Challenge: Modulation by Apolipoprotein E-Deficiency. (uml.edu)

These approaches result in the loss of all histological information pertaining to the in vivo locale of MaSC and progenitor cells. (frontiersin.org)
Instead, we used laser microdissection to excise putative progenitor cells and control cells from their in situ locations in cryosections and characterized the molecular properties of these cells. (frontiersin.org)
MaSC/progenitor cells were identified based on their ability to retain bromodeoxyuridine for an extended period. (frontiersin.org)
Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles. (rupress.org)

Five members of the Plk family have been discovered in humans and these serine/threonine kinases have emerged as key players by performing crucial functions in the cell cycle, DNA damage response and neuron biology [ 2 - 6 ]. (oncotarget.com)

The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. (wikipedia.org)
The gene, CDC7, is involved in the regulation of cell cycle because of the gene product Cdc7 kinase. (wikipedia.org)
The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. (nature.com)
The hypoxic regulation of CXCL12 was examined in multiple myeloma plasma cell lines using polymerase chain reaction and western blotting. (haematologica.org)

Insights into the biology of stem cells will be gained by confirmation and characterization of candidate MaSC markers identified in this study. (frontiersin.org)
2002-2004: Postdoctoral Fellow, European Molecular Biology Laboratory, Heidelberg. (igbmc.fr)
6 , 7 CXCL12 is an important mediator of several aspects of MM biology including transendothelial migration, 8 , 9 MM plasma cell migration and retention within the bone marrow, 10 , 11 angiogenesis, 7 and osteoclastic bone resorption. (haematologica.org)

Modulation of tight junction structure in blood-brain barrier endothelial cells. (worthington-biochem.com)
The researchers discovered that they could also make the other hormone, growth hormone, which is made in a different set of cells in the brain called the endothelial cells, proven peptides is ceasing operations effective immediately. (lifeinontario.com)
The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)

A critical length of telomere repeats is required to ensure proper telomere function and avoid the activation of DNA damage pathways that result in replicative senescence or cell death. (nature.com)
This review summarizes current knowledge and our recent studies concerning intracellular signal transduction pathways initiated by carcinogenic metals and the cross-talk that occurs among these pathways in cells in response to metals. (cdc.gov)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Cilia are involved in cell movement and many different chemical signaling pathways. (medlineplus.gov)

We isolated four categories of cells from mammary epithelium of female calves: bromodeoxyuridine label retaining epithelial cells (LREC) from basal (LRECb) and embedded layers (LRECe), and epithelial control cells from basal and embedded layers. (frontiersin.org)
In some embodiments, compositions and methods of the invention are useful for treating mucosal conditions (e.g., diseases and/or infections of mucosal tissue, for example of mucosal epithelial cells). (justia.com)
Papillomaviruses infect epithelial cells of cutaneous or mucosal origin in a variety of vertebrate hosts. (biomedcentral.com)
Upon entry into a basal epithelial cell, the infecting genome is transiently amplified to approximately 50 to 200 copies, establishing a latent infection. (biomedcentral.com)
In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. (wikipedia.org)
Although expression levels of the protein appear to be constant throughout the cell cycle, the protein kinase activity appears to increase during S phase. (wikipedia.org)

however, chromosome replication begins immediately in the daughter cell with the stalk and when the swarmer loses its tail (Stanford). (kenyon.edu)
Several rounds of genome reduplication before chromosome segregation upsets this cycle and leads to polyploidy. (ias.ac.in)
Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
Here, using double-label fluorescence in situ hybridization for the autosome chromosome 21 (chromosome 21 point probes combined with chromosome 21 "paint" probes), along with immunocytochemistry and cell sorting, we present evidence for chromosome gain and loss in the human brain. (jneurosci.org)
Chromosome 21 aneuploid cells constitute ∼4% of the estimated one trillion cells in the human brain and include non-neuronal cells and postmitotic neurons identified by the neuronspecific nuclear protein marker. (jneurosci.org)
Toward determining the presence of constitutional aneuploidy in the human brain, we report here an analysis of the frequency of chromosome 21 gain and loss among neurons and non-neuronal cells isolated from the cerebral cortex and hippocampus of normal individuals ranging from 2 to 86 years of age. (jneurosci.org)
Chromosome 21 was chosen for examination because of the availability of trisomy 21 cells ( Bhattacharyya and Svendsen, 2003 ) that could serve as a positive control for fluorescence in situ hybridization (FISH). (jneurosci.org)

Walther Flemming (Figure 2), a 19th century professor at the Institute for Anatomy in Kiel, Germany, was the first to document the details of cellular division. (visionlearning.com)
In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
Plk3 is expressed throughout the cell cycle and involved in cellular response to DNA damage [ 9 ]. (oncotarget.com)
The ultrastructural study of the cellular modifications (during the life cycle reversion of T. nutricula) showed the presence of both degenerative and apoptotic processes. (researchgate.net)
The ultrastructural study of the cellular modiﬁcations (during the life cycle re version of T. (researchgate.net)

2002). This method achieves rapid and accurate quantification of urinary chromium. (cdc.gov)
NFAT2, as an important transcriptional promoter, regulates expression of TNF-α, myc proto-oncogene protein (c-myc), cyclooxygenase-2 (COX-2), Fas ligand (FasL) and also generates crosstalks with ERK/MAPK pathway and AKT/GSK3b signaling, which achieves its control of the cell fate [7-12]. (researchsquare.com)

In order to analyze the cell cycle regulatory mechanisms and other mechanisms of Caulobacter , many mutant strains have been made and studied. (kenyon.edu)
Sea urchin embryo, DNA-damaged cell cycle checkpoint and the mechanisms initiating cancer development. (baseis.org.py)
The available information suggests that surveillance mechanisms or 'checkpoints' which are known to regulate the eukaryotic cell cycle may be absent or altered in E. histolytica . (ias.ac.in)
For his seminal work on elucidating key molecular-scale mechanisms that govern biogeochemical transformation of contaminants, trace metals, and natural organic matter, which has made significant contributions to the understanding of natural organic and metal cycling in terrestrial ecosystems and remediation of contaminated sites, and also for his contributions to the development of the next generation of scientists and engineers. (ornl.gov)
While the mechanisms responsible for aberrant plasma cell expression of CXCL12 remain to be determined, studies in other systems suggest a role for hypoxia and hypoxia-inducible transcription factors. (haematologica.org)
In this study, we aimed to explore the effect of NFAT2 expression on cell fate of HepG2 cell and its potential mechanisms. (researchsquare.com)

Time- and dose-dependent effects of roundup on human embryonic and placental cells. (baseis.org.py)

Neuron 36 , 241-263 (2002). (lu.se)

In gluconeogenic cells, aspartate is a carbon source for trehalose production, while in glycolytic cells using trehalose for carbon, aspartate is predominantly a nitrogen source for nucleotide synthesis. (elifesciences.org)
For pioneering advances in the field of materials chemistry for the design, synthesis and fabrication of new materials and their translation into new energy technologies, including superconductor wires, electrodes for batteries, solar cells, lithium extraction from geothermal brine and additive manufacturing of magnets, and also for his leadership in developing the next generation of scientists and engineers. (ornl.gov)

There were no changes to the lab site or lab equipment for this component in the NHANES 2017-2018 cycle. (cdc.gov)

Pediatric Brain Tumor Cancer Stem Cells: Cell Cycle Dynamics, DNA Repair, and Etoposide Extrusion. (worthington-biochem.com)
Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)

The sensitivity and Ca 2+ mobilization of HepG2 cells was also inhibited by NFAT2 overexpression. (researchsquare.com)

Telomeric DNA consists of short guanine-rich repeat sequences in all eukaryotes with linear chromosomes, and its length in human somatic cells is remarkably heterogeneous among individuals ranging from 5 to 20 kb, according to age, organ, and the proliferative history of each cell ( Wright and Shay, 2005 ). (nature.com)

Furthermore, NFAT2 participates in the early growth response factor 2 (Egr2)-regulated anergic phenotype which impairs the migration and invasion of leukaemia cells [16]. (researchsquare.com)

As the colony matures, groups of cells exhibiting glycolytic metabolism emerge with spatial organization. (elifesciences.org)

The product encoded by this gene is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. (wikipedia.org)
The gene coding for the Dbf4 or ASK protein is regulated during the different phases of cell cycle. (wikipedia.org)
This was studied by using the CtrA gene, which encodes for an important cell cycle regulatory protein. (kenyon.edu)
The vast majority of these cells did not divide, suggesting that the transgene was indeed regulated in a similar fashion as the endogenous GFAP gene. (lu.se)

The term mitosis refers specifically to the process whereby the nucleus of the parent cell splits into two identical nuclei prior to cell division. (visionlearning.com)
The preprophase band (PPB) is a transient ring of microtubules that forms before mitosis in land plants, and delineates the cytokinetic division plane established at telophase. (silverchair.com)
In addition, these drugs are known to induce serious side effects due to inhibition of mitosis in other proliferating cells (mainly bone marrow and gut) as well as inhibition of other microtubules-dependent functions, such as neuronal processes [ 18 , 19 ]. (biomedcentral.com)

Previous molecular characterizations of mammary stem cells (MaSC) have utilized fluorescence-activated cell sorting or in vitro cultivation of cells from enzymatically dissociated tissue to enrich for MaSC. (frontiersin.org)
In vitro neurosphere assays revealed striking increases in the number of neurosphere forming cells from p107 −/− brains that exhibited enhanced capacity for self-renewal. (rupress.org)
Compared to control cells, PC3 cells lacking PI3K-C2β form smaller and more compact colonies in vitro and they form tumours more slowly in vivo in the first weeks after cells implant. (biomedcentral.com)

Thus, the secretion of gall wasps stimulates plant cell growth and overrules homeostasis of the affected leaf area - this is similar to tumour outgrowth. (nature.com)
The mathematical model is a set of six coupled differential equations governing the time evolution of both the tumour cell population (cells of Glasgow osteosarcoma, a mouse tumour) and the mature jejunal enterocyte population, to be shielded from unwanted side effects during a treatment by oxaliplatin. (numdam.org)
The eradication problem consists in finding the drug infusion law able to minimise the number of tumour cells while preserving a minimal level for the villi population. (numdam.org)
On the other hand, the containment problem searches for a quasi periodic treatment able to maintain the tumour population at the lowest possible level, while preserving the villi cells. (numdam.org)
Tumour growth in vivo was assessed using a xenograft model of PC3 cells upon PI3K-C2β downregulation and in combination with docetaxel. (biomedcentral.com)

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. (bio-protocol.org)
CXCL12 is a constitutively expressed chemokine which binds primarily to the CXCR4 receptor and regulates cell growth, chemotaxis, myelopoiesis, lymphopoiesis, and development of the nervous and cardiovascular systems. (haematologica.org)

Papillomaviruses undergo a complex life cycle requiring regulated DNA replication. (biomedcentral.com)

Studies on the protozoan parasite, Entamoeba histolytica suggest that in its proliferative phase, this organism may accumulate polyploid cells. (ias.ac.in)
however, the level of telomerase activity is low or absent in the majority of stem cells regardless of their proliferative capacity. (nature.com)
As stem cells have elongated proliferative capacity, they should have a mechanism that maintains telomere length through many cell divisions. (nature.com)
The ability of cancer cells to sustain proliferative signals was the first of six hallmarks of cancer that were described in a seminal review attempting to rationalise the complexity of neoplastic disease [ 1 ]. (biomedcentral.com)

2005). In addition to its part in the meiotic cell cycle, Maskin has been reported to play a role in the translational control of cyclin B1 in early embryonic cell division in (Groisman et al. (euromed2016.com)

12 It is well established that hypoxia is an important selective force in the evolution of tumor cells, 13 and elevated expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been documented in several human cancers. (haematologica.org)
Plk1 inhibitors target all rapidly dividing cells irrespective of tumor cells or non-transformed normal but proliferating cells. (oncotarget.com)
In this regard, restoration of p53 in tumor cells with loss or mutation of p53 will reinforce the cytotoxicity of combined Polo-like kinase 1 therapy and provide a proficient strategy for combating relapse and metastasis of cancer. (oncotarget.com)

These increased levels of p53 may initiate cell death. (wikipedia.org)
Newly synthesized Yph1p was required for cells to exit G 0 and initiate cell division. (rupress.org)

Inhibition of Cell Survival by Curcumin Is Associated with Downregulation of Cell Division Cycle 20 (Cdc20) in Pancreatic Cancer Cells. (bvsalud.org)
In the current study, we explore whether curcumin exhibits its anti- cancer function through inhibition of oncoprotein cell division cycle 20 (Cdc20) in pancreatic cancer cells . (bvsalud.org)
Thus, inactive p53 is not associated with a susceptible cytotoxicity of Polo-like kinase 1 inhibition and could rather foster the induction of polyploidy/aneuploidy in surviving cells. (oncotarget.com)

Mitochondria, the energy-producing powerhouses of cells, are also the primary intracellular site of oxygen consumption and the major source of reactive oxygen species (ROS). (prohealth.com)
Intracellular signal transduction of cells in response to carcinogenic metals. (cdc.gov)
Generally, NFAT2 locates in cytoplasm with an hyperphosphorylation in quiescent cells, while it can be activated through dephosphorylating by intracellular Ca 2+ increase activated calcineurin [5]. (researchsquare.com)

this means that most eukaryotic cells have the Cdc7 kinase protein. (wikipedia.org)

Samples were thawed before mincing and incubated in Ca 2+ /Mg 2+ -free PBS supplemented with 2 m m EGTA for 30-60 min at 4°C. After incubation, samples were triturated with a series of 1 ml pipette tips of decreasing diameter, filtered with a 40 μm cell filter (BD Biosciences, Bedford, MA), and centrifuged at 500 × g for 5 min. (jneurosci.org)

However, the underlying rules that enable division of labor within cell populations remain to be deciphered. (elifesciences.org)
Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
The objective of this investigation is to determine whether treatment with the H2 receptor antagonist ranitidine alters immune suppression, through modulation of immune cell populations. (drugpatentwatch.com)

Exposure to pesticides as risk factor for non-Hodgkin's lymphoma and hairy cell leukemia: Pooled analysis of two Swedish case-control studies. (baseis.org.py)
Prolonged exposure to hypoxia strongly up-regulated CXCL12 expression in multiple myeloma plasma cells and hypoxia-inducible factor-2 was found to play a key role in this response. (haematologica.org)

Here we show that loss of function of Physcomitrella patens PpTON1 strongly affects development of the moss gametophore, phenocopying the developmental syndrome observed in Arabidopsis ton1 mutants: mutant leafy shoots display random orientation of cell division and severe defects in cell elongation, which are correlated with absence of PPB formation and disorganization of the cortical microtubule array in interphase cells. (silverchair.com)
The class II PI3K isoform PI3K-C2β was downregulated in prostate cancer PC3 cells and cervical cancer HeLa cells using selective siRNAs and the effect on cell growth was determined in the absence or presence of the microtubule-stabilizing agent/anti-cancer drug docetaxel. (biomedcentral.com)

In turn, the plant produces GA, which seems to combat the improper growth signals and re-establishes cell-cycle control. (nature.com)
It is one of the few derived traits specific to embryophytes, in which it is involved in the spatial control of cell division. (silverchair.com)
Urine samples are processed, stored, and shipped to the Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA for analysis. (cdc.gov)

Here we show a novel function for Retinoblastoma family member, p107 in controlling stem cell expansion in the mammalian brain. (rupress.org)

The chronotherapy concept takes advantage of the circadian rhythm of cells physiology in maximising a treatment efficacy on its target while minimising its toxicity on healthy organs. (numdam.org)

A Non-Aggressive, Highly Efficient, Enzymatic Method for Dissociation of Human Brain-Tumors and Brain-Tissues to Viable Single-Cells. (worthington-biochem.com)
The cascade continued until several weeks later, millions of cells were dividing - powering the exponential pattern of growth that eventually formed all of the organs and tissues of your body. (visionlearning.com)
He began a series of live observations under the microscope using dyed samples of animal tissues and found that a particular mass of material inside the nucleus of cells absorbed the dye quite well. (visionlearning.com)

However, the cell numbers in blastocysts did not differ among groups. (molcells.org)
although it is derived from cells of the renal tubular epithelium, it has several histological subtypes which differ in their clinical outcome and biological features. (hindawi.com)

The antiproliferative effect of compounds was determined by WST-1 test, and nuclear morphology changes in cancer cells stained with Giemsa were evaluated. (japsonline.com)
Analysis of the effectiveness of caffeine and MG132 for improving somatic cell nuclear transfer (SCNT) technology using cryopreserved eggs showed that supplementation did not improve the blastocyst formation rate of cloned mouse eggs. (molcells.org)
Nuclear factor of activated T cells 2 (NFAT2) has been reported to regulate the development and malignancy of few tumors. (researchsquare.com)

Through this organization, cells in each state exhibit true division of labor, providing growth/survival advantages for the whole community. (elifesciences.org)

In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)

This metabolic plasticity of aspartate enables carbon-nitrogen budgeting, thereby driving the biochemical self-organization of distinct cell states. (elifesciences.org)
Several drugs targeting distinct phases of the cell cycle have been developed but the inability of many of them to discriminate between normal and cancer cells has strongly limited their clinical potential because of their reduced efficacy at the concentrations used to limit adverse side effects. (biomedcentral.com)

Reported results for all assays meet the Division of Laboratory Sciences' QA/QC performance criteria for accuracy and precision, similar to the Westgard rules (Caudill et al. (cdc.gov)
Clonogenic assays were performed to determine the ability of PC3 and HeLa cells to form colonies upon PI3K-C2β downregulation in the absence or presence of docetaxel. (biomedcentral.com)

Yph1p levels were high in proliferating cells, but declined as cells entered the quiescent phase. (rupress.org)

Cyclin-dependent kinase 6 associates with CYCLIN D and phosphorylates RETINOBLASTOMA PROTEIN during G1 PHASE of the CELL CYCLE. (bvsalud.org)

Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)

Anatomy28

Organisms13

Diseases3

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes83

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science5

Health Care2

20002

Apoptosis13

Proliferation12

Proteins7

Differentiation10

Progression6

Biol5

Asymmetric cell div2

Genes7

Progenitor cells4

Kinases1

Regulation4

Biology3

Endothelial Cells3

Pathways4

Epithelial5

Protein kinase2

Chromosome7

Cellular5

Achieves2

Mechanisms6

Roundup1

Neuron1

Synthesis2

20171

Cancer Stem2

Overexpression1

Sequences1

Leukaemia cells1

Metabolism1

Gene4

Mitosis3

Vitro3

Tumour5

Regulates2

Replication1

Proliferative4

Meiotic1

Tumor cells3

Initiate cell2

Inhibition3

Intracellular3

Eukaryotic1

Biosciences1

Populations3

Exposure2

Microtubule2

Control3

Stem cell1

Physiology1

Tissues3

Differ2

Nuclear3

Survival1

Somatic1

Distinct2

Assays2

Quiescent1

Phase of the cell cycle1

Vivo1