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  • allogeneic
  • Such organ-selective depletion of host tissue APCs also markedly reduced the trafficking of allogeneic CD8 + T cells into the livers and spleens, but not PLN and MLN, of B6 recipients compared with that of the control mice. (jimmunol.org)
  • Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28. (springer.com)
  • To this end, protocols are provided for the assessment of survival rates, weight loss, chimerism, donor‐host cytotoxicity, and cytokine and proliferative responses to mitogenic or allogeneic stimuli. (currentprotocols.com)
  • Targeting costimulatory molecules with antagonist antibodies could dampen the excessive immune response that occurs, while preserving the beneficial graft vs leukemia (GVL) of the allogeneic response. (frontiersin.org)
  • However, the allogeneic T-cell response is often necessary to eliminate residual malignant cells, an effect referred to as graft vs leukemia (GVL). (frontiersin.org)
  • skin graft
  • Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. (springer.com)
  • The transplanted tissue is called a skin graft. (wikipedia.org)
  • The grafting serves two purposes: reduce the course of treatment needed (and time in the hospital), and improve the function and appearance of the area of the body which receives the skin graft. (wikipedia.org)
  • There are two types of skin grafts, the more common type is where a thin layer is removed from a healthy part of the body (the donor section) like peeling a potato, or a full thickness skin graft, which involves pinching and cutting skin away from the donor section. (wikipedia.org)
  • A full thickness skin graft is more risky, in terms of the body accepting the skin, yet it leaves only a scar line on the donor section, similar to a Cesarean section scar. (wikipedia.org)
  • For full thickness skin grafts, the donor section will often heal much more quickly than the injury and is less painful than a partial thickness skin graft. (wikipedia.org)
  • Skin grafts can be: Split-thickness A split-thickness skin graft (STSG) is a skin graft including the epidermis and part of the dermis. (wikipedia.org)
  • Full-thickness A full-thickness skin graft consists of the epidermis and the entire thickness of the dermis. (wikipedia.org)
  • The donor site is either sutured closed directly or covered by a split-thickness skin graft. (wikipedia.org)
  • For more extensive tissue loss, a full-thickness skin graft, which includes the entire thickness of the skin, may be necessary. (wikipedia.org)
  • This usually produces a split-thickness skin graft, which contains the epidermis with only a portion of the dermis. (wikipedia.org)
  • versus tumor
  • However, this alloreactivity not only has negative effects but also mediates graft versus tumor (GvT) effects and supposedly facilitates engraftment. (wiley.com)
  • induces
  • During the first phase, the conditioning regimen (irradiation and/or chemotherapy) leads to damage, activation of host tissues, including intestinal mucosa, and induces the secretion of inflammatory cytokines ( 8 - 11 ). (jimmunol.org)
  • STEM CELLS
  • While the two syndromes differ markedly in immunopathogenesis, both can be induced by the two main methods presented: transfer of allogenic donor lymphocytes and stem cells into irradiated hosts, and transfer of parental strain lymphocytes and stem cells into unirradiated, immune‐competent F1 strain hosts. (currentprotocols.com)
  • depletion
  • Depletion of host hepatic and splenic macrophages and DCs significantly inhibited the proliferation of donor C3H.SW CD8 + T cells in the spleen, but not in the PLN or MLN, of B6 mice. (jimmunol.org)
  • therapy
  • Since 2009, Resimmune is being tested against cutaneous T cell lymphoma, and is in a Phase II trial: A-dmDT390-bisFv(UCHT1) Immunotoxin Therapy for Patients With T-cell Diseases. (wikipedia.org)
  • syndrome
  • Importantly, a significant proportion of patients develop an early graft-versus-host disease-like syndrome likely due to transient suppression of self-tolerance, a mechanism that may be necessary for effective cancer immunotherapy. (aacrjournals.org)