Colchicine is an anti-inflammatory agent that disrupts cytoskeletal functions by inhibiting B-tubulin polymerization, preventing neutrophil activation, degranulation, and migration. (medscape.com)
Acetylated α-tubulin is a cytoskeletal protein characteristic of neuronal microtubules and ciliary structures [ 14 , 15 ]. (biomedcentral.com)
Similarly, the expression of other proteins such as the protein disulphide isomerase and cytoskeletal proteins (tubulin, myosin, actin, extendin, and ubiquitin) also remain constant [37,38]. (globaltechbiz.com)
Inhibitors3
Despite the relevance of sCD95L levels found in serum in other kind of carcinomas, we determined that serum levels screening library of sCD95L in women were not relevant as a biomarker in Inhibitors,Modulators,Libraries cervical cancer, since we found undetectable concentrations of this protein by ELISA assays in all women analyzed. (pdgfreceptor.com)
Infection in Neuronal Cells SK N MC neuroblastoma till cells were grown to 1 105 con fluency in T25 flasks for the Inhibitors,Modulators,Libraries capase assay or in 4 well chamber slides for the immunocytochemis try analysis. (pdgfreceptor.com)
To verify Inhibitors,Modulators,Libraries neuronal phenotype, cells were incubated with primary antibodies specific for III tubulin diluted in PBS for 1 hr at 37 C. The cells were then rinsed with PBS prior to incubating the cells for 1 hr at 37 C with goat anti mouse secondary anti body at 1 2000. (pdgfreceptor.com)
Apoptosis1
The cellular FLICE-inhibitory protein (c-FLIP) is a modulator of death receptor-mediated apoptosis and plays a major role in T- and B-cell homeostasis. (ashpublications.org)
Microtubules2
The principal mode of action for albendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules. (drugbank.com)
It works by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. (drugbank.com)
Alpha4
Mechanics of motility: distinct dynein binding domains on alpha- and beta-tubulin. (wustl.edu)
Cilia were stained using an acetylated alpha‐tubulin antibody (Sigma T6793) which labels the neurons and cilia . (xenbase.org)
a-c) Confocal imaging of acetylated alpha‐tubulin stained whole mount Xenopus embryo . (xenbase.org)
Embryos were fixed and stained with acetylated alpha‐tubulin (Green) (Sigma T6793) and DAPI (Blue). (xenbase.org)
Found2
This increase was verified by immunodetection methods both in OA chondrocytes and cartilage, and we found that the proinflammatory cytokine IL-1β acts as a positive modulator of Hsp90β abundance [ 4 ]. (biomedcentral.com)
One of the main checkpoint modulator of the cell cycle, p38, has been found to be greatly associated with dormant phase in several tumour types [58]. (globaltechbiz.com)
Positive1
Although pregnenolone itself does not possess these activities, its metabolite pregnenolone sulfate is a negative allosteric modulator of the GABAA receptor as well as a positive allosteric modulator of the NMDA receptor. (wikipedia.org)
Functions1
The cilia are composed of three main sections, the axoneme which performs the sensory or movement function, the transition zone which likely contains over 100 proteins which function to anchor the cilia and regulate transport to and from the cilia , and the basal body which is a centriole that functions as a tubulin organizing center to form the cilia . (xenbase.org)
Primary1
The solitary primary cilium is a tubulin-based organelle constructed by the majority of cell types upon exit from the cell cycle. (biomedcentral.com)
Increase1
However, progesterone did and with similar affinity to pregnenolone, although unlike pregnenolone, it did not increase binding of MAP2 to tubulin. (wikipedia.org)