In enzymology, a 20-α-hydroxysteroid dehydrogenase (EC 1.1.1.149) is an enzyme that catalyzes the chemical reaction 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ ⇌ {\displaystyle \rightleftharpoons } 17alpha-hydroxyprogesterone + NAD(P)H + H+ The 3 substrates of this enzyme are 17alpha,20alpha-dihydroxypregn-4-en-3-one, NAD+, and NADP+, whereas its 4 products are 17-alpha-hydroxyprogesterone, NADH, NADPH, and H+. (wikipedia.org)
The systematic name of this enzyme class is 20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase. (wikipedia.org)
20alpha-HSD has been initially described as a progesterone metabolizing enzyme of the ovary. (wikipedia.org)
Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S: Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity. (drugbank.com)
This condition is due to defects in type II 3-beta-hydroxysteroid dehydrogenase, an enzyme that occurs almost exclusively in the gonads and adrenal glands. (medscape.com)
A variety of mutations in the HSD3B2 gene affect the activity of this enzyme, resulting in the extremely variable, phenotypic presentations of 3-beta-hydroxysteroid dehydrogenase deficiency. (medscape.com)
By contrast, cortisol synthesis and secretion is regulated by adrenocorticotropic hormone (ACTH), which stimulates the enzyme P-450scc (20,22 desmolase), with subsequent increased production of all adrenal steroids in both the zona fasciculata and the zona reticularis (see image below). (medscape.com)
ACTH stimulates the enzyme P-450scc (20,22 desmolase) with subsequent increased production of all adrenal steroids. (medscape.com)
Dihydrotestosterone and mestanolone are both very weak in this regard, owing to the fact that these molecules are not very stable in the high enzyme (3-alpha hydroxysteroid dehydrogenase) environment of muscle tissue. (roids.review)
DHT is the conversion product of testosterone at the 5-alpha-reductase enzyme, the result being a hormone that is 3 to 4 times as androgenic and is structurally incapable of forming estrogen. (hilmabiocare.io)
When levels get too high, the 3alpha hydroxysteroid dehydrogenase enzyme converts it to a mostly inactive compound known as 3-alpha (5-alpha-androstan-3alpha,17beta-diol), a prohormone if you will. (hilmabiocare.io)
5-alpha-reductase deficiency - this is an enzyme defect that impairs normal male hormone production. (gaurology.com)
This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. (cancer-genetics.org)
[18] and the enzyme known as Hexose-6-phosphate dehydrogenase appears to influence favorably conversion of these oxygenated metabolites into 7β hydroxyDHEA. (examine.com)
Deficiency7
Classic 3-beta-hydroxysteroid dehydrogenase (3BHSD) deficiency: Patients with classic salt-losing 3-beta-hydroxysteroid dehydrogenase require replacement of glucocorticoids, mineralocorticoids, and sex steroids. (medscape.com)
At puberty, patients with complete 3-beta-hydroxysteroid dehydrogenase deficiency require sex steroid replacement, including testosterone in males and cyclic estrogen-progesterone therapy in females. (medscape.com)
Late-onset (nonclassic) 3-beta-hydroxysteroid dehydrogenase deficiency: The need for replacement therapy varies, depending on the severity of the defect. (medscape.com)
Sex hormone replacement may be required at the time of expected puberty in patients with complete 3-beta-hydroxysteroid dehydrogenase (3BHSD) deficiency. (medscape.com)
Testosterone deficiency may be caused by a defect anywhere along the hypothalamic-pituitary-gonadal axis or a defect in peripheral androgen action (5-alpha reductase deficiency or PAIS). (medscape.com)
3-Beta-hydroxysteroid dehydrogenase (3BHSD) deficiency is a rare form of congenital adrenal hyperplasia that results in decreased production of all 3 groups of adrenal steroids: mineralocorticoids, glucocorticoids, and sex steroids. (medscape.com)
Although first described in male infants with ambiguous genitalia and severe salt wasting, 3-beta-hydroxysteroid dehydrogenase deficiency also occurs in 46,XX female infants (who may have mild clitoromegaly), as well as in older patients who present with a milder or so-called late-onset variant. (medscape.com)
This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. (cancerindex.org)
Oxidoreductase2
AN - infection: coord IM with ACTINOBACILLUS INFECTIONS (IM) HN - 2004 MH - Acyl-CoA Dehydrogenase UI - D042964 MN - D8.811.682.675.150.100 MN - D12.776.331.99 MS - A flavoprotein oxidoreductase that has specificity for medium-chain fatty acids. (nih.gov)
use ACYL-COA DEHYDROGENASE (NM) 1980-2003 MH - Acyl-CoA Dehydrogenase, Long-Chain UI - D044942 MN - D8.811.682.675.150.150 MN - D12.776.331.700 MS - A flavoprotein oxidoreductase that has specificity for long-chain fatty acids. (nih.gov)
2. Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily. (nih.gov)
Protein2
Photoreceptor retinol dehydrogenase (prRDH) is a membrane-associated cytosolic protein that localizes to the outer segments (OS) of rods and cones. (jneurosci.org)
Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. (wikipedia.org)
Enzymes2
An enzymes that catalyzes the reversible reduction-oxidation reaction of 20-alpha- hydroxysteroids , such as from PROGESTERONE to 20-ALPHA- DIHYDROPROGESTERONE . (online-medical-dictionary.org)
The 5alpha-Reductase-3alpha-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids. (thermofisher.com)
Gene2
Accordingly, in mice with targeted deletion of the 20alpha-HSD gene, progesterone blood concentration remain high throughout pregnancy which results in a delay of 2-4 days in parturition. (wikipedia.org)
Labrie Y, Durocher F, Lachance Y, Turgeon C, Simard J, Labrie C, Labrie F: The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species. (drugbank.com)
AKR1C13
AKR1C1, AKR1C2, and AKR1C3 AKR1C1 has high catalytic efficiency as a 20α-HSD and AKR1C2 and AKR1C3 efficiently catalyze this reaction as well. (wikipedia.org)
1. Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. (nih.gov)
18. Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1). (nih.gov)
Type2
siRNA-based breast cancer therapy by suppressing 17β-hydroxysteroid dehydrogenase type 1 in an optimized xenograft cell and molecular biology model in vivo. (cancerindex.org)
Impaired 11β-Hydroxysteroid Dehydrogenase Type 2 Activity in Sweat Gland Ducts in Human Essential Hypertension. (phmsociety.org)
Nonclassic1
Older patients with mild defects in 3-beta-hydroxysteroid dehydrogenase activity (late-onset or nonclassic variant) may present with premature pubic hair development, hirsutism, irregular menstrual cycles or primary amenorrhea. (medscape.com)
Dihydrodiol1
16. Expression of dihydrodiol dehydrogenase and resistance to chemotherapy and radiotherapy in adenocarcinoma cells of lung. (nih.gov)
Glucocorticoids2
Patients with classic salt-losing 3-beta-hydroxysteroid dehydrogenase require initial replacement of glucocorticoids and mineralocorticoid, plus the addition of sex steroids at appropriate, pubertal age. (medscape.com)
Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11β-hydroxysteroid dehydrogenases? (scholaris.sk)
Progesterone2
On a functional level, ovarian 20alpha-HSD is actively involved in the control of progesterone homeostasis in pregnancy of rats and mice. (wikipedia.org)
Indicating that expression of 20alpha-HSD activity is mandatory for the induction of parturition through reduction of progesterone blood concentration. (wikipedia.org)
Syndrome1
Most of 46 XX CAH patients, even if markedly virilised, and 46 XY complete androgen insensitivity syndrome are raised as females. (nih.gov)
Vitro1
however, the AED effect was independent of TNF-alpha suppression, both in vivo and in vitro. (lookformedical.com)
Activity3
While 20alpha-HSD expression and activity is downregulated in the corpus luteum of pregnancy, 24 hrs prior to parturition ovarian 20alpha-HSD activity is acutely stimulated. (wikipedia.org)
Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. (medindex.am)
Ambiguous1
Conventional time-consuming hormonal and genetic work-up provides a genetic diagnosis in around 20-40% of 46,XY cases with ambiguous genitalia. (biomedcentral.com)
Synthesis1
He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3. (wikidoc.org)
Family1
HN - 2004 MH - Acidiphilium UI - D041801 MN - B3.440.400.425.100.110 MN - B3.660.50.10.20 MS - A genus in the family ACETOBACTERACEAE consisting of chemoorganotrophic, straight rods with rounded ends. (nih.gov)