• Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
  • 2001. beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. . (oregonstate.edu)
  • 2003. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. . (oregonstate.edu)
  • 2002. Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. . (oregonstate.edu)
  • Tumors/tumor Bearing Rats (TBR) were 3.8, 2 and 1.56 for C, RB 5% and RB 10%, respectively. (scialert.net)
  • 0.05) reduced the incidence of AOM induced colon tumors in Fisher 344 male rats. (scialert.net)
  • Biochem Biophys Res Commun 2:853-858. (cdc.gov)
  • The effect of cichorium extract and fluorouracil (5-FU) against colorectal cancer (CRC) induced by 1, 2- Dimethyl hydrazine (DMH) was examined in male albino mice. (arjournals.org)
  • These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO 2 from dietary sources. (nature.com)
  • Here, we investigated the antitumorigenic effects of curcumin and 3 acetyl-11-keto-β-boswellic acid (AKBA) on modulation of specific cancer-related miRNAs in colorectal cancer cells and validated their protective effects in vivo using a xenograft mouse model. (arjunanatural.com)
  • Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats. (arjunanatural.com)
  • Kaithwas, Gaurav 2019-10-24 00:00:00 Background: This study evaluates the anti-cancer effects of Tadalafil (potent PDE-5 inhibitor) in female albino wistar rats against n-methyl n-nitrosourea induced mammary gland carcinogenesis. (sagepub.com)
  • 1991. Control of 1,2-dimethylhydrazine-induced crypt hyperplasia by naturalkiller cells and its relevance to carcinogenics. (cdc.gov)
  • E171 or NM-105 for one week did not initiate intestinal inflammation, while a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model. (nature.com)
  • Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. (arjunanatural.com)
  • 1980. Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. (cdc.gov)
  • 2001. Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo. . (oregonstate.edu)
  • The incidence ranges from 64.2 to 78.9 cases/100.000 person-years in the USA, and in Northern Europe, it is of 17 cases/100.000 person-years [ 2 ]. (hindawi.com)
  • In this study we examined the preventive properties of Rice Bran (RB) and germ on the incidence of azoxymethane induced colon tumorigenesis in Fisher 344 male rats. (scialert.net)
  • There was no evidence of increased incidence of carcinogenesis due to Morpholine inhalation at doses up to and including 543 mg/m3. (europa.eu)
  • 2002. Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. . (oregonstate.edu)
  • This inhibition of cGMP conversion leads to 2 mg/kg, p.o. (sagepub.com)
  • 2006. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. . (oregonstate.edu)
  • 2003. Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. . (oregonstate.edu)
  • 2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)
  • 1) self-sufficiency in growth signals, 2) insensitivity to antigrowth signals, 3) evasion of apoptosis, 4) limitless replicative potential, 5) sustained angiogenesis, and 6) tissue invasion/metastasis. (theinterstellarplan.com)
  • It is established that Phycocyanin induces apoptosis in cancer cells by changing the Bcl-2/Bax ratio (Bcl-2 is an anti apoptotic protein, Bax is a pro-apoptotic protein, the ratio of Bcl-2/Bax represents the degree of apoptosis) and the release of Cyt-c in the cytosol (Lu et. (nutraculture.com)
  • It is also understandable that considerable amount of dietary sphingomyelin is delivered into the colon and excreted in the feces. (wikipedia.org)
  • The effect of graded amounts of dietary lactalbumin (L) and casein (C) hydrolyzates on the immune responsiveness of C3H/HeN and DBA/2 strain mice has been investigated by measuring both the specific humoral immune response to sheep red blood cells (SRBC) and the nonspecific splenic cell responsiveness to phytohemagglutinin, concanavalin A and Escherichia coli lipopolysaccharide after stimulation with Mycobacteriurn bovis, strain BCG. (immunehealthscience.com)
  • Membrane-associated and cytoplasmic human chorionic gonadotropin (hCG), its subunits and its fragments were present in human cancer cells of neuroblastomas, medulloblastomas, retinoblastomas, and malignant gliomas of nude mice. (cancerprev.org)
  • 2002. Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). . (oregonstate.edu)
  • This laboratory manual provides cutting-edge methods for generating and characterizing mouse models that accurately recapitulate many features of human cancer. (cshlpress.com)
  • Recent studies on ENPP7 knockout mice clearly showed that digestion of sphingomyelin and generation of ceramide is severely affected in ENPP7 deficiency mice. (wikipedia.org)
  • Twelve C57BL/6 J wild-type mice (WT) and 12 TLR2 knockout mice (TLR2-/-) were used to rapidly establish a colitis-associated cancer (CAC) model via the 1,2-dimethylhydrazine-dextran sodium sulfate (DMH-DSS) method and were divided into the normal WT control group (NC), TLR2 knockout control group (KC), normal wild-type tumor modeling group (NT), and TLR2 knockout tumor modeling group (KT), with 6 mice in each group. (biomedcentral.com)
  • Those at greatest risk for colon cancer are carriers of 1 of 2 familial genetic disorders, familial adenomatous polyposis (FAP) or hereditary non-polyposis colon cancer (HNPCC), also known as Lynch syndrome. (naturalmedicinejournal.com)
  • Role of metformin in suppressing 1, 2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation. (ac.ir)
  • Exenatide suppresses 1, 2-dimethylhydrazine-induced colon cancer in diabetic mice: Effect on tumor angiogenesis and cell proliferation. (ac.ir)
  • Weekly subcutaneous injections of 1,2-dimethethyhydrazine into 6-week-old rats markedly increased thymidylate synthetase (TS) in the poorly differentiated, and thymidine kinase in the well-differentiated adenocarcinomas of the colon. (cancerprev.org)
  • Moreover, ellagic acid reduced the COX-2-induced exacerbation of inflammation. (hindawi.com)
  • In this context, Lafoensia pacari Jaume St. Hilaire (Lythraceae) extracts and ellagic acid reduced most of the phenotypes of experimental ovalbumin-induced allergic airway inflammation [ 16 ], and Punica granatum (Lythraceae) fruit extract reduced the airway inflammation during LPS-induced ALI in mice [ 17 ]. (hindawi.com)
  • Toll-like receptor 2 (TLR2) expression is not limited to cells related to inflammation and immune function. (biomedcentral.com)
  • Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice. (springer.com)
  • Black elderberry extract attenuates inflammation and metabolic dysfunction in diet-induced obese mice. (notulaebotanicae.ro)
  • There are growing concerns that daily oral TiO 2 -NP intake is associated with an increased risk of chronic intestinal inflammation and carcinogenesis. (nature.com)
  • In contrast, colitic cancer, which develops through inflammation-prone carcinogenesis in patients with ulcerative colitis (UC), has a somewhat different etiology ( 9 ). (iiarjournals.org)
  • The laboratory mouse is an important model for addressing questions in cancer biology. (cshlpress.com)
  • In rats orally exposed for one week to E171 at human relevant levels, titanium was detected in the immune cells of Peyer's patches (PP) as observed with the TiO 2 -NP model NM-105. (nature.com)
  • Furthermore, we demonstrated in a mouse xenograft model that both curcumin and AKBA treatments suppressed tumor growth, which corresponded with alterations in the expression of miR-34a and miR-27a, consistent with our in vitro findings. (arjunanatural.com)
  • Metformin suppresses tumor angiogenesis and enhances the chemosensitivity of gemcitabine in a genetically engineered mouse model of pancreatic cancer. (ac.ir)
  • 2003. Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. . (oregonstate.edu)
  • Medicinal plants confer protective effects against a wide range of cancers including colon cancer. (arjournals.org)
  • 2 Overall risk of colon cancer is approximately 5% in the general population without family history, with 92% of colorectal cancers diagnosed after age 50. (naturalmedicinejournal.com)
  • These genetic disorders account for 1-2% and 3-5% of all colorectal cancers, respectively. (naturalmedicinejournal.com)
  • While IBD-related colorectal cancers account for only 1-2% of all CRC cases, CRC accounts for 10-15% of deaths in patients with IBD. (naturalmedicinejournal.com)
  • The general performance of the mice during modeling, the gross changes of the colon and the rectum, and the pathological score of HE staining were used to observe tumor growth. (biomedcentral.com)
  • 2. Viallard C, Larrivée B. Tumor angiogenesis and vascular normalization: alternative therapeutic targets. (ac.ir)
  • We conclude that the protective effects of RB against colon tumorigenesis may possibly be attributed to the synergistic/additive actions of phytochemicals contained in RB. (scialert.net)
  • This study provides evidence to support using Met in combination with Lira as a treatment option for patients with type-2 diabetes and cancer. (ac.ir)
  • As a supplement, CLA has most often been used by adults in doses of 1.6-6.8 grams by mouth daily for 2-12 weeks. (webmd.com)
  • Results: We observed a lower mutation rate in adenomatous polyposis coli (APC) (16.7%(2/12) vs. 75.9%(161/212), respectively, p=0.0001) and KRAS (16.7%(2/12) vs. 42% (89/212), respectively, p=0.04) in colitic cancer than in sporadic CRC. (iiarjournals.org)
  • 2014. Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice. . (oregonstate.edu)
  • The Effects of Genetic Background of Mouse Models of Cancer: Friend or Foe? (cshlpress.com)
  • however, little is known about genetic alterations occurring during UC carcinogenesis. (iiarjournals.org)
  • Colorectal carcinogenesis is considered to develop through multistep genetic or epigenetic alteration along with the pathological change called the adenoma-carcinoma sequence ( 1 - 5 ). (iiarjournals.org)
  • Other chapters cover the use of mouse models to test and optimize drugs in pre-, co-, and post-clinical trials. (cshlpress.com)
  • An appendix specifically addresses the use of mouse cancer models in translational studies and the integration of mouse and human clinical investigations. (cshlpress.com)
  • With respect to cadherin 1 (CDH1) and fibroblast growth factor receptor 2 (FGFR2), the mutational rates for non-neoplastic colorectal mucosa were similar to those in sporadic CRC. (iiarjournals.org)
  • The decrease is caused by expression of a few mutant forms of ENPP7, which lack exon 4, resulting in total inactivation of the enzyme, as found in human colon and liver cancer cells. (wikipedia.org)
  • Tadalafil is a known phosphodiesterase-5 Distinct metastasis and resistance development by self- (PDE-5) inhibitor, which have anti-cancer effects in vari- renewing nascent cancer cells in response with the ous types of cancer [2]. (sagepub.com)
  • Phycocyanin lowers the amount of cyclooxygenase-2 which is up regulated in cancer cells. (nutraculture.com)
  • Dongkui bayberry fruit extract (BFE) prepared using the ultrasonic method exhibited a significantly higher value for the total phenolic content (TPC) and had lower 50% inhibitory concentration (IC 50 ) values of scavenging activities against 1,1-diphenyl-2- picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS), and hydrogen peroxide (H 2 O 2 ), as well as reducing power compared to the other treatment. (notulaebotanicae.ro)
  • The TPC of the BFE was significantly correlated with its DPPH, ABTS, and H 2 O 2 radical-scavenging and reducing power activities. (notulaebotanicae.ro)
  • More intriguing, the in vitro antiradical capacity of purple corn extract against the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical was greater than that of blueberries ( Vaccinium corymbosum L., Ericaceae), which have shown higher antioxidant values than many other commercial food plants. (purepotentialjuice.com)
  • Sodium nitrite in the drinking water at levels of 10.0, 100.0 and 400.0 maximum admissible concentration accelerated the development of Rauscher Leukemia virus-induced leukemia in mice. (cancerprev.org)
  • Groups 1-6 were administered methylurea plus sodium nitrite (group 1), Morpholine plus sodium nitrite (group 2), methylurea (group 3), Morpholine (group 4), sodium nitrite (group 5) or basal diet alone (group 6). (europa.eu)
  • Although the efficacy of cancer treatment has been improved due to comprehensive therapies such as surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, the prognosis and early diagnosis remain poor and the mortality rate remains high ( 2 ). (frontiersin.org)
  • 2017. AhR activation increases IL-2 production by alloreactive CD4 T cells initiating the differentiation of mucosal-homing Tim3 Lag3 Tr1 cells. . (oregonstate.edu)
  • Dendritic cell frequency increased in PP regardless of the TiO 2 treatment, while regulatory T cells involved in dampening inflammatory responses decreased with E171 only, an effect still observed after 100 days of treatment. (nature.com)
  • In all TiO 2 -treated rats, stimulation of immune cells isolated from PP showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased. (nature.com)
  • 13. Wu X, Li S, Xue P, Li Y. Liraglutide, a glucagon-like peptide-1 receptor agonist, facilitates osteogenic proliferation and differentiation in MC3T3-E1 cells through phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), extracellular signal-related kinase (ERK)1/2, and cAMP/protein kinase A (PKA) signaling pathways involving β-catenin. (ac.ir)
  • 1990. Toxicological profile for 1,2-phenylhydrazine. (cdc.gov)
  • 6. Hu Y, Liu J, Wang G, Xu Y. The effects of exenatide and metformin on endothelial function in newly diagnosed type 2 diabetes mellitus patients: a case-control study. (ac.ir)
  • With an alarming rise in mortality rates, from approximately 6 million deaths in 2000 2 to 10 million deaths in 2022 3 , it has emerged as a formidable research challenge in the scientific community. (nhsjs.com)
  • Dongkui BFE at a concentration of 0.25 mg/mL exhibited significantly greater protection of RAW 264.7 mouse macrophages against H 2 O 2 -induced damage and lipopolysaccharide (LPS)-stimulated nitric oxide production by macrophages, and it displayed remarkable inhibitory effects compared to the other extracts using the ultrasonic extraction method. (notulaebotanicae.ro)
  • The immune responses of mice fed the L diets were found to be significantly greater than those of mice fed the corresponding C diets, especially at the 28% level. (immunehealthscience.com)
  • Animal studies showed that supplement of SM or ceramide in the diet may inhibit the development of colon cancer. (wikipedia.org)
  • Metformin (Met) and Liraglutide (Lira) have been approved to treat type 2 diabetes mellitus and have cardioprotective effects. (ac.ir)
  • The enhancement of immune responsiveness observed in mice fed the 28% L diet was moderately reduced by the addition of phenylalanine to the diet, indicating that the lower level of this amino acid in the L protein may be of some significance. (immunehealthscience.com)
  • Little difference in immune responses was noted among mice fed C, S or W protein diets. (immunehealthscience.com)
  • The effect of 20 g/100 g diet of lactalbumin (L), casein (C), soy (S) and wheat (W) protein on the immune responsiveness of C3H/HeN mice has been investigated by measuring the humoral immune response to the T cell-independent antigen, TNP-Ficoll. (immunehealthscience.com)
  • 8 The National Cancer Institute (NCI) has created an online risk assessment tool to calculate the risk of colon cancer in patients over 50 years old. (naturalmedicinejournal.com)