• Hepatic expression of fatty acid binding protein (FABP), very low density apolipoprotein II (ApoVLDL-II) and apolipoprotein B (ApoB) genes increased in both ad lib and restricted breeders following photo-stimulation, whereas apolipoprotein A1 (ApoA1) gene expression declined in both groups. (usda.gov)
  • Improvements in total cholesterol, LDL-C, apolipoprotein B (apoB) and non-high density lipoprotein cholesterol (non-HDL-C) compared to baseline. (newhope.com)
  • [ 5 ] Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
  • Apolipoprotein E (ApoE), an important mediator of lipid transportation in plasma and the nervous system, plays a large role in diseases such as atherosclerosis and Alzheimer's. (diva-portal.org)
  • Small-angle neutron scattering shows that the ApoE containing lipid particles form elliptical disc-like structures, similar in shape but larger than nascent or discoidal HDL based on Apolipoprotein A1 (ApoA1). (diva-portal.org)
  • We aimed to estimate intra-, inter-individual and cohort variability of multi-omics profiles (blood DNA methylation, gene expression, miRNA, proteins and serum and urine metabolites) measured 6 months apart in 156 healthy children from five European countries. (biomedcentral.com)
  • Description: A sandwich ELISA kit for detection of Patatin Like Phospholipase Domain Containing Protein 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (resourcerecovery.be)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Angiopoietin Like Protein 4 (ANGPTL4) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (ksiazkiwnauce.pl)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Angiopoietin Like Protein 4 (ANGPTL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (ksiazkiwnauce.pl)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Angiopoietin Like Protein 4 (ANGPTL4) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. (ksiazkiwnauce.pl)
  • Both lipids and glycogen are known to interfere with the first step in the two-dimensional polyacrylamide gel electrophoresis (2D-PAGE), the isoelectric focusing. (hindawi.com)
  • Lipids, polysaccharides and nucleic acids bind to proteins which increases the viscosity of the samples and often results in horizontal streaking on the 2D-PAGE. (hindawi.com)
  • The nonpolar lipids (ie, cholesterol ester, triglycerides [TGs]) reside in a core surrounded by more polar components (eg, free cholesterol, phospholipids, proteins). (medscape.com)
  • This led to two-to threefold more cholesterol accumulation over a 16-h period. (ewha.ac.kr)
  • An apolipoprotein B blood test is useful in evaluating the risk of developing cardiovascular disease and monitoring treatment for high cholesterol. (walkinlab.com)
  • In this review, we focus on the association of gene and protein of apoA5 with obesity and metabolic syndrome, and provide new insights into the physiological role of apoA5 in humans, giving a potential therapeutic target for obesity and associated disorders. (biomedcentral.com)
  • In recent years, a newly discovered apolipoprotein has been proved to be closely related to the occurrence of obesity and metabolic syndrome. (biomedcentral.com)
  • A team of researchers from the University of Florida College of Medicine in Jacksonville, FL compared the effects of two dietary interventions on CVD risk factors in 47 women with metabolic syndrome. (newhope.com)
  • A Mediterranean-style low-glycemic-load diet emphasizing "good" fats, whole grains, fresh produce, and fish, has been shown to be effective in addressing metabolic syndrome, a cluster of conditions that affects nearly a third of adults in the U.S. and increases their risk to develop cardiovascular disease, type 2 diabetes, and many other chronic diseases. (newhope.com)
  • We used mass-spectrometry based proteomic analysis of unstimulated and carbachol stimulated newborn wild-type (WT) and cystic fibrosis transmembrane conductance regulator (CFTR) null (CF) piglet airways to study proteins in the airway surface liquid and mucus, to investigate if levels of MUC5AC and MUC5B were affected by carbachol stimulation and whether the proteins clustered according to function. (biomedcentral.com)
  • Samples collected from newborn wild-type (WT) and cystic fibrosis transmembrane conductance regulator (CFTR) null (CF) piglets revealed that distinct proteins were bound to the mucus as opposed to the ones easily washed off and associated with the airway liquid. (biomedcentral.com)
  • MS/MS experiments showed that the protein cargo of large LpA-I particles was more diverse. (cdc.gov)
  • Human HDL and isolated particles containing both APOA1 and APOA2 exhibit a much wider range and variation of particle sizes than LpA-I, indicating that APOA2 is likely the major contributor to HDL size heterogeneity. (cdc.gov)
  • Polymorphisms that slightly vary native peptides or inflammatory processes set the stage for abnormal protein folding and amyloid fibril deposition. (medscape.com)
  • The reason why Peter Lansbury and others used the term 'natively unfolded' for a-synuclein and other proteins, especially peptides, is that they do not exist, to a significant degree, in the same kind of stable structure that larger native proteins like myoglobin do. (alzforum.org)
  • See also David Thirumalai's Emerging Ideas on the Molecular Basis of Protein and Peptide Aggregation ' (.pdf). (alzforum.org)
  • Among the least stable features, we identified 1% cross-omics co-variation between CpGs and metabolites (e.g. glucose and CpGs related to obesity and type 2 diabetes). (biomedcentral.com)
  • In this article, we use the term Aboriginal to report on Prevalence of obesity and associated comorbidities was research that included 2 or more of these distinct groups higher among women than men. (cdc.gov)
  • Among men, Canadian Community Health Survey, the prevalence of factors were age, apolipoprotein A1 level, apolipoprotein B obesity among people who self-identified as Aboriginal level, and insulin resistance. (cdc.gov)
  • Expression of sterol regulatory element binding protein 1 (SREBP-1), ATP-citrate lyase (ACL), fatty acid synthase (FAS), malic enzyme (ME), acetyl-CoA carboxylase (ACC), and stearoyl-CoA (?9) desaturase 1 (SCD1) genes in ad lib birds declined from their highest levels just prior to photo-stimulation to reduced levels as the birds came into and maintained egg production. (usda.gov)
  • The protein level of key genes was detected using Western blot. (bvsalud.org)
  • Streamlining Regulon Identification in Bacteria Regulons are a group of genes that can be turned on or off by the same regulatory protein. (doe.gov)
  • These results indicate a distinct separation between proteins in the washable surface liquid and the mucus fraction. (biomedcentral.com)
  • CONCLUSIONS: RPL6, NCL, LDHA and APOA1 are the DEPs in the plasma exosomes of patients with TLE before and after therapy. (bvsalud.org)
  • C-reactive protein (CRP) is an acute-phase protein of the pentraxin family produced in the liver in response to inflammatory signals, particularly interleukin-6, which is synergistically enhanced by IL-1β. (nature.com)
  • 2 However, the CRP concentration rises quickly up to 1000 mg l −1 in the first few days following an acute-phase stimulus and decreases back to baseline with a half-life of 19 h when the stimulus has ceased. (nature.com)
  • In fractions 1-4 from newborn CF piglets an additional cluster containing acute phase proteins was observed, suggesting an early inflammatory response in CF piglets. (biomedcentral.com)
  • Native or wild-type quaternary protein structure is usually born from a single translated protein sequence with one ordered conformation with downstream protein interactions. (medscape.com)
  • There are 182 Native proteins. (proteogenix-products.com)
  • The interactions of the two drugs and substrate were researched by UV-vis absorption and fourier transform infrared (FT-IR). (bvsalud.org)
  • Furthermore, elevated CRP levels are associated with an increased risk of type 2 diabetes in adults 16 and are correlated with insulin resistance in children. (nature.com)
  • Below is a small sample of the many proteins, growth factors, transcription factors it contains. (plurisomes.com)
  • Protein Folding and Neurodegeneration: Biophysics to the Rescue? (alzforum.org)
  • Our results indicate these two "omics" data sets supplement one another. (biomedcentral.com)
  • Amyloidosis results from the accumulation of pathogenic amyloids-most of which are aggregates of misfolded proteins-in a variety of tissues. (medscape.com)
  • Neuronal injury in the hippocampal dentate gyrus and ribosomal protein L6 (RPL6) expression in the brain tissues were detected using H&E staining, Nissl staining, and Western blot. (bvsalud.org)
  • In order to gain the best possible protein separation on 2D-PAGE, an optimized sample preparation protocol for placental proteins was developed. (hindawi.com)
  • Tension pneumothorax and simple pneumothorax are two types of lung conditions that lead to a collapsed lung. (factdr.com)
  • All types of amyloid consist of one major fibrillar protein that defines the type of amyloid. (medscape.com)
  • A third study, also in Malaysia, used human subjects with type 2 diabetes. (vitanetonline.com)
  • The prevalence of atherosclerotic cardiovascular disease is higher in patients with type 2 diabetes, a disorder characterized by hyperinsulinemia and insulin resistance. (ewha.ac.kr)
  • These studies suggest that hyperinsulinemia could promote macrophage foam cell formation and thus may contribute to atherosclerosis in patients with type 2 diabetes. (ewha.ac.kr)
  • Our neutron reflection results demonstrate that the protein variants interact differently with the model membranes, adopting different protein conformations. (diva-portal.org)
  • The first is a parasite of non-human mammals and causes nagana, while the latter two are zoonotic infecting both humans and animals and cause African trypanosomiasis. (wikipedia.org)
  • It was not known whether the human sleeping sickness and nagana were similar or the two disease were caused by similar parasites. (wikipedia.org)
  • Due to the large number of proteins, no protein array platform has yet been designed that covers the entire human placental proteome. (hindawi.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Patatin Like Phospholipase Domain Containing Protein 2 (PNPLA2) in tissue homogenates, cell lysates and other biological fluids. (resourcerecovery.be)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Patatin Like Phospholipase Domain Containing Protein 2 (PNPLA2) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (resourcerecovery.be)
  • We previously showed human HDL containing apolipoprotein A-I (APOA1) but not apolipoprotein A-II (APOA2), designated LpA-I, is composed primarily of two discretely sized populations. (cdc.gov)
  • AIM OF THE STUDY: This study aims to analyze differentially expressed proteins (DEPs) in the plasma exosomes of patients with temporal lobe epilepsy (TLE) and after the Chaihu-Longgu-Muli Decoction (CLMD) therapy and to explore the biomarkers of TLE and the potential targets of CLMD in treating TLE. (bvsalud.org)
  • Highly sensitive and specific recombinant antibody microarrays allowing screening of crude protein extracts are also being developed [ 14 ]. (hindawi.com)
  • 200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. (novusbio.com)
  • Antibody with azide - store at 2 to 8C. (novusbio.com)
  • In addition to confirming previous works regarding mRNA expression in Mecp2 -deficient animals, the current study identified hundreds of novel protein targets. (biomedcentral.com)
  • The High Sensitivity C-Reactive Protein (hs-CRP) Blood Test, Cardiac Risk Assessment measures the hs-CRP levels in the blood to assess the risk of developing cardiovascular disease. (walkinlab.com)
  • To address which proteins are collected on the bundled strands and which are not, we compared proteins easily washed off the tracheobronchial surface with the protein composition of Alcian blue stained mucus using mass spectrometry-based proteomics. (biomedcentral.com)
  • Advances in mass spectrometry-based proteomics have facilitated recent interest in the examination of global protein expression to better understand the biology between transcriptional and translational regulation. (biomedcentral.com)
  • Alternatively, increased levels of these proteins could indicate altered lung development in the CF piglets. (biomedcentral.com)
  • Among them, RPL6, NCL, and LDHA protein levels were downregulated and APOA1 protein level was upregulated in the plasma exosomes of TLE patients. (bvsalud.org)
  • But with two projects, communities are forming to generate high quality genomes to benefit researchers. (doe.gov)
  • The most recent research came in the form of two studies, both of which made use of a tropical fruit, known as the annato. (vitanetonline.com)
  • Many mechanisms of protein function contribute to amyloidogenesis, including "nonphysiologic proteolysis, defective or absent physiologic proteolysis, mutations involving changes in thermodynamic or kinetic properties, and pathways that are yet to be defined. (medscape.com)
  • This would fundamentally change our conventional thinking about protein structure-function relationship, no? (alzforum.org)
  • I do not think there is a contradiction to the conventional thinking of protein structure-function relation. (alzforum.org)
  • Hits common to both data sets indicate disrupted cellular metabolism, calcium signaling, protein stability, DNA binding, and cytoskeletal cell structure. (biomedcentral.com)
  • We propose a ratchet model based on the trefoil structure of APOA1 whereby the helical cage maintaining particle structure has two 'settings' - large and small - that accounts for these findings. (cdc.gov)
  • CLMD treatment, the protein level of RPL6, NCL, and LDHA was increased, and the APOA1 protein level was decreased. (bvsalud.org)
  • Similar to αβ T cells, γδ T cells also develop in embryos, and their intra-thymic development shows strict regulation and flexible plasticity [ 2 ]. (explorationpub.com)
  • The mammalian bloodstream forms are notable for their cell surface proteins, variant surface glycoproteins, which undergo remarkable antigenic variation, enabling persistent evasion of host adaptive immunity leading to chronic infection. (wikipedia.org)
  • Structurally apolipoproteins depend on their amphipathicity, and Ab is also an amphipathic molecule as a recent (Apr 18) Science paper mentions and the article by Charlie Glabe of 1994 showed. (alzforum.org)
  • Several selected protein targets were validated by Western blot analysis. (biomedcentral.com)