Alpha2-Antiplasmin: The Devil You Don't Know in Cerebrovascular and Cardiovascular Disease. (medscape.com)
Hanss MM, Farcis M, Ffrench PO, de Mazancourt P, Dechavanne M. A splicing donor site point mutation in intron 6 of the plasmin inhibitor (alpha2 antiplasmin) gene with heterozygous deficiency and a bleeding tendency. (medscape.com)
Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding. (qxmd.com)
alpha2-antiplasmin (alpha2-AP) is the main physiologic plasmin inhibitor in mammalian plasma. (qxmd.com)
Generated plasmin is quickly inactivated by its main inhibitor alpha2-antiplasmin. (medscape.com)
Activated factor XI can be inactivated by antithrombin III, alpha1-protease inhibitor, C1 inhibitor, and alpha2-antiplasmin. (medscape.com)
Deficiency10
Persons who are heterozygous for alpha 2-PI deficiency have variable bleeding, generally mild or none. (medscape.com)
To determine the clinical significance of acquired α 2 -antiplasmin deficiency in patients with bleeding disorders, I reviewed the results of assays performed on 184 patients over a 4-year period. (jamanetwork.com)
Thirty-two evaluable patients had α 2 -antiplasmin activity levels of less than 50% of normal (defined as severe deficiency), and 35 patients had levels between 50% and 75% of normal (mild deficiency). (jamanetwork.com)
Most patients with severe α 2 -antiplasmin deficiency had either liver disease or disseminated intravascular coagulation and/or fibrinolysis, or both. (jamanetwork.com)
There was a high incidence of severe α 2 -antiplasmin deficiency among patients with acute promyelocytic leukemia. (jamanetwork.com)
Five patients with pathologic bleeding had no identifiable coagulation abnormalities other than α 2 -antiplasmin deficiency. (jamanetwork.com)
The group with severe α 2 -antiplasmin deficiency had a significantly higher incidence of life-threatening or fatal bleeding and the most striking laboratory evidence of hyperfibrinolysis. (jamanetwork.com)
Using the presence of severe α 2 -antiplasmin deficiency as an indication for therapy, ε-aminocaproic acid treatment was associated with cessation of life-threatening bleeding in 8 of 11 patients. (jamanetwork.com)
Deficiency of Alpha-2 antiplasmin may cause the development of atherosclerosis. (gsu.edu)
Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. (wikipedia.org)
Affinity's a2-Antiplasmin (α 2 AP also known as Alpha 2-Plasmin Inhibitor or α 2 PI) Polyclonal Antibody - HRP Conjugated is a whole IgG purified from antiserum conjugated to horseradish peroxidase. (affinitybiologicals.com)
A protein inhibitor called alpha 2-antiplasmin in blood stops the clot-busting effects of plasmin. (harvard.edu)
2-AP) is a major fibrinolysis inhibitor, whose complete, congenital absence has been found to be associated with a distinct hemorrhagic diathesis. (tno.nl)
Alpha-2-antiplasmin is an inhibitor of serine proteases, mainly plasmin. (cryopep.com)
4 "Rotational thromboelastometry indicated that the inhibitor ZED3197 (Figure 2), in a dosedependent manner, slightly prolonged clot formation, reduced clot firmness and facilitated clot lysis without affecting the clotting time, indicating minimal impact on hemostasis. (zedira.com)
Fibrinolysis2
Occasionally, decompensated liver disease also causes excessive fibrinolysis and bleeding due to decreased hepatic synthesis of alpha 2-antiplasmin. (merckmanuals.com)
In parallel, FXIIIa incorporates α2-antiplasmin rendering the clot biochemically stable by preventing premature fibrinolysis by plasmin. (diapharma.com)
Plasminogen activator1
By inhibiting α-2 antiplasmin, dextran serves as a plasminogen activator and therefore possesses thrombolytic features. (the-medical-dictionary.com)
ELISA KIT1
The TECHNOZYM® PAP Complex ELISA kit allows the detection of plasmin / alpha-2-antiplasmin complexes in human plasma. (cryopep.com)
Antibody1
The antibody therefore does not recognize free α2-antiplasmin or free plasminogen. (cryopep.com)
Hereditary disorder1
In a rare hereditary disorder, the level of alpha 2-antiplasmin is severely low, and excessive bleeding can occur. (msdmanuals.com)
Antithrombin1
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. (lookformedical.com)
Clinical2
Abdul S, Leebeek FW, Rijken DC, Uitte de Willige S. Natural heterogeneity of α2-antiplasmin: functional and clinical consequences. (medscape.com)
2,3 However, no compound blocking FXIIIa entered clinical trials yet. (zedira.com)
Glycoprotein3
Bovine AHSG/Alpha-2-HS-glycoprotein ELISA Kitis available at Gentaur for Next week Delivery. (researchd.com)
It is a glycoprotein, molecular weight approximately 70,000 that migrates in the alpha 2 region in immunoelectrophoresis. (lookformedical.com)
Complex2
Of antisera which are specific for subregions of the H-2 complex, only those which contain anti-H-2K or anti-H-2D activity are effective. (tno.nl)
Alpha-2-antiplasmin reacts rapidly to plasmin to form a PAP complex. (cryopep.com)
Plasma2
In plasma, the noncovalent FXIII-A 2 B 2 heterodimer is bound to fibrinogen. (diapharma.com)
Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. (clevelandcliniclabs.com)
Clot2
In addition, FXIII decorates the blood clot with α 2 -antiplasmin preventing premature degradation by plasmin. (zedira.com)
Both cross-linking and α 2 -antiplasmin incorporation increase the biochemical and physicochemical stability of the mature clot. (zedira.com)
Gene1
Inactivation of the murine alpha2-AP gene was achieved by replacing, through homologous recombination in embryonic stem cells, a 7-kb genomic sequence encoding the entire murine protein (exon 2 through part of exon 10, including the stop codon) with the neomycin resistance expression cassette. (qxmd.com)
Protein1
This system separates mutations that (1) result in decreased synthesis of the protein (Glu117Stop or Type II) producing no measurable FXI in the homozygous state, (2) abnormal dimerization of the protein (Phe283Leu or Type III) producing approximately 10% of FXI in the homozygous state, or (3) dimerization that results in the FXI protein to be poorly secreted (Ser225Phe and Cys398Tyr). (medscape.com)
Activity1
Alpha 2-antiplasmin blocks the activity of plasmin , which is a substance in the blood that helps dissolve blood clots. (msdmanuals.com)
Excessive1
Doctors can measure the level of alpha 2-antiplasmin in people who have excessive bleeding and have had other causes excluded. (msdmanuals.com)
Liver1
This finding is supported by 2 reports of patients undergoing liver transplant. (medscape.com)
During the 24-hour period after insulin the plasminogen and fast and slow antiplasmin levels did not change. (aspetjournals.org)
Mouse1
Antisera directed against histocompatibility-2 antigens of the mouse suppress the formation of spleen colonies by pluripotent hemopoietic stem cells. (tno.nl)
Moreover, 2 randomized controlled trials were at unclear risk of bias, 1 trial at low risk of bias and 1 trial at high risk of bias, which did not have the information for the primary outcome. (bvsalud.org)
Effect1
STUDY ELIGIBILITY CRITERIA: The inclusion criteria were randomized controlled trials that compared the effect of 2 aspirin dosage regimens during pregnancy for the prevention of PE initiated in the first trimester of pregnancy. (bvsalud.org)
Fast1
Unfortunately, the quick action of alpha 2-antiplasmin is sometimes too fast, leaving clots in the body to do their damage. (harvard.edu)
Risk1
METHODS: Of note, 2 reviewers independently screened all citations, selected studies, and evaluated the risk of bias. (bvsalud.org)