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  • selective
  • Discovery and Development of N-4-(l-Cyclobutylpiperidin-4-yloxy) phenyl-2-(morpholin-4-yl) acetamide dihydrochloride (SUVN-G3031): A Novel, Potent, Selective and Orally Active Histamine H3 Receptor Inverse Agonist with Robust Wake-Promoting Activity. (bioportfolio.com)
  • neurones
  • Somatosensory cortex layer 2/3 neurones with pyramidal shaped somata were selected using an infrared differential interference contrast optics, and recordings were made with patch pipettes (4 MΩ) filled with (in mM) 50 KCl, 55 K-gluconate, 10 NaCl, 10 HEPES, 2 MgATP, 0.1 EGTA, pH 7.35. (rupress.org)
  • GABA
  • In vesicular gamma-amino butyric acid (GABA) transporter (VGAT)-channelrhodopsin2 (ChR2)-enhanced yellow fluorescent protein (EYFP) transgenic mice, NCAM is expressed postnatally at perisomatic synaptic puncta of EYFP-labeled parvalbumin, somatostatin and calretinin-positive interneurons, and in the neuropil in the anterior cingulate cortex (ACC). (frontiersin.org)
  • theanine
  • The concentrations of norepinephrine, 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole acetic acid (5HIAA) in the brain regions were unaffected by the theanine administration except in striatum. (springer.com)
  • neurons
  • In keeping with the notion of random convergence and divergence of OB axons in PCx, electrophysiological studies show that each odorant activates an apparently random population of from 3% to 15% of the neurons in layer 2 of the PCx at low concentration ( Stettler and Axel, 2009 ). (elifesciences.org)
  • However, anatomical reconstructions of individual layer 6 corticothalamic (L6 CT) neurons include examples with axonal processes ramifying within layer 5, and the relative input of the overall population of L6 CT neurons to layers 4 and 5 is not well understood. (stanford.edu)
  • We compared the synaptic impact of L6 CT cells on neurons in layers 4 and 5. (stanford.edu)
  • inhibitory
  • Laser scanning photostimulation revealed that NCAM deletion increased the strength of close-in inhibitory connections to layer 2/3 pyramidal cells of the ACC. (frontiersin.org)
  • synaptic plasticity
  • Transmission is not static but can be modulated by activity on various time scales, giving rise to short-term plasticity ( 1 ) and longer-lasting forms of synaptic plasticity ( 2 ). (pnas.org)
  • cortex
  • Thus, the 2-layer integrative behavior of olfactory PN dendrites provides a parsimonious account for the nonlinear remapping of the odor code from bulb to cortex. (elifesciences.org)
  • Effects
  • Effects of thiol-reagents on [ 3 H]α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding to rat telencephalic membranes. (springer.com)
  • release
  • Posttetanic potentiation (PTP) is an enhancement of transmitter release on a minute time scale ( 3 - 5 ), which is most likely induced by the buildup of spatially averaged, residual Ca 2+ in the nerve terminal during high-frequency firing periods ( 6 - 9 ). (pnas.org)
  • series
  • Then a series of 5-(pyrimidin-2-ylamino)picolinonitrile derivatives as CHK1 inhibitors were discovered by further rational optimization. (bioportfolio.com)
  • Development
  • Throughout development and in both layers, sites displaced by kainate were present at low density and sites displaced by D,L-2-amino-4-phosphonobutyric acid were not detected. (muscimol.xyz)
  • critical
  • As predicted by theory for a critical branching process, the propagation obeys a power law with an exponent of -3/2 for event sizes, with a branching parameter close to the critical value of 1. (jneurosci.org)