2 adrenergic receptors. Medical search. Frequent questions

Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis? (jci.org)
Adrenergic alpha-2 Receptor Agonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "Adrenergic alpha-2 Receptor Agonists" by people in this website by year, and whether "Adrenergic alpha-2 Receptor Agonists" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Adrenergic alpha-2 Receptor Agonists" by people in Profiles. (rush.edu)
When tested with beta-adrenergic agonists, the maximal adenylyl cyclase response mediated by this mutant receptor was less than one-half of that seen with the wild-type receptor. (duke.edu)
The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is occupied by stimulatory agonists. (duke.edu)
These agents compete with beta-adrenergic agonists for available beta-receptor sites. (medscape.com)
Cooling augmented contractions evoked by the alpha 2-adrenergic agonists B-HT 920 and UK 14304 but did not affect responses to the full alpha 1-adrenergic agonist phenylephrine. (johnshopkins.edu)
Therefore, cooling reduces alpha 1-adrenergic responsiveness in canine cutaneous veins, but in the case of full alpha 1-adrenergic agonists such as norepinephrine and phenylephrine the inhibitory effect of cooling is buffered by an alpha 1-adrenoceptor reserve. (johnshopkins.edu)
However, how agonists with varying efficacy modulate these receptor states to initiate cellular responses is not well understood. (nih.gov)
Agonists generally exert efficacy by stabilizing the active Nb80-stabilized receptor state (R80). (nih.gov)
In contrast, for a number of partial agonists, both stabilization of R80 and destabilization of the inactive, Nb60-bound state (R60) contribute to their ability to modulate receptor activation. (nih.gov)
Multiple agonists of G-protein coupled receptors (GPCRs), beta-adrenergic receptors (β-ARs) in particular, scored in this screen. (biorxiv.org)
Guanfacine is in a class of medications called centrally acting alpha 2A -adrenergic receptor agonists. (medlineplus.gov)

clenbuterol and other β2 adrenergic agents remain banned not as a beta-agonist, but rather an anabolic agent. (wikipedia.org)
BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. (jci.org)
Moreover, bilateral intra-vBNST injection of the β-2 AR agonist, clenbuterol, but not the β-1 agonist, dobutamine, reinstated cocaine seeking, suggesting that activation of vBNST β-2 AR is both necessary for stress-induced reinstatement and sufficient to induce cocaine seeking. (marquette.edu)
Scholars@Duke publication: A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. (duke.edu)
Activation of guanyl nucleotide regulatory proteins (G proteins) by hormones and neurotransmitters appears to require the formation of high affinity agonist-receptor-G protein ternary complexes. (duke.edu)
Nevertheless, D267-273 exhibited high affinity agonist binding identical to that of the wild-type receptor. (duke.edu)
In addition, agonist-induced sequestration of the receptor, a property not mediated by Gs, was also normal. (duke.edu)
These findings indicate that the formation of high affinity agonist-receptor-Gs complexes is not sufficient to fully activate Gs. (duke.edu)
Our data thereby suggest that the molecular determinants of the beta 2-adrenergic receptor involved in formation of the ternary complex are not identical to those that transmit the agonist-induced stimulatory signal to Gs. (duke.edu)
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. (duke.edu)
However, the contractions evoked by the partial alpha 1-adrenergic agonist St 587 were virtually abolished by cooling. (johnshopkins.edu)
Terbutaline Sulfate Injection is a beta-adrenergic receptor agonist used for the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema . (rxlist.com)
Terbutaline sulfate injection, USP is a beta-adrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. (rxlist.com)
studies have shown that the R- and S-enantiomers of racemic albuterol, a β 2 -adrenergic receptor agonist used in asthma treatment, have differential effects on the contractile properties of airway smooth muscle. (scirp.org)
Ephedrine sulfate injection is an alpha- and beta-adrenergic agonist and a norepinephrine-releasing agent that is indicated for the treatment of clinically important hypotension occurring in the setting of anesthesia. (nih.gov)
We sought to determine the influence of an inhaled ß-agonist on the diffusing capacity of the lungs for carbon monoxide (DLCO), alveolar- capillary membrane conductance (D(M)), pulmonary capillary blood volume (Vc), and peripheral oxygen saturation (SaO(2)) in subjects with CF, when compared to matched healthy subjects , according to genetic variation of the ß(2)- adrenergic receptor (ADRB2). (bvsalud.org)

G-protein-coupled receptors (GPCRs) modulate many physiological processes by transducing a variety of extracellular cues into intracellular responses. (nih.gov)

In this model, Beta2-Adrenergic Receptor (B2AR) - T4 Lysozyme fusion was developed to allow for structure solution. (proteopedia.org)
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. (duke.edu)

Immunofluorescence staining of fixed A431 cells with anti-Beta 2 adrenergic receptor antibody R11/E1 (Ab01586) Immunofluorescence analysis of paraformaldehyde fixed A431 cells on Shi-fix™ coverslips stained with the chimeric rabbit IgG version of R11/E1 (Ab01586-23.0) at 10 µg/ml for 1h followed by Alexa Fluor® 488 secondary antibody (2 µg/ml), showing membrane staining. (absoluteantibody.com)

R11/E1 antibody recognizes human beta-2 adrenergic receptor. (absoluteantibody.com)
The alternative inactive state of the human beta(2)-adrenergic receptor originally exposed in molecular dynamics simulations was investigated using various analysis tools to evaluate causality between correlated residue-pair fluctuations and suggest allosteric communication pathways. (khas.edu.tr)

The present data indicate that activated alpha 2-adrenergic and muscarinic receptors inhibit dihydropyridine-sensitive Ca2+ channels via pertussis toxin-sensitive G proteins without the involvement of a cAMP-dependent intermediate step. (mdc-berlin.de)
High-potency antipsychotics have a higher affinity for dopamine receptors and less for alpha-adrenergic and muscarinic receptors. (msdmanuals.com)

The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline), a hormone and neurotransmitter whose signaling, via adenylate cyclase stimulation through trimeric Gs proteins, increases cAMP, and, via downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. (wikipedia.org)
Aim: There are inter-individual variations in the impact of the Beta-2 adrenergic receptor (ADRB2) polymorphisms on salbutamol response in asthmatic patients. (authorea.com)
These results suggest that there are differences in lung diffusion and peripheral SaO(2) according to genetic variation of the ADRB2 at position 27 which could play a potential role in dosing options or adjustments that may be required according to genotype . (bvsalud.org)

Recombinant monoclonal antibody to Beta 2 adrenergic receptor. (absoluteantibody.com)

Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. (duke.edu)
Doxazosin mesylate is a quinazoline compound that is a selective alpha1-adrenergic antagonist. (medscape.com)

citation needed] This receptor-channel complex is coupled to the Gs G protein, which activates adenylyl cyclase, catalysing the formation of cyclic adenosine monophosphate (cAMP) which then activates protein kinase A, and counterbalancing phosphatase PP2A. (wikipedia.org)

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. (duke.edu)
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. (duke.edu)
Preoperatively, prepare patients with pheochromocytomas by treating them with an alpha-blocker or a tyrosine hydroxylase inhibitor, such as metyrosine, for 1-2 weeks, after which administration of a beta-blocker can be considered. (medscape.com)
It has been found through scientific studies that Yohimbine Hydrochloride is an alpha 2 adrenergic receptor inhibitor. (kidneyurology.org)

Stimulation of the ß(2)- adrenergic receptors mediates mucociliary clearance and bronchodilation. (bvsalud.org)

Protein kinase A then goes on to phosphorylate (and thus inactivate) myosin light-chain kinase, which causes smooth muscle relaxation, accounting for the vasodilatory effects of beta 2 stimulation. (wikipedia.org)
In contrast, Beta-1 adrenergic receptors are coupled only to Gs, and stimulation of these results in a more diffuse cellular response. (wikipedia.org)
In the normal eye, beta-2 stimulation by salbutamol increases intraocular pressure via net: Increase in production of aqueous humour by the ciliary process, Subsequent increased pressure-dependent uveoscleral outflow of humour, despite reduced drainage of humour via the Canal of Schlemm. (wikipedia.org)
In such cases, beta-2 stimulation with its consequent increase in humour production is highly contra-indicated, and conversely, a topical beta-2 antagonist such as timolol may be employed. (wikipedia.org)
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. (duke.edu)
Stimulation of Gi-coupled receptors leads to the activation of mitogen-activated protein kinases (MAP kinases). (duke.edu)
It may be used to treat excessive beta-receptor stimulation in patients with inoperable metastatic pheochromocytoma. (medscape.com)

Its drug action is transient and alpha-adrenergic blockade incomplete. (medscape.com)
Khabibrakhmanov I.I. The effect of α1 -adrenergic receptor subtypes blockade on the rat myocardium inotropy / I.I. Khabibrakhmanov, N.I. Ziyatdinova, T.L. Zefirov // Journal of Pharmacy Research. (kpfu.ru)
Cooling (from 37 to 24 degrees C) augmented contractions to norepinephrine under control conditions and after alpha 1-adrenergic blockade (prazosin) but not following alpha 2-adrenergic blockade (rauwolscine). (johnshopkins.edu)

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (absoluteantibody.com)

This antibody was raised by immunizing mice with beta-2 adrenergic receptor. (absoluteantibody.com)
This antibody is recommended for the detection and analysis of the beta-2 adrenergic receptor. (absoluteantibody.com)

It is an alpha1- and alpha2-adrenergic blocking agent that blocks circulating epinephrine and norepinephrine action, reducing hypertension that results from catecholamine effects on alpha receptors. (medscape.com)
Adrenergic receptors bind the norepinephrine, epinephrine and catecholamines. (kidneyurology.org)
Due to the property of blocking the alpha 2 adrenergic receptors, the levels of blood epinephrine and norepinephrine is increased. (kidneyurology.org)
With norepinephrine, this permits the potentiating effect of cooling on the alpha 2-adrenergic component of the response to predominate. (johnshopkins.edu)

The other clone (M alpha 2-10H) closely resembles the human alpha 2-C10 subtype in sequence but binds with significantly lower affinity to yohimbine and rauwolscine, members of a distinct class of bulky alpha 2-selective antagonists commonly used to evaluate alpha 2-AR function in vivo. (aspetjournals.org)

Analysis of these receptors identified a conservative Cys201 to Ser201 change in the fifth transmembrane domain of M alpha 2-10H as being responsible for the low affinity of the mouse receptor for yohimbine. (aspetjournals.org)
The beta-2-adrenergic receptor binds adrenaline with far grater affinity than noradrenaline. (absoluteantibody.com)
We show that Nb60 stabilizes a previously unappreciated low-affinity receptor state which corresponds to one of two inactive receptor conformations as delineated by X-ray crystallography and NMR spectroscopy. (nih.gov)
Antipsychotic drugs are divided into conventional antipsychotics and 2nd-generation antipsychotics (SGAs) based on their specific neurotransmitter receptor affinity and activity. (msdmanuals.com)
Low-potency antipsychotics, which are rarely used, have less affinity for dopamine receptors and relatively more affinity for alpha-adrenergic, muscarinic, and histaminic receptors. (msdmanuals.com)

Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding. (aspetjournals.org)
Molecular cloning and ligand binding studies have shown the alpha 2 class of adrenergic receptor (alpha 2-AR) to be a family of at least three related subtypes in humans. (aspetjournals.org)
To begin this process, we have isolated two mouse genomic clones encoding alpha 2-AR subtypes and expressed these genes in COS-7 cells for binding studies. (aspetjournals.org)
This group also found that while both receptor subtypes were seen in the membranes and cytoplasm of cell bodies, the β 2 receptor subtype, but not the β 1 , was localized to the nucleus. (frontiersin.org)

Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. (wikipedia.org)
PAH was induced in S-D rats by a combination of a VEGF-receptor blocker followed by 4 weeks of 10% hypoxia (SuHx).Gene expression was evaluated by RT-PCR and confirmed by western blot. (ersjournals.com)
Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly and Thr164Ile were suggested to have an effect in heart failure. (biomedcentral.com)
In this study sample, we were not able to demonstrate an overall influence of polymorphisms Gln27Glu and Arg16Gly of beta-2 receptor gene on prognosis. (biomedcentral.com)
These findings substantiate the hypotheses that polymorphisms Arg16Gly, Gln27Glu and Thr164Ile of beta-2 receptor gene might be functional and might be associated with differences in the survival rate of patients with heart failure. (biomedcentral.com)
We performed this study to evaluate the polymorphisms Gln27Glu, Arg16Gly, and Thr164Ile of the beta-2 receptor gene relative to demographic and clinical variables, as well as, survival rate in a series of patients with heart failure of different etiologies. (biomedcentral.com)
Adenovirus-mediated gene transfer of human β 2 AR rescued these defects. (elsevierpure.com)
beta(1)-Adrenergic receptor gene polymorphisms and the acute response to atenolol in healthy young Japanese subjects. (druglib.com)
Polymorphisms at codons 49 and 389 of the beta(1)-adrenergic receptor gene have been shown to alter the receptor function in vitro, whereas it remains controversial whether they influence the response to beta-blocker in vivo. (druglib.com)
B 2 adrenergic receptor gene polymorphism effect on childhood asthma severity and response to treatment. (cdc.gov)

To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (βARs), one that predominately recognizes neurons (βAR 248) and the other astrocytes (βAR 404), to characterize the microenvironments of DβH and βAR. (frontiersin.org)
Conventional antipsychotics (see table Conventional Antipsychotics ) act primarily by blocking the dopamine-2 receptor (dopamine-2 blockers). (msdmanuals.com)

Here we demonstrate that, in the vBNST, corticotropin releasing factor (CRF) is expressed in neurons that innervate the ventral tegmental area (VTA), a site where the CRF receptor antagonist antalarmin prevents the reinstatement of cocaine seeking by a stressor, intermittent footshock, following intravenous self-administration in rats. (marquette.edu)

iScience 2022 Jan 19;25(2):103771. (lu.se)

At low doses, alpha-adrenergic receptor blockers may be used as monotherapy in the treatment of hypertension. (medscape.com)
As a result, concurrent diuretic therapy may be required to maintain the hypotensive effects of alpha-receptor blockers. (medscape.com)

Interestingly, Beta-2 adrenergic receptor was observed to localize exclusively to the T-tubular network of adult cardiomyocytes, as opposed to Beta-1 adrenergic receptor, which is observed also on the outer plasma membrane of the cell Activation of the β2 adrenoreceptor with long-acting agents such as oral clenbuterol and intravenously-infused albuterol results in skeletomuscular hypertrophy and anabolism. (wikipedia.org)

It should be possible to extend the analysis of alpha 2-AR subtype function to the animal level through the use of experimental mammalian embryology in mice. (aspetjournals.org)
We have recently demonstrated that neonatal astrocytes derived from mice lacking beta-2 adrenergic receptors (β 2 AR) possess higher proliferation rates, as compared to wild-type cells, an attribute that was shown to involve insulin-like growth factor (IGF) signaling. (medsci.org)
We characterized the metabolic phenotype of β 2 AR-null C57Bl/6N mice (β 2 AR -/- ) by performing in vivo and ex vivo experiments. (elsevierpure.com)
Adult β 2 AR -/- mice featured glucose intolerance, and pancreatic islets isolated from these animals displayed impaired glucose-induced insulin release, accompanied by reduced expression of peroxisome proliferator-activated receptor (PPAR)γ, pancreatic duodenal homeobox-1 (PDX-1), and GLUT2. (elsevierpure.com)
Moreover, islets from 20-month-old β 2 AR +/+ mice exhibited reduced density of β 2 AR compared with those from younger animals, paralleled by decreased levels of PPARγ, PDX-1, and GLUT2. (elsevierpure.com)
Overexpression of β 2 AR in aged mice rescued glucose intolerance and insulin release both in vivo and ex vivo, restoring PPARγ/PDX-1/GLUT2 levels. (elsevierpure.com)
Our data indicate that reduced β 2 AR expression contributes to the age-related decline of glucose tolerance in mice. (elsevierpure.com)
Ad-mRLN, but not Ad-GFP, treatment reversed the increased left ventricular collagen content in beta(2)AR mice to control levels without affecting collagen levels in other heart chambers or in the lung and kidney. (nih.gov)

This is a nonselective alpha-adrenergic blocking agent. (medscape.com)
This is a nonselective beta-adrenergic receptor blocker. (medscape.com)

Assessing the binding of 17 ligands of varying efficacy to the β2AR in the absence and presence of Nb60 or Nb80 reveals large ligand-specific effects that can only be explained using an allosteric model which assumes equilibrium amongst at least three receptor states. (nih.gov)
These data demonstrate that ligands can initiate a wide range of cellular responses by differentially stabilizing multiple receptor states. (nih.gov)

After primary treatment with an alpha-receptor blocker, propranolol hydrochloride may be used as adjunctive therapy if control of tachycardia becomes necessary before or during surgery. (medscape.com)

Many presume that such adrenergic receptors may inhibit erection. (kidneyurology.org)
Fig. 2: Mutations at the interface of the FluPol A dimer inhibit cRNA to vRNA replication. (nature.com)

These experiments suggest that cooling augments alpha 2-adrenergic responsiveness without affecting alpha 1-adrenergic responsiveness. (johnshopkins.edu)
Furthermore, the enhanced adrenergic receptor sensitivity suggests an augmented sympathetic responsiveness. (cdc.gov)

The purpose of this study was to evaluate functional genetic polymorphisms of physiologic pathways related to the regulation of the cardiovascular function (alpha-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B2 receptor) and exercise muscle vasodilatation in apparently healthy men and women. (scipedia.com)
R. Nunes, L. Barroso, A. Pereira, M. Rondon, C. Negrão, J. Krieger and A. Mansur, Alpha2A-adrenergic receptor and eNOS genetic polymorphisms are associated with exercise muscle vasodilatation in apparently healthy individuals, IJC Heart & Vasculature (2016). (scipedia.com)
Influence of genetic variation of the ß2-adrenergic receptor on lung diffusion in patients with cystic fibrosis. (bvsalud.org)
A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. (lu.se)

A surface of the kinase domain critical for the allosteric activation of G protein-coupled receptor kinases. (absoluteantibody.com)
G protein-coupled receptor activation leads to the membrane recruitment and activation of G protein-coupled receptor kinases, which phosphorylate receptors and lead to their inactivation. (duke.edu)

This appears to be mediated by cAMP induced PKA phosphorylation of the receptor. (wikipedia.org)
It was successfully used in the in vivo phosphorylation assays during Western blot detections of beta-2 adrenergic receptor (Huang et al. (absoluteantibody.com)

This finding raises the possibility that discrete regions of the receptor mediate ternary complex formation, whereas different loci may be involved in other aspects of G protein activation. (duke.edu)

2023;49(2):e12891. (lu.se)
270(2): 864-876 (2023) doi:10.1007/s00415-022-11418-y. (lu.se)

We identified these autoantibodies as immunoglobulin G directed against peptide sequences from the second extracellular loop of these receptors. (ox.ac.uk)
Ligand binding to an extracellular orthosteric pocket propagates conformational change to the receptor cytosolic region to promote binding and activation of downstream signalling effectors such as G proteins and β-arrestins. (nih.gov)

It inhibits postsynaptic alpha-adrenergic receptors, resulting in the vasodilation of veins and arterioles and a decrease in total peripheral resistance and blood pressure. (medscape.com)

Beta-2 Adrenergic Receptor s (B2ARs) are a type of G Protein-Coupled Receptor (GPCR) . (proteopedia.org)

Since Yohimbine Hydrochloride is a blocker of adrenergic receptors, it would help in curing erectile dysfunctions. (kidneyurology.org)

Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. (duke.edu)
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. (duke.edu)

In the present study, we investigated whether these polymorphisms influence the acute changes of heart rate and blood pressure induced by the beta(1)-adrenergic receptor-selective blocker atenolol in healthy young Japanese. (druglib.com)

In patients harboring alleles Gly16 and Glu27, previoulsy associated with increased down regulation of beta-2 adrenergic receptors, a statistically significant difference relative to prognosis has not been demonstrated. (biomedcentral.com)
The purinergic P2X 7 receptor: regulation of uterine function in labour and preterm labour. (nottingham.ac.uk)

The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. (jci.org)
Enhancing ceramide degradation also endows these metabolic benefits, and adiponectin exerts their antidiabetic, cardioprotective, and insulin-sensitizing actions through activating its receptors, which are ligand-activated ceramidases ( 23 ). (frontiersin.org)
Metabolic syndrome (MetS) is a cluster of consumption of saturated fats to unsaturated fats, metabolic risk factors for cardiovascular disease and increase the intake of fruits, vegetables, legumes type 2 diabetes. (bvsalud.org)
Diabetes mellitus, a world-wide increasing disease, is related to a heterogeneous group of metabolic disorders characterized by hyperglycemia resulting from either defects in secretion or insulin action or even both 1-2 . (bvsalud.org)

According to the World Health Organization (WHO) global report, ~422 million adults were living with diabetes in 2014 ( 1 ), and that cardiovascular diseases account for 31% mortality worldwide ( 2 ). (frontiersin.org)
Although significant reductions have occurred in the incidence of cardiovascular disease (CVD) since the mid-1970s, this is still the primary cause of morbidity and mortality in many countries [1,2]. (who.int)
The study has 2 major components: phase 1, a cross sectional prevalence study of cardiovascular disease and associated risk factors, and phase 2, a prospective 20-year follow-up study [9]. (who.int)

Sequence homology and ligand binding data allow the assignment of one clone (M alpha 2-4H) as the mouse homolog of the human alpha 2-C4 subtype. (aspetjournals.org)
To define the domain(s) responsible for this unusual binding property, we constructed a series of M alpha 2-10H/human alpha 2-C10 chimeric receptors. (aspetjournals.org)
Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (rush.edu)
This is a long-acting adrenergic alpha-receptor blocker that can produce and maintain a chemical sympathectomy. (medscape.com)
Cooling and alpha 1- and alpha 2-adrenergic responses in cutaneous veins: role of receptor reserve. (johnshopkins.edu)
Experiments were designed to determine the effects of cooling on alpha 1- and alpha 2-adrenergic responses in isolated canine cutaneous veins. (johnshopkins.edu)
Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. (aspetjournals.org)
The pharmacological characteristics of alpha-1 and alpha-2 adrenergic receptors in young (6 month) and old (4.5-5 year) female rabbit urethra were studied using isolated muscle bath techniques. (aspetjournals.org)
Stuckey et al19 evaluated whether an 8-week and central alpha 2-1 and beta-adrenergic receptors. (bvsalud.org)

The contribution of a β-2 AR-regulated vBNST-to-VTA pathway that releases CRF was investigated using a disconnection approach. (marquette.edu)
Significance Statement Here we identify β-adrenergic receptor (β-AR) signaling as an essential pathway controlling ER-Mito contacts. (biorxiv.org)

Interestingly, with aging, wild-type (β 2 AR +/+ ) littermates developed impaired insulin secretion and glucose tolerance. (elsevierpure.com)

abstract = "In this study, we investigated the significance of β 2- adrenergic receptor (β 2AR) in age-related impaired insulin secretion and glucose homeostasis. (elsevierpure.com)

To date, however, mutagenesis studies with the beta 2-adrenergic receptor have not clarified this question since mutant receptors with impaired abilities to activate Gs have generally possessed a diminished capacity to form the ternary complex as assessed in binding assays. (duke.edu)

Our cancer studies have expanded to include oesophageal cancer with emphasis on oestrogen receptor expression and function in this malignancy. (nottingham.ac.uk)
expression of 25-hydroxylase ( Cyp27a1 ), 1 α -hydroxylase ( Cyp27b1 ), and vitamin D receptor ( Vdr ) was analyzed by real-time polymerase chain reaction. (medscape.com)
in both IR cells and obese SAT, protein expression of β 2 -adrenergic receptor was reduced. (medscape.com)

Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. (duke.edu)

These studies have not, however, identified distinct subtype-specific functions for these receptors in vivo. (aspetjournals.org)

Putative corresponding receptors were identified using antagonistic drugs, and synthesized peptide sequences corresponding to segments of these receptors were used to identify the target epitopes. (ox.ac.uk)

A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. (duke.edu)
Chronic human heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased levels of betaAR kinase 1 (betaARK1), which seems critical to the pathogenesis of the disease. (duke.edu)
Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). (duke.edu)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates its membrane-associated receptor substrates, such as the beta-adrenergic receptor, triggering events leading to receptor desensitization. (duke.edu)

Anatomy25

Organisms15

Diseases4

Chemicals and Drugs151

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes41

Information Science3

Health Care1

Agonists14

Agonist16

GPCRs1

Beta2-Adrenergic Receptor2

Anti-beta 2 Adrene1

Human beta-2 adrene2

Muscarinic Receptors2

ADRB23

Monoclonal Antibody1

Alpha1-adrenergic2

Cyclic adenosine mon1

Inhibitor4

Mediates1

Stimulation7

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Norepinephrine4

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Affinity5

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Gene10

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Rats1

20221

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Mice8

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Ligands2

Propranolol1

Inhibit2

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Genetic4

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Mediate1

20232

Extracellular2

Postsynaptic1

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Yohimbine1

Cardiac2

Selective1

Regulation2

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Cardiovascular3

Alpha9

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Interestingly1

Abstract1

Activate1

Expression3

Molecular1

Vivo1

Antagonistic1

Kinase4