- 2'-5' oligoadenylate synthetase-like 2 is a protein that in the house mouse is encoded by the Oasl2 gene. (wikipedia.org)
- Figure 2: Postulated G-protein-mediated signal transduction process in normal and regenerating endothelial cells. (nature.com)
- It has been recently found that the carboxy-terminal domain (CTD) of rotavirus VP3 has a 2'-5'- phosphodiesterase (PDE) activity that is able to functionally substitute for the PDE activity of the mouse hepatitis virus ns2 protein . (bvsalud.org)
- While 2'-5'-oligoadenylate synthetase (OAS)-like gene was upregulated at the 6th hour post infection up to 3.3 fold, Mx protein was downregulated marginally. (usda.gov)
- Expression of IFN-inducible protein IP-30 was suppressed up to 2.4 fold but that of interferon-inducible 58 kDa with tetratricopeptide repeats 5 (IFIT-5) was increased up to 20.1 fold in the early stage of infection (6 hrs post infection). (usda.gov)
- The PKR is indirectly activated by the dsRNA (actually by 2'-5' oligoadenylate produced by the 2'-5' oligoadenylate-synthetase which is produced due to TLR3 activation), and begins transferring phosphate groups ( phosphorylating ) to a protein known as eIF-2 , a eukaryotic translation initiation factor. (wikidoc.org)
- bone morphogenetic protein 2 [Source:HGN. (gsea-msigdb.org)
- CDC42 effector protein 2 [Source:HGNC Sy. (gsea-msigdb.org)
- They are important post-transcriptional regulators of gene expression in plants, metazoans, and mammals, and are predicted to control the activity of 30% of all protein-coding genes [ 2 ]. (biomedcentral.com)
- Monoclonal Antibodies to Coronavirus SARS-CoV-2 RBD Domain Description :2019 Coronavirus SARS-CoV-2 Spike S1 RBD Protein, human IgG1 Fc tag. (lifetein.com)
- Finally, US11 has been recently shown to also counteract the activity of the 2'-5' oligoadenylate synthetase (OAS), a cellular protein critical for host cell defense [ 15 ]. (biomedcentral.com)
- In response, cells produce the interferon inducible RNA-dependent protein kinase (PKR) that, when bound to viral dsRNA, phosphorylates eukaryotic initiation factor 2αand attenuates viral protein translation. (uleth.ca)
- PRRSV employs −1 PRF directed by RNA secondary and tertiary structures within its viral genome (canonical PRF), as well as a noncanonical −1 and −2 PRF that are stimulated by the interactions of PRRSV nonstructural protein 1β (nsp1β) and host protein poly(C)-binding protein (PCBP) 1 or 2 with the viral genome. (uleth.ca)
- The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates. (thermofisher.com)
- The expression of IFN-β-responsive genes, including protein kinase R (PKR) and 2′, 5′-oligoadenylate synthetase (OAS), were significantly elevated in the Ad:IFN-β-transduced cells by 12-fold and 25-fold, respectively. (monash.edu)
- Interferon stimulates the expression of a number of genes encoding enzymes with antiviral activities, including myxovirus resistance-1 (MxA), 2-5-oligoadenylate synthetase 1 (OAS-1) and double-stranded RNA-dependent protein kinase (PKR). (ox.ac.uk)
- Activation of PERK elicits a transient global protein synthesis shutdown through the phosphorylation of the alpha subunit of the eukaryotic translation initiation factor 2 (eIF2α). (ucsb.edu)
- Conversely, whereas both OAS3_S381 and R381 variants were able to block DENV-1 infection, the anti-DENV-2 activity observed for OAS3_S381 was largely lost for the R381 variant. (nih.gov)
- While both OAS1-p42 and p46 showed antiviral activity against DENV-2, only OAS1-p42 presented anti-DENV-1 activity. (nih.gov)
- Oligoadenylate synthetases are antiviral enzymes that counteract viral attack by degrading viral RNA. (embl.de)
- Later on, once viral proteins are synthesized, the phosphodiesterase activity of VP3 degrades the cellular 2'-5'-oligoadenylates, which are potent activators of RNase L, preventing its activation. (bvsalud.org)
- This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. (thermofisher.com)
- Inducing interferon: Abidor activates 2,5-oligoadenylate synthetase (OAS) to induce interferon production, degrade viral mRNA, and prevent viral replication. (pharmaceutical-sale.net)
- Here, we identify that host factors allow increased virus replication and cytokine production, providing a mechanism for understanding the severity of virus disease in CF. Increased virus is due to lack of nitric oxide synthase 2 (NOS2) and 2', 5' oligoadenylate synthetase (OAS) 1 induction in response to virus or IFNgamma. (nih.gov)
- Instead RNaseL is activated by 2',5'-linked oligoadenylates (2-5As), small RNA-like molecules generated by 2',5'-oligoadenylate synthetases (OASs), which work as direct sensors of double-stranded RNA. (ucsb.edu)
- Rotavirus Controls Activation of the 2'-5'-Oligoadenylate Synthetase/RNase L Pathway Using at Least Two Distinct Mechanisms. (bvsalud.org)
- PERK activation results in expression of CHOP, which turns on the gene encoding the death receptor 5 (DR5), whose ligand-independent activation pushes the cell towards death. (ucsb.edu)
- Upon the occupancy of ACE2 by SARS-CoV-2, the increased serum level of free Angiotensin II (Ang II) due to a reduction of ACE2-mediated degradation promotes activation of the NF-kappa B pathway via Ang II type 1 receptor (AT1R), followed by interleukin-6 (IL-6) production. (kegg.jp)
- We compared the effect of OAS gene family variants on 2 DENV serotypes in cell culture. (nih.gov)
- Then, the recombinant plasmid was verified by colony PCR (Figure 1 , lane 2) and restriction enzymes digestion (Figure 1 , lane 3). (biomedcentral.com)
- Among the findings of the transcriptomic analysis was the discovery that the innate immune system's rapid response (six hours after the injections) involved the modulation of four different pathways: TLR (toll-like receptor), RIG-I (viral invasion sensors), OAS (2',5'- oligoadenylate synthetase and RNase L) and oncostatin-M (corresponding to the interleukin-6 family inflammation pathway). (eurekalert.org)
- 2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine. (cdc.gov)
- Together, nsp1β and one of the PCBPs act as transactivators that bind a C-rich motif near the shift site to stimulate −1 and −2 PRF, thereby enabling the ribosome to generate two frameshift products that are implicated in viral immune evasion. (uleth.ca)
- Researchers identified that individuals with a deficiency of myeloid differentiation primary response 88 (MyD88) and interleukin-1 receptor-associated kinase 4 (IRAK-4) due to an autosomal recessive condition were highly susceptible to developing hypoxemic coronavirus disease 2019 (COVID-19) pneumonia when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (news-medical.net)
- 2',5'-Oligoadenylate Synthetase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- therefore we strongly recommend targeting verification of the derived mice with 5' or 3' LRPCR and/or Loss of Allele analysis. (mmrrc.org)
- This particular phosphodiesterase cleaves the 2'-5'-phosphodiester bond of the oligoadenylates, antagonizing the OAS / RNase L pathway. (bvsalud.org)
- This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. (embl.de)
- However, cytokines IL-2, IL-6, IL-16, IL-17 as well as IL-4 receptor(IL-4R) and IL-21R were downregulated between 1.2 and 10.8 fold. (usda.gov)
- J Innate Immun (2018) 10 (2): 131-144. (karger.com)
- MMRRC Testing of KOMP ES Cell clones includes development of genotyping protocols, genetic verification at the 3' and 5' ends, vector copy number = 1, presence or loss of Y chromosome, and mycoplasma and MPV testing. (mmrrc.org)
- The transduction of the adenoviral vector efficiency, ranging from 2% to 100%, was dependent on the multiplicity of infection (moi) (0.4-50 plaque-forming units [pfu]/cell). (monash.edu)
- complement C3d receptor 2 [Source:HGNC S. (gsea-msigdb.org)
- adiponectin receptor 2 [Source:HGNC Sy. (gsea-msigdb.org)
- SARS-CoV-2 infects alveolar epithelial cells [mainly alveolar epithelial type 2 (AEC2) cells] through the angiotensin-converting enzyme 2 (ACE2) receptor. (kegg.jp)
- While there is some controversy surrounding recent research that claims that miR-155 may display anti-oncogenic or pro-immunological benefits (Cell Rep 2:1697-1709, 2012), most research seems to point to the importance of anti-miRs, with anti-miR-155 in particular, for cancer therapy. (biomedcentral.com)
- Ex vivo infection of PBLs with VSV elicited upregulated expression of RIG-I, MDA-5, tetherin, IFITM3, and MxA . (karger.com)
- An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. (umassmed.edu)
- One of these pathways is the 2'-5'-oligoadenylate synthetase ( OAS )/ RNase L pathway. (bvsalud.org)
- Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. (microbiologyresearch.org)
- In general, the array data that we enter in GeneNetwork have been log transformed and then z-score normalized, but instead of leaving the mean at 0 and the standard deviation of 1 unit, the data is rescaled to a mean of 8 units with a standard deviation of 2 units (what we call 2Z + 8 normalized data). (genenetwork.org)
- Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (kegg.jp)
- 2 Department of General Medicine, School of Medicine, College of Medicine, Taipei Medical University Department of Primary Care Medicine, Taipei Medical University Hospital, Taipei City. (nih.gov)