• It differs from epoetin alfa (recombinant human erythropoietin) in containing 5 N-linked oligosaccharide chains, whereas epoetin alfa contains 3. (medscape.com)
  • Protection was blocked by the coapplication of a soluble Epo receptor (sEpoR) or an antibody against EpoR (anti-EpoR). (jneurosci.org)
  • Soluble transferrin receptor-1 (sTfR1) concentrations are increased in the plasma under two conditions that are associated with increased iron absorption, i.e. iron deficiency and increased erythropoiesis. (karger.com)
  • IL-6 exerts various biological activities on responding cell populations through its binding to transmembrane IL-6 receptor as well as to soluble IL-6 receptor. (biomedcentral.com)
  • In vivo, the increase in CYP3A6 by hypoxia is associated with the increased expression and nuclear translocation of hypoxia-inducible factor-1 (HIF-1), activator protein 1 (AP-1), and constitutive androstane receptor ( Fradette and du Souich, 2003 ). (aspetjournals.org)
  • The physiologic regulation of the red cell mass depends upon enhanced transcription of the erythropoietin (Epo) gene in response to hypoxia. (grantome.com)
  • In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)
  • Binding of a 30 kDa ligand erythropoietin (Epo), changes the receptor's conformational change, resulting in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e. (wikipedia.org)
  • Once activated, JAK2 phosphorylates distal parts of receptors which subsequently serve as docking sites for downstream signaling molecules. (biomedcentral.com)
  • This medicine is thought to work by blocking an enzyme known as Janus kinase 2 (JAK2), which can be found in some receptors on the surface of cells and is involved in the production and growth of blood cells. (europa.eu)
  • ivermectin harganya attivatore continuo del recettore dell'eritropoietina (Continuous erythropoietin receptor activator) Bij ischemie van de wonde of bij immuungecompromitteerden kan het echter gebeuren ivermectin for stomach ulcers bacteribeginnen woekeren en toch een infectie veroorzaken. (tommieingesprek.nl)
  • EPO activates the neuronal EPO receptor and, subsequently, JAK-2 and thereby PI3K. (jneurosci.org)
  • Acioglu C, Heary RF, Elkabes S . Roles of neuronal toll-like receptors in neuropathic pain and central nervous system injuries and diseases. (neurotree.org)
  • Acioglu C, Mirabelli E, Baykal AT, Ni L, Ratnayake A, Heary RF, Elkabes S . Toll like receptor 9 antagonism modulates spinal cord neuronal function and survival: direct versus astrocyte-mediated mechanisms. (neurotree.org)
  • EPO acts by binding to its specific transmembrane receptor (EPOR). (biomedcentral.com)
  • To clarify the hypothesis that overproduction of IL-6 elevates hepcidin levels and contributes to the development of cancer-related anemia, we evaluated anti-IL-6 receptor antibody treatment of cancer-related anemia in an IL-6-producing human lung cancer xenograft model. (biomedcentral.com)
  • Mice bearing LC-06-JCK were administered rat anti-mouse IL-6 receptor antibody MR16-1 and their serum hepcidin levels and hematological parameters were determined. (biomedcentral.com)
  • The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. (wikipedia.org)
  • EPO and its receptors (EPOR) are expressed in multiple brain cells during brain development and upregulated in the adult brain after injury. (biomedcentral.com)
  • Khariv V, Acioglu C, Ni L, Ratnayake A, Li L, Tao YX, Heary RF, Elkabes S . A link between plasma membrane calcium ATPase 2 (PMCA2), estrogen and estrogen receptor α signaling in mechanical pain. (neurotree.org)
  • 2003): Effect of melatonin on estrogen and progesterone receptors in relation to uterine contraction in rats. (ankara.edu.tr)
  • Subsequently, from the obtained uterus samples, determination of the levels of asymmetrical dimethyl arginin (ADMA), symmetrical dimethyl arginin (SDMA), and arginine was made using the high-performance liquid chromatography (HPLC) and levels of Heat shock protein 90 (Hsp90), TLR4 (Toll Like Receptor 4) and NFκB (Nuclear factor kappa-light-chain-enhancer of activated B cells) were measured using the Western blot technique. (ankara.edu.tr)
  • Stimulates erythropoietin, which increases red blood cell mass. (medscape.com)
  • They included androgens (male hormones), glucocorticoids (a type of steroid) and erythropoietin (a hormone that stimulates the production of red blood cells) to treat anaemia, and surgery or radiation to remove or shrink the enlarged spleen. (europa.eu)
  • Pallottie A, Ratnayake A, Ni L, Acioglu C, Li L, Mirabelli E, Heary RF, Elkabes S . A toll-like receptor 9 antagonist restores below-level glial glutamate transporter expression in the dorsal horn following spinal cord injury. (neurotree.org)
  • Effects of aliskiren-loaded nanoparticles on (pro-)renin and renin receptor gene expression in the heart and kidney of spontaneously hypertensive rats. (sav.sk)
  • We will also assess whether the function of this nuclear receptor in mediating Epo gene expression is affected by a putative natural ligand. (grantome.com)
  • HNF-4 is an orphan nuclear receptor which is constitutively expressed in kidney and liver, and cooperates with HIF-1 to give maximal hypoxic induction. (grantome.com)
  • Li Y, Korgaonkar AA, Swietek B, Wang J, Elgammal FS, Elkabes S , Santhakumar V . Toll-like receptor 4 enhancement of non-NMDA synaptic currents increases dentate excitability after brain injury. (neurotree.org)
  • Erythropoietin is essential for red blood cell production and may be required because of decreased erythropoietin levels in renal failure. (medscape.com)
  • A translocation involves the mechanical breakage and reconnection between different chromosomes (Obata 1999). (sarcomahelp.org)
  • The mechanism of action is similar to that of endogenous erythropoietin, which interacts with stem cells to increase red blood cell production. (medscape.com)
  • NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
  • Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
  • These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)
  • To some extent the cuanto tiempo dura la ivermectina en el cuerpo humano site of production is beside the point as far as government road work is concerned. (tommieingesprek.nl)
  • In an in vitro model of cerebral ischemia (oxygen glucose deprivation, OGD) we investigated whether erythropoietin (EPO) plays a critical role in ischemic preconditioning. (jneurosci.org)
  • Li L, Acioglu C, Heary RF, Elkabes S . Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases. (neurotree.org)
  • These are believed to cause the destruction of RBC precursors and decrease the number of erythropoietin receptors on progenitor cells. (medscape.com)
  • 80%) and biological pathways (such as adipocytokine, Notch, Hedgehog and NOD-like receptor signaling) were not identified by previous gene array studies. (mdpi.com)
  • Li L, Ni L, Eugenin EA, Heary RF, Elkabes S . Toll-like Receptor 9 Antagonism Modulates Astrocyte Function and Preserves Proximal Axons following Spinal Cord Injury. (neurotree.org)
  • Heiman A, Pallottie A, Heary RF, Elkabes S . Toll-like receptors in central nervous system injury and disease: a focus on the spinal cord. (neurotree.org)
  • Ha T, Liu L, Kelley J (2011): Toll-like receptors: new players in myocardial ischemia/reperfusion injury. (ankara.edu.tr)
  • 1999): Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia. (ankara.edu.tr)