• Why is imipenem and meropenem resistance important? (cdc.gov)
  • Imipenem and meropenem are carbapenem antimicrobial agents used to treat a variety of serious infections when an organism is resistant to the primary agent of choice. (cdc.gov)
  • How much resistance to imipenem or meropenem occurs in clinical isolates? (cdc.gov)
  • What Gram-negative organisms are resistant to imipenem and/or meropenem? (cdc.gov)
  • Studies suggest meropenem may be more stable than imipenem. (cdc.gov)
  • Meropenem is slightly more active than imipenem against Gram-negative organisms. (cdc.gov)
  • Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation. (druglib.com)
  • Meropenem versus imipenem-cilastatin for the treatment of hospitalized patients with complicated skin and skin structure infections: results of a multicenter, randomized, double-blind comparative study. (druglib.com)
  • Pharmacokinetic evaluation of meropenem and imipenem in critically ill patients with sepsis. (druglib.com)
  • Prophylaxis with meropenem of septic complications in acute pancreatitis: a randomized, controlled trial versus imipenem. (druglib.com)
  • A randomized, controlled clinical trial on meropenem versus imipenem/cilastatin for the treatment of bacterial infections. (druglib.com)
  • Meropenem versus imipenem/cilastatin as empirical monotherapy for serious bacterial infections in the intensive care unit. (druglib.com)
  • Meropenem versus imipenem/cilastatin in the treatment of sepsis in Chinese patients. (druglib.com)
  • Cost-effectiveness study of imipenem/cilastatin versus meropenem in intra-abdominal infections. (druglib.com)
  • The antibiotic susceptibility test revealed multiple resistance to the antibiotics imipenem and meropenem in the carbapenem class. (ophrp.org)
  • Stenotrophomonas maltophilia isolates are intrinsically resistant to imipenem. (cdc.gov)
  • VRE accounted for almost 25% of enterococcus isolates in NNIS ICUs in 1999 (94), and 28.5% in 2003 (93). (cdc.gov)
  • To identify risk factors associated with the emergence of imipenem heteroresistance, a retrospective case-control study was undertaken involving cases with subsequent clinical isolates of the same genotype showing loss of imipenem susceptibility and matched controls with isolates belonging to imipenem-susceptible MDR-AB. (shengsci.com)
  • An insertion sequence (ISAba1) was found in the promoter region of a class C β-lactamase gene (bla(ADC-29)) in most imipenem-heteroresistant MDR-AB isolates. (shengsci.com)
  • Our results demonstrate substantial national and regional increases in carbapenem resistance among clinical isolates of Acinetobacter species over the period 1999-2006. (marynmckenna.com)
  • The prevalence of imipenem resistance among Pseudomonas aeruginosa isolates at a 195-bed tertiary care medical center in Cali, Colombia, rose from 2% in 1996 to 28% in 1997 and to over 40% in 2003. (uea.ac.uk)
  • Sixty-six resistant isolates collected between February 1999 and July 2003 from hospitalized patients (n = 54) and environmental samples (n = 12) were subjected to a fuller analysis. (uea.ac.uk)
  • Only 4 of 13 resistant isolates (2 clinical isolates and 2 environmental isolates) assigned to other PFGE types carried blaVIM alleles, whereas the others were less multiresistant and mostly had lower levels of imipenem resistance (MICs, =32 µg/ml) which was not significantly reduced by EDTA. (uea.ac.uk)
  • A search of the computerized database at the National Taiwan University Hospital was made for cefotaxime-resistant and cefmetazole-susceptible isolates of Escherichia coli and Klebsiella pneumoniae (which may be extended-spectrum β-lactamase-producing strains) in pediatric wards and intensive care units between 1999 and 2001. (ntu.edu.tw)
  • Imipenem when used with cilastatin can be more proconvulsive as Imipenam levels are raised in presence of cilastatin. (ommegaonline.org)
  • Amino Acid Neurotransmitter Levels In the Cerebral Cortex of Mice Receiving Imipenem/ Cilastatin- Lack of Excitotoxicity in the Central Nervous system. (ommegaonline.org)
  • Broad aerobic gram-negative activity: β-lactam/β-lactamase inhibitor combinations, fluoroquinolones, ceftriaxone, or imipenem-cilastatin. (jamanetwork.com)
  • Broad anaerobic activity: β-lactam/β-lactamase inhibitor combinations, clindamycin, or imipenem-cilastatin. (jamanetwork.com)
  • Similarly, between 1999 and 2003, Pseudomonas aeruginosa resistance to fluoroquinolone antibiotics increased from 23% to 29.5% in NNIS ICUs (74). (cdc.gov)
  • Also, a 3-month survey of 15 Brooklyn hospitals in 1999 found that 53% of A. baumannii strains exhibited resistance to carbapenems and 24% of P. aeruginosa strains were resistant to imipenem (10). (cdc.gov)
  • Here we report the clinical impact and mechanism of imipenem heteroresistance (imipenem minimum inhibitory concentration of 6-32 μg/mL with the presence of resistant cells inside the inhibition zone of Etest strips or disks) in multidrug-resistant A. baumannii (MDR-AB). (shengsci.com)
  • Leo, R.J., Ballow, C.H. Seizure activity associated with imipenem use: clinical case reports and review of the literature. (ommegaonline.org)
  • Streptococcus species [ 3 ], although an in- tion as determined by the Wagner classifi- creasing number of patients have been en- cation. (who.int)
  • Yusuf HR, Atrash HK, Grosse SD, Parker CS, Grant AM. Emergency department visits made by patients with sickle cell disease: a descriptive study, 1999-2007. (cmcedmasters.com)
  • However, studies have shown false resistance to imipenem in commercially prepared test panels due to degradation of the drug or to a manufacturing problem where concentrations of imipenem were too low (1,2,4,5). (cdc.gov)
  • Popovic JR 1999 National Hospital Discharge Survey: annual summary with detailed diagnosis and procedure data. (jamanetwork.com)
  • Susceptibility of the Acinetobacter calcoaceticus-A. baumannii complex to imipenem, meropenem, sulbactam and colistin. (nih.gov)
  • Why is imipenem and meropenem resistance important? (cdc.gov)
  • Imipenem and meropenem are carbapenem antimicrobial agents used to treat a variety of serious infections when an organism is resistant to the primary agent of choice. (cdc.gov)
  • How much resistance to imipenem or meropenem occurs in clinical isolates? (cdc.gov)
  • What Gram-negative organisms are resistant to imipenem and/or meropenem? (cdc.gov)
  • Studies suggest meropenem may be more stable than imipenem. (cdc.gov)
  • Meropenem is slightly more active than imipenem against Gram-negative organisms. (cdc.gov)
  • Imipenem and meropenem, members of the carbapenem class of beta-lactam antibiotics, are among the most broadly active antibiotics available for systemic use in humans. (nih.gov)
  • Stenotrophomonas maltophilia is typically resistant to both imipenem and meropenem. (nih.gov)
  • In general, the in vitro activity of imipenem against aerobic gram-positive cocci is somewhat greater than that of meropenem, whereas the in vitro activity of meropenem against aerobic gram-negative bacilli is somewhat greater than that of imipenem. (nih.gov)
  • Infusion-related nausea and vomiting, as well as seizures, which have been the main toxic effects of imipenem, occur no more frequently during treatment with meropenem than during treatment with other beta-lactam antibiotics. (nih.gov)
  • The main product varieties include a series of independently developed drugs, such as meropenem, imipenem, faropenem, Beineng, Suneng, piperacillin sodium tazobactam sodium for injection, cefoperazone sodium sulbactam sodium for injection, desloratadine tablets and irbesartan tablets. (joincare.com)
  • Enterobacteriaceae group showed higher statistically significant resistance in the second study period against ceftriaxone, quinolone and piperacillin/tazobactam, whilst no resistance observed against imipenem/ meropenem. (aku.edu)
  • The susceptibility pattern of Acinetobacter species shifted from sensitive to highly resistant one with significant p values against ceftriaxone, quinolone, piperacillin/tazobactam and imipenem/meropenem. (aku.edu)
  • Carbapenem resistance was calculated as resistance (R) to at least one of the following antibiotics: imipenem and meropenem. (who.int)
  • In case of severe prostatitis, choose intravenous therapy: ampicillin/clavulanic acid 2.2 g 1-1-1 i.v., cephalosporin i.v. combined with gentamicin 3 mg/kg i.v. 1-0-0, or broad spectrum antibiotics like imipenem or meropenem. (urology-textbook.com)
  • 4. Following the review of square box listings on the EML and EMLc, the Expert Committee recommended imipenem + cilastatin be specified as a therapeutic alternative under the square box listing for meropenem on the EML and EMLc for this indication. (essentialmeds.org)
  • those for other agents were available from 1981 to 1999. (medscape.com)
  • bachelor's at Tecnologia Médica from Universidad Austral de Chile (1996), master's at Pharmacy from Universidade de São Paulo (1999) and doctorate at Pharmacy from Universidade de São Paulo (2004). (fapesp.br)
  • Antifungal susceptibility testing of amphotericin B and fluconazole against 150 blood isolates of Candida species collected from October 1997 to September 1999 was performed by the E test (AB BIODISK, Solna, Sweden) according to the manufacturer's instructions. (medscape.com)
  • 10. Effects of fosfomycin and imipenem-cilastatin on the nephrotoxicity of vancomycin and cisplatin in rats. (nih.gov)
  • In addition to PICC removal, imipenem/cilastatin (IPM/CS), amikacin (AMK), levofloxacin (LVX), and azithromycin (AZM) were started empirically. (biomedcentral.com)
  • However, studies have shown false resistance to imipenem in commercially prepared test panels due to degradation of the drug or to a manufacturing problem where concentrations of imipenem were too low (1,2,4,5). (cdc.gov)
  • Cite this: Antimicrobial Drug Resistance in Pathogens Causing Nosocomial Infections at a University Hospital in Taiwan, 1981-1999 - Medscape - Jan 01, 2002. (medscape.com)
  • The Ralstonia species, later identified as pickettii , was sensitive to quinolones and trimethoprim-sulfamethoxazole only with intermediate sensitivity to piperacillin/tazobactam, imipenem, and cefepime and complete resistance to tobramycin amikacin and gentamycin. (hindawi.com)
  • Stenotrophomonas maltophilia isolates are intrinsically resistant to imipenem. (cdc.gov)
  • difficult including and above therapy of parchment stuffed with expertise, ciprofloxacin, imipenem, excretion, or vancomycin against cars of Streptococcus faecalis and Streptococcus icssdmErnesto. (isn-hi.de)
  • Shenzhen Haibin Pharmaceutical Co., Ltd. began research on a new generation of high-efficiency broad-spectrum antibacterial drug, carbapenem antibiotics, in 1999. (joincare.com)
  • At present, the company focuses on the research and development of carbapenem series of antibiotics, and has not only basically completed the process research of new drugs such as imipenem, faropenem and biapenem, but also greatly optimized and innovated the raw material and branched chain technology of products. (joincare.com)
  • Has experience in Microbiology, focusing on Microbiology, acting on the following subjects: metallo-beta-lactamase, imipenem, brazil, nosocomial infection and klebsiella pneumoniae. (fapesp.br)
  • Available data for inpatient-days at the hospital ranged from 294,946 in 1990 to 566,165 in 1999. (medscape.com)