• The increase in the prevalence of asthma in developed countries 1- 5 and the remarkable differences in asthma prevalence between countries suggests that environmental exposures are important in the development of this disease. (bmj.com)
  • The aim of this study was to investigate time trends in the prevalence of asthma and allergic sensitisation among school children in Germany between 1992 and 2001. (bmj.com)
  • These data, using parental reports and objective measures of allergy, suggest that there has been no further increase in the prevalence of asthma and atopy since 1992. (bmj.com)
  • In the second half of the last century surveys in many countries showed an increase in the prevalence of asthma and allergies among school children. (bmj.com)
  • We therefore aimed to assess the trends in the prevalence of asthma, hay fever, and atopic sensitisation in representative samples of school children living in the south western part of Germany between 1992 and 2001. (bmj.com)
  • A 2020 Japanese cohort study found an increased prevalence of asthma, wheeze, and eczema among children receiving more inactivated vaccines 34 . (vaccinesafety.edu)
  • Internationally, the prevalence of asthma (and related hospitalizations and mortality) continues to rise in adults and children. (cdc.gov)
  • The prevalence of asthma in North America is increasing for all age, sex and racial groups, despite new pharmaceuticals arriving to save the day. (ndnr.com)
  • Prior to 1996, a period prevalence measure was used and was based on the question, "During the past year, did anyone in the family have asthma? (cdc.gov)
  • Our aim was to determine how many United States Olympic athletes who were chosen to participate in the 1996 Summer Olympic Games had a past history of asthma or symptoms that suggested asthma or took asthma medications. (nih.gov)
  • On the basis of these less restrictive criteria, more than 20% of the athletes who participated in the 1996 Olympic Games might have been considered to have had asthma. (nih.gov)
  • Asthma appeared to have been more prevalent in athletes who participated in the 1996 Summer Games than in the general population or in those who participated in the 1984 Summer Games. (nih.gov)
  • The baseline surveys were conducted between October 1992 and March 1993, and then repeated five times during the same season in 1993/4, 1994/5, 1996/7, 1998/9, and 2000/1. (bmj.com)
  • During recovery from an asthma attack (exacerbation), it may appear pus-like due to high levels of white blood cells called eosinophils. (wikipedia.org)
  • The criteria required subjects to have undergone at least one asthma exacerbation in the past year requiring oral steroid treatment. (ersjournals.com)
  • As a result of this exposure, P suffered a recurrence, aggravation, acceleration and exacerbation of her pre-existing asthma. (nationalasthma.org.au)
  • Natural infection with respiratory syncytial virus (RSV) in infancy can increase the risk of asthma in childhood, as well as contribute to asthma exacerbation. (vaccinesafety.edu)
  • Other respiratory viruses such as influenza can also contribute to asthma exacerbation. (vaccinesafety.edu)
  • Thus, RSV vaccine prevents asthma and asthma exacerbation, and influenza vaccine prevents asthma exacerbation, by protecting against natural infection. (vaccinesafety.edu)
  • Influenza vaccines do not cause asthma or asthma exacerbation. (vaccinesafety.edu)
  • Other vaccines currently routinely recommended to the general population in the U.S. * have not been shown to cause asthma or asthma exacerbation. (vaccinesafety.edu)
  • The 2012 report on adverse effects of vaccines by the Institute of Medicine (IOM) 1 , now called the National Academy of Medicine (NAM), described a number of studies with sufficient validity and precision that all found no association between inactivated influenza vaccination and asthma exacerbation 2-10 . (vaccinesafety.edu)
  • The report described several studies with sufficient validity and precision that generally reported no association between live attenuated influenza vaccination (LAIV) and asthma exacerbation as well 11-17 . (vaccinesafety.edu)
  • We combine indoor air quality modeling with a previously developed discrete event model for pediatric asthma exacerbation to simulate the effects of different types of energy retrofits implemented at an affordable housing site in Boston, MA. (biomedcentral.com)
  • Chest radiographic imaging (see the images below) is an important tool in the examination of patients with an exacerbation of asthma, but patients should not be left waiting in the treatment room for a radiograph before treatment. (medscape.com)
  • Depending on the person, asthma symptoms may become worse at night or with exercise. (wikipedia.org)
  • Asthma is classified according to the frequency of symptoms, forced expiratory volume in one second (FEV1), and peak expiratory flow rate. (wikipedia.org)
  • Long-acting beta agonists (LABA) or antileukotriene agents may be used in addition to inhaled corticosteroids if asthma symptoms remain uncontrolled. (wikipedia.org)
  • Some people with asthma rarely experience symptoms, usually in response to triggers, whereas others may react frequently and readily and experience persistent symptoms. (wikipedia.org)
  • Smoking during pregnancy and after delivery is associated with a greater risk of asthma-like symptoms. (wikipedia.org)
  • In children and adults, sensitive to indoor allergens, the severity of asthma symptoms may vary with the level of exposure. (cdc.gov)
  • She had wheezing and allergy symptoms in childhood, and her mother and 1 cousin have confirmed asthma. (cmaj.ca)
  • The presence of certain key symptoms may suggest the presence of asthma, but can also result from airway inflammation alone, from chronic rather than reversible airflow limitation, or from other respiratory and nonrespiratory conditions. (cmaj.ca)
  • Moreover, asthma symptoms correlate poorly with abnormalities of lung function 9 and airway inflammation, 10 , 11 and thus in isolation may suggest a less severe form of the disease than is actually present. (cmaj.ca)
  • Asthma is an inflammatory disease 13 associated with symptoms resulting from abnormalities of airway function, in particular wide, short-term variations in airflow resistance in the intrapulmonary airways. (cmaj.ca)
  • The chronic inflammation of asthma is associated with airway hyperresponsiveness that leads to recurrent symptoms, yet lung function may nevertheless remain normal. (cmaj.ca)
  • Identification of airway hyperresponsiveness thus has clinical value, particularly in the diagnosis of asthma in people with normal spirometry results or with symptoms uncharacteristic of asthma. (cmaj.ca)
  • Patients with exercise-induced asthma (EIA) usually present complaining of exercise-related respiratory symptoms. (medscape.com)
  • The common pitfalls in asthma occur with downplaying of symptoms or patient complaints. (medscape.com)
  • RESULTS BHR or the presence of asthma symptoms at screening did not result in a significantly disproportionate number of physician visits during the next 10 years for 4 or more upper or lower respiratory tract infections when compared with patients who did not have these findings at the beginning of the study. (annfammed.org)
  • The presence of asthma symptoms correlated with an increased risk of an asthma diagnosis or allergic rhinitis in the group of patients who did not have asthma diagnosed at start of the study. (annfammed.org)
  • To improve our knowledge of the natural history of asthma, we observed a primary care cohort of children and adolescents that had been screened 10 years earlier for respiratory tract signs and symptoms by Kolnaar et al. (annfammed.org)
  • From these findings and other physiological and clinical data reported in this paper, it is suggested that severe asthma might be a different form of asthma rather than an increase in asthma symptoms. (ersjournals.com)
  • Effective management of workers suspected to have occupational asthma involves the identification and investigation of symptoms suggestive of asthma immediately they occur. (bmj.com)
  • Data on symptoms of asthma and hay fever were collected using questions from the International Study of Asthma and Allergies in Childhood (ISAAC). (bmj.com)
  • Symptoms occurring in this way, irrespective of the presence of allergens and ongoing airway sensitisation, explain why allergen avoidance is poorly effective in alleviating wheeze and why asthma is made worse by stress. (bmj.com)
  • It is astounding that doctors who administer intravenous magnesium to save the lives of patients who are suffering a severe asthma attack do not recommend that their patients consume at least the recommended daily allowance (the amount necessary to prevent deficiency symptoms like asthma and heart disease) of magnesium each day. (electroherbalism.com)
  • Chronic sinus infections can cause symptoms simliar to asthma as the mucus drains into the lungs. (electroherbalism.com)
  • For short term relief of asthma symptoms, Enzymatic Therapy makes a product called Air Power, which decongests and opens up the lungs and the sinuses, addressing excess mucus production. (electroherbalism.com)
  • As Hulda Clark recommends, asthma inhalers should always be carried with one for many years even after asthma symptoms are no longer a problem. (electroherbalism.com)
  • However, aggravation of pre-existing asthma by workplace exposure and occupational COPD are also briefly addressed and some consideration is given to other work-related airway disorders (such as asthma-like symptoms and occupational rhinitis). (ersjournals.com)
  • In mild to moderate acute asthma, beta 2 agonists may be equally as effective from a metered dose inhaler/spacer combination compared with a nebulizer for control of acute symptoms, and may be associated with a shorter duration of stay in the emergency department and reduced adverse effects. (aafp.org)
  • The asthma action plans that are currently available are limited in scope, focussing predominantly on symptom management strategies (actions) to follow in the presence of deteriorating symptoms [ 14 , 20 ]. (biomedcentral.com)
  • Although this investigation was limited due to the relatively small size of this population, data showed development of new respiratory symptoms and asthma among crab processing workers over the six weeks of crab processing. (cdc.gov)
  • [ 1 ] Chest radiography is the initial imaging evaluation in most individuals with symptoms of asthma. (medscape.com)
  • Whether neonatal S. pneumoniae pneumonia promoted adulthood allergic asthma was associated with vitamin A levels remains unclear. (nature.com)
  • We also explored the effects of vitamin A supplement after neonatal S. pneumoniae pneumonia on the development of adulthood allergic asthma. (nature.com)
  • They are often used in allergic asthma where the antihistamine effect overrides side effects. (yarchive.net)
  • Describe the impact of occupational exposures on adult asthma prevalence. (cdc.gov)
  • In contrast, atopy may be less important in patients with adult asthma and other factors such as intolerance to aspirin and related nonsteroidal anti-inflammatory drugs (NSAIDs) as well as occupational exposures have been suggested to play an important role in adults with more severe asthma 1 , 8 . (ersjournals.com)
  • Research studies have estimated that up to 25% of adults with asthma have work-related asthma, and 15% of adult-onset asthma may be caused by hazardous occupational exposures. (nationalasthma.org.au)
  • 3] In addition, by highlighting a potential occupational cause for a patient's asthma, medical practitioners can assist in advising about avoiding future exposures at work, contribute to accurate data collection and thereby influence future workplace safety regulation. (nationalasthma.org.au)
  • Growing awareness of the link between work exposures and the development of work-related asthma is key for driving better health and safety practices. (nationalasthma.org.au)
  • In 1988, the National Institute for Occupational Safety and Health (NIOSH) reported diesel exhaust as a potential occupational carcinogen and recommended that employers reduce workers' exposures [NIOSH 1998]. (cdc.gov)
  • Our data suggest that neonatal S. pneumoniae pneumonia induce serum vitamin A deficiency and long-time lung vitamin A reduction, vitamin A supplement after neonatal S. pneumoniae pneumonia inhibit the progression of asthma by altering CD4 + T cell subsets. (nature.com)
  • Patients with more severe disease are increasingly likely to have impaired lung function as studies have shown that despite the use of high doses of inhaled and oral corticosteroids, severe asthma is associated with a component of airflow obstruction that appears either nonreversible or at best difficult to reverse 1 , 6 . (ersjournals.com)
  • 2 The National Heart, Lung, and Blood Institute's 2007 Expert Panel Report 3 presents clinical practice guidelines for the diagnosis and management of asthma and identifies four components deemed essential for effective management of the disease. (uspharmacist.com)
  • As of recent times, asthma has emerged as one of the most common forms of occupational lung disease. (nationalasthma.org.au)
  • Asthma is a lung disease that is characterized by three airway problems: obstruction, inflammation and hyper responsiveness. (jaxmed.com)
  • High-resolution CT scan of the thorax obtained during expiration demonstrates a mosaic pattern of lung attenuation in a patient with asthma. (medscape.com)
  • The American Academy of Pediatrics has published a book about childhood environmental health problems, which states: "Avoiding environmental allergens and irritants is one of the primary goals of good asthma management" [AAPCEH 2003]. (cdc.gov)
  • Several studies support the importance of allergies and allergens in triggering and exacerbating asthma. (cdc.gov)
  • Sensitization to indoor allergens and the spores of outdoor molds is a risk factor for the development of asthma in children and adults. (cdc.gov)
  • Cockroach allergens also may increase a child's risk of developing asthma [IOM 2000, Etzel 2003]. (cdc.gov)
  • demonstrated that 39% of doctor diagnosed pediatric asthma can be attributed to residential risk factors including environmental tobacco smoke (ETS) and indoor allergens [ 2 ]. (biomedcentral.com)
  • 2002]. Diesel particles may promote expression of the immunologic response phenotype (Th2) associated with asthma and allergic disease and may have greater immunologic effects in the presence of environmental allergens. (cdc.gov)
  • Several hundred occupational agents, mainly allergens but also irritants and substances with unknown pathological mechanisms, have been identified as causing work-related asthma. (ersjournals.com)
  • These guidelines are mainly directed towards new onset asthma induced by workplace allergens, agents with unknown pathomechanisms and irritants. (ersjournals.com)
  • The focus of my research is the environmental and molecular biology of allergens and the allergic reaction, including Epidemic Thunderstorm Asthma (ETSA) events, and identify novel inhibitors for allergy prevention and treatment. (edu.au)
  • Asthma, particularly severe asthma, is strongly associated with development of chronic obstructive pulmonary disease (COPD). (wikipedia.org)
  • Indacaterol is a β 2 -agonist bronchodilator in development for the treatment of asthma and chronic obstructive pulmonary disease (COPD). (ersjournals.com)
  • 9 ]. Similar relationships exist for occupational chronic obstructive pulmonary disease (COPD), which typically occurs after long-term exposure and shows some overlap with work-related asthma [ 10 , 11 ]. (ersjournals.com)
  • ABSTRACT: Over the last several decades, multiple studies have identified improper asthma rescue inhaler technique as a clinically important correlate of unstable disease and increased use of healthcare services. (uspharmacist.com)
  • ABSTRACT While airways reactivity is among the characteristics of asthma, it is not considered a sufficient condition diagnostically and the methacholine challenge is a non-specific diagnostic aid in cases of chronic cough and reactive airways disease. (who.int)
  • The prevention and treatment of asthma induced by S. pneumoniae pneumonia is crucial, while it remains indistinctly. (nature.com)
  • Canadian guidelines for the diagnosis and treatment of asthma have existed since 1989 and were most recently updated in 2003. (cmaj.ca)
  • One half of the known asthmatic patients at the onset of the study (21 of 44) had no further visits to their physicians for treatment of asthma during the next 10 years. (annfammed.org)
  • The availability of a once-daily β 2 -agonist could be expected to improve the treatment of asthma by providing patients with greater convenience and sustained bronchodilation. (ersjournals.com)
  • These findings indicate that SEAC is a suppressor of airway inflammation and remodeling, and may therefore be useful as an anti-inflammatory drug for the treatment of asthma. (spandidos-publications.com)
  • Corticosteroids are the most effective anti-inflammatory medications for the treatment of asthma. (jaxmed.com)
  • Inhaled corticosteroids are safe and effective for the treatment of asthma. (jaxmed.com)
  • Sara states that she has never received a diagnosis of asthma. (cmaj.ca)
  • The case used here focuses on the diagnosis of asthma in adults. (cmaj.ca)
  • Thus, a conclusive diagnosis of asthma is based on tests designed to detect rapid changes in the forced expiratory volume in 1 second (FEV 1 ) or peak expiratory flow. (cmaj.ca)
  • Measurement of sputum eosinophilia has been proposed for clinical use in the diagnosis of asthma. (cmaj.ca)
  • Of the 699 athletes who completed the questionnaire, 107 (15.3%) had a previous diagnosis of asthma, and 97 (13.9%) recorded use of an asthma medication at some time in the past. (nih.gov)
  • One hundred seventeen (16.7%) reported use of an asthma medication, a diagnosis of asthma, or both (which was our basis for the diagnosis of asthma). (nih.gov)
  • Given the established association between asthma and pain and ACS in this same cohort, 7 - 9 and the recognized risk of death in patients with even a single episode of ACS, 10 we used data collected prospectively over the 20-year term of the CSSCD to test the hypothesis that a concurrent diagnosis of asthma in patients with SCA is associated with increased mortality. (haematologica.org)
  • This is because a diagnosis of asthma is unclear in young children, and death from bacterial infection in children under the age of 5 was frequent in the era of the CSSCD study. (haematologica.org)
  • Asthma was classified by a clinical diagnosis of asthma recorded during the medical history, an acute asthma event during the study period, or use of prescribed asthma medications on a clinic visit form. (haematologica.org)
  • Many conditions may resemble asthma, making it difficult for health professionals to be certain of a diagnosis of asthma. (electroherbalism.com)
  • At the early-season survey, five individuals noted a previous doctor-diagnosis of asthma. (cdc.gov)
  • Over the course of the season, one of the participants with a previous doctor-diagnosis of asthma experienced significant work-related worsening of asthma. (cdc.gov)
  • In addition, one individual working in crab processing and one individual engaged in related activities acquired a new doctor-diagnosis of asthma during the season. (cdc.gov)
  • The value of chest radiography is in revealing complications or alternative causes of wheezing and the minor importance of wheezing in the diagnosis of asthma and its exacerbations. (medscape.com)
  • Nevertheless, CT scans can demonstrate a number of findings that support the diagnosis of asthma. (medscape.com)
  • The aim of this cross-sectional study was to determine the metacholine response positivity and diagnosis of asthma in patients with chronic cough presenting to a hospital in Tehran during 2007 and 2008. (who.int)
  • Sensitization to house dust mites is an important risk factor for asthma exacerbations and the development of asthma. (cdc.gov)
  • The current view of asthma is that of a chronic disease with periodic clinical exacerbations, 1 a considerable change from our previous view of asthma as primarily episodic in nature. (annfammed.org)
  • Higher asthma prevalence among specific race/ethnic groups translates into a higher proportion of those groups at risk of adverse asthma outcomes such as exacerbations, need for emergent care, and in rare cases, death. (cdc.gov)
  • A modeling study in the UK found that energy retrofits when not combined with adequate ventilation could lead to several negative health impacts, including increased asthma exacerbations [ 9 ]. (biomedcentral.com)
  • Acute exacerbations of asthma are characterized by tachypnea, increased work of breathing (chest wall recession in young children and use of accessory muscles in older children), tachycardia, and reduced oxygen saturation levels. (aafp.org)
  • It usually is more useful in the initial diagnosis of bronchial asthma than in the detection of exacerbations, although it is valuable in excluding complications such as pneumonia and asthma mimics, even during exacerbations. (medscape.com)
  • Although bronchial thickening, hyperinflation, and focal atelectasis suggest asthma when they are present, chest radiographs obtained during asthma exacerbations can demonstrate normal findings, which reduce its sensitivity as a diagnostic tool. (medscape.com)
  • The NIOSH study consisted of early-season and late-season medical and environmental surveys during the 1998 opilio snow crab season. (cdc.gov)
  • Asthma often begins in childhood, and the rates have increased significantly since the 1960s. (wikipedia.org)
  • It hypothesises that the way in which stress during pregnancy is associated with childhood asthma could be through effects on the developing nervous system. (bmj.com)
  • The only indication for ipratropium bromide for acute childhood asthma is in combination with salbutamol for acute severe wheezing. (aafp.org)
  • Acute childhood asthma is a common clinical emergency presenting across a range of ages and with a range of severities. (aafp.org)
  • This review was designed to assess the current evidence for best management of acute childhood asthma. (aafp.org)
  • Although the number of new cases of childhood asthma appears to be declining, the prevalence rate for adults continues to rise [ 4 ]. (biomedcentral.com)
  • The NHIS was redesigned in 1997, and from 1997-2000, there was no established national point prevalence measure (see "asthma attack prevalence" definition). (cdc.gov)
  • How an environmental pollutant may affect asthma severity [IOM 2000]. (cdc.gov)
  • METHODS Children and young adults who were born between 1967 and 1979 within 1 of 4 affiliated family practices of the Nijmegen Department of Family Medicine, the Netherlands, were asked to participate in an asthma study in 1989. (annfammed.org)
  • Registry-based twin studies, using well-established methods to estimate the relative genetic (nature) versus environmental (nurture) determinants of asthma, suggest that genetic factors account for approximately 60%-80% of asthma susceptibility, with only a modest or no effect attributable to environmental effects shared between family members. (bmj.com)
  • Records were extracted for all persons with a pulmonary NTM International Classification of Diseases code (031.0) hospitalized in the 11 states with continuous data available from 1998 through 2005. (cdc.gov)
  • Our study describes the prevalence, demographic characteristics, and trends of pulmonary NTM-associated hospitalizations during 1998-2005. (cdc.gov)
  • Asthma is a chronic, debilitating, and potentially fatal pulmonary disorder characterized by persistent inflammation and reversible obstruction of the airways. (uspharmacist.com)
  • 1 , 11 , 12 Participants were assessed at least once for asthma on a supplemental history form and/or a pulmonary function intake form. (haematologica.org)
  • Although no evidence exists to support the use of oxygen in acute asthma, it is known to be effective and should be administered when oxygen saturation levels fall below 94% in all cases of acute asthma. (aafp.org)
  • Although there is little evidence to support the use of inhaled bronchodilators, they remain one of the first-line treatment choices for acute asthma. (aafp.org)
  • In severe acute asthma, we do not know whether there is a difference between continuous and intermittent nebulized beta 2 agonists. (aafp.org)
  • In severe acute asthma, we do not know whether intravenous aminophylline and salbutamol differ in effectiveness because we found insufficient evidence from one small randomized controlled trial. (aafp.org)
  • What are the effects of treatments for acute asthma in children? (aafp.org)
  • Acute asthma may be classified as severe or moderate. (aafp.org)
  • Acute asthma remains a common and sometimes serious presentation. (aafp.org)
  • The proportion of children with acute asthma presenting to primary care in England and Wales fell between 1993 and 1998. (aafp.org)
  • The proportion of all children admitted to the hospital in England and Wales who had acute asthma fell slightly between 1998 and 2004, from around 19 per 1,000 admissions to 17 per 1,000. (aafp.org)
  • Current asthma, but not former asthma, is associated with increased all-cause mortality, heart disease mortality, and chronic lower respiratory tract disease mortality. (wikipedia.org)
  • After controlling for established risk factors, individuals with SCA and asthma had a more than two-fold higher risk of mortality (hazard ratio 2.36, 95% CI 1.21 to 4.62, p =0.01). (haematologica.org)
  • Mortality (median age at death) was compared for individuals with and without asthma. (haematologica.org)
  • 3 UK asthma mortality is much higher than other European countries. (bmj.com)
  • This is the second guide to implementing ICD-10 for mortality, and is a supplement to the guide distributed to the States on July 16, 1998, and available at the NCHS website ftp://ftp.cdc.gov/pub/Health_Statistics/NCHS/Publications/ICD9_10Con/let2.doc. (cdc.gov)
  • The triplet and higher-order multiple birth rate declined from an all-time high of 193.5 per 100,000 total births in 1998 to 78.9 in 2022. (cdc.gov)
  • 20 years and highest among mothers aged ≥40 years (517.6 in 1998 and 179.0 in 2022) but differences across the age groups narrowed from 1998 to 2022. (cdc.gov)
  • National Center for Health Statistics, National Vital Statistics System, Natality Data, 1998 and 2022. (cdc.gov)
  • In a cross-sectional observational study, a total of 163 subjects with severe asthma were compared with 158 subjects whose asthma was controlled by low doses of inhaled corticosteroids (median dose of beclomethasone equivalents 666 µg). (ersjournals.com)
  • Despite being treated with higher doses of inhaled corticosteroids (median dose 1773 µg) and for a third of the severe asthmatics also being treated with regular, oral-steroid therapy (median daily dose 19 mg), the subjects with severe asthma met the inclusion criteria. (ersjournals.com)
  • Some small studies of severe asthma, using induced sputum toassess the airway inflammatory response, have shown thatdespite the regular use of high-dose inhaled and oral corticosteroids, eosinophilia persists. (ersjournals.com)
  • In mild to moderate asthma, oral corticosteroids are known to be more effective than placebo. (aafp.org)
  • Long term use of inhaled corticosteroids, such as those used for treating asthma, can also increase the risk of cataracts. (healthy.net)
  • Inhaled β 2 -adrenoceptor agonists are the most effective bronchodilators for the management of asthma 1 . (ersjournals.com)
  • The paper explains the study findings and recommends that everyone involved with the management of asthma respond to its unequivocal results. (buteykobreathing.nz)
  • Proper medications and dosages are important to the management of asthma. (jaxmed.com)
  • The emphasis on enabling self-management of asthma has led to a proliferation of asthma action plans being developed and recommended for routine use within primary as well as secondary asthma care [ 10 ]. (biomedcentral.com)
  • Since severe asthma is a poorly understood, major health problem, 12 clinical specialist centres in nine European countries formed a European Network For Understanding Mechanisms Of Severe Asthma (ENFUMOSA). (ersjournals.com)
  • Females dominated the severe asthma group (female/male ratio 4.4:1 versus 1.6:1 in the controlled asthmatics), and compared with controlled asthmatics, they had a predominantly neutrophilic inflammation (sputum neutrophils, 36 versus 28%) and evidence of ongoing mediator release but less atopy. (ersjournals.com)
  • The findings prompt for longitudinal studies and interventions to define the mechanisms in severe asthma. (ersjournals.com)
  • These more severe asthmatics, which account for ∼10% of the asthmatic population, have a disproportionate impact on healthcare utilisation, accounting for up to at least half of the direct and indirect costs for asthma 2 . (ersjournals.com)
  • There is little information on the pathophysiological mechanisms responsible for severe and persistent asthma. (ersjournals.com)
  • However, the numbers of cells and their state of activation, seem to show little difference between patients with severe asthma compared to patients with the mild-to-moderate form of the disease 3 - 5 . (ersjournals.com)
  • The Global Initiative for Asthma guidelines recognise the role of long-acting β 2 -agonists (LABAs) for the optimal treatment of moderate-to-severe persistent asthma 1 . (ersjournals.com)
  • 1 2 UK data from the Royal College of Physicians' national asthma audit suggests that children are presenting with more severe asthma attacks than recorded in previous audits. (bmj.com)
  • Because this medication works on the inflammatory aspect of asthma, it is used as the primary medication for moderate and severe asthma. (jaxmed.com)
  • For severe asthma, the addition of intravenous salbutamol, aminophylline, or magnesium sulfate is effective compared with the addition of placebo. (aafp.org)
  • In the United States, the number of individuals with self-reported asthma increased by 75% from 1980 to 1994 [Mannino et al. (cdc.gov)
  • Asthma is a heterogeneous disease characterized by airway chronic inflammation together with airway hyperresponsiveness 1 . (nature.com)
  • The inflammation associated with asthma is characteristically eosinophilic. (cmaj.ca)
  • However, some patients with this condition have neutrophilic inflammation, whereas, conversely, some patients without asthma have eosinophilic inflammation. (cmaj.ca)
  • The present study examined the therapeutic effects and action mechanism of a saponin-enriched extract of Asparagus cochinchinensis (SEAC) on airway inflammation and remodeling in an ovalbumin (OVA)-induced asthma model. (spandidos-publications.com)
  • I suppose it's mostly intrinsic asthma where there is inflammation but no allergic-histaminic component, that antihistamines don't carry their weight. (yarchive.net)
  • For the asthma-like outcome, male gender, family history of allergies, elevated ECP (a protein in the blood indicating eosinophilic inflammation), butchering activities and degilling activities were risk factors significantly related with the outcome. (cdc.gov)
  • Fractional exhaled nitric oxide (FeNO) is a reliable, quantitative, non-invasive, simple, and safe biomarker for assessing airways inflammation in asthma. (bvsalud.org)
  • Taken together, these studies make a strong argument for the importance of allergen and irritant exposure as aggravating factors in asthma in both children and adults. (cdc.gov)
  • To estimate the prevalence of dysfunctional breathing in adults with asthma treated in the community. (bmj.com)
  • Asthma is the most common chronic respiratory disease in Canada, affecting about 2.2 million adults and 0.8 million children. (cmaj.ca)
  • In 1989, a cohort of children and young adults from 4 affiliated family practices in the Netherlands was identified for an asthma study based on date of birth. (annfammed.org)
  • A study was undertaken to assess the independent associations of these nutrients with asthma in adults. (bmj.com)
  • A nested case-control study was performed in 515 adults with physician diagnosed asthma and 515 matched controls using dietary data obtained from 7 day food diaries. (bmj.com)
  • Symptomatic asthma in adults is associated with a low dietary intake of fruit, the antioxidant nutrients vitamin C and manganese, and low plasma vitamin C levels. (bmj.com)
  • 1 According to 2013 data from the CDC's National Health Interview Survey, there are currently 16.5 million adults (7%) and 6.1 million children (8.3%) living with asthma in the United States. (uspharmacist.com)
  • 1 Asthma is a common chronic illness that affects approximately 9% of African-American adults 2 and 15% of African-American children. (haematologica.org)
  • Analysis of a survey of 1875 primary school children in the Netherlands found no association between receiving DTP-IPV vaccine and asthma or other atopic disorders (e.g., hay fever, eczema, food allergy) 22 . (vaccinesafety.edu)
  • Asthma and other atopic diseases in Australian children. (mja.com.au)
  • Atopy has long been recognised as the risk factor that has the greatest influence on the emergence of persistent asthma inchildhood, especially sensitisation to aeroallergens in the home 7 . (ersjournals.com)
  • The present study examined the bronchodilator and safety profiles of single-dose indacaterol in intermittent or persistent asthma. (ersjournals.com)
  • The aim of the current study was to examine the bronchodilator profile of a range of indacaterol doses in patients with intermittent or persistent asthma. (ersjournals.com)
  • 3 12 Asthma has been linked with symptomatic hyperventilation in several studies, 13 - 15 and this may be related to the increased anxiety and depression indices found in asthmatic patients. (bmj.com)
  • Current asthma prevalence is an estimate of the percent of the population with current asthma at the time of the survey. (cdc.gov)
  • Current asthma prevalence indicates the percentage of each population subgroup that is theoretically at risk for adverse asthma outcomes, such as asthma emergency room visits or hospitalizations. (cdc.gov)
  • Generally, current asthma prevalence is higher among minority and low income populations of children(3). (cdc.gov)
  • Current asthma prevalence based on survey data is a self-reported measure which is not confirmed by comparison to medical records. (cdc.gov)
  • Current asthma prevalence does not provide information about asthma severity or control that also affect disparities in adverse asthma outcomes. (cdc.gov)
  • Puerto Rican children have among the highest rates, while Mexican children have among the lowest rates of current asthma prevalence(4,5). (cdc.gov)
  • Asthma is a long-term inflammatory disease of the airways of the lungs. (wikipedia.org)
  • The pollutant might act as an inciter or trigger, leading to an asthma attack in an individual with hyper-responsive airways. (cdc.gov)
  • Asthma is an inflammatory disorder of the airways associated with airflow obstruction and bronchial hyperresponsiveness that varies in severity across the spectrum of the disease. (ersjournals.com)
  • Asthma is a chronic inflammatory disease of the airways characterized by episodic wheezing and reversible airway obstruction. (aafp.org)
  • Yes, while airways cough of more than 3 weeks duration, tory, physical examination and the reactivity is among the characteristics of cough without a known cause, age methacholine test results were analysed asthma, it is not considered a sufficient above 10 years and normal radiography statistically using the chi-squared test. (who.int)
  • From the November 1998 issue of Coping with Asthma and Allergies . (ent-consult.com)
  • Exposure to animals or animal products in the workplace can cause asthma and allergies. (cdc.gov)
  • Work-related asthma accounts for 5-25% of all adult asthma cases and is responsible for a significant socioeconomic burden. (ersjournals.com)
  • Some 5-25% of new cases of adult asthma can be directly attributed to work-related exposure [ 2 - 6 ]. (ersjournals.com)
  • Sometimes the oral form is used for a short period of time when the patient's asthma is out of control. (jaxmed.com)
  • Posteroanterior chest radiograph demonstrates a pneumomediastinum in bronchial asthma. (medscape.com)
  • The specificity of HRCT for bronchial asthma is limited by the similarity of its changes to those of other diseases, such as bronchiectasis, chronic bronchitis, emphysema, and bronchopulmonary aspergillosis. (medscape.com)
  • Diffuse panbronchiolitis is prevalent in Japan and the Far East, and it may mimic bronchial asthma with wheezing, coughing, dyspnea on exertion, and sinusitis. (medscape.com)
  • Asthma is characterized by recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing. (wikipedia.org)
  • Two studies of the 2013-2014 and 2014-2015 flu seasons in the United Kingdom study found that LAIV was well tolerated among those with well-controlled asthma or recurrent wheezing 19,20 . (vaccinesafety.edu)
  • There are few primary prevention measures that can be used to prevent asthma from developing, or to address the disparity in asthma prevalence. (cdc.gov)
  • Thus, the Federal Action Plan (4) includes increasing primary asthma prevention research as one of its four main strategies to address asthma disparities. (cdc.gov)
  • The guidelines aim to improve the prevention, identification, and management of occupational asthma by providing evidence based recommendations on which future practice can be based. (bmj.com)
  • This evidence review and its recommendations focus on interventions and outcomes to provide a robust approach to the prevention, identification, and management of occupational asthma, based on and using the best available medical evidence. (bmj.com)
  • Inhaled beta2 agonists are the medication of choice for the treatment of acute flare-ups of asthma and for the prevention of exercise-induced asthma. (jaxmed.com)
  • The aim of the European Respiratory Society work-related asthma guidelines is to present the management and prevention options of work-related asthma and their effectiveness. (ersjournals.com)
  • This online archive of the CDC Prevention Guidelines Database is being maintained for historical purposes, and has had no new entries since October 1998. (cdc.gov)
  • All adult patients aged 17-65 with diagnosed asthma who were receiving treatment. (bmj.com)
  • Patients at different treatment steps of the British Thoracic Society asthma guidelines were affected equally. (bmj.com)
  • 14 In one series, 42% of patients attending a hospital asthma clinic showed evidence of hyperventilation disorder as assessed by capnographic responses and Nijmegen questionnaire scores. (bmj.com)
  • BACKGROUND We examined the natural history of asthma in a primary care cohort of patients 10 years after the cohort was stratified for asthma risk by responses to a questionnaire and bronchial hyperresponsiveness (BHR) testing. (annfammed.org)
  • CONCLUSIONS In primary care, BHR testing has limited value in predicting subsequent respiratory tract disease for patients who have asthma diagnosed by a physician. (annfammed.org)
  • The highly variable nature of the clinical course of asthma makes it difficult for physicians and patients to know at any given time how much treatment is necessary and for how long. (annfammed.org)
  • Longitudinal outcome studies of primary care patients with asthma should help us create this linkage and understand the developmental epidemiology of asthma. (annfammed.org)
  • Multiple-dose, dose-ranging studies 7 , 8 in patients with asthma have shown that indacaterol provides effective bronchodilation with fast onset of action (within 5 min), which is sustained for ≥24 h on once-daily dosing. (ersjournals.com)
  • 5,6 A recent assessment of patient ability to properly self-administer asthma rescue medication found that only 7% of patients surveyed were able to operate a pressurized metered-dose inhaler (pMDI) per the approved protocol. (uspharmacist.com)
  • Liu Y, Zhang S, Li DW and Jiang SJ: Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: a meta-analysis of randomized placebo-controlled trials. (spandidos-publications.com)
  • Despite the substantial data about work related asthma in Australia, many patients are not aware that their condition is caused or exacerbated by work. (nationalasthma.org.au)
  • Understanding the link between asthma and exposure/and or employment, identifying and referring to an appropriate medical specialist and directing patients to additional support systems available through our legal compensation systems can be an important way for medical practitioners to support the holistic care of patients. (nationalasthma.org.au)
  • 4 Exploring new hypotheses about the cause of asthma might usefully result in changes in treatment to the benefit of patients. (bmj.com)
  • Asthma and allergy specialists recognize the importance of clearing sinus infections in their patients. (ent-consult.com)
  • We aim to recruit a total of 80 primary care patients with active asthma from at least eight practices across two health boards in Scotland (10 patients per practice resulting in ~40 in each arm). (biomedcentral.com)
  • Patients in the intervention arm will be asked to complete a novel goal-setting tool immediately prior to an asthma review consultation. (biomedcentral.com)
  • Patients in the control arm will receive a usual care guideline-based review of asthma. (biomedcentral.com)
  • Asthma management guidelines recommend that patients with asthma should be offered self-management support that focusses on individual needs and is reinforced by written personalised action plans [ 10 ]. (biomedcentral.com)
  • Asthma is a chronic inflammatory disease characterized by T-lymphocyte and eosinophil infiltration, mucus overproduction and airway hyper-responsiveness. (spandidos-publications.com)
  • To accomplish this, alterations of the nitric oxide (NO) level, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression levels, as well as variations in immune cell numbers, immunoglobulin E (IgE) concentration, histopathological structure and inflammatory cytokine levels were measured in lipopolysaccharide (LPS)-activated RAW264.7 cells or an OVA-induced mouse model of asthma treated with SEAC. (spandidos-publications.com)
  • Additionally, in the OVA-induced asthma model, the number of immune cells in the bronchoalveolar lavage fluid, the concentration of OVA-specific IgE, the infiltration of inflammatory cells, the bronchial thickness and the levels of the inflammatory mediators interleukin-4 (IL-4), IL-13 and COX-2 were significantly lower in the OVA + SEAC‑treated group compared with the OVA + vehicle‑treated group. (spandidos-publications.com)
  • Other anti-inflammatory medications are being tested in clinical trials in the U.S., but are not yet approved for asthma treatment. (jaxmed.com)
  • Asthma is fundamentally an inflammatory problem. (yarchive.net)
  • Nitric oxide has different roles in asthma as both an endogenous modulator of airway function and a pro-inflammatory mediator. (bvsalud.org)
  • From 1970 to 1990 increasing rates of asthma and allergic sensitisation were observed in several countries. (bmj.com)
  • 9 Kuehni and colleagues found an increase in current wheeze in young preschool children from 12% in 1990 to 26% in 1998. (bmj.com)
  • The main outcome measures were physician diagnosed asthma and current symptomatic asthma (diagnosed asthma and self-reported wheeze within the previous 12 months). (bmj.com)
  • Inherent in these components is a recognition of the need for proper, thorough, and repeated education on the use of asthma inhalers. (uspharmacist.com)
  • 8 However, despite the significant expenditure of health care resources on people with asthma, as well as decades of improvements in diagnosis and treatment and regular updates of evidence-based clinical practice guidelines, asthma control at the population level remains suboptimal. (cmaj.ca)
  • Although many clinicians diagnose asthma on the basis of a trial of therapy, objective measurements are necessary to confirm the clinical diagnosis. (cmaj.ca)
  • The use of symptom questionnaires can be of clinical use in predicting asthma. (annfammed.org)
  • 2, 3 Information about the natural history of asthma in primary care populations remains a missing link between our biological knowledge of the disease and our clinical management of it. (annfammed.org)
  • Most clinical studies of asthma have used a combination of bronchial hyperresponsiveness (BHR) testing and responses to respiratory questionnaires to assist with an asthma diagnosis. (annfammed.org)
  • Of the 2,557 individuals enrolled, 76.8% (n=1,963) had adequate clinical data to classify asthma. (haematologica.org)
  • Their family physicians' diagnoses of upper and lower respiratory tract disease and asthma were prospectively collected during the next 10 years and were analyzed. (annfammed.org)
  • Occupational asthma is the most frequently reported work related respiratory disease in many countries. (bmj.com)
  • This work was commissioned by the British Occupational Health Research Foundation to assist the Health and Safety Executive in achieving its target of reducing the incidence of occupational asthma in Great Britain by 30% by 2010. (bmj.com)
  • The most important action to prevent cases of occupational asthma is to reduce exposure at source. (bmj.com)
  • Those workers who are confirmed to have occupational asthma should be advised to avoid further exposure completely and early in the course of their disease to offer the best chance of recovery. (bmj.com)
  • Medical practitioners can be well placed to identify occupational asthma on the basis of having a long-standing relationship with the patient. (nationalasthma.org.au)
  • Work-related asthma has become one of the most common occupational diseases. (ersjournals.com)
  • Frequently, sensitisation and new-onset occupational asthma occur in the early period of exposure to high molecular weight (HMW) agents. (ersjournals.com)
  • This was reiterated recently by the American Thoracic Society (ATS) who declared that "the clinician must be aware of the potential occupational etiologies for obstructive airway disease and consider them in every patient with asthma or COPD" [ 4 ]. (ersjournals.com)
  • Title : Preventing asthma in animal handlers Corporate Authors(s) : National Institute for Occupational Safety and Health. (cdc.gov)
  • Data for asthma outcomes (such as hospitalizations) by Hispanic origin in national data sets are more limited. (cdc.gov)
  • Around 3.2 million children had at least one asthma attack in 2016, resulting in more than 80 thousand hospitalizations [ 1 ]. (biomedcentral.com)
  • Our previous study showed that neonatal Streptococcus pneumoniae ( S. pneumoniae ) infection promoted asthma development. (nature.com)
  • The aim of this study was to investigate the effects of neonatal S. pneumoniae pneumonia on vitamin A expressions, to explore the effects of vitamin A supplement after neonatal S. pneumoniae pneumonia on adulthood asthma development. (nature.com)
  • 9, 10 The objective of the current study was to clarify the natural history of respiratory tract complaints and asthma in primary care. (annfammed.org)
  • This study also suggests that asthma may influence the sport that an athlete chooses. (nih.gov)
  • Parental reports of asthma, hay fever, and wheezing and measurements of specific serum IgE antibodies were investigated in six serial cross sectional surveys of 9-11 year old school children in three study areas in south west Germany. (bmj.com)
  • Over the 9 year study period no increase in the prevalence of current wheezing and asthma was observed. (bmj.com)
  • HRCT remains the most sensitive study for morphologic changes associated with asthma. (medscape.com)
  • These natural procedures are a help not only to the occaisonal infection, but also to longer term asthma and allergy sufferers. (ent-consult.com)
  • Preliminary work suggests that a brief, intensive, patient-centred intervention may be successful in supporting people with asthma to participate in life roles and activities they value. (biomedcentral.com)
  • This recognition suggests that imaging has an important role in differentiating asthma from its mimics and that further diagnostic evaluation and treatment of nonasthma conditions may be necessary. (medscape.com)
  • Asthma is, in essence, still quite different from other chronic diseases, such as hypertension or hyperlipidemia, the natural histories of which we now know quite well. (annfammed.org)
  • 1998]. The immunologic evidence is consistent with results of epidemiologic studies that associate traffic-related air pollution, especially diesel exhaust particles, with an increase in respiratory diseases. (cdc.gov)
  • Only about 11% of the athletes who participated in the 1984 Summer Olympic Games were reported to have had exercise-induced asthma on the basis of other criteria that may have been less restrictive. (nih.gov)
  • This is a palliative since it does not address a base cause of asthma, but it can be used to relieve short term problems. (electroherbalism.com)
  • While medicine categorizes people into different types of asthma: e.g. exertional, emotional, environmental, allergic, non-allergic and idiopathic, Buteyko disregards these labels and addresses the cause of asthma. (ndnr.com)
  • It is believed that the recent increased rates of asthma are due to changing epigenetics (heritable factors other than those related to the DNA sequence) and a changing living environment. (wikipedia.org)
  • Alaska Native/American Indian and multiracial children also have higher rates of asthma compared to non-Hispanic white children(3). (cdc.gov)
  • A number of other health conditions occur more frequently in people with asthma, including gastroesophageal reflux disease (GERD), rhinosinusitis, and obstructive sleep apnea. (wikipedia.org)
  • Cavities occur more often in people with asthma. (wikipedia.org)
  • Supporting self-management behaviours is recommended guidance for people with asthma. (biomedcentral.com)
  • Asthmatics whose disease is inadequately controlled have more extensive use of asthma medication. (ersjournals.com)
  • 4%) of the athletes were currently taking an asthma medication at the time that they were processed in Atlanta or noted that they took asthma medications on a permanent or semipermanent basis and were considered to have active asthma. (nih.gov)
  • Even in cases in which asthma is acceptably controlled (despite poor technique), pMDI operator error contributes to an estimated $5 to $7 billion annual loss of misfired medication and to the increased frequency of adverse events resulting from the systemic exposure that accompanies undesired oropharyngeal deposition of medication. (uspharmacist.com)