RheumatoidRheumatologyClinicalPathogenesis of arthritisKinaseAcuteTherapyInduce arthritisCollagen-inducedInflammatoryChronicEpitopeRheumatismGlomerulonephritisCartilageSynovial fluidResearchPathologyImmuneDisordersJointsJournal of ExperInductionSeverePatientsInfectionJointPresentHumanStudiesCellsPageSearchActivityCellular
Rheumatoid37
- In genetically susceptible individuals, this antigenic stimulation may ultimately result in the expression of overt rheumatoid arthritis (RA) via molecular mimicry, a process whereby foreign peptides, similar in structure to endogenous peptides, may cause antibodies or T-lymphocytes to cross-react with both foreign and endogenous peptides and thereby break immunological tolerance. (cambridge.org)
- These therapies inhibit the proinflammatory action of TNF-α in common autoimmune diseases such as rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease. (frontiersin.org)
- Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
- Osteoarthritis (OA) and rheumatoid arthritis (RA) are common joint disorders that are considered to be different diseases due to their unique molecular mechanisms and pathogenesis. (researchsquare.com)
- Chemokines and chemokine receptors are critical players in the disease processes of two inflammatory joint diseases: rheumatoid arthritis (RA) and osteoarthritis (OA) (1). (researchsquare.com)
- Pulsed electromagnetic field therapy or PEMF therapy, harnesses the power of frequency specific microcurrent for osteoarthritis or rheumatoid arthritis using pulsed electromagnetic fields. (earthpulse.net)
- While magnetic therapy for arthritis has traditionally been done using static magnetic therapy, a far more efficient way to use magnetic therapy to fight rheumatoid arthritis and osteoarthritis is by using pulsed electromagnetic field therapy also known as PEMF therapy. (earthpulse.net)
- The field of pulsed electromagnetic field therapy for osteoarthritis and rheumatoid arthritis is fraught with red-herring studies (studies designed to fail) to show PEMF has no validity. (earthpulse.net)
- Her rheumatoid arthritis is about 80% less than before. (earthpulse.net)
- PEMF promotes various healing mechanisms, and has been shown in peer reviewed studies to promote bone and connective tissue regeneration, even where degenerative conditions like rheumatoid arthritis exist. (earthpulse.net)
- Add nutritional support and recovery from both osteoarthritis and rheumatoid arthritis can be surprising. (earthpulse.net)
- Mycoplasma fermentans has been associated with rheumatoid arthritis. (biomedcentral.com)
- Recently, it was detected in the joints and blood of patients with rheumatoid arthritis, but it is not clear yet how the bacteria enter the body and reach the joints. (biomedcentral.com)
- Bartholomew isolated M. hominis , M. hyorhinis and M. arthritidis from the synovial fluid in 14 of 17 patients with rheumatoid arthritis, systemic lupus erythematosus and Reiter's Syndrome in 1965 [ 8 ]. (biomedcentral.com)
- reported the presence of Mycoplasma fermentans in the synovial fluid of patients with rheumatoid arthritis [ 7 ], but these results could not be reproduced in further investigations probably because of the fastidious growth requirements of the microorganism [ 9 ]. (biomedcentral.com)
- Recent studies have also shown the presence of M. fermentans DNA and specific antibodies to the bacteria in the synovial fluid of patients with rheumatoid arthritis [ 13 ]. (biomedcentral.com)
- This mycoplasma has been detected in blood of patients with rheumatoid arthritis, producing systemic mycoplasmal infections [ 14 ], these results suggest that M. fermentans may play a role in the development of the disease. (biomedcentral.com)
- MALP-2 could induce the release of macrophage-derived 5'-nucleotidase, this enzyme may occur in joints in excessive amounts when M. fermentans is present in patients with rheumatoid arthritis [ 16 ]. (biomedcentral.com)
- However, vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune system, such as diabetes, asthma, and rheumatoid arthritis. (mdpi.com)
- Susan was post menopausal, and had been taking prednisone (a synthetic steroid) for her diagnosis of rheumatoid arthritis. (jeffreydachmd.com)
- Tom, a 46 year old gentleman with severe incapacitating pain and swelling in the joints arrived in my office with a diagnosis of rheumatoid arthritis. (jeffreydachmd.com)
- My previous article discussed the connection between autoimmune diseases such as Lupus and Rheumatoid arthritis with Gluten Sensitivity, and the benefits of a gluten-free diet. (jeffreydachmd.com)
- The "Nightshade Vegetabes" are a food group implicated in both osteo-arthritis and rheumatoid arthritis. (jeffreydachmd.com)
- The cause of most arthritic problems, including osteo- and rheumatoid arthritis , is the so-called nightshades . (jeffreydachmd.com)
- This APL may qualify for rheumatoid arthritis immunotherapy. (biomedcentral.com)
- In rheumatoid arthritis (RA), articular cartilage is destroyed by chronic inflammation that is characterised by activated lymphocytes and major histocompatibility complex (MHC) class II expressing cells in synovial tissue. (biomedcentral.com)
- Two of these involved experimental models of Delayed Onset Muscle Soreness (DOMS) and Rheumatoid Arthritis. (laserintervention.com)
- Very low frequencies of collagen/matrix-specific CD4 + cells could be isolated from the PBMC or synovial fluid (SF) 4 of patients with rheumatoid arthritis (RA), using class II tetramers that contained two joint-specific Ags ( 5 ). (aai.org)
- 1998) Comparative sequence analysis of the human T cell receptor beta chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies: Evidence for antigenic selection of T cells in the synovium. (scirp.org)
- Efficacy and safety of Tacrolimus (FK506) in treatment of rheumatoid arthritis: a randomized, double blind, placebo controlled dose-finding study. (bvsalud.org)
- It is used for the treatment of osteoarthritis, rheumatoid arthritis, and pauciarticular and polyarticular course juvenile rheumatoid arthritis. (springeropen.com)
- Our primary focus has been on rheumatoid arthritis (RA), but we've found that experimental systems and techniques used to study RA are relevant to many other inflammatory diseases, and we now have active research programs in vasculitis, myositis and lupus. (edu.au)
- Rheumatoid Arthritis - Neuropsychology, Depression and Anxiety. (bvsalud.org)
- Impact of Rheumatoid Arthritis in cognitive functions has not been well acknowledged in Portugal. (bvsalud.org)
- We measured the results of 60 Rheumatoid Arthritis female patients (study group), comparing every patient in a case control paired plan (years in school and age), with control subjects (n = 60, in a total of 120 subjects). (bvsalud.org)
- lactis HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis. (bvsalud.org)
- Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273. (cdc.gov)
Rheumatology1
- Clinical and experimental rheumatology , 14 (2), 183-185. (elsevierpure.com)
Clinical7
- Studies in two models of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE) and Theiler's murine encephalitogenic virus-induced demyelinating disease (TMEV-IDD) have shown conclusively that epitope spreading plays a pathological role in ongoing disease and that blocking this process by inducing tolerance to spread myelin epitopes or blocking costimulation of T cells (necessary for epitope spreading) blocks (EAE) or inhibits (TMEV-IDD) ongoing clinical disease. (nature.com)
- Clinical & Experimental Immunology, 104, 343-350. (scirp.org)
- Clinical and Experimental Immunology, Vol. 107, Núm. (ucm.es)
- Clinical and Experimental Immunology, Vol. 102, Núm. (ucm.es)
- Clinical and Experimental Immunology, Vol. 101, Núm. (ucm.es)
- IFN-gamma production by LNC was found to be further increased at the time of clinical manifestation of arthritis and could be up-regulated by co-culture with type II collagen. (ox.ac.uk)
- Clinical and experimental medicine 2023 0 0. (cdc.gov)
Pathogenesis of arthritis1
- Our findings help to explain the pathogenesis of arthritis. (researchsquare.com)
Kinase1
Acute2
- M. fermentans produced an acute arthritis in rabbits. (biomedcentral.com)
- unexpectedly, this effect was even more pronounced in acute than in chronic AIA, underlining the essential role of CD4+ T-cells in the acute phase of experimental arthritis. (irpa2006europe.com)
Therapy1
- Despite the beneficial effects shown by well designed pulsed magnetic field therapy studies for arthritis, funding for PEMF research in this field only results in two or three well designed studies per year. (earthpulse.net)
Induce arthritis2
- P-140 was also injected in the trachea of 14 rabbits in order to test the ability of the bacteria to reach the joints and induce arthritis. (biomedcentral.com)
- The role of Th1 responses in the development of CIA was further emphasized by the observation that immunization of mice with type II collagen in incomplete Freund's adjuvant, which normally fails to induce arthritis, resulted in a predominantly Th2 cytokine profile. (ox.ac.uk)
Collagen-induced3
- In this study, we found that peritoneal B1a cells underwent proliferation and migrated to the inflamed joint tissue with upregulated RANKL expression during collagen-induced arthritis (CIA) development in mice. (oncotarget.com)
- Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis. (ox.ac.uk)
- Murine collagen-induced arthritis (CIA) is an example of an autoimmune disease in which immunization with cartilage-derived type II collagen induces, firstly, a T cell response to type II collagen and, secondly, the manifestation of a destructive inflammatory response in affected joints. (ox.ac.uk)
Inflammatory3
- Antibiotic treatment-resistant Lyme arthritis is a chronic inflammatory joint disease that follows infection with Borrelia burgdorferi ( Bb ). (aai.org)
- Anti-inflammatory and antioxidative effects of Guggulsterone in an experimental rat model of inflammatory bowel disease. (supaveda.com)
- NK cell-derived GM-CSF potentiates murine autoantibody-induced inflammatory arthritis and is negatively regulated by CIS. (edu.au)
Chronic1
Epitope1
- Convincing evidence for the pathological role of epitope spreading is also seen in experimental autoimmune myasthenia gravis (EAMG) and adjuvant arthritis. (nature.com)
Rheumatism2
Glomerulonephritis1
- Involvement of tumor necrosis factor-alpha in the pathogenesis of experimental and human glomerulonephritis. (ucm.es)
Cartilage1
- The addition of pulsed electromagnetic fields to nutritional supplementation for cartilage and bone matrix regeneration in arthritis and other long standing joint / bone issues provides synergistic effects. (earthpulse.net)
Synovial fluid1
- detected M. fermentans by PCR in 88% of synovial fluid samples from patients with different arthritis [ 2 ]. (biomedcentral.com)
Research2
- According to Phillip Conaghan, rheumatologist and spokesperson for the Arthritis Research Campaign, 'We start seeing signs of it in people in their thirties and forties. (patrickholford.com)
- Recent research makes it very clear that joint degeneration as seen in arthritis is actually a metabolic disorder - an extension of 'metabolic syndrome' the driving force behind diabetes, heart disease, obesity and Alzheimer's. (patrickholford.com)
Pathology1
- Experimental and toxicologic pathology, 58(6), 377-381. (supaveda.com)
Immune1
- These observations, together with experimental studies, suggest a critical role for vitamin D in the modulation of immune function. (mdpi.com)
Disorders1
- Dysregulated functions of B1 cells have been implicated in the disease progression of various autoimmune disorders, but it remains largely unclear whether B1 cells are involved in the pathogenesis of autoimmune arthritis. (oncotarget.com)
Joints3
- The purpose of this study was to determine the ability of M. fermentans to induce experimental arthritis in rabbits following inoculation of the bacteria in the trachea and knee joints. (biomedcentral.com)
- Rabbits intracheally injected with P-140 showed induced arthritis and the bacteria could be isolated from lungs, blood, heart, kidney, spleen, brain and joints. (biomedcentral.com)
- But the usual story we are told is that joint aches and arthritis are just about 'wear and tear' on the joints but this is a very partial truth. (patrickholford.com)
Journal of Exper1
- Journal of Experimental Medicine, 209, 761-774. (scirp.org)
Induction1
- These abilities are used by mycoplasmas during the induction of natural arthritis in animals. (biomedcentral.com)
Severe1
- Joint swelling appeared first in rabbits injected with P-140, which caused a more severe arthritis than PG-18. (biomedcentral.com)
Patients4
- Soixante-douze virgule deux pour cent des patients déclaraient satisfaits de leur prise en charge. (bvsalud.org)
- Conclusion: Le développement extensif de la chirurgie ambulatoire est basé sur la sélection des patients à qui l'on propose ce type de prise en charge. (bvsalud.org)
- Elle a concerné les patients àgés de plus de 15 ans pris en charge dans le service et décédés en hospitalisation, en réanimation ou au bloc opératoire. (bvsalud.org)
- Il s'agissait d'une étude descriptive de 74 patients hospitalisés dans le Service en 2017. (bvsalud.org)
Infection1
- Approximately 800 cases of psittacosis (infection with Chlamydia psittaci) were reported to CDC from 1987 through 1996, and most resulted from exposure to pet birds, usually parrots, macaws, cockatiels, and parakeets. (cdc.gov)
Joint2
- Arthritis was elicited on Day 0 by injection of 100 g mBSA in 25 l saline into the right knee joint cavity, while the left knee remained untreated. (irpa2006europe.com)
- Severity (R)-Lansoprazole of arthritis was examined by grading of cellular infiltration and joint destruction as previously described [16]. (irpa2006europe.com)
Present1
Human3
- Our analysis at the clonal level demonstrates that human LFA-1α L326-345 behaves as a partial agonist, perhaps playing a role in perpetuating symptoms of arthritis. (aai.org)
- Komatsu, T., Moriya, N. and Shiohara, T. (1996) T cell receptor (TCR) repertoire and function of human epidermal T cells: Restricted TCR V alpha-V beta genes are utilized by T cells residing in the lesional epidermis in fixed drug eruption. (scirp.org)
- establish mechanisms of action by studying the effects of the same chemicals in experimental animals and on human cells in vitro, allowing for a better prediction of human carcinogenicity and assessment of carcinogenic mechanisms. (who.int)
Studies1
- Several controlled studies have been conducted since 1996 using the BioFlex Professional System. (laserintervention.com)
Cells3
- We have analyzed the Ag-specific CD4 + T cells in treatment-resistant Lyme arthritis, using class II tetramers, and have shown that arthritis-associated Borrelia burgdorferi ( Bb) sensu stricto outer surface protein A (OspA)-specific T cells can be identified with this technology. (aai.org)
- Together, these results have demonstrated a pathogenic role of B1a cells in the development of autoimmune arthritis through RANKL-mediated osteoclastogenesis. (oncotarget.com)
- These findings indicate that Th1 responses are predominant at the time of onset of arthritis and that the activation of collagen-specific Th1 cells may result in suppression of Th2 activity. (ox.ac.uk)
Page1
- https://en.wikipedia.org/wiki/File:Daniel_Hale_Williams.jpg From Wikipedia page: Daniel Hale Williams. (heart.org)
Search1
- A number of different search strategies in Medline (1966 to September 1996), Embase (1981 to September 1996), and the Oxford Pain Relief Database (1950-94) 4 were used to locate reports by using individual drug name (generic and proprietary) together with the words "administration, topical," "gel," "ointment," "aerosol," "cream," and combinations of these, without restriction to English language. (bmj.com)
Activity1
- Anti-arthritic activity of Commiphora mukul extract in experimental arthritis. (supaveda.com)
Cellular1
- Here we describe the cellular pathways involved in the host response to experimental pneumococcal meningitis in specified disease states and brain regions. (biomedcentral.com)