1993 receptors dopamine. Medical search. Frequent questions

Arnsten AF, Cai JX, Murphy BL, Goldman-Rakic PS (1994) Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys. (yale.edu)
The receptor was proved to be mGluR6 by Numura and coauthors (1994) and Vardi and Morigawa (1997) using immunocytochemistry against the cloned mGluR6 receptor. (utah.edu)
1994). Association of dopamine D2 receptor molecular variant with schizophrenia. (geneticsmr.com)
Additional data on the clinical aspects of Ibogaine in the treatment of chemical dependence were reported by Kaplan (1993), Sisko (1993), Sanchez-Ramos & Mash (1994), and Sheppard (1994). (mindvox.com)
1992) first published Ibogaine's ability to reverse cocaine-induced dopamine increases and later reported on Ibogaine's reduction of cocaine-induced motor activity and other effects (1994). (mindvox.com)

These agents are ergot derivatives and dopamine receptor agonists. (medscape.com)
Too much dopamine has been linked to schizophrenia, too little to Parkinson's disease (which is why patients taking antipsychotics would usually not be prescribed dopamine agonists, while patients with Parkinson's disease are given L-Dopa, a dopamine precursor). (provincequebec.com)
1 The recent discovery of endogenous cannabinoids and cannabinoid receptors, the development of cannabinoid agonists and antagonists, and the continued debate over legalization for medicinal purposes has stimulated recent public interest in marijuana. (aafp.org)
Since restless legs syndrome occurs commonly, but not exclusively, in people who suffer from Parkinson's disease that causes shaking and loss of coordination, the same drugs are used to treat both diseases, but these so called dopamine agonists lose their beneficial effects over time. (drmirkin.com)
Research has shown that combinations of low doses of dopamine agonists, such as levodopa and ropinirole, can control restless legs syndrome for many months or years (1,2). (drmirkin.com)
New dopamine agonists for the treatment of Parkinson's disease. (drmirkin.com)
In addition to the established oral ergoline dopamine agonists bromocriptine, lisuride and pergolide new compounds have been developed and investigated in studies to further improve long-term therapy of Parkinson's disease. (drmirkin.com)
Dihydroergocriptine and cabergoline are also ergoline dopamine agonists. (drmirkin.com)
7) Newer dopamine agonists in the treatment of restless legs syndrome. (drmirkin.com)
We studied 253 consecutive PD patients who were not receiving levodopa or dopamine agonists (disease duration ⩽10 years). (bmj.com)
10 Gender differences in the earlier stage of PD, before initiation of dopamine agonists or levodopa, have not been investigated. (bmj.com)

Berger B, Trottier S, Verney C, Gaspar P, Alvarez C (1988) Regional and laminar distribution of the dopamine and serotonin innervation in the macaque cerebral cortex: a radioautographic study. (yale.edu)
Functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis resulted in the differentially expressed proteins in the FM and OA groups are mostly involved in the coagulation and complement system-related pathways, serotonin pathways, dopamine pathways, glutamate pathways and acute phase reactions. (ncl.edu.tw)
The symptomatic effects of drug abuse are a result of alterations in the functioning of the following neurotransmitters or their receptors: acetylcholine, dopamine, γ-aminobutyric acid, norepinephrine, opioids and serotonin. (aafp.org)
Psychedelic drugs stimulate serotonin release, and sedative-hypnotic drugs potentiate the γ-aminobutyric acid receptor. (aafp.org)
Some speculate that the drug blocks serotonin and dopamine receptors in the brain. (attorneygroup.com)
In the brain, the primary role of CB1 receptors is to regulate the release of neurotransmitters such as dopamine, serotonin, and glutamate. (revitaloutdoors.com)
Site-specific regulation of corticosteroid and serotonin receptor subt. (erowid.org)
Synthesis and serotonin receptor affinities of a series of trans-2-(in. (erowid.org)
Biogenic amine is a chemically imprecise term which, by convention, includes the catecholamines epinephrine, norepinephrine, and dopamine, the indoleamine serotonin, the imidazolamine histamine, and compounds closely related to each of these. (bvsalud.org)

Within the striatum, CB1 receptors have been shown to be localized on the same neurons as G i -coupled dopamine D2 receptors. (jneurosci.org)
In striatal neurons in primary culture, both the CB1 receptor agonist [3-(1,1-dimethylheptyl)-11-hydroxy-Δ 8 tetrahydrocannabinol] (HU210) and the D2 receptor agonist quinpirole inhibited forskolin-stimulated cAMP accumulation when applied separately. (jneurosci.org)
Pertussis toxin treatment of striatal neurons prevented the inhibition of cAMP accumulation by D2 receptors but unmasked a cannabinoid receptor-mediated stimulatory effect on cAMP accumulation. (jneurosci.org)
CB1 receptors have been identified on both subpopulations of medium spiny neurons ( Mailleux and Vanderhaeghen, 1992 ). (jneurosci.org)
Alzheimer C, Schwindt PC, Crill WE (1993) Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex. (yale.edu)
Berger B, Febvret A, Greengard P, Goldman-Rakic PS (1990) DARPP-32, a phosphoprotein enriched in dopaminoceptive neurons bearing dopamine D1 receptors: distribution in the cerebral cortex of the newborn and adult rhesus monkey. (yale.edu)
Brown AM, Schwindt PC, Crill WE (1993) Voltage dependence and activation kinetics of pharmacologically defined components of the high-threshold calcium current in rat neocortical neurons. (yale.edu)
When a neurotransmitter binds to a receptor, an extracellular signal is transduced into an intracellular one, causing a functional change inside target neurons. (psychiatrictimes.com)
Loss of dopamine producing neurons is a distinctive feature of Parkinson's disease (Lotharius & Brundin, 2002). (provincequebec.com)
Dysbindin-1 influences how many D2 receptors are available on neurons' outer surfaces to receive dopamine signals from neighboring cells. (namisanmateo.org)
NGF is a neurotrophic factor critical for the survival and maintenance of sympathetic and sensory neurons, and it binds to the high-affinity tyrosine kinase receptor, TrkA, leading to its phosphorylation and the subsequent activation of PI3K/Akt/GSK3β pathways. (biomedcentral.com)
The idea to use transplants of dopa- ment of protocols that allow generation of fully functional mine-producing cells to substitute for the lost midbrain and safe midbrain dopamine neurons from stem cells. (lu.se)
Based on these observations, the dopamine neu- from dopamine neurons implanted into the brain pa- rons used for transplantation in these experiments renchyma with the goal of reinnervating the dener- were neuroblasts obtained from mid-trimester rat vated striatum.8,9 Rats with unilateral, 6-hydroxydo- fetuses. (lu.se)
VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)

Conversely, the opposite is true in patients with schizophrenia, they have an abnormally high D2 activity, which is predicted by the classic hypothesis that schizophrenia is related to dopamine hyperactivity leading to the logical consequence that all antipsychotics act as dopamine antagonists. (provincequebec.com)
Thus, minor alleles can be viewed as analogous to their respective dopamine receptor antagonists (although this neglects developmental effects), and thus provide natural experiments to dissect aspects of human physiology. (biomedcentral.com)

Angulo MC, Lambolez B, Audinat E, Hestrin S, Rossier J (1997) Subunit composition, kinetic, and permeation properties of AMPA receptors in single neocortical nonpyramidal cells. (yale.edu)
1997). Polymorphism of dopamine receptors and transporter genes in neuropsychiatric diseases. (geneticsmr.com)

Two subtypes of cannabinoid receptors have been identified. (jneurosci.org)
Cepeda C, Buchwald NA, Levine MS (1993) Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated. (yale.edu)
Role of various 5-HT receptor subtypes in mediating neuroendocrine eff. (erowid.org)

It participates in the body's endocannabinoid system by binding to cannabinoid receptors, the same receptors that the psychoactive compound THC in cannabis acts on. (revitaloutdoors.com)
Cannabinoid Receptors: G-protein coupled receptors that are an important part of the endocannabinoid system. (revitaloutdoors.com)
There are two cannabinoid receptors, simply known as CB1 and CB2 receptors. (revitaloutdoors.com)
This allows for the active cannabinoids to bind to cannabinoid receptors in the body and brain to create the desired effect of the product. (revitaloutdoors.com)

and Daniel R. Weinberger, M.D., a Scientific Council Member, 2000 and 1990 Distinguished Investigator, and 1993 Lieber Prizewinner at Johns Hopkins University. (namisanmateo.org)
El treball Activation of facilitation calcium channels in chromaffin cells by D1 dopanine receptors through a cAMP/protein kinase A-dependent mechanism, publicat a Nature el 1990 (348:239-242) va ser el guardonat amb el tercer Premi d'Investigació Dr. Antoni Esteve. (esteve.org)

Tetanic stimuli to layer I-II afferents in rat prefrontal cortex induced long-term depression (LTD) of layer I-II to layer V pyramidal neuron glutamatergic synapses when tetani were coupled to bath application of dopamine. (jneurosci.org)
Immunoblot analyses with anti-active mitogen-activated protein kinases (MAP-Ks) revealed that D1 receptors, D2 receptors, group I mGluRs, and group II mGluRs all contribute to MAP-K activation in prefrontal cortex, and that combined activation of dopamine receptors and mGluRs synergistically or additively activate MAP-Ks. (jneurosci.org)
Durstewitz D, Seamans JK, Sejnowski TJ (2000) Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex. (yale.edu)
Brozoski TJ, Brown RM, Rosvold HE, Goldman PS (1979) Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. (yale.edu)
1 Chronic use upregulates the expression of D 2 receptors, while downregulating the expression of D 1 and D 5 receptors in the prefrontal cortex. (drugbank.com)

whereas dopamine D2 receptors inhibit adenylate cyclase via G i -proteins ( Sibley and Monsma, 1992 ). (jneurosci.org)
Cepeda C, Radisavljevic Z, Peacock W, Levine MS, Buchwald NA (1992) Differential modulation by dopamine of responses evoked by excitatory amino acids in human cortex. (yale.edu)
Glick (1992) and Cappendijk (1993) discovered in the animal model that multiple administrations of Ibogaine over time were more effective than a single dose in interrupting or attenuating the self-administration of morphine and cocaine, supporting Lotsof's findings in human subjects (1985). (mindvox.com)

Also at this time researchers discovered that dopamine depletion in the striatum played a role in Parkinson's disease. (psychiatrictimes.com)
Pathogenesis of Parkinson's disease: Dopamine, Vesicles and -synuclein. (provincequebec.com)

Do the brain's dopamine levels and reward center ever return to normal after drug use stops? (serviciosolavarria.com)
Antipsychotic medications work by modulating signaling from the brain's dopamine D2 receptors. (namisanmateo.org)

5Aminomethyl propionic acid, or AMPA, is a chemical that specifically activates this glutamate-receptor subtype. (serviciosolavarria.com)
4N-methyl-d-aspartate, or NMDA, is a chemical that specifically activates this glutamate-receptor subtype. (serviciosolavarria.com)
This invaginating contact is known to bear metabotropic glutamate receptors in the bipolar dendrite membrane (Fig. 5). (utah.edu)
Caged compounds are made by bonding caging moieties with target chemicals, such as calcium, glutamate (Glu), and dopamine ( Ellis-Davies, 2007 ). (eneuro.org)

Our results suggest that, in women, the development of symptomatic PD may be delayed by higher physiological striatal dopamine levels, possibly due to the activity of oestrogens. (bmj.com)

C. Wegner, G. Teuchert-Noodt, and R.R. Dawirs, "Demonstration of dopamine immunoreactivity in open and closed type endocrine cells of gerbil (Meriones unguiculatus) stomach", LIFE SCIENCES , vol. 59, 1996, pp. 1407-1413. (uni-bielefeld.de)
1996). Further association study on dopamine D2 receptor variant S311C in schizophrenia and affective disorders. (geneticsmr.com)

This study analyzes the correlates of two genetic polymorphisms, the TaqI A polymorphism in the dopamine receptor D2 (DRD2) gene and the 48 base pair (bp) repeat polymorphism in the dopamine receptor D4 (DRD4) gene. (biomedcentral.com)

Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis toxin-sensitive G-protein. (jneurosci.org)
In this study we have examined the interactions of CB1 and D2 receptors on adenylate cyclase. (jneurosci.org)
Both D1 and D2 dopamine receptors also couple to adenylate cyclase via G-proteins. (jneurosci.org)

Cepeda C, Levine MS (1998) Dopamine and N-methyl-D-aspartate receptor interactions in the neostriatum. (yale.edu)

Ropinirole and pramipexole are two non-ergoline derivates without affinity for D1 receptors but with high affinity for the dopamine D3 receptor subtype. (drmirkin.com)

Because the neurobiological substrate of cariprazine has remained elusive, we took advantage of PharmacoSTORM to provide in vivo evidence that cariprazine predominantly binds to D 3 dopamine receptors on Islands of Calleja granule cell axons but avoids dopaminergic terminals. (nature.com)
Slower G-protein-linked receptor systems, as seen in the dopaminergic system, work through second-messenger systems, such as cyclic adenosine monophosphate (cAMP), and have a longer duration of action. (psychiatrictimes.com)
In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus-castus: Direct evidence for a dopaminergic principle by the dopamine receptor assay. (naturalnews.com)
Absence of dopamine-beta-hydroxylase in some catecholamine-containing sympathetic ganglion cells of the dog: evidence for dopaminergic autonomic neurones. (uni-bielefeld.de)
Dopaminergic cells in the superior cervical ganglion of the rat: light and electron microscopic study using an antibody against dopamine. (uni-bielefeld.de)
1 Remoxipride displays weaker binding to D 2 dopaminergic receptors that dopamine. (drugbank.com)

Fast receptor systems, such as the GABAA receptor and the nicotinic receptor at the neuromuscular junction, involve the direct binding of a neurotransmitter to a ligand-gated channel, which opens or closes the channel. (psychiatrictimes.com)

Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene. (wikipedia.org)
This gene encodes the D3 subtype of the dopamine receptor. (wikipedia.org)
Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. (provincequebec.com)
13 ]] for the evolution of dopamine gene polymorphisms that have been primarily investigated in industrialized settings. (biomedcentral.com)

These findings are discussed along with the likely modulatory function of dopamine in peripheral tissues. (uni-bielefeld.de)
Peripheral dopamine receptors, potential targets for a new class of antihypertensive agents. (uni-bielefeld.de)
CB2 Receptor: First discovered in 1993, they're the peripheral receptors for cannabinoids. (revitaloutdoors.com)

Interestingly, in their article, Seeman & Kapur (2000) expose the contradiction that surrounds D2 receptors and the mental illness. (provincequebec.com)

Remoxipride is an discontinued atypical antipsychotic selective for dopamine D2 receptors. (drugbank.com)
Remoxipride is an atypical antipsychotic agent that is specific for dopamine D 2 receptors. (drugbank.com)
Remoxipride is an atypical antipsychotic dopamine D 2 antagonist. (drugbank.com)
The only evidence-based treatment for these patients is clozapine, an atypical antipsychotic with relatively weak dopamine antagonism. (biomedcentral.com)

They act on postsynaptic dopamine receptors while causing no effect on other anterior pituitary functions. (medscape.com)
The dopamine cells of the hypothalamus project via the tuberoinfundibular tract to the infundibulum and anterior pituitary. (psychiatrictimes.com)

Cannabinoids exert many of their effects through activation of G i -protein-coupled receptors. (jneurosci.org)

Mimic dopamine action of inhibition of prolactin release. (medscape.com)

No association of dopamine D2 receptor molecular variant Cys311 and schizophrenia in Chinese patients. (geneticsmr.com)
Remoxipride is a weak selective dopamine D 2 receptor antagonist that was once used in the treatment of schizophrenia. (drugbank.com)
The dopamine hypothesis [ 13 ] is arguably the most well-known and well-supported neurochemical model of schizophrenia, but has been unable to explain the occurrence of treatment-resistant schizophrenia. (biomedcentral.com)

Allosteric modulators of sigma-1 receptor (Sig1R) are described as compounds that can increase the activity of some Sig1R ligands that compete with (+)-pentazocine, one of the classic prototypical ligands that binds to the orthosteric Sig1R binding site. (frontiersin.org)
Synthesis and pharmacological evaluation of substituted naphth[1,2,3-de]isoquinolines (dinapsoline analogues) as D1 and D2 dopamine receptor ligands. (semanticscholar.org)

LTD by dopamine + 1 S ,3 R -ACPD coapplication was also blocked by postsynaptic injection of synthetic MAP-K substrate peptide. (jneurosci.org)
Our results suggest that dopamine receptors and groups I and II mGluRs cooperate to induce LTD through converging postsynaptic activation of MAP-Ks. (jneurosci.org)

Previously, CB1 receptors have been shown to inhibit D1 receptor-mediated cAMP accumulation ( Bidaut-Russell and Howlett, 1991 ). (jneurosci.org)

In this area, dopamine acts directly to inhibit the release of prolactin. (psychiatrictimes.com)
APO, a direct acting DA receptor agonist, decreases prolactin (PRL) and stimulates growth hormone (GH), adrenocorticotropic hormone (ACTH) and cortisol secretion. (mdpi.com)

For clinical purposes, each receptor can be considered the site of action of only one specific neurotransmitter. (aafp.org)
As newer drugs of abuse are identified, physicians only need to know the affected neurotransmitter and receptor site to recognize the resultant signs and symptoms. (aafp.org)

This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. (wikipedia.org)

Minor alleles of the human dopamine receptor polymorphisms, DRD2/TaqI A and DRD4/48 bp, are related to decreased functioning and/or numbers of their respective receptors and have been shown to be correlated with body mass, height and food craving. (biomedcentral.com)
DRD2 and DRD4 are both considered D2-like receptors and have similar functions and distributions, but are distinct. (biomedcentral.com)

The role of GABAA receptors in mediating[…]ntral nervous system. (serviciosolavarria.com)

Interestingly, a second antiserum that was generated against the third extracellular loop of the G protein-coupled receptor no longer immunoprecipitated the receptor when covalently labeled with [3H2]azido-CP-96,345. (shengsci.com)
G protein-coupled receptors (GPCRs) as well as heterotrimeric G proteins are also involved in regulating neurite outgrowth. (biomedcentral.com)

The involvement of dopamine in reward anticipation has largely been established. (provincequebec.com)
Ikemoto (2007) reviews scientific literature to arrive at a better understanding of the dopamine reward circuitry. (provincequebec.com)
The authors hypothesized that since dopamine is responsible for motivation and reward feelings, individuals lacking dopamine may be overindulging to fill the chemical messenger void. (provincequebec.com)
Dopamine reward circuitry: Two projection systems form the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. (provincequebec.com)
1 , 4 , 7 , 10 - 14 Marijuana stimulates the dopamine pathway from the ventral tegmental area to the nucleus accumbens, which is believed to be a reward system of the brain. (aafp.org)
Prefrontal dopamine D1 receptor (D1R) mediates behavior related to anxiety, reward and memory, and is involved in inflammatory processes, all of which are affected in bipolar disorder. (springeropen.com)

Here we examine the relationships between genetic polymorphisms of dopamine receptor genes and several phenotypes in Ariaal men. (biomedcentral.com)

Such effect was completely reversed both by the opioid receptor antagonist naloxone and by the unselective muscarinic receptor antagonist atropine. (researchgate.net)

In 1979, Kebabian and Calne determined that at least two dopamine receptors mediated this system, and for the next decade the actions of dopamine were viewed as being mediated by two dopamine receptors, D1 and D2. (psychiatrictimes.com)
Cardiovascular and renal actions of dopamine: potential clinical applications. (uni-bielefeld.de)

Bergson C, Mrzljak L, Smiley JF, Pappy M, Levenson R, Goldman-Rakic PS (1995) Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain. (yale.edu)

Rather, all known abused drugs affect a limited number of neurotransmitters by agonism or antagonism of a specific receptor site 2 ( Table 1 ) . (aafp.org)

Furthermore, FSCV allows for the study of dopamine uptake using Michaelis-Menten based kinetic modeling of uptake parameters, allowing researchers to assess dopamine transporter function. (serviciosolavarria.com)

The regulation of α-Syn aggregation and clearance enhances brain-derived neurotrophic factor (BDNF) secretion, which ultimately ameliorates neuroinflammation and oxidative stress while promoting neurogenesis and interacting with other DA receptors. (wikipedia.org)
Dopamine and the regulation of cell proliferation in gerbil (Meriones unguiculatus) pyloric mucosa. (uni-bielefeld.de)

In the brain, the principal dopamine systems arise from cells in the midbrain and the hypothalamus. (psychiatrictimes.com)

This article is intended as the clinician's practical guide to the current understanding of dopamine receptors and their role in neuropsychiatric illness. (psychiatrictimes.com)

1 It gained approval in the UK in 1989 but was withdrawn in 1993 after it was found to be associated with an increased incidence of aplastic anemia. (drugbank.com)

Stimulation of cAMP accumulation was not observed after pertussis toxin treatment of CHO cells expressing the human CB2 receptor, suggesting that this novel signaling pathway is unique to the cannabinoid CB1 receptor. (jneurosci.org)

Finally, we can pharmacologically probe the contribution of different regulatory systems, including the D2 dopamine autoreceptor and nicotinic acetylcholine receptor (nAChR), to dopamine release. (serviciosolavarria.com)

There has been an explosion of interest and information regarding dopamine receptors in the human brain. (psychiatrictimes.com)
Dopamine is one of the major excitatory neurotransmitters in the brain. (provincequebec.com)
Activities such as eating, hugging and exercising can generate dopamine production in the brain. (serviciosolavarria.com)
While I started my career as a developmental neurobiologist and pediatric neurologist interested in how dopamine was affected during early brain injury, I shifted my research focus radically nearly 25 years ago in an attempt to repurpose already FDA-approved medicines for the treatment of neurologic disease associated with HIV-1 infection. (rochester.edu)
The majority of CB1 receptors are concentrated in the central nervous system throughout the brain and spinal cord. (revitaloutdoors.com)

We report two cases of TSS with puerperal infection that could be diagnosed at the early stage of the clinical course by detecting a marked expansion of T-cell-receptor Vβ2-positive T cells, as measured by flow cytometric analysis. (cdc.gov)

An azido derivative of [3H2](2S, 3S)-cis-2-(diphenylmethyl)-N-((2-methoxyphenyl) methyl)-1-azabicyclo[2.2.2]octon-3-amine (CP-96,345), a potent nonpeptide antagonist of the substance P (SP) (neurokinin-1) receptor, was synthesized and shown to have an affinity for the human SP receptor similar to that of the parent compound, CP-96,345. (shengsci.com)

S. aureus produces several superantigenic exotoxins, including TSS toxin-1 (TSST-1), which activate a vast number of T cells in a T-cell-receptor Vβ-selective manner ( 1 , 2 ). (cdc.gov)

Human granulosa cells (GCs) derived from women undergoing in vitro fertilization (IVF) are an adequate model for endocrine cells of the follicle and the corpus luteum and were therefore employed in an attempt to decipher their DA receptor repertoire and functionality. (biomedcentral.com)
A previous study showed D 2 in human GCs, which are linked to cAMP, and the present study reveals the full spectrum of DA receptors present in these endocrine cells, which also includes D 2 -like receptors, linked to calcium. (biomedcentral.com)

For clinicians to make effective use of the new drugs that will emerge from this active research area, they will need to understand how dopamine affects behavior and keep abreast of the developments in dopamine pharmacology. (psychiatrictimes.com)

Specific signs and symptoms are associated with the neurotransmitters and receptors affected by each drug class. (aafp.org)
By recognizing symptomatic changes related to particular neurotransmitters and their receptors, family physicians can accurately determine the drug class and intervene appropriately to counteract drug-induced effects. (aafp.org)

In particular, we demonstrate the release of a synthetic receptor-specific agonist that exerts physiological effects on long-term synaptic plasticity. (eneuro.org)

Opiates act on both opioid and adrenergic receptor sites. (aafp.org)

For example, laboratory rats and mice learn to self-administer drugs of abuse unless they were given dopamine blockers (for a list of works see Ikemoto, 2007). (provincequebec.com)

In the last three years, seven distinct dopamine receptors have been identified. (psychiatrictimes.com)

Recent advances in molecular genetics have revealed the two-receptor model to be a gross oversimplification. (psychiatrictimes.com)
L'11 de maig de 1993 es va celebrar a Barcelona una taula rodona sobre la investigació sobre càncer a Espanya, des de la biologia molecular fins a la clínica. (esteve.org)
When Chinese hamster ovary cells expressing the human SP receptor were photolabeled with this compound and analyzed with the use of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fluorography, several radioactive bands were observed, including a major band centered at molecular mass 80 kDa, the expected value for the SP receptor expressed in Chinese hamster ovary cells. (shengsci.com)

Serotonergic agents that activate 5HT2A receptors prevent NMDA antagon. (erowid.org)

Anatomy22

Organisms7

Diseases8

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Psychiatry and Psychology12

Phenomena and Processes11

Disciplines and Occupations1

Health Care1

19945

Agonists11

Serotonin9

Neurons14

Antagonists2

19972

Subtypes3

Cannabinoid receptors4

19902

Prefrontal cortex5

19923

Parkinson's2

Brain's dopamine2

Glutamate4

Striatal dopamine1

19962

Polymorphism1

Adenylate cyclase3

19981

High-affinity1

Dopaminergic6

Nicotinic receptor1

Gene4

Peripheral3

20001

Atypical antipsychotic4

Anterior pituitary2

Cannabinoids1

Inhibition1

Schizophrenia3

Ligands2

Postsynaptic2

19911

Prolactin2

Neurotransmitter2

Cognitive1

DRD22

GABAA1

Protein-coupled2

Reward6

Phenotypes1

Muscarinic1

Actions2

19951

Antagonism1

Transporter1

Regulation2

Midbrain1

Neuropsychiatric1

19891

Signaling pathway1

Pharmacologically1

Brain5

Clinical1

Affinity1

Selective1

Endocrine cells2

Behavior1

Neurotransmitters2

Physiological1

Opioid1

Blockers1

Distinct1

Molecular3

NMDA1