1993 adhesion molecules adhesion molecules leukocyte. Medical search. Frequent questions

A large body of evidence now implicates increased leukocyte-endothelial cell adhesion as a key early event in the development of diabetic retinopathy. (diabetesjournals.org)
We recently reported that raised activity of the glycosylating enzyme core 2 β 1,6- N -acetylglucosaminyltransferase (GlcNAc-T) through protein kinase C (PKC)β2-dependent phosphorylation plays a fundamental role in increased leukocyte-endothelial cell adhesion and capillary occlusion in retinopathy. (diabetesjournals.org)

ICAM-1 is an 85 kDa type I transmembrane glycoprotein that is encoded by Icam1 (Intercellular adhesion molecule 1). (bdbiosciences.com)
Bombeli,T., Schwartz,B.R., and Harlan,J.M. (1998): Adhesion of Activated Platelets to Endothelial Cells: Evidence for a GPIIb/IIIa-dependent Bridging Mechanism and Novel Roles for Endothelial Intercellular Adhesion Molecule 1 (ICAM-1), α V β 3 -Integrin and GPIbα. (9dok.net)
Inflammatory markers neopterin and soluble intercellular adhesion molecule (sICAM-1) appeared to be clinically useful for isolated assessments of disease activity. (who.int)

Smoking causes inappropriate leukocyte activation, leukocyte-endothelial adhesion, and neutrophil entrapment in the microvasculature, which may help initiate local tissue destruction. (umanitoba.ca)
Neutrophil function and molecular analysis in severe leukocyte adhesion deficiency type I without separation delay of the umbilical cord. (lu.se)
These effects include reduced airway mucus secretion 17 and anti-inflammatory properties, including decreased airway neutrophil accumulation through a reduction in expression of pro-inflammatory cytokines, e.g. interleukin (IL)-8, and adhesion molecule production, e.g. macrophage adhesion molecule-1 18 - 20 . (ersjournals.com)
Selectins contribute to both SSRBC and neutrophil adhesion (PMN) in vitro and in SCD mouse models. (functionalfluidics.com)

Infliximab can also Dapagliflozin (BMS512148) reduce the quantity of inflammatory cells in the sites of inflammation because it decreases the levels of chemokines and endothelial adhesion molecules, however it does not produce a generalized suppression of cellular Dapagliflozin (BMS512148) immune function (Cornillie et al 2001). (lavoixdesrroms.org)
This results in leukocyte activation and enhanced leukocyte‐endothelial adhesion. (comprehensivephysiology.com)
Kakkar, A.K. and Lefer, D.J. (2004) Leukocyte and endothelial adhesion molecule studies in knockout mice. (scirp.org)
Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. (cdc.gov)

Genetic heterogeneity, suggested by clusters of patients with the same human leukocyte antigen or autoimmune markers, may predispose to inflammatory bowel disease (IBD). (northwestern.edu)

Addressin is a lesser-used term to describe the group of adhesion molecules that are involved with lymphocyte homing, commonly found at high-endothelial venules (HEVs) where lymphocytes exit the blood and enter the lymph node. (wikipedia.org)
Abstract Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci. (umanitoba.ca)
A novel CD18 genomic deletion in a patient with severe leucocyte adhesion deficiency: a possible CD2/lymphocyte function-associated antigen-1 functional association in humans. (lu.se)
Human CD44 molecules appear to serve as lymphocyte adhesion molecules with numerous functions in extracellular matrix binding, cell migration, hemopoisis, and lymphocyte homing (3). (ancell.com)

Adhesion molecules are, therefore, central and critical components of the immune and inflammatory system. (umanitoba.ca)
Elevated concentrations of soluble adhesion molecules may simply reflect ongoing inflammatory processes. (umanitoba.ca)
CD31 (PECAM-1) is an adhesion receptor with signaling function that is implicated in vascular wound healing, angiogenesis and transendothelial migration of leukocyte inflammatory responses. (thetechnoant.info)
Doerschuk is interested in the mechanisms through which the lungs produce cytokines, chemokines and other regulatory inflammatory mediators in response to bacterial, viral, and other pathogens that then induce the production of other mediators and adhesion molecules on endothelial cells and result in the recruitment of leukocytes. (unclineberger.org)
Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes. (9dok.net)
Muller, W.A. (2003) Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (scirp.org)

The mechanism by which mast cell mediated angiogenesis has been attributed to synthetizing pro-angiogenic micro-molecules including heparin, histamine, basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and various cytokines such as tumor necrosis factor-a (TNF-a) and interleukin (IL)-8 (9-11). (iranpath.org)
TNF- is definitely produced primarily by triggered macrophages and T lymphocytes, among additional cells, induces additional proinflammatory cytokines including interleukin-1 (IL-1) and IL-6 and enhances leukocyte migration by inducing manifestation of adhesion molecules by endothelial cells and leukocytes. (lavoixdesrroms.org)
The early events in atherogenesis are stimulated on the one hand by cytokines that chemoattract leukocytes and on the other hand by decrease in circulating molecules that protect endothelial cells (ECs) from injury. (biomedcentral.com)
Platelets interact with leukocytes through both adhesive mechanisms as well as release of cytokines/chemokines. (comprehensivephysiology.com)
Among these proteins, annexin is known to inhibit phospholipase A2 and thus block the production of mediators and arachidonic acid metabolites such as the COX-2 enzyme, leukotrienes and prostaglandins, cytokines, interleukins, adhesion molecules and enzymes such as collagenase 24,25 . (bvsalud.org)

Endothelial-Leukocyte Adhesion Molecules Bevilacqua, M P 1993-04-01 00:00:00 One decade ago, vascular endothelium was commonly considered a 'nonÂ- stick' lining of blood vessels that functioned only to prevent blood coaguÂ- lation and to separate the vascular space from tissues. (sagepub.com)
Nowhere has the excitement been more intense than in the study of the molecular mechanisms of leukocyte adhesion to endothelium. (sagepub.com)
The selectins, two of which are found on endothelium and one on leukocytes, support adhesion through the recognition of carbohydrates. (sagepub.com)
However, endothelium that has regenerated after percutaneous coronary intervention is incompetent in terms of its integrity and function, with poorly formed cell junctions, reduced expression of antithrombotic molecules, and decreased nitric oxide production. (nature.com)
On the basis of its potential to block anti-collagen type II (CII) antibody-induced arthritis (CAIA) and to suppress the conformational activation of β 2 -integrins in leukocytes, the present study was undertaken to investigate its interference with leukocyte adherence to cytokine-activated endothelium. (biomedcentral.com)
Leukocyte rolling and firm adhesion to the synovial endothelium in an early response to the anti-CII antibody transfer were significantly decreased in ALP-pretreated mice. (biomedcentral.com)
Preventive administration of ALP as a single dose of 100 μg per mouse led to a significant suppression of leukocyte rolling on, and of firm adhesion to, the synovial venular endothelium. (biomedcentral.com)
Staphylococcus aureus interactions with the endothelium: the role of bacterial 'secretable expanded repertoire adhesive molecules' (SERAM) in disturbing host defense systems. (9dok.net)

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. (wikipedia.org)
The selectin adhesion molecules and chemoattractant receptors synergistically regulate leukocyte migration into lymphoid tissues and sites of inflammation, but little is known about how these families of receptors modulate each other's function. (upenn.edu)
Interactions between L-selectin and chemoattractant receptors were therefore examined using transfected rat basophilic leukemia cell lines (RBL-2H3) that expressed human L-selectin along with human leukocyte chemoattractant receptors. (upenn.edu)
Heparins exhibit blockade of P‐selectin‐mediated adhesion. (functionalfluidics.com)
In this study, a standardized flow adhesion assay was used to evaluate the effects of sevuparin on the adhesion of sickle whole blood to cultured endothelial cells and vascular cell adhesion molecule‐1 (VCAM‐1), and sickle‐leucocyte rolling adhesion on L‐selectin. (functionalfluidics.com)
Major cell adhesion molecule interactions include (platelet‐leukocyte) P‐selectin‐PSGL‐1 and GP1bα‐Mac‐1. (comprehensivephysiology.com)
Chen,M. and Geng,J.G. (2006): P-Selectin mediates adhesion of leukocytes, platelets and cancer cells in inflammation, thrombosis, cancer growth and metastasis. (9dok.net)
We demonstrated for the first time that gene silencing of endothelial E-selectin using siRNA transfection in human umbilical vein endothelial cells (HUVECs) causes inhibition of EPC adhesion under flow conditions. (scirp.org)
Our experiments have shown the importance of E-selectin in EPC adhesion to HUVECs and the potential utility of gene silencing of E-selectin in EPC recruitment. (scirp.org)
Yoshida, M. and Gimbrone, M.A. Jr. (1997) Novel roles for E-selectin in endothelial-leukocyte adhesion. (scirp.org)
For instance, studies in mice have demonstrated that CD4+ T cells activated in cutaneous lymph nodes upregulate trafficking determinants specific for the skin, such as P-selectin ligand, while T cells responding to antigen in intestinal lymph nodes express high levels the gut-associated adhesion molecule integrin α4β7 and acquire responsiveness to the intestinal CC-chemokine ligand CCL25 [ 2 ]. (biomedcentral.com)

In contrast, and indeed the main difference between the two molecules, ICAM molecules are involved with naïve T-cell re-circulation. (wikipedia.org)
Upregulation of ICAM-1 highlights an underlying mechanism for leucocyte influx, and could also explain the predisposition to respiratory tract viral infections following NO 2 exposure since ICAM-1 is a major receptor for rhino and respiratory syncytial viruses. (bmj.com)
1A29 mAb inhibits Phorbol 12-Myristate 13-Acetate (PMA)-induced aggregation of phytohemagglutinin (PHA)-stimulated splenic blasts, as well as the adhesion of mitogen-stimulated blasts to high endothelial venule (HEV) cells and purified ICAM-1. (bdbiosciences.com)
Endothelial members of the immunoglobulin superfamily including ICAM-l and VCAM-l / INCAM-IIO bind to leukocyte cell-surface integrins. (sagepub.com)

The comet assay was used to measure the DNA damage induced in vitro by nicotine in human leukocytes as the extent of DNA migration in the comet head area, tail length, percent DNA in the tail, and Olive tail moment. (who.int)

Recent efforts resulted in the identification, characterization, and c loning of multiple endothelial cell-surface glycoproteins that support adhesion through an interaction with specific ligands (or counter-receptors) on leukocytes. (sagepub.com)
MHC class II molecules are specialized peptide receptors that play a critical role in initiating and regulating immune responses by binding peptide fragments that are 10-30 amino acids long [ 1 ] and present them on the surface of antigen-presenting cells for recognition by CD4 + T cells. (biomedcentral.com)
Circulating memory T cells can be divided into tissue-specific subsets, which traffic through distinct tissue compartments during physiologic immune surveillance, based on their expression of adhesion molecules and chemokine receptors. (biomedcentral.com)

Human vascular endothelial cells (EC) 3 display both class I and class II MHC molecules and are directly recognized by CD8 + and CD4 + alloreactive T cells, respectively ( 12 , 13 , 14 , 15 ). (aai.org)
Polymorphonuclear neutrophils (PMNs) contribute to postischemic reperfusion damage in many organs and tissues, a prerequisite being adhesion of PMNs to vascular endothelial cells. (silverchair.com)

1997. The Leukocyte Antigen FactsBook Academic Press. (biolegend.com)

The potential of recombinant ALP to block the interactions of leukocytes with the endothelial lining was concomitantly investigated in vitro and in vivo . (biomedcentral.com)
Because adhesion processes involve orderly interactions of membrane proteins, it appeared possible that "membrane effects" of volatile anesthetics could interfere. (silverchair.com)
Examples of adhesive interactions between platelets (red) and leukocytes (blue). (comprehensivephysiology.com)

Mouse monoclonal to CD31.COB31 monoclonal reacts with human CD31, a 130-140kD glycoprotein, which is also known as platelet endothelial cell adhesion molecule-1 (PECAM-1). (thetechnoant.info)

In addition to smoke-induced alterations to membrane bound endothelial and leukocyte adhesion molecule expression, which may help explain the above phenomena, smoking has a profound influence on circulating adhesion molecule profiles, most notably sICAM-1 and specific sCD44 variants. (umanitoba.ca)
Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95. (lu.se)
We reasoned that a bias (either enrichment or depletion) of CSF T cell expression of known organ-specific trafficking determinants might suggest that homing of T cells to the subarachnoid space could be governed by a CNS-specific adhesion molecule or chemokine receptor. (biomedcentral.com)

The exact pathogenic mechanism by which capillary nonperfusion, as demonstrated by fluorescein angiography, occurs is still unclear, but recent experimental animal studies ( 3 - 5 ) demonstrate that increased leukocyte entrapment in retinal capillaries of diabetic rats is an early event associated with areas of capillary nonperfusion and the development of endothelial cell damage. (diabetesjournals.org)

However, increasing evidence suggests that specific soluble adhesion molecules are immunomodulatory, and that alterations to soluble adhesion molecule profiles may represent a significant risk factor for several diverse diseases. (umanitoba.ca)

Major histocompatibility complex (MHC) class II molecules are heterodimeric glycoproteins consisting of α and β chains, with approximate molecular mass of 33 kDa and 28 kDa respectively. (biomedcentral.com)

He continued researching multiple functions of PECAM and searching for unknown adhesion molecules. (sciencehistory.org)

Platelets contain a number of integrins and cell adhesion molecules on their surface which bind to both leukocytes and endothelial cells (green). (comprehensivephysiology.com)

3. B.F. Hynes, et al, (1993) Adv Immunol 54: 271-335. (ancell.com)

Breese et al 1994) and improved concentrations of TNF have been found in the stools of children with CD (Nicholls et Dapagliflozin (BMS512148) al 1993). (lavoixdesrroms.org)

Although the mechanism of action of volatile anesthetics remains unclear in these preliminary studies, their inhibitory effect on ischemia-induced adhesion of PMNs may be beneficial for the heart during general anesthesia. (silverchair.com)

An IL-1β-activated endothelial layer formed by a murine glomerular cell line (glEND.2) was used to assay the interaction with human leukocytes in vitro . (biomedcentral.com)

In various comÂ- binations, these and other molecules support leukocyte adhesion to the vessel wall and extravasation, key steps in our response to infection and tissue injury. (sagepub.com)

These findings support the notion that the newly uncovered properties of ALP to interfere with cytokine signalling and upregulation of adhesion molecules in endothelial cells are likely to contribute to the therapeutic potential of ALP in immune-complex-induced tissue injury. (biomedcentral.com)

Basic and translational studies address the mechanisms of host defense that focus on leukocyte recruitment, edema, and lung injury using in vivo, translational, imaging, cell biological, immunological, and molecular approaches. (unclineberger.org)
In: Proceedings of the medical defense bioscience review (1993) held in Baltimore, Maryland on 10-13 May 1993. (cdc.gov)

The 1A29 antibody can reportedly inhibit leucocyte infiltration in in vivo systems, blocks induction of experimental allergic encephalomyelitis, and reduces NK-cell adhesion to tumor cells. (bdbiosciences.com)

A statistical analysis of intravital microscopic images recorded from the knee joints of untreated control mice during an early time span of 24 hours after the transfer of anti-CII mAbs [ 10 ] revealed an antibody-induced increase in leukocyte adhesion to the vessel walls. (biomedcentral.com)

Thus, intravital fluorescence microscopic imaging of leukocyte rolling and firm adhesion to postcapillary venules were performed in the knee joints of DBA1/J mice after intravenous injection of anti-CII mAbs. (biomedcentral.com)

Unique CD18 mutations involving a deletion in the extracellular stalk region and a major truncation of the cytoplasmic domain in a patient with leukocyte adhesion deficiency type 1. (lu.se)

It is an autoimmune skin disorder characterized by the loss of intercellular adhesion of keratinocytes in the upper parts of the epidermis (acantholysis), resulting in the formation of superficial blisters. (medscape.com)

05). Exposure to 1 and 2 MAC isoflurane was similarly effective, whereas basal adhesion was not significantly influenced. (silverchair.com)

Muller discusses his work examining how leukocytes bind to endothelial cells and his fellow Pew scholars who work on endothelial cells. (sciencehistory.org)

Most of the energy (ATP) generated in the mitochondria requires oxygen, but in the absence of oxygen some energy can be generated in the cytoplasm outside of the mitochondria by glycolysis , wherein a glucose molecule produces two molecules of ATP and lactate. (benbest.com)

Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene. (lu.se)
Functional characterization of natural killer cells in type I leukocyte adhesion deficiency. (lu.se)

Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene. (wikipedia.org)

1993. Sulfur mustard inhalation induced respiratory lesions in guinea pigs: Physiological, biochemical and histological study. (cdc.gov)

Anatomy42

Organisms10

Diseases6

Chemicals and Drugs117

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes50

Disciplines and Occupations1

Technology, Industry, Agriculture1

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Increased leukocyte-endothelial2

Intercellular adhesion3

Neutrophil4

Endothelial adhesion4

Human leukocy1

Lymphocyte4

Inflammatory6

Cytokines5

Endothelium8

Selectin11

ICAM4

Migration1

Receptors3

Vascular endothelial2

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Interactions3

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Expression3

Entrapment1

Soluble1

Glycoproteins1

PECAM1

Integrins1

Immunol1

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Mechanism1

Assay1

Extravasation1

Cytokine1

Defense2

Infiltration1

Vessel1

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Extracellular1

Autoimmune1

Significantly1

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Mucosal1

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