• We have successfully used a DNA.cDNA molecular hybridization assay to directly determine the presence or absence of human beta globin gene sequences in 20 human-mouse somatic cell hybrids, each of which contained a different subset of human chromosomes. (eurekamag.com)
  • All human chromosomes were present in one or more cell lines devoid of the human beta globin gene except for 6, 8, 9, 11, and 13. (eurekamag.com)
  • Among these latter chromosomes, only chromosome 11 was present in the six hybrid clones that contained the human beta globin gene. (eurekamag.com)
  • In fact, chromosome 11 was the only human chromosome that was present in all of the six hybrid clones found to be positive for the human beta globin gene. (eurekamag.com)
  • 157-BNPT-4 contained the human beta globin gene while 157-BNPT-1 did not. (eurekamag.com)
  • two lines positive for human beta globin gene sequences also contained human gamma globin gene sequences while one line was negative for both beta and gamma gene sequences. (eurekamag.com)
  • Complete nucleotide sequence of the 5' noncoding region of rabbit beta-globin mRNA. (wikidata.org)
  • The primer mix amplifies essentially all HPV types found in the genital tract along with the human β-globin gene. (cdc.gov)
  • I. Use of a DNA copy of reticulocyte 9 S RNA to estimate globin gene dosage in mouse tissues. (wikidata.org)
  • The assay is specific for the individual human globin genes and will detect the presence of a globin gene if the relevant chromosome is present in only 10% of the cells of a hybrid population. (eurekamag.com)
  • The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. (wikipedia.org)
  • They compared fragments of DNA from individuals' beta-globin genes, which produce a protein in hemoglobin. (asu.edu)
  • On the basis of these results, the human beta and gamma globin genes have been assigned to human chromosome 11. (eurekamag.com)
  • The syntheiss of high yields of full-length reverse transcripts of globin mRNA. (wikidata.org)
  • Sequence at the 3' end of globin mRNA shows homology with immunoglobulin light chain mRNA. (wikidata.org)
  • [ 5 ] Heme and globin chains (alpha and beta) in adults are manufactured in separate cell compartments-mitochondria and cytoplasm, respectively-and then combined in cytoplasm in an amazingly accurate manner. (medscape.com)
  • In the non-pathological condition known as hereditary persistence of fetal hemoglobin (HPFH), gamma globin expression is continued into adulthood. (wikipedia.org)
  • Oxidative damage by reactive oxygen species (generated by free globin chains and labile plasma iron) is believed to be one of the main contributors to cell injury, tissue damage, and hypercoagulability in patients with thalassemia. (hindawi.com)
  • It also includes biotinylated β-globin primers as an internal control for sample amplification. (cdc.gov)
  • However, several recent publications broadly reviewing health aspects of carbon monoxide have also been used including those of the Commission of the European Communities (1974), NAS/NRC (1977), US Department of Health, Education and Welfare (1970, 1972), and Committee on the Challenges of Modern Society (1972). (inchem.org)
  • 1977). "Human beta-globin messenger RNA. (wikipedia.org)
  • He has been jointly appointed in Human Biology and Anthropology at Stanford since 1977, when he came from the Society of Fellows at the University of Michigan. (stanford.edu)
  • 1977) 1 The Sanger technique soon took over and by the 1990s it was the only technique used to sequence DNA. (blogspot.com)
  • Although the novel hexaco-ordinated globin cytoglobin was identified in activated hepatic stellate cells more than 10 years ago, its role in stellate cell biology and liver fibrosis remains enigmatic. (biomedcentral.com)
  • Also, in cases of beta-thalassemia and related conditions, gamma chain production may be maintained, possibly as a mechanism to compensate for the mutated beta-globin. (wikipedia.org)
  • Samples that are negative for HPV and the β-globin control indicate lack of a suitable sample and are considered inadequate for interpretation. (cdc.gov)
  • Also, in cases of beta-thalassemia and related conditions, gamma chain production may be maintained, possibly as a mechanism to compensate for the mutated beta-globin. (wikipedia.org)
  • 1977). "Human beta-globin messenger RNA. (wikipedia.org)
  • 1. Protein tyrosine phosphatase-dependent activation of beta-globin and delta-aminolevulinic acid synthase genes in the camptothecin-induced IW32 erythroleukemia cell differentiation. (nih.gov)
  • 11. Regulation of beta-globin mRNA accumulation by heme in dimethyl sulfoxide (DMSO)-sensitive and DMSO-resistant murine erythroleukemia cells. (nih.gov)
  • One high velocity deformation of solids symposium tokyojapan august 2427 1977 1978 licensed denied on the Missouri River itself, while the oral was learned off a license, the Bad River. (droomhus.de)
  • The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. (wikipedia.org)
  • In the non-pathological condition known as hereditary persistence of fetal hemoglobin (HPFH), gamma globin expression is continued into adulthood. (wikipedia.org)
  • 20. Butyrate induces expression of transfected human fetal and endogenous mouse embryonic globin genes in GM 979 erythroleukemia cells. (nih.gov)
  • O'Neill D, Yang J, Erdjument-Bromage H, Bornschlegel K, Tempst P, Bank A , Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. (coriell.org)
  • Other studies include erythroid differentiation, globin gene expression and related pathophysiology of sickle cell disease and other hemoglobinopathies. (nih.gov)
  • 15. Induction of globin gene expression in cultured erythroleukemia cells by butyric acid. (nih.gov)
  • Rabek JP, Papaconstantinou J , Identification of a stable nuclear RNA complementary to the 3'-end flanking sequences of the mouse beta-major globin gene. (coriell.org)
  • Sarthak Sengupta received his M.Sc (1977) and Ph.D (1983) degrees in Anthropology from Dibrugarh and Gauhati University respectively. (kalpazpublications.com)
  • Activation of γ-globin expression by hypoxia-inducible factor 1α. (nih.gov)
  • It also includes biotinylated β-globin primers as an internal control for sample amplification. (cdc.gov)
  • Samples that are negative for HPV and the β-globin control indicate lack of a suitable sample and are considered inadequate for interpretation. (cdc.gov)
  • His current research interest are genetical demography, globin gene distribution, population genetics, bio-social studies, diet and nutrition, indigenous health practices and disadvantaged tribal population groups of North East India. (kalpazpublications.com)