• Ebola virus, another filovirus, was first described in 1976 during two hemorrhagic fever epidemics in Zaire and Sudan. (cdc.gov)
  • Since 1976, 10 large filovirus outbreaks involving more than 100 persons have been documented from the Congo Basin, Gabon, Sudan, and Uganda. (cdc.gov)
  • Some medical conditions, particularly fractures, lacerations, costoclavicular syndrome, connective tissue diseases, vascular disorders such as Buerger's disease, generalized atherosclerosis, or a long history of high blood pressure, may result in the same signs and symptoms as primary Raynaud's phenomenon. (cdc.gov)
  • Collagen is a connective tissue protein that can be extracted from fish skin waste. (ipb.ac.id)
  • Steroid myopathy in connective tissue disease. (medscape.com)
  • Light-chain deposition disease (LCDD) is the deposition of monoclonal light chains in multiple organs. (medscape.com)
  • [ 5 , 6 ] LCDD was first described in 1976 in two patients with end-stage renal disease as granular deposits of free light chains in multiple organs, including the kidneys, that did not stain with Congo red. (medscape.com)
  • The wide variety of signs and symptoms in PGM3 -CDG are likely due to impaired glycosylation of proteins and lipids that are needed for the normal function of many organs and tissues. (medlineplus.gov)
  • In the acute period of pneumonia, the pathogen can be identified using PCR (polymerase chain reaction). (pedobearpics.com)
  • Many other outbreaks associated with drinking water have been reported, yet Cryptosporidium , a coccidian protozoan parasite, was only identified as a human pathogen in 1976 [6,7]. (who.int)
  • During these outbreaks, transmission chains resulted from direct person-to-person spread in households and nosocomial transmissions through contact with body fluids, dead bodies, or infectious fomites. (cdc.gov)
  • It first came to prominence in 1982 with two outbreaks in the United States associated with the consumption of hamburgers from a fast-food chain [10]. (who.int)
  • Since from these three countries, possibly due health measures such as case identifica- then Sudan faced two more outbreaks to constant movement of people across tion, contact tracing, patient isolation of EVD, in 1979 and 2004, in places their porous borders, raising a high and quarantine to break the chain of which are now part of South Sudan ( 9 ). (who.int)
  • Nonetheless, what has recently emerged is that insulin resistance alone (in the non-β-cell target tissues of the hormone) cannot cause diabetes without β-cell failure ( 10 ). (diabetesjournals.org)
  • Indeed, although targeted disruption of the muscle insulin receptor causes a marked defect of insulin action in this tissue, the phenotype of such animals is modest with a lack of diabetes ( 11 ). (diabetesjournals.org)
  • Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE. (bvsalud.org)
  • Brush AH (1976) Waterfowl feather proteins: Analysis of use in taxonomic studies. (springer.com)
  • Frenkel MJ, Gillespie JM (1976) The proteins of the keratin component of bird's beaks. (springer.com)
  • [ 20 ] Mesangial nodularity within the glomerulus occurs from the increased deposition of extracellular matrix proteins mixed with kappa light chains. (medscape.com)
  • During this process, complex chains of sugar molecules (oligosaccharides) are added to proteins and fats (lipids). (medlineplus.gov)
  • During the development of an organism, tissues are sculpted into different three-dimensional forms. (elifesciences.org)
  • The number of mitochondria in a cell can vary widely by organism , tissue , and cell type. (wikipedia.org)
  • The MCT feeding was associated with transient increases in plasma carnitine and carnitine esters, and feeding odd-chain MCT (tri-C5 or tri-C7) led to elevated levels of propionylcarnitine in plasma. (ncsu.edu)
  • [ 22 ] One study demonstrated that the concomitant injection of branched-chain amino acids with dexamethasone seemed to reverse the reduction of total protein concentration induced by the steroid in rat muscles. (medscape.com)
  • Susceptibility to infections, without concomitant hyper-IgE, reported in 1976, is caused by hypomorphic mutation in the phosphoglucomutase 3 (PGM3) gene. (medlineplus.gov)
  • To determine the effect of thiamine (vitamin B,) on collagen production during wound healing, hydroxyproline content (HP), lysyl oxidase activity (LO), and pepsin-solubilized collagen components were examined in dermis, wound fluid, and artificially induced granulation tissue from surgically wounded rats. (coek.info)
  • These conclusions are, however, based only on differences observed in neutral salt-soluble and -insoluble collagen extracts of tissue taken from cotton-induced granulomas in thiamine-deficient rats compared to normal rats. (coek.info)
  • The purpose of the current study was to compare the excitability and contractility of myooids engineered from skeletal muscles of 32-month-old rats with that of myooids engineered from adult rat tissue. (josam.org)
  • The current proteomic study revealed that impaired protein regulation was more prominent in the muscle tissue of female diabetic rats, which were more susceptible to STZ-induced diabetes. (karger.com)
  • The motor domain at the N-terminus of the myosin heavy chain binds actin filaments in an ATP-dependent manner. (elifesciences.org)
  • The light chains bind to the central neck domain of the myosin heavy chain and have structural and regulatory functions ( Heissler and Sellers, 2014 ). (elifesciences.org)
  • The C-terminal tail of the myosin heavy chain associates with the tails of other myosin heavy chains and promotes the assembly into bipolar filaments. (elifesciences.org)
  • A ) Domain organization of the myosin heavy chain and myosin fragments used to study the biochemical properties of myosin. (elifesciences.org)
  • Skeletal muscle myosin heavy chain (MHC) content was measured and MHC isoforms were separated on SDS-PAGE gels and quantified. (josam.org)
  • An additional study was identified from the terrestrial toxicity database that examined the toxicity of cobalt to growing pigs (Huck & Clawson, 1976). (europa.eu)
  • In vivo oxidation rates of systemically infused medium-chain fatty acids were evaluated using neonatal pigs. (ncsu.edu)
  • The various fatty acids were oxidized equally well, regardless of chain length, and satisfied up to 60 to 70% of the animals’ energy requirements, depending on the rate of infusion. (ncsu.edu)
  • Approximately half the fatty acids were straight chain, even 12 to 24 carbon, saturated acids, the remainder being even 16 to 24 carbon, mono-unsaturated fatty acids. (microbiologyresearch.org)
  • From the toxicokinetic behaviour of mono- and oligomeric acids in mammals it can be assumed that unsaturated monomeric C16-C18 fatty acids are more readily absorbed than saturated fatty acids like octadecanoic and isooctadecanoic acid but less readily than fatty acids with shorter chain length. (europa.eu)
  • Hence, no significant bioaccumulation in animal tissue is expected for Dimerised Fatty Acids due to general low absorbed amounts and their metabolic fate in organisms. (europa.eu)
  • Non-muscle cell contractility is critical for tissues to adopt shape changes. (elifesciences.org)
  • Genetic differences between viruses identified during the Mubende SVD outbreak were linked with epidemiological data to better interpret viral spread and contact tracing chains. (cdc.gov)
  • Abnormal samples can increase risk for poor data quality,15 we cardiac development appears to occur through a were interested in replicating these experiments process that is heterogeneous and complex, with using fresh frozen cardiac tissue instead of formalin both environmental and genetic risk factors.1 fixed tissue after decades of storage. (cdc.gov)
  • L-carnitine ( -hydroxy -trimethylaminobutyrate) is a water-soluble quaternary amine that exists naturally in micro-organisms, plants and animals and is required for the long chain fatty acid transfer from cytoplasm to mitochondrial matrix for subsequent -oxidation and energy production (Bremer, 1983). (scialert.net)
  • Rich, P. R. & Maréchal, A. The mitochondrial respiratory chain. (nature.com)
  • College of Wisconsin, current era from 28 patients with septal defects who factor HEY2 in formalin fixed tissue taken from a Milwaukee, Wisconsin, USA underwent cardiac surgery and who were enrolled in our collection of hearts with atrial septal defects congenital heart disease tissue bank. (cdc.gov)
  • [email protected] from anatomically normal tissue located at a site remote were primarily identified within malformed from the defect (right atrial appendage). (cdc.gov)
  • Ebola hemorrhagic Disease (EHD) is a severe, often-fatal disease in humans that was first identified in 1976 in Democratic Republic of the Congo (formerly Zaire) in Africa. (sciepub.com)
  • It allows you to detect foci of pneumonia in the lung tissue, to timely identify the development of pleurisy. (pedobearpics.com)
  • Myosin is a hexamer composed of two myosin heavy chains, two regulatory light chains (RLCs), and two essential light chains (ELCs) ( Figure 1A ). (elifesciences.org)
  • It is a rare disease characterized by deposition of nonamyloid immunoglobulin light chains, which unlike amyloid do not stain with Congo red and do not exhibit a fibrillar structure when examined ultrastructurally. (medscape.com)
  • A single clonal plasma cell is responsible for the overproduction of kappa chains and more rarely, lambda light chains. (medscape.com)
  • [ 9 ] although in LCDD only light chains will be observed. (medscape.com)
  • The necessary criterion to make the diagnosis of LCDD requires that all tissues to be stained for kappa and light chains and the tissue must exhibit kappa fixation along the tubular basement membrane. (medscape.com)
  • Amyloid light-chain (AL)-amyloidosis consists predominantly of lambda light chains, whereas kappa light chains are predominantly involved in LCDD. (medscape.com)
  • Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction. (academicinfluence.com)
  • Protein consists of long polypeptide chains to determine the sequences of the amino acids. (ukessays.com)
  • The sequences of amino acids in a polypeptide chain determine the final three dimensional structure of the protein which ultimately functions for various biological activities in the living organisms. (ukessays.com)
  • A protein chain folds into a distinct three dimensional shape that is stabilized by non-covalent interactions between the regions of linear sequences of amino acid and is specified by amino acid sequences. (ukessays.com)
  • To represent the primary structures of the protein, the N-terminus is always written on the left sides and the C-terminus is on the right end of the chain. (ukessays.com)
  • A single peptide may contain multiple types of secondary structures in various protein of the chain depending on its structures. (ukessays.com)
  • Ebola virus has also been implicated in small chains of transmission among persons with direct contact with intermediary hosts, mostly nonhuman primates in the central African countries of Gabon and Republic of the Congo. (cdc.gov)
  • The underlying pathophysiology of endocardial fibroelastosis (EFE) is believed to be deposition of acellular fibrocartilagenous tissue in the subendothelial layer of the endocardium predominantly involving the inflow tracts, apices of either left or both ventricles. (medscape.com)
  • Correlations were established (or verified) between the mechanical properties of the tissues and the molecular size of the keratin monomers, between the mechanical properties and the x-ray diffraction patterns of the tissues, and between the Polyacrylamide gel electrophoresis (PAGE) patterns of the keratins and certain aspects of growth patterns of the structures. (springer.com)
  • Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the importance of myosin motor activity cell and tissue shape changes. (elifesciences.org)
  • Both high- and low-molecular-weight collagenous components extracted from granulation tissue were greater for +3B, and +B,, than for -B,. The most dramatic findings were in the higher molecular weight component characterized as Type III collagen. (coek.info)
  • Threat of importation of EVD and occurs through direct contact with as an event of acute febrile illness as- in the Eastern Mediterranean tissue or bodily fluids of an infected ani- sociated with a high case fatality rate, Region mal ( 5 ). (who.int)
  • 5 mM ADP, yet few studies use such high [ADP] in permeabilized tissues and cells. (mitophysiology.org)
  • By bioaccumulation , where one form of life the other eats, toxins can accumulate in feeders up into the food chain , including to humans. (cultu.be)
  • The Mubende variant glycoprotein amino acid sequences exhibited 99.7% similarity altogether and a maximum of 96.1% glycoprotein similarity compared to historical SUDV strains from 1976. (cdc.gov)
  • LCDD is categorized as a monoclonal immunoglobulin deposition disease in the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues. (medscape.com)
  • This pendant and chain will be wrapped in acid free tissue paper and an organza gift bag. (joannasjewellery.co.uk)
  • These data are discussed in relation to previous work from our laboratory that has shown significant effects of fatty acid chain length on utilization of orally administered medium-chain triglyceride supplements. (ncsu.edu)
  • A short chain of amino acid linked by peptide bond is referred as oligopeptide and long chain is polypeptide. (ukessays.com)
  • Alpha (α) helix: it is a cylindrical rod like helical arrangement of the amino acid in the polypeptide chain which is maintained by the hydrogen bond parallel to it. (ukessays.com)
  • The alterations observed in the collagen contents and maturation of granulation tissue demonstrate an involvement of thiamine in wound repair and scar development. (coek.info)
  • Type I collagen, which has the chain composition a12, (~2 is the major collagen species in mature skin, bone, and tendon [7]. (coek.info)
  • Skin and granulation tissue also contain various amounts of type III collagen, al (III)3 [ 161. (coek.info)
  • Effect of feeding medium-chain triglycerides on the plasma carnitine ester profile. (ncsu.edu)
  • The concentration of carnitine in animals varies widely across species, tissue type and nutritional status of the animal (Rabie et al . (scialert.net)
  • The myosin motor domain, the light chain binding neck and the tail domain of the heavy chain are indicated. (elifesciences.org)
  • The defect in the myosin motor activity in these mutants is evident in developing Drosophila embryos where tissue recoil following laser ablation is decreased compared to wild-type tissue. (elifesciences.org)
  • The adjacent polypeptide chain in a β-sheet can be either parallel or antiparallel. (ukessays.com)
  • Among these factors, we can mention the accurate diagnosis, maintenance of the aseptic chain, knowledge on tooth anatomy, correct chemical-mechanical preparation, tridimensional obturation of root canal system, proservation, and when necessary, the use of intracanal medication. (bvsalud.org)
  • The risk to fish-eating predators is related to the water-fish-animal or water-invertebrate-animal aquatic food chain pathways. (europa.eu)
  • Cell adhesion molecules in the regulation of animal form and tissue pattern. (academicinfluence.com)
  • A simple method for the isolation and purification of total lipids from animal tissues. (microbiologyresearch.org)
  • We propose that the BPTI decamer, with a heparin chain threading the decamer channel, plays a functional role in the mast cell. (lu.se)
  • Prior to tissue engineering of functional skeletal muscle from satellite cells harvested from aged mammals, two key questions must be addressed. (josam.org)
  • To study the capacity of satellite cells to form into functional skeletal muscle tissue de novo in culture, we have developed several in vitro tissue models. (josam.org)
  • Improving piglet survival by nutritional means: Efforts to enhance the efficacy of medium-chain triglycerides. (ncsu.edu)
  • A soil-worm-bird pathway is designated as the terrestrial food chain as described by Romijn et al. (europa.eu)
  • This concentration suggests a substantial safety factor for exposure, further evidence that indirect toxicity for secondary poisoning through the terrestrial food chain is unlikely. (europa.eu)
  • The food chain exposures to terrestrial and aquatic organisms seem less critical compared to direct toxicity of cobalt towards wildlife birds and mammals and safe thresholds for direct toxicity will therefore also be protective for secondary poisoning through the terrestrial and aquatic food chains. (europa.eu)
  • In contrast, dermal granulation tissue has a high proportion of type III compared to the smaller amount normally present in mature skin [ 21. (coek.info)
  • This is because of the high mortality rate (up to 90%) associated with the disease, and also its propensity for person-to-person spread through close contact with infected tissues and body fluids of affected persons, particularly in the unprotected home-care setting and during preparation of bodies for burial, while spread is amplified in hospitals with poor infection control practices. (sciepub.com)
  • Methods for methanolysis of sphingolipids and direct determination of long-chain bases by gas chromatography. (microbiologyresearch.org)
  • Overall, our data highlights that myosin activity is required for rapid cell contraction and tissue folding in developing Drosophila embryos. (elifesciences.org)
  • As previously discu ssed, cobalt has a low bioaccumulation potential in both aquatic and terrestrial pathways (see section 4.4) and as an essential element for plants and animals (Gal et al 2008) homeostatic mechanisms maintain cobalt concentrations in tissues and body fluids within ideal levels by actively accumulating or depurating cobalt depending on metabolic requirements. (europa.eu)
  • We describe the energy fluxes from the environment, through the body, towards the brain with a mathematical "supply chain" model and test whether its predictions fit medical and experimental data sets from our and other research groups. (frontiersin.org)
  • Pakistan Journal of Biological Sciences, 10: 1970-1976. (scialert.net)
  • One of the great advantages of tissue engineering of skeletal muscle is that adult skeletal muscle contains many myogenic precursor stem cells, termed "satellite cells", which are involved in the repair and regeneration of skeletal muscle throughout the lifespan. (josam.org)
  • Since the first reported clinical trial in 1995, MSCs have been increasingly used for clinical research ranging from immunological intervention to tissue engineering and trauma repair[ 2 - 6 ]. (biomedcentral.com)
  • Substantial external support is always required during these events to ensure appropriate clinical management of patients, sufficient infection control procedures in difficult healthcare environments, intensive contact tracing to identify the chains of transmission of the virus. (sciepub.com)
  • The persons affected had contact with the blood or tissues of monkeys or with other infected persons. (cdc.gov)
  • Cell shape changes and cell movements drive these tissue-scale transformations. (elifesciences.org)
  • A monoclonal population of plasma cells can be detected in the bone marrow, and an altered serum-free light chain ratio is present. (medscape.com)