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  • live births
  • There are different records for different populations and the list is as follows: 1 in every 5,000-15,000 births or as high as 1 in every 300-700 live births among Yupik Eskimos of Alaska. (medigest.uk)
  • Medical
  • If you believe that you are suffering from any of the symptoms of 3 beta hydroxysteroid dehydrogenase deficiency it is important that you obtain an accurate diagnosis from a medical professional to ensure that you obtain the correct medication or treatment for your condition. (medigest.uk)
  • There are medical conditions that carry similar symptoms associated with 3 beta hydroxysteroid dehydrogenase deficiency and therefore the information provided by Medigest is offered as a guideline only and should never be used in preference to seeking professional medical advice. (medigest.uk)
  • vivo
  • To test the hypothesis that increased β-cell 11β-HSD1 is diabetogenic, we used the insulin-I promoter ( 10 ) to drive β-cell-specific 11β-HSD1 elevation in vivo in C57Bl/KsJ mice, a strain prone to high-fat (HF) diet-induced β-cell failure ( 11 ). (diabetesjournals.org)
  • Islets
  • Expression of type 1 11beta-HSD mRNA was detected by reverse transcriptase-polymerase chain reaction in islets isolated from ob/ob mice and also from human tissue. (ox.ac.uk)
  • The presence of 11beta-HSD in islets supports the concept that reactivation of inert circulating hormone precursors in a cell-specific manner plays a major role in glucocorticoid physiology in rodents and man. (ox.ac.uk)
  • molecular
  • 1 Molecular Metabolism Group, University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, U.K. (diabetesjournals.org)
  • regulates
  • Poly (ADP-ribose) polymerase (PARP-1) regulates developmental morphogenesis and chemotaxis in Dictyostelium discoideum. (nih.gov)
  • protein
  • A1 (selective 11beta-HSD1 inhibitor) abolished enzyme activity and blocked the increase in pSer(307) IRS1 and reduction in total IRS1 protein after treatment with 11DHC but not corticosterone. (ox.ac.uk)
  • Heterologous production of 11beta-HSD1, devoid of its N-terminal transmembrane segment, is possible but yields only small amounts of soluble protein. (ox.ac.uk)
  • By co-overexpressing GroEL/ES and adding an 11beta-HSD1 inhibitor during protein synthesis, we have increased the accumulation of soluble 11beta-HSD1 by more than one order of magnitude. (ox.ac.uk)
  • Moreover, active site titration of human 11beta-HSD1 revealed that at least 75% of the protein in a typical preparation represents active enzyme. (ox.ac.uk)
  • Biochemical analysis showed that the 3-hydroxyacyl-CoA dehydrogenase activity of the D-bifunctional protein was completely inactive, whereas the enoyl-CoA hydratase component was active. (steroids-australia.net)
  • Their findings showed that the D-bifunctional protein plays an essential role in the peroxisomal beta-oxidation pathway that cannot be compensated for by the L-specific bifunctional protein. (steroids-australia.net)
  • Despite aggregation as inclusion bodies might represent a source of relatively pure proteins for further refolding or extraction [ 29 - 33 ], or unexpectedly, a new type of nano-microparticulate biomaterials for biotechnological and biomedical applications [ 34 - 39 ], the use of recombinant proteins for most of biotechnological and biomedical applications requires fully soluble protein versions. (biomedcentral.com)
  • cellular
  • Crucial role of poly (ADP-ribose) polymerase (PARP-1) in cellular proliferation of Dictyostelium discoideum. (nih.gov)
  • syndrome
  • The most robust evidence in support of a pathogenetic role of this enzyme in the development of the metabolic syndrome has been reported in experimental animals, whereas results of human studies are less convincing with several case control and cross-sectional studies showing an association between with 11beta-HSD-1 setpoint and individual features of the metabolic syndrome. (unimi.it)
  • Mice
  • The benefit of higher β-cell 11β-HSD1 exhibited a threshold because homozygous MIP-HSD1 tg/tg mice and diabetic Lep db/db mice with markedly elevated β-cell 11β-HSD1 levels had impaired basal β-cell function. (diabetesjournals.org)
  • tissue
  • In this review, we discuss both the genetic and enzymatic characterization of 11beta-HSD1, as well as describing its role in physiology and pathology in a tissue-specific manner. (ox.ac.uk)
  • 11. A method of relieving inflammation of bodily tissue of a mammal suffering from multiple sclerosis which comprises administering to the mammal in need thereof a therapeutically effective anti-inflammatory amount of a pharmaceutical composition according to claim 1. (freepatentsonline.com)
  • Cells
  • In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol. (abcam.com)