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Lipid MetabolismLipidsLipid ALipid Metabolism DisordersEnergy MetabolismLipid BilayersTriglyceridesLiverFatty AcidsCholesterolLipid PeroxidationGlucosePhospholipidsLipid PeroxidesAdipose TissueFatty Acids, NonesterifiedMetabolismOxidation-ReductionInsulinDietary FatsPPAR alphaBlood GlucoseLipoproteinsLipolysisSterol Regulatory Element Binding Protein 1Gene Expression RegulationBody WeightLipogenesisInsulin ResistancePhosphatidylcholinesMice, Inbred C57BLReceptors, Cytoplasmic and NuclearHyperlipidemiasRNA, MessengerLipoprotein LipaseOrphan Nuclear ReceptorsAdipocytesMetabolic Networks and PathwaysObesityFatty LiverGene Expression ProfilingModels, BiologicalDietSignal TransductionMuscle, SkeletalAcetatesKineticsMice, KnockoutTime FactorsHomeostasisLipaseHepatocytesMolecular Sequence DataCholesterol, HDLDiet, High-FatMembrane MicrodomainsCells, CulturedChromatography, Thin LayerLipid Metabolism, Inborn ErrorsPeroxisome Proliferator-Activated ReceptorsGlycerolSterol Regulatory Element Binding ProteinsFastingMagnetic Resonance SpectroscopyChromatography, High Pressure LiquidMicrosomes, LiverRats, WistarFatty Acids, UnsaturatedOleic AcidGlycolysisRats, Sprague-DawleyCytochrome P-450 Enzyme SystemCholesterol, LDLAdipose Tissue, WhiteBiological TransportHypolipidemic AgentsCarbon RadioisotopesEatingLipoproteins, VLDLApolipoproteins ECell LineApolipoproteins BCarbohydrate MetabolismBiotransformationTranscription FactorsCarbon IsotopesCell MembranePPAR gammaMutationOleic AcidsOligonucleotide Array Sequence AnalysisCarrier ProteinsLipoproteins, LDLSterolsOxidative StressGene ExpressionOxygen ConsumptionOrgan SizeApolipoproteinsCarnitine O-Palmitoyltransferase
LipoproteinsChanges in lipidCarbohydrate metabolismBiosynthesisMetabolicDisordersLipoprotein MetabolismError of lipid metabolism2017Products of lipid digestionAccumulationControl of lipidIntracellular lipidOxidative metabolismDropletsApolipoproteinsCirculating lipid levelsAbnormal lipidHomeostasisGlucoseAtherosclerosisProteinsSynthesisIntestinalAdipose tissue2021Novel lipid2019Cardiac2020Acetyl-CoA carboxyEnzymeSerumCholesterolDietaryObesityPeroxidationDiabetesRegulatesSpecificityLiverAbstractEnzymesTumourDeficiencyGenesAffectsEndocrinology2016MoleculesFatsMechanismsRespiratoryTriglyceridesDiseasesGlycerolGeneticMitochondrial functionTumor
Lipoproteins3
Changes in lipid3
  • Fig. 4: Low glycaemic diets impair tumour SCD, which interacts with changes in lipid availability to affect tumour growth. (nature.com)
  • Our results suggest that the start of pregnancy is associated with several changes in lipid metabolism, including fewer variables associated with de novo lipogenesis and fewer PUFA-containing lipids in the circulation. (cam.ac.uk)
  • Several of the changes in lipid metabolism in healthy pregnancies were less apparent or occurred later in dams who developed GDM. (cam.ac.uk)
Carbohydrate metabolism4
Biosynthesis4
  • Despite well-known roles of lipin-1 in lipid biosynthesis and transcriptional regulation, the pathogenic mechanisms leading to rhabdomyolysis remain unknown. (nih.gov)
  • LD increments were reversed on exclusion of OA and were prevented by inhibition of acyl-CoA synthetase (with Triacsin C) and thus lipid biosynthesis. (unlp.edu.ar)
  • Yu L, Fan J, Zhou C, Xu C (2020) Chloroplast lipid biosynthesis is fine-tuned to thylakoid membrane remodeling during light acclimation. (bnl.gov)
  • Yu L, Fan J, Yan C, Xu C (2018) Starch Deficiency Enhances Lipid Biosynthesis and Turnover in Leaves. (bnl.gov)
Metabolic6
  • This unexpected dual role of FoxO1 in promoting insulin sensitivity and lipid synthesis in addition to glucose production has the potential to explain the peculiar admixture of insulin resistance and sensitivity that is commonly observed in the metabolic syndrome. (jci.org)
  • Sun B, Kudo M, Hayashi M, Qin LL, Wu LL, Liu TH, Gao M. YNCRG Alleviated Hepatic Steatosis in Metabolic Syndrome Model Rats by Improving Lipid Metabolism and Chronic Inflammatory Reaction. (lidsen.com)
  • We found that YNCRG can reduce the accumulation of lipids in the liver of rats with metabolic syndrome, probably by affecting lipid metabolism and the signaling pathway associated with inflammatory reactions. (lidsen.com)
  • In particular, we have expensive exprience in Arabidopsis molecular genetics, fluoresecence imaging, ultrastrctural studies using electron microscopy, lipid metabolic analysis using radiolabeled isotopes and physiological studies using chlorophyll fluorometers and photosynthesis systems. (bnl.gov)
  • We find that glioma tumors adapt to stress through increased recruitment of lipids, resulting in a lipid storing metabolic phenotype as a potentially targetable driver of tumor development. (lu.se)
  • Using comprehensive metabolomic analysis, we demonstrate unexpected metabolic differences in fatty acid metabolism between mutant IDH1 and IDH2 in patient samples with targetable metabolic interventions. (lu.se)
Disorders4
  • Numerous genetic disorders are caused by errors in fatty acid metabolism. (wikipedia.org)
  • These disorders may be described as fatty oxidation disorders or as a lipid storage disorders, and are any one of several inborn errors of metabolism that result from enzyme defects affecting the ability of the body to oxidize fatty acids in order to produce energy within muscles, liver, and other cell types. (wikipedia.org)
  • Levy E. Insights from human congenital disorders of intestinal lipid metabolism. (medlineplus.gov)
  • In this review we are summarizing the changes in the gut microbiome observed in spaceflight and analog models, focusing particularly on the effects on metabolism, the musculoskeletal and immune systems and neurobehavioral disorders. (frontiersin.org)
Lipoprotein Metabolism3
Error of lipid metabolism1
  • Two decades later, Sjögren-Larsson syndrome was shown to be an inborn error of lipid metabolism caused by deficient activity of fatty alcohol:NAD oxidoreductase. (medscape.com)
20173
  • 2017 Oct 11;8(1):865. (bcm.edu)
  • Therefore, in accordance with Annex VIII, Column 1, Item 8.8 of Regulation (EC) No. 1907/2006 (REACH) and with the Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance (ECHA, 2017), assessment of the toxicokinetic behaviour was conducted based on relevant available information. (europa.eu)
  • Fan J, Yu L, Xu C (2017) A Central Role for Triacylglycerol in Membrane Lipid Breakdown, Fatty Acid β-Oxidation, and Plant Survival under Extended Darkness. (bnl.gov)
Products of lipid digestion2
  • The products of lipid digestion are mixed with bile salt and vitamins to form what? (flashcardmachine.com)
  • The decomposition products of lipid digestion form mixed micelles with bile acids . (amboss.com)
Accumulation4
  • Here we show that primary myoblasts from lipin-1-deficient patients exhibit a dramatic decrease in LPIN1 expression and phosphatidic acid phosphatase 1 activity, and a significant accumulation of lipid droplets (LD). (nih.gov)
  • One of the main objectives is to discover new genetic engineering targets for enhancing lipid accumulation in plant vegetative tissues, particularly those that have synergistic effects with previously known genes, pathways or regulatory circuits. (bnl.gov)
  • Xu C, Shanklin J (2016) Triacylglycerol Metabolism, Function, and Accumulation in Plant Vegetative Tissues. (bnl.gov)
  • Hepatocellular lipid accumulation is thought to simultaneously stimulate mitochondrial fatty acid oxidation and the production of ROS, thereby promoting lipid peroxidation and damage of mitochondrial DNA (mtDNA) ( 3 ). (spandidos-publications.com)
Control of lipid2
  • We tested this hypothesis using an established mouse model of diet-induced obesity with pregnancy-associated loss of glucose tolerance and a novel lipid analysis tool, Lipid Traffic Analysis, that uses the temporal distribution of lipids to identify differences in the control of lipid metabolism through a time course. (cam.ac.uk)
  • Hesse D, Jaschke A, Chung B, Schurmann A. Trans-Golgi proteins participate in the control of lipid droplet and chylomicron formation. (medlineplus.gov)
Intracellular lipid2
  • He then moved to the Department of Biochemistry and Molecular Biology at Michigan State University where he worked with Christoph Benning as a postdoc on the biochemistry and molecular genetics of plant lipids and the molecular mechanisms of intracellular lipid transport. (bnl.gov)
  • To accomplish this, they are equipped with numerous large mitochondria and abundant intracellular lipid for oxidative metabolism. (medscape.com)
Oxidative metabolism1
Droplets2
  • Neutral lipids - involved in many cellular processes - are stored as lipid droplets (LD), those mainly cytosolic (cLD) along with a small nuclear population (nLD). (unlp.edu.ar)
  • Yu L, Fan J, Zhou C, Xu C (2021) Sterols are required for the coordinated assembly of lipid droplets in developing seeds. (bnl.gov)
Apolipoproteins1
Circulating lipid levels1
  • Enforcing cancer cell SCD expression or raising circulating lipid levels through a higher-fat CR diet confers resistance to the effects of CR. (nature.com)
Abnormal lipid2
Homeostasis2
Glucose2
Atherosclerosis2
Proteins1
  • Hydration of Lipid-binding Proteins by ten anti-parallel b-strands. (lu.se)
Synthesis2
  • ASP increases the efficiency of triacylglycerol synthesis in adipocytes leading to enhanced postprandial lipid clearance. (diabetesjournals.org)
  • We identified a lipid synthesis enzyme [acetyl CoA carboxylase 1 (ACC1)] as a synthetic lethal target in mutant IDH1 (mIDH1), but not mIDH2, cancers. (lu.se)
Intestinal1
  • Once a lipid enters the intestinal lumen, bile is secreted into the lumen to emulsify the lipid contents. (amboss.com)
Adipose tissue1
20213
  • manuscripts are undertaken in 11.7 days from acceptance to publication (median values for papers published in this journal in the second half of 2021, 1-2 days of FREE language polishing time is also included in this period). (lidsen.com)
  • Yu L, Zhou C, Fan J, Shanklin J, Xu C (2021) Mechanisms and functions of membrane lipid remodeling in plants. (bnl.gov)
  • Yu L, Zhou C, Fan J, Xu C (2021) Using 14C-acetate Pulse-chase Labeling to Study Fatty Acid and Glycerolipid Metabolism in Plant Leaves. (bnl.gov)
Novel lipid1
  • Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. (novusbio.com)
20194
  • Weekly number of ED visits were examined during January 1, 2019-May 30, 2020. (cdc.gov)
  • 2019;25(1):130-140. (broadinstitute.org)
  • Fan J, Zhou C, Yu L, Li P, Shanklin J, Xu C (2019) Diversion of Carbon Flux from Sugars to Lipids Improves the Growth of an Arabidopsis Starchless Mutant. (bnl.gov)
  • Fan J, Yu L, Xu C (2019) Dual Role for Autophagy in Lipid Metabolism in Arabidopsis. (bnl.gov)
Cardiac3
  • The cardiac tissues were used for detecting IL-1 β , nuclear factor kappa B (NF- κ B), inhibitor molecule protein (I κ B), and IL-1 receptor (IL-1R) by ELISA and P65, P-P65, I κ B, and phosphorylated inhibitor molecule protein α (P-I κ B α ) for western blotting. (hindawi.com)
  • Immunohistochemical staining was employed to assess the distribution of inflammatory cytokine IL-1 β in arteries and cardiac tissues. (hindawi.com)
  • Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism. (rndsystems.com)
20201
Acetyl-CoA carboxy1
  • Expression of sterol regulatory element binding protein 1 (SREBP-1), ATP-citrate lyase (ACL), fatty acid synthase (FAS), malic enzyme (ME), acetyl-CoA carboxylase (ACC), and stearoyl-CoA (?9) desaturase 1 (SCD1) genes in ad lib birds declined from their highest levels just prior to photo-stimulation to reduced levels as the birds came into and maintained egg production. (usda.gov)
Enzyme2
  • and Interleukin- (IL-) 1 β , IL-37, IL-38, NT-proBNP, hs-cTNI, and Ischemia-modified albumin (IMA) by enzyme-linked immunosorbent assay (ELISA). (hindawi.com)
  • Paraoxonase 1 (PON1) is an HDL associated enzyme that catalyzes a number of different reactions including the hydrolysis of the toxic oxon metabolites of the insecticides diazinon and chlorpyrifos. (cdc.gov)
Serum1
Cholesterol7
Dietary2
  • Dietary methionine influences therapy in mouse cancer models and alters human metabolism. (nature.com)
  • The increase in whole-body fatness may reduce fish fillet quality, which is a process that can be influenced by dietary lipid digestibility depending on the lipid's fatty acid profile (Caballero et al. (scielo.cl)
Obesity1
  • A recent example of the importance of adipocyte function to have profound systemic effects is provided by the report that mice specifically lacking insulin signaling in adipocytes (FIRKO mouse) are not only lean, leptin sensitive, and obesity resistant ( 1 ), but live almost 20% longer than wild-type control animals ( 2 ). (diabetesjournals.org)
Peroxidation1
Diabetes8
  • Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes. (cam.ac.uk)
  • The aim of the current study was to test the hypothesis that maternal lipid metabolism was modulated during normal pregnancy and that these modulations are altered in gestational diabetes mellitus (GDM). (cam.ac.uk)
  • Wendy Frost, Advanced Dietitian in Paediatrics, reports on an audit amongst children with type 1 diabetes carried out with the aim of identifying those who are potentially more at risk of cardiovascular disease. (uk.com)
  • Children and young people with type 1 diabetes (T1D) are faced with an increased risk of developing cardiovascular disease (CVD). (uk.com)
  • The National Institute of Clinical Excellence (NICE) guidelines 1 recommend considering statin treatment for the primary prevention of cardiovascular disease in all adults with type 1 diabetes, and offering statin treatment to adults with type 1 diabetes who are older than 40 years of age or who have had diabetes for more than 10 years. (uk.com)
  • Data was collected from hospital records and analysed for HbA1c, BMI percentile and lipids for children over 12 years of age in our paediatric diabetes clinic. (uk.com)
  • type 1 diabetes. (who.int)
  • 1%) segmental transplantations from living donors have been done, but this procedure has substantial risks for the donor (eg, splenic infarction, abscess, pancreatitis, pancreatic leak and pseudocyst, secondary diabetes), which limit its widespread use. (msdmanuals.com)
Regulates1
  • AS Mutlu, SM Gao, H Zhang, MC Wang " Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans . (bcm.edu)
Specificity1
  • These findings may have significant implications for the strength, specificity and kinetics of lipid binding. (lu.se)
Liver5
  • A study in 1979 of initiating reactions in complex lipid syntheses in rat liver peroxisomes was conducted. (medscape.com)
  • Samples of liver and abdominal fat pad were collected at the following times: 1) just prior to photo-stimulation, 2) after photo-stimulation at first egg, and 3) through peak egg production. (usda.gov)
  • Several studies on Rhamdia quelen have inves-tigated the protein requirements, and only lipid sources, such as vegetable oils, cod liver oil and lard, were tested (Losekann et al. (scielo.cl)
  • Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts. (nih.gov)
  • The pancreas is cooled in situ with iced saline slush, then removed en bloc with the liver (for transplantation into a different recipient) and the 2nd portion of the duodenum containing the ampulla of Vater. (msdmanuals.com)
Abstract1
  • ABSTRACT industrialized countries (1, 2). (lu.se)
Enzymes3
  • 1. Cholecystokinin: releases bile/pancreatic enzymes on gallbladder in presence of lipids. (flashcardmachine.com)
  • After ingested fats (lipids) are cleaved by enzymes, lipids are absorbed in the small intestine and transported via the lymphatic system into the bloodstream. (amboss.com)
  • Ingested fats (lipids) are cleaved by enzymes (e.g., pancreatic lipase ) and absorbed in the small intestine . (amboss.com)
Tumour4
  • Upregulation of stearoyl-CoA desaturase (SCD), which synthesises monounsaturated fatty acids, is required for cancer cells to proliferate in a lipid-depleted environment, and CR also impairs tumour SCD activity to cause an imbalance between unsaturated and saturated fatty acids to slow tumour growth. (nature.com)
  • By contrast, although KD also impairs tumour SCD activity, KD-driven increases in lipid availability maintain the unsaturated to saturated fatty acid ratios in tumours, and changing the KD fat composition to increase tumour saturated fatty acid levels cooperates with decreased tumour SCD activity to slow tumour growth. (nature.com)
  • Lien, E. C. & Vander Heiden, M. G. A framework for examining how diet impacts tumour metabolism. (nature.com)
  • LACTB is a tumour suppressor that modulates lipid metabolism and cell state. (broadinstitute.org)
Deficiency2
  • Lipin-1 deficiency is associated with massive rhabdomyolysis episodes in humans, precipitated by febrile illnesses. (nih.gov)
  • Microarray analysis of patients' myotubes identified 19 down-regulated and 51 up-regulated genes, indicating pleiotropic effects of lipin-1 deficiency. (nih.gov)
Genes2
  • The expression levels of LPIN1-target genes [peroxisome proliferator-activated receptors delta and alpha (PPARδ, PPARα), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), acyl-coenzyme A dehydrogenase, very long (ACADVL), carnitine palmitoyltransferase IB and 2 (CPT1B and CPT2)] were not affected while lipin-2 protein level, a closely related member of the family, was increased. (nih.gov)
  • This manuscript examined the effects of full feeding versus feed restriction of female broiler breeder chickens during egg production on the functioning of genes related to fat metabolism. (usda.gov)
Affects2
Endocrinology3
20161
  • Li N, Xu C, Li-Beisson Y, Philippar K (2016) Fatty Acid and Lipid Transport in Plant Cells. (bnl.gov)
Molecules1
  • At 300 K, the water mol- ecules in the cavity exchange positions on a time-scale of about 1 ns and exchange with external water on longer time-scales (0.01 -1 ms). Exchange of water molecules among hydration sites within the cavity should be strongly coupled to ligand motion. (lu.se)
Fats1
  • Lipids are different kinds of fats circulating in the body.Metabolism is a description of how it is made,utilized and dispensed by the body. (healthtap.com)
Mechanisms2
  • Therefore, it is important to understand the genetic regulatory mechanisms for controlling fat metabolism in poultry during rearing and breeding periods of production. (usda.gov)
  • Xu's research group focuses on understanding the regulatory mechanisms controlling lipid metabolism, trafficking and storage in plants. (bnl.gov)
Respiratory2
  • Not only did curcumin treatment increase mitochondrial DNA (mtDNA) copy number in hepatocytes, but it also increased levels of transcriptional factors that regulate mitochondrial biogenesis, including peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1α), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam). (spandidos-publications.com)
  • Any kind of tobacco smoking is harmful tothe bodily systems, includingthe cardiovascular and respiratory systems[1][2]. (who.int)
Triglycerides2
  • Triglycerides are lipid compounds composed of a glycerol esterified to 3 fatty acid chains of varying length and composition. (medscape.com)
  • [ 4 ] If pancreatitis is likely or potentially threatening and levels of triglycerides are found to be 1000 mg/dL or greater, immediate institution of lipid lowering therapy should begin. (medscape.com)
Diseases2
  • Buruli ulcer (BU) is a necrotizing infection of the skin and soft tissue caused by the environmental bacterium Mycobacterium ulcerans ( 1 , 2 ) and is 1 of 20 neglected tropical diseases recognized by the World Health Organization ( 3 ). (cdc.gov)
  • For shorter spaceflights up to 6 months, these effects could be reversed but when moving on to exploration missions of 1 year and longer, the effects may be much more serious and lead to mission failure, i.e., early return because of malnourishment and consequent diseases or even survival of space travelers as has been seen with some pioneering expeditions on Earth. (frontiersin.org)
Glycerol3
  • Since diacylglycerols are synthesized via phosphatidic acid, they will usually contain a saturated fatty acid at the C-1 position on the glycerol moiety and an unsaturated fatty acid at the C-2 position. (hmdb.ca)
  • These are glycerolipids lipids containing a common glycerol backbone to which at least one fatty acyl group is esterified. (hmdb.ca)
  • These are diacylglycerols containing a glycerol acylated at positions 1 and 2. (hmdb.ca)
Genetic3
  • This information will be useful to researchers studying the control of fat metabolism and body weight in chickens and turkeys, as well as, producers in formulating new genetic selection and feeding strategies for commercial poultry flocks. (usda.gov)
  • Dr. Xu's research group uses a combination of molecular genetic, cell biological, biochemical and physiological approaches to dissect the regulatory network governing lipid metaoblism, homoestasis and storage. (bnl.gov)
  • [ 1 ] Family studies indicated that Sjögren-Larsson syndrome (SLS) was a genetic disorder with autosomal recessive inheritance. (medscape.com)
Mitochondrial function1
  • Recent studies have identified the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) as a regulator of mitochondrial function in tissues specialized for thermogenesis, such as brown adipose. (jci.org)
Tumor2