1 tat protein. Medical search. Frequent questions

Exposure to HIV-1 trans-activator of transcription (Tat) protein potentiates the psychostimulant effects of cocaine, but the functional consequences of the interaction between HIV-1 Tat and other abused drugs is poorly understood. (eurekaselect.com)

Tat contains a protein transduction domain (PTD), which is also known as a cell-penetrating peptide. (wikipedia.org)
This work aimed to clone, express, purify and evaluate the protective effect antioxidant of this enzyme on skin cells when fused to transactivator of transcription (TAT) protein transduction domain of HIV-1 and Abalone (Ab) peptides to allow cell penetration. (pimac.org)

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)
This protein kinase is calcium-independent and phospholipid-dependent. (nih.gov)
Recent reports demonstrate that the expression of protein kinase C alpha (PKCα) in triple-negative breast cancer (TNBC) correlates with decreased survival outcomes. (oncotarget.com)
Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)
CDK9 (cyclin-dependent kinase 9) is a member of the cyclin-dependent protein kinase family. (thermofisher.com)

TAT, tyrosine aminotransferase. (rupress.org)
tyrosine, which is a building block of most proteins. (medlineplus.gov)
About 1 in 10 of all newborns have temporarily elevated levels of tyrosine (transient tyrosinemia). (medlineplus.gov)
specialized proteins called enzymes break down tyrosine in a five-step process. (medlineplus.gov)
The enzyme produced from the TAT gene, called tyrosine aminotransferase enzyme, is involved in the first step in the process. (medlineplus.gov)
Variants in the FAH , TAT , or HPD gene reduce the activity of one of the enzymes that break down tyrosine. (medlineplus.gov)

Tat then binds to cellular factors and mediates their phosphorylation, resulting in increased transcription of all HIV genes, providing a positive feedback cycle. (wikipedia.org)
In this study, HIV-1 Subtype C tat and nef genes were cloned into an expression plasmid and their expression investigated in Salmonella. (ajol.info)
His research expanded to the mechanism regulating the transcription of cellular and viral genes and characterized the protein SRSF1 as a strong inhibitor of HIV-1 replication. (fau.edu)
We found that the acidic domain of MZF-1 and the heparin-binding domain of Elk-1 facilitate the heterodimeric interaction between the two genes before the complex formation binds to the PKCα promoter. (oncotarget.com)
Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
The Tat protein activates transcription of HIV-1 genes. (nih.gov)
1, 2 To date, four genes responsible for non-syndromic X linked mental retardation have been identified using this method. (bmj.com)
Variants (also called mutations) in the FAH , TAT , and HPD genes can cause tyrosinemia types I, II, and III, respectively. (medlineplus.gov)

In molecular biology, Tat is a protein that is encoded for by the tat gene in HIV-1. (wikipedia.org)
The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. (nih.gov)
His work on RNA binding proteins and SRSF1 has been continuously funded by the NIH and has recently expanded to the study of the role played by multiple RNA binding proteins on cellular gene transcription and T cell development and functions. (fau.edu)
2017) Tat is a multifunctional viral protein that modulates cellular gene expression and functions. (fau.edu)
2015) SRSF1 inhibition of HIV-1 gene expression. (fau.edu)
2006). Covalent Attachment of Low Molecular Weight Poly(ethylene imine) Improves Tat Peptide Mediated Gene Delivery. (igem.org)
Endogenous MCM7 MicroRNA Cluster as a Novel Platform to Multiplex Small Interfering and Nucleolar RNAs for Combinational HIV-1 Gene Therapy. (ca.gov)
From NCBI Gene: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. (nih.gov)
Therefore, by synthesizing the N gene sequence of SARS-CoV-2, constructing the pET-28a (+)-N recombinant plasmid, we expressed the N protein in E.coli and obtained 15 mAbs against SARS-CoV-2-N protein by the hybridomas and ascites, then an immunochromatographic test strip method detecting N antigen was established. (pimac.org)
However, other mechanisms of disease causation have also been described where (1) a breakpoint disrupts or alters gene expression via a position effect 7 or (2) a cryptic deletion or duplication is identified at the translocation breakpoint. (bmj.com)
Study of mcr-1 Gene-Mediated Colistin Resistance in Enterobacteriaceae Isolated from Humans and Animals in Different Countries. (cdc.gov)

The nucleotide sequences of HIV-1 sub-subtypes A6, A1, A2, A3, A4, subtype B and the reference nucleotide sequence were obtained from the Los Alamos international database. (crie.ru)
This was followed-up in his post-doctoral research at UC Santa Cruz (1996-2001) where he was awarded the prestigious Human Frontier Science Program fellowship and published breakthrough work characterizing the key RNA sequences and the cellular proteins that modulate the alternative splicing of the HIV-1 messenger RNA (mRNA). (fau.edu)
Dr. Prasad and colleagues compared the sequences of the Tat protein of the two clades and noted a key difference. (flinn.org)
Mitochondria import nuclearly-encoded proteins, made in the cell cytoplasm, into the mitochondrial matrix where their mitochondrial targeting sequences are removed by proteolysis. (tcdb.org)
Bacteria also export (to the periplasm) N-tails of membrane proteins synthesized without leader sequences by a Sec (Type IIPS)-independent mechanism. (tcdb.org)

Typically, OMVs are dominated by outer membrane proteins, while the cytoplasmic membrane proteins and cytoplasmic proteins are the primary contents of MVs. (nature.com)
The protein localizes to cytoplasmic bodies. (nih.gov)
2022 ). The YidC transmembrane (TM) groove is essential for a high- affinity interaction, and the hydrophilic nature of the YidC groove plays an important role in protein transport across the cytoplasmic membrane bilayer to the periplasmic side. (tcdb.org)

Tat is a transcriptional activator protein, which stimulates RNA polymerase II-mediated transcription elongation. (uni-goettingen.de)
In binding to TAR, Tat alters the properties of the transcription complex, recruits the positive transcription elongation complex (P-TEFb) of cellular CDK9 and cyclin T1, and hence increases the production of full-length viral RNA. (wikipedia.org)
Tat protein also associates with RNA polymerase II complexes during early transcription elongation after the promoter clearance and before the synthesis of full-length TAR RNA transcript. (wikipedia.org)
This interaction of Tat with RNA polymerase II elongation complexes is P-TEFb-independent. (wikipedia.org)
The viral Tat protein enhances transcript elongation from the HIV-1 promoter, controlling the switch between latency and active viral production. (sbir.gov)

HIV-1 Tat belongs to the accessory proteins of HIV and has regulatory functions during the transcription of the viral RNA. (uni-goettingen.de)
Tat is a regulatory protein that drastically enhances the efficiency of viral transcription. (wikipedia.org)
Like other lentiviruses, HIV-1 encodes a trans-activating regulatory protein (Tat), which is essential for efficient transcription of the viral genome. (wikipedia.org)
The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. (ox.ac.uk)
The HIV-1 regulatory proteins Rev and Tat are expressed early in the virus life cycle and thus may be important targets for the immune control of HIV-1-infection and for effective vaccines. (ox.ac.uk)
CD8+ T cell responses against Tat and Rev were found in up to 19 and 37% of HIV-1-infected individuals, respectively, indicating that these regulatory proteins are important targets for HIV-1-specific CTL. (ox.ac.uk)
Tat and Nef are very important regulatory proteins of HIV-1. (ajol.info)

CDC guidelines recommend testing for HIV infection with a US Food and Drug Administration (FDA)-approved antigen/antibody immunoassay that detects HIV-1 and HIV-2 antibodies and the HIV-1 p24 antigen, with supplemental testing after a reactive assay result to differentiate between HIV-1 and HIV-2 antibodies. (medscape.com)
The harvested prokaryotic tat-GFP fusion protein will serve as an assay, allowing us to determine the kinetic parameters for our system. (igem.org)

Tat is concentrated in the nucleus and nucleolus of infected cells. (uni-goettingen.de)

During his tenure at FAU, Dr. Caputi has developed novel techniques to study RNA - RNA binding proteins interactions and made important contributions to our understanding of how cellular proteins modulate the replication of the HIV-1 genome. (fau.edu)
Mitochondrial TAT transports folded proteins in those eukaryotes with TatA and TatC subunits encoded in the mitochondrial genome. (tcdb.org)

Does the HIV-1 tat protein translocate across lipid membranes? (uni-goettingen.de)
By means of atomic force microscopy (AFM) and fluorescence microscopy binding of the protein onto solid supported planar lipid membranes was ruled out. (uni-goettingen.de)
Additionally, a Tat mutant, which has a reduced basic cluster, showed the ability of forming pores, so that fluorescent dyes with a size of 0.5 kDa could pass the lipid membrane. (uni-goettingen.de)
By means of confocal laser scanning microscopy (CLSM) the translocation of fluorescently labeled full length Tat (Tat-AF633) across lipid bilayers was visualized with a concomitant accumulation of the protein at the membrane interface. (uni-goettingen.de)
The translocation of Tat across lipid bilayers was not dependent on the concentration of Tat in a range of 0.1 - 1.0 µM, but on the presence of ions and on the presence of the cone shaped lipid DOPE. (uni-goettingen.de)
2018 ). Through YidC, proteins are inserted into the lipid bilayer via the SecYEG-dependent complex, but YidC functions as a chaperone in protein folding processes. (tcdb.org)

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. (nih.gov)
Less well appreciated is the fact that the PD-1/PD-L1 axis also regulates antiviral immune responses and is therefore modulated by a number of viruses. (frontiersin.org)

Therefore, Tat interacts with Cyclin T1 and binds to the TAR RNA element. (uni-goettingen.de)
The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. (nih.gov)

For example, MVs from E. coli under envelope stress contain multiple misfolded proteins, whose release enhances bacterial survival [ 9 ]. (nature.com)

2018) Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells. (fau.edu)
Clinical studies have shown that blocking the PD-1 pathway is effective against several types of cancer including melanoma, lymphoma, lung, and renal cancer ( Sanmamed and Chen, 2018 ). (frontiersin.org)
Together with James P. Allison, who worked on another co-inhibitory receptor called cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), Tasuku Honjo was awarded the Nobel Prize in Physiology or Medicine 2018 for the discovery of cancer therapy by inhibition of negative immune regulation ( Wolchok, 2018 ). (frontiersin.org)

Where the clade B Tat protein contained the amino acid cysteine at a specific position in the Tat protein, the clade C Tat had the amino acid serine. (flinn.org)

The main goal of the work was to analyze the characteristics of Tat protein in HIV-1 A6 variant, that is, to identify substitutions characteristic for A6 and A1 variants, as well as to compare the frequency of mutations in functionally significant domains in sub-subtype A6 and subtype B. (crie.ru)
Tat protein of sub-subtype A6 have some characteristics that make it possible to reliably distinguish it from other HIV-1 variants. (crie.ru)
Our results, obtained using live virus in an animal model to compare genetic variants, suggest that a drug that targets HIV-1 Tat might prevent the neurological effects of AIDS. (flinn.org)
An analysis of the sera from mice immunized with both variants of the protein revealed that the mRBD expressed in CHO cells provides a significantly stronger humoral immune response compared with the RBD expressed in E.coli cells. (pimac.org)

TAT data for 2017 and current public health laboratory TB testing methods are also included in this report. (cdc.gov)
2017 national averages for each of the four TAT indicators remain below national targets. (cdc.gov)

Finally, anti-HIV RNA decoys that aim to titrate out early essential viral replication proteins Tat and Rev are constructed. (ca.gov)
Titprot is a simple Monte Carlo program to titrate proteins and changed the conformation of residues, as well as rotate hydrogen atoms. (lu.se)

one is located on TAR RNA and the other one on RNA polymerase II near the exit site for nascent mRNA transcripts, which suggests the involvement of two Tat molecules in facilitating one round of HIV-1 mRNA synthesis. (wikipedia.org)
USA (3), Mexico (4), and Brazil (1) by polymerase chain reac- was used for all PCR amplification. (cdc.gov)
Origin, host range, lot composition, and polymerase chain sequence (GenBank L28944) between positions 1 and 410 (3). (cdc.gov)
1. Inoshima Y, Morooka A, Sentsui H. Detection and diagnosis of parapoxvirus by the polymerase chain reaction. (cdc.gov)

The minimum Tat sequence that can mediate specific TAR binding in vitro has been mapped to a basic domain of 10 amino acids, comprising mostly Arg and Lys residues. (wikipedia.org)
This protein was produced in an in vitro wheat germ expression system that should preserve correct conformational folding that is necessary for biological function. (novusbio.com)

Unlike the heparinase-independent transduction of isolated PTD polypeptide, internalization of full-length Tat is mediated by interactions with negatively-charged heparan sulfate proteoglycans at the cell surface. (wikipedia.org)

Firstly, it binds with high affinity to Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), found on the inner surface of the cell membrane, to facilitate Tat recruitment. (wikipedia.org)

Full length Tat is capable of translocating across a membrane even though an attached fluorescent dye alters the interaction of the protein with the membrane. (uni-goettingen.de)

This variant was absent from the gnomAD variant database ( gnomAD v2.1.1 , June 2021). (alzforum.org)

These data suggest that the next therapeutic strategy in treating PKCα-related cancer will be developed from blocking MZF-1/Elk-1 interaction through their binding domain. (oncotarget.com)

The protein consists of between 86 and 101 amino acids depending on the subtype. (wikipedia.org)
HIV type 1 (HIV-1) sub-subtype A6 is the most widespread in Russia. (crie.ru)

Tat then crosses the plasma membrane to reach the extracellular space. (wikipedia.org)
Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. (colorado.edu)
Both endogenous and enhanced green fluorescent protein (EGFP)-fused Gβ2 and Gγ2 proteins were detected in the nucleus at baseline, whereas a fraction of EGFP-Gβ2 and DsRed2-GR comigrated to the nucleus or the plasma membrane, depending on the exposure of cells to dexamethasone or somatostatin, respectively. (rupress.org)

These results illustrate that the translocation mechanism is not directly dependent on the pore formation process but presumably relies on an accumulation of the protein at the membrane, which causes a disturbance of the membrane structure to let the protein through. (uni-goettingen.de)
The nuclear localisation signal found within the PTD, GRKKR, mediates further translocation of Tat into the cell nucleus. (wikipedia.org)
The chloroplast albino 3 (ALB3) protein appears to integrate the light harvesting chlorophyll-binding protein into thylakoid membranes using a pathway that is distinct from the chloroplast Sec translocation pathway. (tcdb.org)

Inhibition of Tat has been investigated. (wikipedia.org)
Furthermore, three of the combinatorial constructs tested potently suppressed viral replication during a 1-month HIV challenge, with greater than 5-log inhibition compared with untransduced, HIV-1-infected CEM T lymphocytes. (ca.gov)

Conservation and variation of the parapoxvirus GM-CSF inhibitory factor (GIF) proteins. (cdc.gov)

In 2003, Dr. Caputi was hired as an Assistant Professor at FAU where he continued his work on the molecular biology of HIV-1 and the mechanisms regulating cellular and viral splicing. (fau.edu)

Instead, a destabilization of the membrane by Tat was observed. (uni-goettingen.de)
The size of the pores was smaller than the protein, so that the labeled protein with a mass of 11.6 kDa passed the membrane, whereas a fluorescent dye with a mass of 10 kDa could not enter the vesicles interior. (uni-goettingen.de)
These results demonstrate that pore formation is not the sole mechanism, by which the full length protein passes a membrane. (uni-goettingen.de)
Originally characterised by Frankel and Pabo (1988) and Green and Loewenstein (1988), this domain allows Tat to enter cells by crossing the cell membrane. (wikipedia.org)
They then export some of these proteins as well some mitochondrially-encoded proteins to the inter membrane space, or they insert them into the inner membrane. (tcdb.org)
Insertion of a membrane protein via the Oxa1p export machinery follows the 'positive-inside' rule for membrane protein topology. (tcdb.org)
The matrix exposed C-terminal α-helical domain of Oxa1 can bind mitochondrial ribosomes to facilitate co-translational insertion of proteins into the mitochondrial membrane ( Jia et al . (tcdb.org)
2001 ). Mitochondria have two, one for co-translational, and one for post-translational insertion of membrane proteins. (tcdb.org)
2007 ). Several Oxa1-type insertases in the ER serve as catalytically active core subunits in the ER membrane protein complex (EMC), the guided entry of tail-anchored (GET) and the GET- and EMC-like (GEL) complex. (tcdb.org)
Mitochondria inherited three inner membrane translocases Sec, TAT and Oxa1 (YidC) from its bacterial ancestor. (tcdb.org)
At different stages of the insertion process, conformational changes in YidC's TM domain and membrane core have a mechanistic effect on Pf3 coat protein insertion. (tcdb.org)

Tat secretion by infected cells is highly active, and export is the major destination for HIV-1 Tat. (wikipedia.org)

29(1): 107, 2023 08 09. (bvsalud.org)

Accession A0045 Original code A Description Missense mutation in the exon 1 Date 12-Jan-2000 (Rel. (lu.se)
1, Created) Date 03-Oct-2000 (Rel. (lu.se)
Accession A0036 Description Frameshift deletion in the exon 1 Date 11-Jan-2000 (Rel. (lu.se)
1, Created) Date 11-Jan-2000 (Rel. (lu.se)

If supplemental testing for HIV-1/HIV-2 antibodies shows nonreactive or indeterminant results (or if acute HIV infection or recent exposure is suspected or reported), an HIV-1 nucleic acid test is recommended to differentiate acute HIV-1 infection from a false-positive test result. (medscape.com)
HLA- em DRB1 /em genotypes, high disease activity, high disability scores, and high levels of acute phase proteins [2]. (exposed-skin-care.net)
Upregulation of PD-1 and its ligands PD-L1 and PD-L2 is observed during acute virus infection and after infection with persistent viruses including important human pathogens such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV). (frontiersin.org)
Experimental evidence suggests that insufficient signaling through the PD-1 pathway promotes immunopathology during acute infection by exaggerating primary T cell responses. (frontiersin.org)
The role of the PD-1/PD-L1 axis during viral infections is further complicated by evidence that PD-L1 also mediates inflammatory effects in the acute phase of an immune response. (frontiersin.org)
The nucleocapsid (N) protein of Severe Acute Respiratory syndrome Coronavirus 2 (SARS-CoV-2) is involved in viral replication, assembly and immune regulation and plays an important role in the viral life cycle. (pimac.org)

These data indicate that Tat and Rev are frequently targeted by CTL in natural HIV-1 infection and may be important targets for HIV vaccines. (ox.ac.uk)
The receptor-binding domain (RBD) of the protein S SARS-CoV-2 is considered to be one of the appealing targets for developing a vaccine against COVID-19. (pimac.org)

Sci Rep. 2020 Aug 19;10(1):14002. (brown.edu)
2020 Feb 5;20(1):45. (brown.edu)

Tat is characterized by high variability, with some amino acid substitutions, including subtypespecific ones, being able to influence on its functionality. (crie.ru)

Nonstructural HIV proteins can become a promising target of future therapeutic agents and vaccines [ 1-3 ]. (crie.ru)
The expression of Tat and Nef in Salmonella vaccines has not previously been investigated. (ajol.info)
Instead of the classical types of vaccines such as live and inactivated viruses, several novel immunogens including protein subunit and DNA vaccines as well as viral and bacterial vectors are currently being examined. (aerzteblatt.de)
The choice of an expression system is essential when developing subunit vaccines, as it ensures the effective synthesis of the correctly folded target protein, and maintains its antigenic and immunogenic properties. (pimac.org)

GT-tg transgenic mice, where Tat protein is conditionally expressed in brain by a doxycycline-dependent GFAP-linked promoter, were used to test the effects of Tat on ethanol-conditioned place preference (CPP). (eurekaselect.com)
Blocking the formation of the heterodimer by transfection of MZF-1 60-72 or Elk-1 145-157 peptide fragments at the MZF-1 / Elk-1 interface decreases DNA-binding activity of the MZF-1 / Elk-1 complex at the PKCα promoter. (oncotarget.com)

However, molecules of a size similar to that of the protein itself do not penetrate vesicles. (uni-goettingen.de)

By antagonizing the CXCR4 receptor, Tat also appears to selectively encourage the reproduction of less virulent M-tropic (macrophage-tropic) strains of HIV (which use the CCR5 receptor) early in the course of infection, allowing the more rapidly pathogenic T-tropic (T-cell-tropic) strains (which use the CXCR4 receptor) to emerge later after mutating from M-tropic strains. (wikipedia.org)
Interferon-induced transmembrane protein 1 (IFITM1) is essential for progression of laryngeal squamous cell carcinoma in an Osteopontin/NF-κB-dependent manner. (nih.gov)
Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion of tumor cells from antitumor immunity. (frontiersin.org)
Programmed cell death 1 (PD-1, also known as CD279) was discovered by Tasuku Honjo et al. (frontiersin.org)
There is ample evidence that PD-1, a member of the immunoglobulin superfamily, regulates the magnitude and quality of T cell responses. (frontiersin.org)
Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell death execution pathways downstream of ced-3 and independent of ced-9 . (colorado.edu)
Ab-TrSOD, when compared to TrSOD, promoted a decrease in the formation of ROS of 19 and 14% at the concentrations of 1 and 6 μmol/L, respectively, indicating that this joplinks Recombinant Human Regulator of G-protein form was more effective in reducing oxidative stress compared to SOD without the cell penetrating peptide (CPP). (pimac.org)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)

It has been suggested that Tat antagonists may be of use in the treatment of HIV infections. (wikipedia.org)

However, the extent to which these proteins are targeted in natural HIV-1 infection as well as precise epitopes targeted by human cytotoxic T lymphocytes (CTL) remain to be defined. (ox.ac.uk)
Our discovery that CD32a+ CD4 T lymphocytes harbor the elusive HIV-1 reservoir is a crucial step towards specific targeting and elimination of this HIV-1 reservoir. (europa.eu)

In 2001, Dr. Caputi moved to Johns Hopkins University, where he held a position of Research Scientist and continued his work on HIV-1 splicing regulation securing his first NIH R01 grant. (fau.edu)
(1) . According to the World Health Report 2001, at any given time about one person in every 10 is suffering from a mental disorder, and about one in four families has a member with a mental disorder, 20% of children and adolescents worldwide suffer from disabling mental illness, and approximately 50% of mental disorders in adults begin before the age of 14 years (2) . (who.int)

HIV disease is caused by infection with HIV-1 or HIV-2, which are retroviruses in the Retroviridae family, Lentivirus genus. (medscape.com)
1 false-positive result per 100 people diagnosed with HIV infection). (medscape.com)
While I started my career as a developmental neurobiologist and pediatric neurologist interested in how dopamine was affected during early brain injury, I shifted my research focus radically nearly 25 years ago in an attempt to repurpose already FDA-approved medicines for the treatment of neurologic disease associated with HIV-1 infection. (rochester.edu)
If chronic infection is established, however, high levels of PD-1 expression can have unfavorable immunological consequences. (frontiersin.org)
Identification of recent cases of hepatitis C virus infection using physical-chemical properties of hypervariable region 1 and a radial basis function neural network classifier. (cdc.gov)
Application of protein typing in molecular epidemiological investigation of nosocomial infection outbreak of aminoglycoside-resistant Pseudomonas aeruginosa. (cdc.gov)

Expression of IFN-induced transmembrane protein 1 in glomerular endothelial cells. (nih.gov)

The latter can replace E. coli YidC for Sec-independent insertion of proteins ( Bloois et al . (tcdb.org)
TrSOD, TAT-TrSOD-Yfp (fused to yellow fluorescent protein) and Ab-TrSOD were expressed in E.coli and purified as soluble proteins. (pimac.org)

In the present study, 57 HIV-1-infected individuals were screened for responses against Tat and Rev by using overlapping peptides spanning the entire Tat and Rev proteins. (ox.ac.uk)

APR) with self-reported laboratory workload and turnaround time (TAT) data, testing algorithms, an organi- zational chart, and responses to three required TB laboratory elements of the CoAg. (cdc.gov)

Proliferation elicited by Recombinant Human IL‑12 (1 ng/mL) is neutralized (green line) by increasing concentrations of Human IL‑12 Polyclonal Antibody (Catalog # AB-219-NA). (rndsystems.com)

Anatomy15

Organisms9

Diseases3

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes43

Information Science3

Trans-Activator of Transcription1

Transduction domain2

Kinase5

Tyrosine6

Genes8

Gene11

Sequences5

Cytoplasmic3

Elongation5

Regulatory7

Assay2

Concentrated in the nucleus1

Genome2

Lipid6

Antiviral2

Interacts2

Enhances1

20183

Serine1

Variants4

20172

Titrate2

Polymerase4

Vitro2

Interactions1

Binds1

Alters1

20211

Interaction1

Subtype2

Plasma membrane3

Translocation3

Inhibition2

Inhibitory1

Molecular biology1

Membrane11

Secretion1

20231

20004

Acute6

Targets2

20202

Amino acid1

Vaccines4

Promoter2

Molecules1

Cell8

Infections1

Lymphocytes2

20012

Infection6

Transmembrane1

Coli2

Peptides1

Responses1

Antibody1