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  • protein
  • May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. (nih.gov)
  • The phosphoinositide 3-kinase/AKT (protein kinase B) signaling pathway negatively regulates follicle activation via the forkhead box O (FOXO) transcription factor in rodents. (elsevier.com)
  • In the current study, protein localization of FOXO1, 3, and 4 as well as their upstream regulator, AKT/p-AKT, was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult. (elsevier.com)
  • Glycerol
  • In glycerophospholipids, two fatty acids are ester-linked to glycerol at C-1 and C-2, and a highly polar or charged (and therefore hydrophilic) head group is attached to C-3 through a phosphodiester bond. (wikipathways.org)
  • Plasmalogens contain a hydrocarbon chain linked to glycerol C-1 via vinyl ether linkage whereas alkylacylglycerophospholipids the alkyl substituent at glycerol C-1 is attached via an ether linkage. (wikipathways.org)
  • metabolism
  • In the present review, we focus on the following investigations of miR-210: 1) its functions of as an oncogene, 2) its functions as a tumor suppressor, 3) its functions in mitochondrial metabolism, and finally, the diagnostic and prognostic value of miR-210 in cancer researches. (biomedcentral.com)
  • activity
  • Increased kinase activity upon interaction with NCS1/FREQ. (uniprot.org)
  • Several natural and unnatural inositol phosphates and analogues were analyzed for their ability to inhibit the in vitro phosphatidylinositol 3-kinase (PI 3-kinase) activity immunoprecipitated from a leukemic T cell line by a p85 monoclonal antibody. (ox.ac.uk)
  • Bultsma Y, Keune WJ, Divecha N. PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha. (springer.com)
  • adult
  • A, Represents the average damaged leaf area in millimeters squared over a period of 5 d inflicted by 1, 5, 15, and 50 adult female spider mites. (plantphysiol.org)
  • B, Represents the number of eggs (black line) and juveniles (dotted line) produced by adult females (2-d-old at day 1 of the experiment). (plantphysiol.org)
  • The photo shows the accumulated damage on day five inflicted by 0, 1, 5, 15, and 50 adult female spider mites. (plantphysiol.org)
  • Ting, A & Zelinski, M 2017, ' Characterization of FOXO1,3 and 4 transcription factors in ovaries of fetal, prepubertal and adult rhesus macaques ' Biology of Reproduction , vol. 96, no. 5, iox034, pp. 1052-1059. (elsevier.com)