• GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of. (oncotarget.com)
  • Mechanically, GL-V9 could increase Trx-1 via activation of AMPK/FOXO3a to suppress DSS-induced colonic oxidative stress. (oncotarget.com)
  • In conclusion, our study demonstrated that GL-V9 attenuated DSS-induced colitis against oxidative stress by up-regulating Trx-1 via activation of AMPK/FOXO3a pathway, suggesting that GL-V9 might be a potential effective drug for colitis. (oncotarget.com)
  • BAK, another antimicrobial QUATS that is structurally similar to CPC, and the pesticide rotenone, a known complex 1 inhibitor, also showed mitochondrial inhibitory and antiestrogenic effects. (nih.gov)
  • Afección causada por la neurotoxina 1-METIL-4-FENIL-1,2,3,6-TETRAHIDROPIRIDINA (MPTP) que ocasiona destrucción selectiva de las neuronas nigroestriadas dopaminérgicas. (bvsalud.org)
  • Scientists can treat mice with the chemical MPTP (1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine) to create an animal model that can provide further insight into Parkinson's. (brainfacts.org)
  • alpha-Synuclein-knockout mice develop without gross abnormality and are resistant to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a mitochondrial inhibitor widely used to model parkinsonism. (ox.ac.uk)
  • Here we show that differentiated human dopaminergic neuron-like cells also have increased resistance to 1-methyl-4-phenylpyridine (MPP+), the active metabolite of MPTP, when alpha-synuclein is knocked down using RNA interference. (ox.ac.uk)
  • MPTP treatment increased the abundance of mitochondrial fission proteins such as dynamin-related protein 1 (Drp1) and phospho-Drp1 Ser616. (biomolther.org)
  • The PD model induced by N-methyl-4-phenylpyridinium (MPP + ) and/or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is one of the most adequate experimental models. (biomolther.org)
  • The glutamate transporter 1 (GLT-1)/excitatory amino acid transporter 2 (EAAT-2) is the primary transporter responsible for removing glutamate from neuronal synapses and the extracellular environment, and it is expressed particularly by astrocytes (Williams et al. (springeropen.com)
  • In the present study, we investigated the ability of quetiapine and other atypical antipsychotics to prevent 1-methyl-4-phenylpyridinium (MPP + )- and b -amyloid (25-35)-induced cell death in PC12 cells. (confex.com)
  • To determine cell survival, PC12 cells were seeded at a density of 4 x 10 4 to 5 x 10 4 cells per well on collagen-coated 96-well plates in 100 m L of culture medium. (confex.com)
  • and additional findings supported inhibition of mitochondrial complex 1 as the underlying mechanism for these effects. (nih.gov)
  • Interestingly, TG2-/- mice were protected against nigrostriatal damage induced by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine, which is converted in vivo into the mitochondrial complex I inhibitor, 1-methyl-4-phenyl-pyridinium ion. (elsevierpure.com)
  • To address whether IC 50 values of MATE1 inhibitors with regard to their extracellular concentrations are affected by the direction of MATE1-mediated transport, we established an efflux assay of 1-methyl-4-phenylpyridinium (MPP + ) and metformin using the human embryonic kidney 293 model transiently expressing human MATE1. (aspetjournals.org)
  • Other studies have shown inhibitors of CDK4 and CDK6 enhance T-cell activation, upregulating major histocompatibility complex (MHC) class I and II, and stabilize programmed death-ligand 1 (PD-L1). (drugbank.com)
  • In the present study, 179 molecules have been tested as inhibitors of the uptake of estradiol-17 beta D-glucuronide (E(2)17 beta G), substrate of OATP1B1/3 (rOatp), or 1-methyl-4-phenylpyridinium (MPP+), substrate of OCT1 (rOct1), into suspended cryopreserved hepatocytes from humans and rats. (elsevierpure.com)
  • This study supports the rationale for a commonly accepted uptake assay with metformin as an in vitro probe substrate for multidrug and toxin extrusion 1-mediated drug-drug interaction risk assessment in drug development. (aspetjournals.org)
  • With 1-methyl-4-phenylpyridinium as a substrate for DAT and NET and serotonin as a substrate for the serotonin transporter, each transporter demonstrated a distinct pattern of inhibition by a panel of amphetamine derivatives and analogs, including amphetamine, methamphetamine (also known as 'ecstasy'), p-chloroamphetamine, 3,4-methylenedioxymethamphetamine, methylphenidate (ritalin), and 5-methoxy-6-methyl-2-aminoindan. (erowid.org)
  • 1 The temporary cell cycle arrest prevents chemotherapy induced DNA damage in healthy cells, reducing the activity of caspases 3 and 7, which reduces apoptosis of healthy cells. (drugbank.com)
  • 1990. Toxicological profile for 1,2-phenylhydrazine. (cdc.gov)
  • Myelin specific CD4 + T helper cells are important in disease initiation and progression through the secretion of proinflammatory cytokines, including interferon-gamma (IFNγ), interleukin (IL)-17 and tumor necrosis factor alpha (TNFα) [1] . (plos.org)
  • Microglia/macrophage can become over-activated under certain circumstances and produce an excess of cytotoxic factors like superoxide, nitric oxide, and tumor necrosis factor-a (TNF-a) [4]. (scirp.org)
  • TLR4 signaling mediated by the linker MyD88 activates the transcription factor nuclear factor kappa B (NF-κB), thereby inducing gene expression of pro-inflammatory factors like tumor necrosis factor (TNF), IL-6, and IL-1β ( Foley, 2015 ). (frontiersin.org)
  • Ketamine, a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, is used as a pediatric anesthetic for surgical procedures. (nih.gov)
  • In vitro studies of striatal vesicles containing the vesicular monoamine transporter (VMAT2): rat versus mouse differences in sequestration of 1-methyl-4-phenylpyridinium. (nih.gov)
  • Electron microscopic images illustrated autophagic cell death, which was confirmed by a Beclin-1 and ATG expression increase, accumulation of acidic vesicles, and rescue by an autophagy inhibitor. (njit.edu)
  • Re-evaluation of 1,2-dimethylhydrazine in the mouse bone marrow micronucleus assay: Observation of a positive response. (cdc.gov)
  • Materials and Methods: Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) reduction assay. (confex.com)
  • ROS, nitrogen oxide, carbon monoxide, and H 2 S), and external signals (e.g. estrogen), which increase the amount of NEMP through nuclear respiration factor-1 (NRF1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and estrogen receptor. (inforang.com)
  • 1 , 3 When trilaciclib is given to patients with retinoblastoma protein-null small cell lung cancer, it does not interfere with the intended chemotherapy induced cytotoxicity of cancer cells. (drugbank.com)
  • 2016 ). Aquaporin-4 (AQP4) is a water channel protein that is expressed by astrocytic end-feet surrounding capillaries and is linked with water transfer into and out of the brain parenchyma (Tang and Yang 2016 ). (springeropen.com)
  • 1-methyl-4-phenyl pyridine (MPP + ) induced SK-N-SH cells were used to construct PD cell models in vitro. (nih.gov)
  • 1991. Control of 1,2-dimethylhydrazine-induced crypt hyperplasia by naturalkiller cells and its relevance to carcinogenics. (cdc.gov)
  • We previously showed that decreased IRP2 levels were observed in 1-methyl-4-phenylpyridinium (MPP + )-treated dopaminergic cells [ 25 ], supporting the physiological role of IRP2 in the control of iron balance. (nature.com)
  • Neural cells collected from the rat forebrain were incubated for 24h with 1, 10 or 20 microM ketamine alone or with ketamine plus 1, 5, 10 or 20 microM 7-nitroindazole. (nih.gov)
  • HEK-293T cells cotransfected with GPR37 and syntenin-1. (guidetopharmacology.org)
  • Furthermore, GL-V9 decreased pro-inflammatory cytokines and ROS production and increased the antioxidant defenses in the mouse macrophage cells RAW264.7 by promoting Trx-1 expression. (oncotarget.com)
  • We developed an in vitro NMJ model to investigate the differential contribution of motoneurons and muscle cells expressing ALS-causing mutation in the superoxide dismutase 1 (SOD1) to neuromuscular dysfunction. (puppyreading.com)
  • Recent rapid advances in PD genetics have revealed a prominent role for mitochondrial dysfunction in the pathogenesis of the disease, and the products of several PD-associated genes, including SNCA , Parkin , PINK1 , DJ-1 , LRRK2 and HTR2A , show a degree of localization to the mitochondria under certain conditions. (medscape.com)
  • [ 1 , 2 ] A complex interplay occurs between mitochondria and other cellular machinery that affects cell survival, as mitochondria not only have a key role in electron transport and oxidative phosphorylation, but they are also the main cellular source of free radicals, and they are involved in calcium homeostasis and in the regulation and instigation of cell-death pathways (Figure 1). (medscape.com)
  • Trilaciclib is inhibits cyclin-dependant kinase 4 (CDK4) at a concentration of 1 nmol/L and cyclin-dependent kinase 5 (CDK5) at 4 nmol/L. 1 , 6 Inhibition of CDK2, CDK5, and CDK7 is over 1000-fold less at these concentrations and inhibition of CDK9 is 50-fold less. (drugbank.com)
  • Although 1-methyl-4-phenylpyridinium (MPP + ) and metformin are prototypical substrates of MATEs, extensive studies have identified various compounds as MATE1 and MATE2-K substrates, including endogenous metabolites such as creatinine ( Terada and Inui, 2008 ). (aspetjournals.org)
  • Three compounds were previously found in the plant-lupeol (1), β-amyrin (2) and 3-β-hydroxyglutin-5-ene (3), and one is being described for the first time to occur in the species: oleanolic acid (4). (phcog.com)
  • The interleukin 1 (IL-1) cytokine family (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ) acts as DAMPs and stimulates sterile inflammation caused by necrosis and increases the inflammation with infection-related tissue damage ( Martin, 2016 ). (frontiersin.org)
  • 1 Inhibition of CDK4 and CDK5 leads to a reversible pause in the cell cycle in the G1 phase for approximately 16 hours. (drugbank.com)
  • Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
  • We treated male Wistar rats with different doses of oral nicotine and passive smoking for 4-week (short-term) and 12-week (long-term) duration, where doses closely mimic the human smoking scenario. (biochemistryconferences.com)
  • As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
  • Os resultados demonstraram que: 1. (ndltd.org)
  • We and others have found associations between PD risk and two nuclear genes involved in mitochondrial maintenance, MTIF3 (mitochondrial translation initiation factor 3) and POLG1 (DNA polymerase gamma 1). (openneurologyjournal.com)
  • However, the role and underlying mechanism of SOS1 intronic transcript 1 (SOS1-IT1) in the progression of PD is still unclear. (nih.gov)
  • 1 , 13 , 14 The catalytic mechanism involves a first step in which FAD undergoes a 2-electron reduction by NADPH. (xiahepublishing.com)
  • These drugs included 93 small-molecule drugs, 36 biologic agents, 15 vaccines, 8 in vivo diagnostic materials, and 1 over-the-counter drug. (alksignaling.com)
  • 4. LncRNA SNHG5 promotes cervical cancer progression by regulating the miR-132/SOX4 pathway. (nih.gov)
  • Asymmetric Synthesis of ( S )-2-Amino-3-(1-naphthyl)propanoic Acid via Chiral Nickel Complex. (cas.cz)
  • Rosmarinic acid (RosA) is a water-soluble phenolic compound that is an ester of caffeic acid and 3, 4-dihydroxyphenyl lactic acid. (frontiersin.org)
  • 1988. Species-specific response to the rodent carcinogens 1,2-dimethylhydrazine and 1,2-dibromo-3-chloropropane in rodent bone-marrow micronucleus assays. (cdc.gov)
  • Generally, sepsis, a major public health burden worldwide, is caused by an unbalanced response from the host to an infection ( 1 , 2 ). (spandidos-publications.com)
  • In both culture and animal models, adaptaquin suppressed elevation of ATF4 and/or CHOP and induction of Trib3 in response to 1-methyl-4-phenylpyridinium and/or 6-hydroxydopamine. (puppyreading.com)